The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite
Open accessAbstract
Development of a highly effective vaccine or antibodies for the prevention and ultimately elimination of malaria is urgently needed. Here we report the isolation of a number of human monoclonal antibodies directed against the Plasmodium falciparum (Pf) circumsporozoite protein (PfCSP) from several subjects immunized with an attenuated Pf whole-sporozoite (SPZ) vaccine (Sanaria PfSPZ Vaccine). Passive transfer of one of these antibodies, monoclonal antibody CIS43, conferred high-level, sterile protection in two different mouse models of malaria infection. The affinity and stoichiometry of CIS43 binding to PfCSP indicate that there are two sequential multivalent binding events encompassing the repeat domain. The first binding event is to a unique 'junctional' epitope positioned between the N terminus and the central repeat domain of PfCSP. Moreover, CIS43 prevented proteolytic cleavage of PfCSP on PfSPZ. Analysis of crystal structures of the CIS43 antigen-binding fragment in complex with the junctional epitope determined the molecular interactions of binding, revealed the epitope's conformational flexibility and defined Asn-Pro-Asn (NPN) as the structural repeat motif. The demonstration that CIS43 is highly effective for passive prevention of malaria has potential application for use in travelers, military personnel and elimination campaigns and identifies a new and conserved site of vulnerability on PfCSP for next-generation rational vaccine design.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Scikit-learn: Machine Learning in Python
Pedregosa, F., Varoquaux, G., Gramfort, A., Michel, V., Thirion, B., Grisel, O., Blondel, M., Müller, A., Nothman, J., Louppe, G., et al. (2012) · arXiv · doi:10.48550/arxiv.1201.0490 · Cited by 71,016
VMD: visual molecular dynamics
Humphrey, W., Dalke, A., & Schulten, K. (1996) · Journal of Molecular Graphics · doi:10.1016/0263-7855(96)00018-5 · Cited by 66,952
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 46,426
UCSF Chimera—A visualization system for exploratory research and analysis
Pettersen, E. F., Goddard, T. D., Huang, C. C., Couch, G. S., Greenblatt, D. M., Meng, E. C., & Ferrin, T. E. (2004) · Journal of Computational Chemistry · doi:10.1002/jcc.20084 · Cited by 45,828
Matplotlib: a 2D graphics environment
Hunter, J. D. (2007) · Computing in Science & Engineering · doi:10.1109/mcse.2007.55 · Cited by 39,249
[20] Processing of X-ray diffraction data collected in oscillation mode
Otwinowski, Z., & Minor, W. (1997) · Methods in Enzymology · doi:10.1016/s0076-6879(97)76066-x · Cited by 33,475
Coot : model-building tools for molecular graphics
Emsley, P., & Cowtan, K. (2004) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444904019158 · Cited by 30,571
PHENIX : a comprehensive Python-based system for macromolecular structure solution
Adams, P. D., Afonine, P. V., Bunkóczi, G., Chen, V. B., Davis, I. W., Echols, N., Headd, J. J., Hung, L.-W., Kapral, G. J., Grosse-Kunstleve, R. W., et al. (2010) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444909052925 · Cited by 23,716
The CCP4 suite: programs for protein crystallography
Collaborative Computational Project, N. 4. (1994) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444994003112 · Cited by 17,270
Scalable molecular dynamics with NAMD
Phillips, J. C., Braun, R., Wang, W., Gumbart, J., Tajkhorshid, E., Villa, E., Chipot, C., Skeel, R. D., Kalé, L., & Schulten, K. (2005) · Journal of Computational Chemistry · doi:10.1002/jcc.20289 · Cited by 16,914
PHENIX: a comprehensive Python-based system for macromolecular structure solution
Adams, P. D., Afonine, P. V., Bunkóczi, G., Chen, V. B., Davis, I. W., Echols, N., Headd, J. J., Hung, L.-W., Kapral, G. J., Grosse-Kunstleve, R. W., et al. (2012) · International Tables for Crystallography · doi:10.1107/97809553602060000865 · Cited by 7,334
CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data
Huang, J., & MacKerell, A. D. (2013) · Journal of Computational Chemistry · doi:10.1002/jcc.23354 · Cited by 4,430
MDTraj: A Modern Open Library for the Analysis of Molecular Dynamics Trajectories
McGibbon, R. T., Beauchamp, K. A., Harrigan, M. P., Klein, C., Swails, J. M., Hernández, C. X., Schwantes, C. R., Wang, L.-P., Lane, T. J., & Pande, V. S. (2015) · Biophysical Journal · doi:10.1016/j.bpj.2015.08.015 · Cited by 2,373
Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1
Wu, X., Yang, Z.-Y., Li, Y., Hogerkorp, C.-M., Schief, W. R., Seaman, M. S., Zhou, T., Schmidt, S. D., Wu, L., Xu, L., et al. (2010) · Science · doi:10.1126/science.1187659 · Cited by 1,730
Self-citationGuerois, R., Nielsen, J. E., & Serrano, L. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)00442-4 · Cited by 1,728
PlasmoDB: a functional genomic database for malaria parasites
Aurrecoechea, C., Brestelli, J., Brunk, B. P., Dommer, J., Fischer, S., Gajria, B., Gao, X., Gingle, A., Grant, G., Harb, O. S., et al. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn814 · Cited by 1,220
Tackling Exascale Software Challenges in Molecular Dynamics Simulations with GROMACS
Páll, S., Abraham, M. J., Kutzner, C., Hess, B., & Lindahl, E. (2015) · Lecture Notes in Computer Science · doi:10.1007/978-3-319-15976-8_1 · Cited by 1,208
IMGT(R), the international ImMunoGeneTics information system(R)
Lefranc, M.-P., Giudicelli, V., Ginestoux, C., Jabado-Michaloud, J., Folch, G., Bellahcene, F., Wu, Y., Gemrot, E., Brochet, X., Lane, J., et al. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn838 · Cited by 1,119
Tiller, T., Meffre, E., Yurasov, S., Tsuiji, M., Nussenzweig, M. C., & Wardemann, H. (2008) · Journal of Immunological Methods · doi:10.1016/j.jim.2007.09.017 · Cited by 1,107
Stoute, J. A., Slaoui, M., Heppner, D. G., Momin, P., Kester, K. E., Desmons, P., Wellde, B. T., Garçon, N., Krzych, U., Marchand, M., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199701093360202 · Cited by 870
Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine
Seder, R. A., Chang, L.-J., Enama, M. E., Zephir, K. L., Sarwar, U. N., Gordon, I. J., Holman, L. A., James, E. R., Billingsley, P. F., Gunasekera, A., et al. (2013) · Science · doi:10.1126/science.1241800 · Cited by 761
Self-citationDame, J. B., Williams, J. L., McCutchan, T. F., Weber, J. L., Wirtz, R. A., Hockmeyer, W. T., Maloy, W. L., Haynes, J. D., Schneider, I., Roberts, D., et al. (1984) · Science · doi:10.1126/science.6204383 · Cited by 712
Live Attenuated Malaria Vaccine Designed to Protect Through Hepatic CD8 + T Cell Immunity
Epstein, J. E., Tewari, K., Lyke, K. E., Sim, B. K. L., Billingsley, P. F., Laurens, M. B., Gunasekera, A., Chakravarty, S., James, E. R., Sedegah, M., et al. (2011) · Science · doi:10.1126/science.1211548 · Cited by 533
Self-citationBonsignori, M., Hwang, K.-K., Chen, X., Tsao, C.-Y., Morris, L., Gray, E., Marshall, D. J., Crump, J. A., Kapiga, S. H., Sam, N. E., et al. (2011) · Journal of Virology · doi:10.1128/jvi.05045-11 · Cited by 423
Self-citationSeven-Year Efficacy of RTS,S/AS01 Malaria Vaccine among Young African Children
Olotu, A., Fegan, G., Wambua, J., Nyangweso, G., Leach, A., Lievens, M., Kaslow, D. C., Njuguna, P., Marsh, K., & Bejon, P. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1515257 · Cited by 421
Rationale for Development of a Synthetic Vaccine Against Plasmodium falciparum Malaria
Zavala, F., Tam, J. P., Hollingdale, M. R., Cochrane, A. H., Quakyi, I., Nussenzweig, R. S., & Nussenzweig, V. (1985) · Science · doi:10.1126/science.2409595 · Cited by 367
Self-citationProtection against malaria at 1 year and immune correlates following PfSPZ vaccination
Ishizuka, A. S., Lyke, K. E., DeZure, A., Berry, A. A., Richie, T. L., Mendoza, F. H., Enama, M. E., Gordon, I. J., Chang, L.-J., Sarwar, U. N., et al. (2016) · Nature Medicine · doi:10.1038/nm.4110 · Cited by 367
Self-citationRational Design of an Epstein-Barr Virus Vaccine Targeting the Receptor-Binding Site
Kanekiyo, M., Bu, W., Joyce, M. G., Meng, G., Whittle, J. R. R., Baxa, U., Yamamoto, T., Narpala, S., Todd, J.-P., Rao, S. S., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.043 · Cited by 366
Self-citationVanderberg, J. P., & Frevert, U. (2004) · International Journal for Parasitology · doi:10.1016/j.ijpara.2004.05.005 · Cited by 324
Circumsporozoite protein is required for development of malaria sporozoites in mosquitoes
Ménard, R., Sultan, A. A., Cortés, C., Altszuler, R., van Dijk, M. R., Janse, C. J., Waters, A. P., Nussenzweig, R. S., & Nussenzweig, V. (1997) · Nature · doi:10.1038/385336a0 · Cited by 322
Hoffman, S. L., Billingsley, P. F., James, E., Richman, A., Loyevsky, M., Li, T., Chakravarty, S., Gunasekera, A., Chattopadhyay, R., Li, M., et al. (2010) · Human Vaccines · doi:10.4161/hv.6.1.10396 · Cited by 297
Self-citationCircumsporozoite proteins of human malaria parasites Plasmodium falciparum and Plasmodium vivax.
Nardin, E. H., Nussenzweig, V, Nussenzweig, R. S., Collins, W. E., Harinasuta, K. T., Tapchaisri, P., & Chomcharn, Y. (1982) · The Journal of experimental medicine · doi:10.1084/jem.156.1.20 · Cited by 290
Four-Year Efficacy of RTS,S/AS01E and Its Interaction with Malaria Exposure
Olotu, A., Fegan, G., Wambua, J., Nyangweso, G., Awuondo, K. O., Leach, A., Lievens, M., Leboulleux, D., Njuguna, P., Peshu, N., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1207564 · Cited by 270
Coppi, A., Tewari, R., Bishop, J. R., Bennett, B. L., Lawrence, R., Esko, J. D., Billker, O., & Sinnis, P. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.10.002 · Cited by 265
Self-citationLiao, H.-X., Levesque, M. C., Nagel, A., Dixon, A., Zhang, R., Walter, E., Parks, R., Whitesides, J., Marshall, D. J., Hwang, K.-K., et al. (2009) · Journal of Virological Methods · doi:10.1016/j.jviromet.2009.02.014 · Cited by 255
Self-citationLyke, K. E., Ishizuka, A. S., Berry, A. A., Chakravarty, S., DeZure, A., Enama, M. E., James, E. R., Billingsley, P. F., Gunasekera, A., Manoj, A., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1615324114 · Cited by 243
Self-citationGaudinski, M. R., Coates, E. E., Houser, K. V., Chen, G. L., Yamshchikov, G., Saunders, J. G., Holman, L. A., Gordon, I., Plummer, S., Hendel, C. S., et al. (2018) · PLOS Medicine · doi:10.1371/journal.pmed.1002493 · Cited by 241
Self-citationBruña-Romero, O., Hafalla, J. C. R., González-Aseguinolaza, G., Sano, G.-I., Tsuji, M., & Zavala, F. (2001) · International Journal for Parasitology · doi:10.1016/s0020-7519(01)00265-x · Cited by 225
Self-citationMarch, S., Ng, S., Velmurugan, S., Galstian, A., Shan, J., Logan, D. J., Carpenter, A. E., Thomas, D., Sim, B. K. L., Mota, M. M., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.06.005 · Cited by 212
Self-citationCasares, S., Brumeanu, T.-D., & Richie, T. L. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.05.033 · Cited by 194
White, M. T., Bejon, P., Olotu, A., Griffin, J. T., Riley, E. M., Kester, K. E., Ockenhouse, C. F., & Ghani, A. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061395 · Cited by 184
Isolation of human monoclonal antibodies from peripheral blood B cells
Huang, J., Doria-Rose, N. A., Longo, N. S., Laub, L., Lin, C.-L., Turk, E., Kang, B. H., Migueles, S. A., Bailer, R. T., Mascola, J. R., et al. (2013) · Nature Protocols · doi:10.1038/nprot.2013.117 · Cited by 168
Chapter 5 Isothermal Titration Calorimetry
Freire, E., Schön, A., & Velázquez‐Campoy, A. (2009) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(08)04205-5 · Cited by 160
Self-citationStructure of the Plasmodium falciparum Circumsporozoite Protein, a Leading Malaria Vaccine Candidate
Plassmeyer, M. L., Reiter, K., Shimp, R. L., Kotova, S., Smith, P. D., Hurt, D. E., House, B., Zou, X., Zhang, Y., Hickman, M., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.013706 · Cited by 158
Oyen, D., Torres, J. L., Wille-Reece, U., Ockenhouse, C. F., Emerling, D. E., Glanville, J., Volkmuth, W., Flores-García, Y., Zavala, F. P., Ward, A. B., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1715812114 · Cited by 156
Self-citationMarch, S., Ramanan, V., Trehan, K., Ng, S., Galstian, A., Gural, N., Scull, M. A., Shlomai, A., Mota, M. M., Fleming, H. E., et al. (2015) · Nature Protocols · doi:10.1038/nprot.2015.128 · Cited by 152
Self-citationFoquet, L., Hermsen, C. C., van Gemert, G., Braeckel, E. V., Weening, K., Sauerwein, R. W., Meuleman, P., & Leroux-Roels, G. G. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70349 · Cited by 150
Neutralization of Plasmodium falciparum Merozoites by Antibodies against PfRH5
Douglas, A. D., Williams, A. R., Knuepfer, E., Illingworth, J. J., Furze, J. M., Crosnier, C., Choudhary, P., Bustamante, L. Y., Zakutansky, S. E., Awuah, D., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1302045 · Cited by 145
Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies
Triller, G., Scally, S. W., Costa, G., Pissarev, M., Kreschel, C., Bosch, A., Marois, É., Sack, B. K., Murugan, R., Salman, A. M., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.11.007 · Cited by 132
Self-citationEpstein, J. E., Rao, S., Williams, F. B., Freilich, D., Luke, T. C., Sedegah, M., Vega, P. D. L., Sacci, J. B., Richie, T. L., & Hoffman, S. L. (2007) · The Journal of Infectious Diseases · doi:10.1086/518510 · Cited by 128
Self-citationMurphy, S. C., Prentice, J. L., Williamson, K., Wallis, C. K., Fang, F. C., Fried, M., Pinzon, C., Wang, R., Talley, A. K., Kappe, S. H. I., et al. (2012) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2012.10-0658 · Cited by 124
Self-citationComplete attenuation of genetically engineered Plasmodium falciparum sporozoites in human subjects
Kublin, J. G., Mikolajczak, S. A., Sack, B. K., Fishbaugher, M. E., Seilie, A. M., Shelton, L., VonGoedert, T., Firat, M., Magee, S., Fritzen, E., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aad9099 · Cited by 105
Self-citationPlasmodium falciparum antigenic diversity: Evidence of clonal population structure
Rich, S. M., Hudson, R. R., & Ayala, F. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13040 · Cited by 99
Wheatley, A. K., Whittle, J. R. R., Lingwood, D., Kanekiyo, M., Yassine, H. M., Steven, S., Narpala, S., Prabhakaran, M. S., Matus‐Nicodemos, R., Bailer, R. T., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402835 · Cited by 98
Self-citationBinding and Invasion of Liver Cells by Plasmodium falciparum Sporozoites
Rathore, D., Sacci, J. B., Vega, P. D. L., & McCutchan, T. F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m106862200 · Cited by 95
Ancsin, J. B., & Kisilevsky, R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401979200 · Cited by 92
Sack, B. K., Miller, J. L., Vaughan, A. M., Douglass, A. N., Kaushansky, A., Mikolajczak, S. A., Coppi, A., González‐Aseguinolaza, G., Tsuji, M., Zavala, F. P., et al. (2013) · Infection and Immunity · doi:10.1128/iai.01249-13 · Cited by 90
Self-citationPlasmodium Falciparum-Infected Anopheles Stephensi Inconsistently Transmit Malaria to Humans
Rickman, L. S., Jones, T. R., Long, G. W., Paparello, S. F., Schneider, I., Paul, C. F., Beaudoin, R. L., & Hoffman, S. L. (1990) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1990.43.441 · Cited by 86
Self-citationEspinosa, D. A., Gutierrez, G. M., Rojas-López, M., Noe, A. R., Shi, L., Tse, S., Sinnis, P., & Zavala, F. P. (2015) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv154 · Cited by 86
Self-citationVaughan, A. M., Mikolajczak, S. A., Camargo, N. M., Lakshmanan, V., Kennedy, M. F., Lindner, S. E., Miller, J. L., Hume, J. C. C., & Kappe, S. H. I. (2012) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2012.10.004 · Cited by 76
Self-citationZeeshan, M., Alam, M. T., Vinayak, S., Bora, H., Tyagi, R. K., Alam, M. S., Choudhary, V., Mittra, P., Lumb, V., Bharti, P. K., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043430 · Cited by 70
Espinosa, D. A., Christensen, D., Muñoz, C. A., Singh, S. P., Locke, E., Andersen, P. L., & Zavala, F. P. (2017) · npj Vaccines · doi:10.1038/s41541-017-0011-y · Cited by 68
Self-citationBriney, B. S., Willis, J. R., Hicar, M. D., Thomas, J. W., & Crowe, J. E. (2012) · Immunology · doi:10.1111/j.1365-2567.2012.03605.x · Cited by 65
Fisher, C. R., Sutton, H. J., Kaczmarski, J. A., McNamara, H. A., Clifton, B. E., Mitchell, J. A., Cai, Y., Dups, J., D'Arcy, N. J., Singh, M., et al. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006469 · Cited by 53
Sack, B. K., Mikolajczak, S. A., Fishbaugher, M. E., Vaughan, A. M., Flannery, E. L., Nguyen, T. U., Betz, W., Navarro, M. J., Foquet, L., Steel, R. W. J., et al. (2017) · npj Vaccines · doi:10.1038/s41541-017-0028-2 · Cited by 51
Self-citationGhasparian, A., Moehle, K., Linden, A., & Robinson, J. A. (2005) · Chemical Communications · doi:10.1039/b510812h · Cited by 44
Tanabe, K., Mita, T., Palacpac, N., Arisue, N., Tougan, T., Kawai, S., Jombart, T., Kobayashi, F., & Horii, T. (2013) · Vaccine · doi:10.1016/j.vaccine.2012.12.039 · Cited by 34
Cited by
Malaria Vaccines: Recent Advances and New Horizons
Draper, S. J., Sack, B. K., King, C. R., Nielsen, C. M., Rayner, J. C., Higgins, M. K., Long, C. A., & Seder, R. A. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.06.008 · Cited by 331
Self-citationHIV-1 Vaccines Based on Antibody Identification, B Cell Ontogeny, and Epitope Structure
Kwong, P. D., & Mascola, J. R. (2018) · Immunity · doi:10.1016/j.immuni.2018.04.029 · Cited by 304
Self-citationMalaria vaccines since 2000: progress, priorities, products
Duffy, P. E., & Patrick Gorres, J. (2020) · npj Vaccines · doi:10.1038/s41541-020-0196-3 · Cited by 266
Suscovich, T. J., Fallon, J. K., Das, J., Demas, A. R., Crain, J., Linde, C. H., Michell, A., Natarajan, H., Arevalo, C., Broge, T., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.abb4757 · Cited by 142
Self-citationBroadly inhibitory antibodies to severe malaria virulence proteins
Reyes, R. A., Raghavan, S. S. R., Hurlburt, N. K., Introini, V., Bol, S., Kana, I. H., Jensen, R. W., Martinez-Scholze, E., Gestal-Mato, M., López-Gutiérrez, B., et al. (2024) · Nature · doi:10.1038/s41586-024-08220-3 · Cited by 35
Self-citation
Metadata
- Authors
- Kisalu, N. K., Idris, A. H., Weidle, C., Flores-Garcia, Y., Flynn, B. J., Sack, B. K., Murphy, S., Schön, A., Freire, E., Francica, J. R., Miller, A. B., Gregory, J., March, S., Liao, H.-X., Haynes, B. F., Wiehe, K., Trama, A. M., Saunders, K. O., Gladden, M. A., Monroe, A., Bonsignori, M., Kanekiyo, M., Wheatley, A. K., McDermott, A. B., Farney, S. K., Chuang, G.-Y., Zhang, B., Kc, N., Chakravarty, S., Kwong, P. D., Sinnis, P., Bhatia, S. N., Kappe, S. H. I., Sim, B. K. L., Hoffman, S. L., Zavala, F., Pancera, M., & Seder, R. A.
- Venue
- Nature Medicine
- Published
- 2018-03-19
- Volume
- 24
- Issue
- 4
- Pages
- 408-416
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2791741332
- Cited by
- 293
- References
- 67
- FWCI
- 31.72
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.