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Cited by 592

The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.

Vaccines: past, present and future

Open access
Plotkin, Stanley A·2005·Nature Medicine
DOI 10.1038/nm1209
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Abstract

The vaccines developed over the first two hundred years since Jenner's lifetime have accomplished striking reductions of infection and disease wherever applied. Pasteur's early approaches to vaccine development, attenuation and inactivation, are even now the two poles of vaccine technology. Today, purification of microbial elements, genetic engineering and improved knowledge of immune protection allow direct creation of attenuated mutants, expression of vaccine proteins in live vectors, purification and even synthesis of microbial antigens, and induction of a variety of immune responses through manipulation of DNA, RNA, proteins and polysaccharides. Both noninfectious and infectious diseases are now within the realm of vaccinology. The profusion of new vaccines enables new populations to be targeted for vaccination, and requires the development of routes of administration additional to injection. With all this come new problems in the production, regulation and distribution of vaccines.

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Crossref · 10.1038/nm1209

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Metadata

Authors
Plotkin, S. A.
Venue
Nature Medicine
Publisher
Springer Science and Business Media LLC
Published
2005-04
Volume
11
Issue
S4
Pages
S5-S11
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
DOI
10.1038/nm1209
OpenAlex
W2034219960
Cited by
592
References
63
FWCI
6.55
Type
journal article
Language
en
Open access
bronze

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.