Generation of C5a in the absence of C3: a new complement activation pathway

Complement: a key system for immune surveillance and homeostasis

Ricklin, D., Hajishengallis, G., Yang, K., & Lambris, J. D. (2010) · Nature Immunology · doi:10.1038/ni.1923 · Cited by 3,654

Complement and its role in innate and adaptive immune responses

Dunkelberger, J. R., & Song, W.-C. (2010) · Cell Research · doi:10.1038/cr.2009.139 · Cited by 1,932

Complement System Part I – Molecular Mechanisms of Activation and Regulation

Merle, N. S., Church, S. E., Fremeaux-Bacchi, V., & Roumenina, L. T. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00262 · Cited by 1,620

The immune system’s role in sepsis progression, resolution, and long-term outcome

Delano, M. J., & Ward, P. A. (2016) · Immunological Reviews · doi:10.1111/imr.12499 · Cited by 880

Discovery and Development of the Complement Inhibitor Eculizumab for the Treatment of Paroxysmal Nocturnal Hemoglobinuria

Rother, R. P., Rollins, S. A., Mojcik, C. F., Brodsky, R. A., & Bell, L. (2007) · Nature Biotechnology · doi:10.1038/nbt1344 · Cited by 778

The role of the anaphylatoxins in health and disease

Klos, A., Tenner, A. J., Johswich, K.-O., Ager, R. R., Reis, E. S., & Köhl, J. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2009.04.027 · Cited by 730

The Role of Complement in Inflammatory Diseases From Behind the Scenes into the Spotlight

Markiewski, M. M., & Lambris, J. D. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.070166 · Cited by 722

TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord

Kroner, A., Greenhalgh, A. D., Zarruk, J. G., Passos dos Santos, R., Gaestel, M., & David, S. (2014) · Neuron · doi:10.1016/j.neuron.2014.07.027 · Cited by 655

Thromboinflammation: challenges of therapeutically targeting coagulation and other host defense mechanisms

Jackson, S. P., Darbousset, R., & Schoenwaelder, S. M. (2019) · Blood · doi:10.1182/blood-2018-11-882993 · Cited by 616

Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells

Strainic, M. G., Liu, J., Huang, D., An, F., Lalli, P. N., Muqim, N., Shapiro, V. S., Dubyak, G. R., Heeger, P. S., & Medof, M. E. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.001 · Cited by 580

Thrombomodulin Mutations in Atypical Hemolytic–Uremic Syndrome

Delvaeye, M., Noris, M., De Vriese, A., Esmon, C. T., Esmon, N. L., Ferrell, G., Del-Favero, J., Plaisance, S., Claes, B., Lambrechts, D., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810739 · Cited by 554

Thrombosis in paroxysmal nocturnal hemoglobinuria

Hill, A., Kelly, R. J., & Hillmen, P. (2013) · Blood · doi:10.1182/blood-2012-09-311381 · Cited by 478

Phagocyte-derived catecholamines enhance acute inflammatory injury

Flierl, M. A., Rittirsch, D., Nadeau, B. A., Chen, A. J., Sarma, J. V., Zetoune, F. S., McGuire, S. R., List, R. P., Day, D. E., Hoesel, L. M., et al. (2007) · Nature · doi:10.1038/nature06185 · Cited by 475

Paroxysmal nocturnal haemoglobinuria

Hill, A., DeZern, A. E., Kinoshita, T., & Brodsky, R. A. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.28 · Cited by 448

The role of complement in biomaterial-induced inflammation

Nilsson, B., Ekdahl, K. N., Mollnes, T. E., & Lambris, J. D. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2006.06.020 · Cited by 431

Complement and Its Receptors: New Insights into Human Disease

Holers, V. M. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120154 · Cited by 430

Humoral immunity, inflammation and cancer

Tan, T.-T., & Coussens, L. M. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.01.001 · Cited by 417

Context-dependent roles of complement in cancer

Roumenina, L. T., Daugan, M. V., Petitprez, F., Sautès-Fridman, C., & Fridman, W. H. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0210-0 · Cited by 389

Microglia Phenotypes in Aging and Neurodegenerative Diseases

Wendimu, M. Y., & Hooks, S. B. (2022) · Cells · doi:10.3390/cells11132091 · Cited by 336

Plasma complement components and activation fragments: Associations with age-related macular degeneration genotypes and phenotypes

Reynolds, R., Hartnett, M. E., Atkinson, J. P., Giclas, P. C., Rosner, B., & Seddon, J. M. (2009) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.09-3928 · Cited by 294

Intravascular immunity: the host–pathogen encounter in blood vessels

Hickey, M. J., & Kubes, P. (2009) · Nature Reviews Immunology · doi:10.1038/nri2532 · Cited by 251

New Insights of an Old Defense System: Structure, Function, and Clinical Relevance of the Complement System

Ehrnthaller, C., Ignatius, A., Gebhard, F., & Huber-Lang, M. (2011) · Molecular Medicine · doi:10.2119/molmed.2010.00149 · Cited by 226

Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis

Langer, H. F., Chung, K.-J., Orlova, V. V., Choi, E. Y., Kaul, S., Kruhlak, M. J., Alatsatianos, M., DeAngelis, R. A., Roche, P. A., Magotti, P., et al. (2010) · Blood · doi:10.1182/blood-2010-01-261503 · Cited by 176

The complement cascade: Yin-Yang in neuroinflammation—neuro-protection and -degeneration

Alexander, J. J., Anderson, A. J., Barnum, S. R., Stevens, B., & Tenner, A. J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05668.x · Cited by 177

Crosstalk between the renin–angiotensin, complement and kallikrein–kinin systems in inflammation

Bekassy, Z., Lopatko Fagerström, I., Bader, M., & Karpman, D. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-021-00634-8 · Cited by 167

C5a and TNF-α Up-Regulate the Expression of Tissue Factor in Intra-Alveolar Neutrophils of Patients with the Acute Respiratory Distress Syndrome

Kambas, K., Markiewski, M. M., Pneumatikos, I. A., Rafail, S. S., Theodorou, V., Konstantonis, D., Kourtzelis, I., Doumas, M. N., Magotti, P., DeAngelis, R. A., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.11.7368 · Cited by 127

Dendritic cell function in allostimulation is modulated by C5aR signaling

Peng, Q., Li, K., Wang, N., Li, Q., Asgari, E., Lu, B., Woodruff, T. M., Sacks, S. H., & Zhou, W. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804186 · Cited by 116

The relative importance of local and systemic complement production in ischaemia, transplantation and other pathologies

Li, K., Sacks, S. H., & Zhou, W. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.06.006 · Cited by 98

Deficiency of complement C3a and C5a receptors prevents angiotensin II–induced hypertension via regulatory T cells

Chen, X.-H., Ruan, C.-C., Ge, Q., Ma, Y., Xu, J.-Z., Zhang, Z.-B., Lin, J.-R., Chen, D.-R., Zhu, D.-L., & Gao, P.-J. (2018) · Circulation Research · doi:10.1161/circresaha.117.312153 · Cited by 92

C5a Enhances Dysregulated Inflammatory and Angiogenic Responses to Malaria In Vitro: Potential Implications for Placental Malaria

Conroy, A., Serghides, L., Finney, C., Owino, S. O., Kumar, S., Gowda, D. C., Liles, W. C., Moore, J. M., & Kain, K. C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004953 · Cited by 81

Complement deficiency promotes cutaneous wound healing in mice

Rafail, S., Kourtzelis, I., Foukas, P. G., Markiewski, M. M., DeAngelis, R. A., Guariento, M., Ricklin, D., Grice, E. A., & Lambris, J. D. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402354 · Cited by 72

C5a anaphylatoxin and its role in critical illness-induced organ dysfunction

Wood, A. J. T., Vassallo, A., Summers, C., Chilvers, E. R., & Conway‐Morris, A. (2018) · European Journal of Clinical Investigation · doi:10.1111/eci.13028 · Cited by 45

ATP-Nlrp3 Inflammasome-Complement Cascade Axis in Sterile Brain Inflammation in Psychiatric Patients and its Impact on Stem Cell Trafficking

Ratajczak, M. Z., Mack, A., Bujko, K., Domingues, A., Pedziwiatr, D., Kucia, M., Ratajczak, J., Ulrich, H., Kucharska-Mazur, J., & Samochowiec, J. (2019) · Stem Cell Reviews and Reports · doi:10.1007/s12015-019-09888-1 · Cited by 32

Sterile Inflammation of Brain, due to Activation of Innate Immunity, as a Culprit in Psychiatric Disorders

Ratajczak, M. Z., Pedziwiatr, D., Cymer, M., Kucia, M., Kucharska-Mazur, J., & Samochowiec, J. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00060 · Cited by 27

Complement activation: a critical mediator of adverse fetal outcomes in placental malaria?

Conroy, A. L., McDonald, C. R., Silver, K. L., Liles, W. C., & Kain, K. C. (2011) · Trends in Parasitology · doi:10.1016/j.pt.2011.02.005 · Cited by 26

Complement halts angiogenesis gone wild

Kahr, W. H. A. (2010) · Blood · doi:10.1182/blood-2010-08-297648 · Cited by 11