Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

Notch Signaling: Cell Fate Control and Signal Integration in Development

Artavanis-Tsakonas, S., Rand, M. D., & Lake, R. J. (1999) · Science · doi:10.1126/science.284.5415.770 · Cited by 5,909

Generalized lacZ expression with the ROSA26 Cre reporter strain

Soriano, P. (1999) · Nature Genetics · doi:10.1038/5007 · Cited by 5,237

Bone Marrow Stromal Stem Cells: Nature, Biology, and Potential Applications

Bianco, P., Riminucci, M., Gronthos, S., & Robey, P. G. (2001) · Stem Cells · doi:10.1634/stemcells.19-3-180 · Cited by 1,944

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

Schroeter, E. H., Kisslinger, J. A., & Kopan, R. (1998) · Nature · doi:10.1038/30756 · Cited by 1,624

Reaching a Genetic and Molecular Understanding of Skeletal Development

Karsenty, G., & Wagner, E. F. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00157-0 · Cited by 1,611

Mutations in NOTCH1 cause aortic valve disease

Garg, V., Muth, A. N., Ransom, J. F., Schluterman, M. K., Barnes, R., King, I. N., Grossfeld, P. D., & Srivastava, D. (2005) · Nature · doi:10.1038/nature03940 · Cited by 1,509

HES and HERP families: Multiple effectors of the notch signaling pathway

Iso, T., Kedes, L., & Hamamori, Y. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10208 · Cited by 1,259

Stromal Stem Cells: Marrow‐Derived Osteogenic Precursors

Owen, M. E., & Friedenstein, A. J. (2007) · Novartis Foundation symposium · doi:10.1002/9780470513637.ch4 · Cited by 1,225

Notch signaling is essential for vascular morphogenesis in micePreprint

Krebs, L. T., Xue, Y., Norton, C. R., Shutter, J. R., Maguire, M., Sundberg, J. P., Gallahan, D., Closson, V., Kitajewski, J., Callahan, R., et al. (2000) · Genes & Development · doi:10.1101/gad.14.11.1343 · Cited by 1,065

Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer

Logan, M., Martin, J. F., Nagy, A., Lobe, C., Olson, E., & Tabin, C. (2002) · Genesis · doi:10.1002/gene.10092 · Cited by 1,022

Mechanisms of bone development and repair

Salhotra, A., Shah, H. N., Lévi, B., & Longaker, M. T. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00279-w · Cited by 1,302

Building strong bones: molecular regulation of the osteoblast lineage

Long, F. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3254 · Cited by 1,211

Notch signaling pathway: architecture, disease, and therapeutics

Zhou, B., Lin, W., Long, Y., Yang, Y., Zhang, H., Wu, K., & Chu, Q. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00934-y · Cited by 1,216

Endothelial Notch activity promotes angiogenesis and osteogenesis in bone

Ramasamy, S. K., Kusumbe, A. P., Wang, L., & Adams, R. H. (2014) · Nature · doi:10.1038/nature13146 · Cited by 1,071

Bone biomaterials and interactions with stem cells

Gao, C., Peng, S., Feng, P., & Shuai, C. (2017) · Bone Research · doi:10.1038/boneres.2017.59 · Cited by 748

Genetic Control of Bone Formation

Karsenty, G., Kronenberg, H. M., & Settembre, C. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113308 · Cited by 667

Development of the Endochondral SkeletonPreprint

Long, F., & Ornitz, D. M. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008334 · Cited by 698

Osteoblast Differentiation at a Glance

Rutkovskiy, A., Stensløkken, K., & Vaage, J. (2016) · Medical science monitor basic research/Medical science monitor. Basic research · doi:10.12659/msmbr.901142 · Cited by 620

Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells

Sethi, N. S., Dai, X., Winter, C. G., & Kang, Y. (2011) · Cancer Cell · doi:10.1016/j.ccr.2010.12.022 · Cited by 587

The roles of signaling pathways in bone repair and regeneration

Majidinia, M., Sadeghpour, A., & Yousefi, B. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26042 · Cited by 526

Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation

Lin, G. L., & Hankenson, K. D. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23287 · Cited by 525

Bone physiological microenvironment and healing mechanism: Basis for future bone-tissue engineering scaffolds

Zhu, G., Zhang, T., Chen, M., Yao, K., Huang, X., Zhang, B., Li, Y., Liu, J., Wang, Y., & Zhao, Z. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.03.043 · Cited by 516

Germline and somatic genetics of osteosarcoma — connecting aetiology, biology and therapy

Gianferante, D. M., Mirabello, L. J., & Savage, S. A. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.16 · Cited by 477

Runx2, an inducer of osteoblast and chondrocyte differentiation

Komori, T. (2018) · Histochemistry and Cell Biology · doi:10.1007/s00418-018-1640-6 · Cited by 468

Blood vessel formation and function in bone

Sivaraj, K. K., & Adams, R. H. (2016) · Development · doi:10.1242/dev.136861 · Cited by 454

Silk fibroin/hydroxyapatite composites for bone tissue engineering

Farokhi, M., Mottaghitalab, F., Samani, S., Shokrgozar, M. A., Kundu, S. C., Reis, R. L., Fatahi, Y., & Kaplan, D. L. (2017) · Biotechnology Advances · doi:10.1016/j.biotechadv.2017.10.001 · Cited by 435

Blood flow controls bone vascular function and osteogenesis

Ramasamy, S. K., Kusumbe, A. P., Schiller, M., Zeuschner, D., Bixel, M. G., Milia, C., Gamrekelashvili, J., Limbourg, A., Medvinsky, A., Santoro, M. M., et al. (2016) · Nature Communications · doi:10.1038/ncomms13601 · Cited by 439

The RUNX family: developmental regulators in cancer

Ito, Y., Bae, S.-C., & Chuang, L. S. H. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3877 · Cited by 399

Notch Signaling and the Skeleton

Zanotti, S., & CANALIS, E. M. (2016) · Endocrine Reviews · doi:10.1210/er.2016-1002 · Cited by 331

Canonical Notch Signaling Is Dispensable for the Maintenance of Adult Hematopoietic Stem Cells

Maillard, I., Koch, U., Dumortier, A., Shestova, O., Xu, L., Sai, H., Pross, S. E., Aster, J. C., Bhandoola, A., Radtke, F., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.02.011 · Cited by 317

Notch Signaling in the Regulation of Stem Cell Self-Renewal and Differentiation

Liu, J., Sato, C., Cerletti, M., & Wagers, A. J. (2010) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(10)92012-7 · Cited by 318

The material and biological characteristics of osteoinductive calcium phosphate ceramics

Tang, Z., Li, X., Tan, Y., Fan, H., & Zhang, X. (2017) · Regenerative Biomaterials · doi:10.1093/rb/rbx024 · Cited by 308

Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in bone

Tu, X., Delgado‐Calle, J., Condon, K. W., Maycas, M., Zhang, H., Carlesso, N., Taketo, M. M., Burr, D. B., Plotkin, L. I., & Bellido, T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409857112 · Cited by 286

Uncovering the periosteum for skeletal regeneration: The stem cell that lies beneath

Roberts, S. J., van Gastel, N., Carmeliet, G., & Luyten, F. P. (2014) · Bone · doi:10.1016/j.bone.2014.08.007 · Cited by 263

Cell autonomous requirement of connexin 43 for osteocyte survival: Consequences for endocortical resorption and periosteal bone formation

Bivi, N., Condon, K. W., Allen, M. R., Farlow, N., Passeri, G., Brun, L. R., Rhee, Y., Bellido, T., & Plotkin, L. I. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.548 · Cited by 261

Identification of differentially expressed genes between osteoblasts and osteocytes

Paić, F., Igwe, J. C., Nori, R., Kronenberg, M. S., Franceschetti, T., Harrington, P., Kuo, L., Shin, D., Rowe, D. W., Harris, S. E., et al. (2009) · Bone · doi:10.1016/j.bone.2009.06.010 · Cited by 271

The endothelium–bone axis in development, homeostasis and bone and joint disease

Tuckermann, J., & Adams, R. H. (2021) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00682-3 · Cited by 258

The Regulation of Valvular and Vascular Sclerosis by Osteogenic Morphogens

Boström, K. I., Rajamannan, N. M., & Towler, D. A. (2011) · Circulation Research · doi:10.1161/circresaha.110.234278 · Cited by 260

Mitogen-Activated Protein Kinase Pathways in Osteoblasts

Greenblatt, M. B., Shim, J., & Glimcher, L. H. (2013) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122347 · Cited by 256

Endothelial Jagged-1 Is Necessary for Homeostatic and Regenerative Hematopoiesis

Poulos, M. G., Guo, P., Kofler, N. M., Pinho, S., Gutkin, M. C., Tikhonova, A. N., Aifantis, I., Frenette, P. S., Kitajewski, J., Rafii, S., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.07.048 · Cited by 249

Role of Notch signaling in regulating innate immunity and inflammation in health and disease

Shang, Y., Smith, S. M., & Hu, X. (2016) · Protein & Cell · doi:10.1007/s13238-016-0250-0 · Cited by 250

MSC Transplantation Improves Osteopenia via Epigenetic Regulation of Notch Signaling in Lupus

Liu, S., Liu, D., Chen, C., Hamamura, K., Moshaverinia, A., Yang, R., Liu, Y., Jin, Y. J., & Shi, S. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.08.018 · Cited by 247

Molecular genetics of osteosarcoma

Rickel, K., Fang, F., & Tao, J. (2016) · Bone · doi:10.1016/j.bone.2016.10.017 · Cited by 255

miRNA-34c regulates Notch signaling during bone development

Bae, Y., Yang, T., Zeng, H., Campeau, P. M., Chen, Y., Bertin, T., Dawson, B., Munivez, E. M., Tao, J., & Lee, B. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds129 · Cited by 244

miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2

Wei, J., Shi, Y., Zheng, L., Zhou, B., Inose, H., Wang, J., Guo, X.-D. E., Grosschedl, R., & Karsenty, G. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201201057 · Cited by 223

Potential mechanisms underlying the Runx2 induced osteogenesis of bone marrow mesenchymal stem cells.

(2015) · PubMed Central · Cited by 208

Age-related alterations in mesenchymal stem cells related to shift in differentiation from osteogenic to adipogenic potential: Implication to age-associated bone diseases and defects

Kim, M. J., Kim, C., Choi, Y. S., Kim, M., Park, C., & Suh, Y. (2012) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2012.03.014 · Cited by 216

Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development

Hosaka, Y., Saito, T., Sugita, S., Hikata, T., Kobayashi, H., Fukai, A., Taniguchi, Y., Hirata, M., Akiyama, H., Chung, U., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1207458110 · Cited by 202

Notch Inhibits Osteoblast Differentiation and Causes Osteopenia

Zanotti, S., Smerdel‐Ramoya, A., Stadmeyer, L., Durant, D., Radtke, F., & CANALIS, E. M. (2008) · Endocrinology · doi:10.1210/en.2008-0140 · Cited by 200

Hes1: a key role in stemness, metastasis and multidrug resistance

Liu, Z.-H., Dai, X., & Du, B. (2015) · Cancer Biology & Therapy · doi:10.1080/15384047.2015.1016662 · Cited by 198

Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis

Isidor, B., Lindenbaum, P., Pichon, O., Bezieau, S., Christian Dina, C., Jacquemont, S., Martin‐Coignard, D., Thauvin‐Robinet, C., Merrer, M. F. L., Mandel, J., et al. (2011) · Nature Genetics · doi:10.1038/ng.778 · Cited by 196

Molecular and Cellular Aspects of Calcific Aortic Valve Disease

Towler, D. A. (2013) · Circulation Research · doi:10.1161/circresaha.113.300155 · Cited by 199

Notch and disease: A growing field

Louvi, A., & Artavanis‐Tsakonas, S. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.02.005 · Cited by 199

Wnt pathway, an essential role in bone regeneration

Chen, Y., & Alman, B. A. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22020 · Cited by 191

Exosome: A Novel Approach to Stimulate Bone Regeneration through Regulation of Osteogenesis and Angiogenesis

Qin, Y., Sun, R., Wu, C., Wang, L. Y., & Zhang, C. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17050712 · Cited by 187

TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J

Zhao, B., Grimes, S. N., Li, S., Hu, X., & Ivashkiv, L. B. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20111566 · Cited by 182

Natural and synthetic polymers/bioceramics/bioactive compounds-mediated cell signalling in bone tissue engineering

Rao, S., Harini, B., Shadamarshan, P., Balagangadharan, K., & Selvamurugan, N. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.09.029 · Cited by 184

FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging

Li, H., Liu, P., Xu, S., Li, Y., Dekker, J. D., Li, B., Fan, Y., Zhang, Z., Hong, Y., Yang, G., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci89511 · Cited by 180

Functional Comparison of Chronological and In Vitro Aging: Differential Role of the Cytoskeleton and Mitochondria in Mesenchymal Stromal Cells

Geißler, S., Textor, M., Kühnisch, J., Könnig, D., Klein, O., Ode, A., Pfitzner, T., Adjaye, J., Kasper, G., & Duda, G. N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052700 · Cited by 180

RBPjκ-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development

Dong, Y., Jesse, A. M., Kohn, A., Gunnell, L. M., Honjo, T., Zuscik, M. J., O’Keefe, R. J., & Hilton, M. J. (2010) · Development · doi:10.1242/dev.042911 · Cited by 180

Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB

Saito, T., & Tanaka, S. (2017) · Arthritis Research & Therapy · doi:10.1186/s13075-017-1296-y · Cited by 179

The Association of Notch2 and NF-κB Accelerates RANKL-Induced Osteoclastogenesis

Fukushima, H., Nakao, A., Okamoto, F., Shin, M., Kajiya, H., Sakano, S., Bigas, A., Jimi, E., & Okabe, K. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00299-08 · Cited by 178

The developmental biology of genetic Notch disorders

Mašek, J., & Andersson, E. R. (2017) · Development · doi:10.1242/dev.148007 · Cited by 183

TNF and Bone Remodeling

Zhao, B. (2017) · Current Osteoporosis Reports · doi:10.1007/s11914-017-0358-z · Cited by 178

Magnesium Chloride promotes Osteogenesis through Notch signaling activation and expansion of Mesenchymal Stem Cells

Díaz‐Tocados, J. M., Herencia, C., Martinez-Moreno, J. M., de Oca, A. M., Rodríguez-Ortiz, M. E., Vergara, N., Blanco, A., Steppan, S., Almadén, Y., Rodríguez, M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-08379-y · Cited by 176

Sources of Adult Mesenchymal Stem Cells Applicable for Musculoskeletal Applications - A Systematic Review of the Literature

Mafi, R., Hindocha, S., Mafi, P., Griffin, M., & Khan, W. S. (2011) · The Open Orthopaedics Journal · doi:10.2174/1874325001105010242 · Cited by 175

Notch-Deficient Skin Induces a Lethal Systemic B-Lymphoproliferative Disorder by Secreting TSLP, a Sentinel for Epidermal Integrity

Demehri, S., Liu, Z., Lee, J., Lin, M., Crosby, S. D., Roberts, C. J., Grigsby, P. W., Miner, J. H., Farr, A. G., & Kopan, R. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060123 · Cited by 174

Teriparatide as a Chondroregenerative Therapy for Injury-Induced Osteoarthritis

Sampson, E. R., Hilton, M. J., Tian, Y., Chen, D., Schwarz, E. M., Mooney, R. A., Bukata, S. V., O’Keefe, R. J., Awad, H. A., Puzas, J. E., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002214 · Cited by 173

Regulation of Hematopoiesis and Osteogenesis by Blood Vessel–Derived Signals

Ramasamy, S. K., Kusumbe, A. P., Itkin, T., Gur‐Cohen, S., Lapidot, T., & Adams, R. H. (2016) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-111315-124936 · Cited by 176

Stem cell niche-specific Ebf3 maintains the bone marrow cavityPreprint

Seike, M., Omatsu, Y., Watanabe, H., Kondoh, G., & Nagasawa, T. (2018) · Genes & Development · doi:10.1101/gad.311068.117 · Cited by 169

Notch signaling contributes to the pathogenesis of human osteosarcomas

Engin, F., Bertin, T., Ma, O., Jiang, M., Wang, L., Sutton, R. E., Donehower, L. A., & Lee, B. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp057 · Cited by 167

Notochordal Cells in the Adult Intervertebral Disc: New Perspective on an Old Question

Risbud, M. V., & Shapiro, I. M. (2011) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v21.i1.30 · Cited by 161

Targeting Notch signalling by the conserved miR‐8/200 microRNA family in development and cancer cells

Vallejo, D. M., Caparrós, E., & Domínguez, M. (2011) · The EMBO Journal · doi:10.1038/emboj.2010.358 · Cited by 157

New understanding and treatments for osteoporosis

Mazziotti, G., Bilezikian, J. P., CANALIS, E. M., Cocchi, D., & Giustina, A. (2011) · Endocrine · doi:10.1007/s12020-011-9570-2 · Cited by 151

Analysis of αSMA-Labeled Progenitor Cell Commitment Identifies Notch Signaling as an Important Pathway in Fracture Healing

Matthews, B. G., Grčević, D., Wang, L., Hagiwara, Y., Roguljić, H., Joshi, P., Shin, D., Adams, D. J., & Kalajzić, I. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2140 · Cited by 149

Glucocorticoid-Induced Osteoporosis

Frenkel, B., White, W., & Tuckermann, J. P. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-2895-8_8 · Cited by 154

Notch and the Skeleton

Zanotti, S., & CANALIS, E. M. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01285-09 · Cited by 148

Signaling Pathways Involved in Osteogenesis and Their Application for Bone Regenerative Medicine

Hayrapetyan, A., Jansen, J. A., & van den Beucken, J. J. J. P. (2014) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2014.0119 · Cited by 146

Negative regulation of osteoclastogenesis and bone resorption by cytokines and transcriptional repressors

Zhao, B., & Ivashkiv, L. B. (2011) · Arthritis Research & Therapy · doi:10.1186/ar3379 · Cited by 144

Notch pathway regulation of chondrocyte differentiation and proliferation during appendicular and axial skeleton development

Mead, T. J., & Yutzey, K. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902306106 · Cited by 141

miR-181a promotes osteoblastic differentiation through repression of TGF-β signaling molecules

Bhushan, R., Grünhagen, J., Becker, J., Robinson, P. N., Ott, C., & Knaus, P. I. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.12.008 · Cited by 140

Biomaterial-induced pathway modulation for bone regeneration

Vermeulen, S., Birgani, Z. N. T., & Habibović, P. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121431 · Cited by 141

Genetic and Transcriptional Control of Bone Formation

Javed, A., Chen, H., & Ghori-Javed, F. Y. (2010) · Oral and Maxillofacial Surgery Clinics of North America · doi:10.1016/j.coms.2010.05.001 · Cited by 143

DNA damage drives accelerated bone aging via an NF- κ B–dependent mechanism

Chen, Q., Liu, K., Robinson, A. R., Clauson, C. L., Blair, H. C., Robbins, P. D., Niedernhofer, L. J., & Ouyang, H. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1851 · Cited by 135

Notch Activation as a Driver of Osteogenic Sarcoma

Tao, J., Jiang, M., Jiang, L., Salvo, J. S., Zeng, H., Dawson, B., Bertin, T., Rao, P. H., Chen, R., Donehower, L. A., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.07.023 · Cited by 137

Metabolic regulation of skeletal cell fate and function in physiology and disease

van Gastel, N., & Carmeliet, G. (2021) · Nature Metabolism · doi:10.1038/s42255-020-00321-3 · Cited by 137

Osteoblast Lineage-Specific Effects of Notch Activation in the Skeleton

CANALIS, E. M., Parker, K., Feng, J. Q., & Zanotti, S. (2012) · Endocrinology · doi:10.1210/en.2012-1732 · Cited by 131

Bone marrow mesenchymal stem cells

Ohishi, M., & Schipani, E. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22399 · Cited by 129

Hypoxic Regulation of Nucleus Pulposus Cell Survival

Risbud, M. V., Schipani, E., & Shapiro, I. M. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090734 · Cited by 133

Signaling network regulating osteogenesis in mesenchymal stem cells

Thomas, S., & Jaganathan, B. G. (2021) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-021-00635-1 · Cited by 134

The Convergence of Fracture Repair and Stem Cells: Interplay of Genes, Aging, Environmental Factors and Disease

Hadjiargyrou, M., & O’Keefe, R. J. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2373 · Cited by 127

Osteoblastogenesis regulation signals in bone remodeling

Zuo, C., Huang, Y., Bajis, R., Sahih, M., Li, Y., Dai, K., & Zhang, X. (2012) · Osteoporosis International · doi:10.1007/s00198-012-1909-x · Cited by 129

Modulation of Notch-1 Signaling Alleviates Vascular Endothelial Growth Factor–Mediated Diabetic Nephropathy

Lin, C., Wang, F., Hsu, Y.-C., Chen, C., Tseng, M., Saleem, M. A., Chang, P., & Wang, J. (2010) · Diabetes · doi:10.2337/db09-0663 · Cited by 126

NOTCH signaling in skeletal progenitors is critical for fracture repair

Wang, C., Inzana, J. A., Mirando, A. J., Ren, Y., Liu, Z., Shen, J., O’Keefe, R. J., Awad, H. A., & Hilton, M. J. (2016) · Journal of Clinical Investigation · doi:10.1172/jci80672 · Cited by 118

Osteogenesis of Adipose-Derived Stem Cells

Grottkau, B. E., & Lin, Y. (2013) · Bone Research · doi:10.4248/br201302003 · Cited by 117

Effects of age on bone mRNA levels of sclerostin and other genes relevant to bone metabolism in humans

Roforth, M. M., Fujita, K., McGregor, U. I., Kirmani, S., McCready, L. K., Peterson, J. M., Drake, M. T., Monroe, D. G., & Khosla, S. (2013) · Bone · doi:10.1016/j.bone.2013.10.019 · Cited by 121

Osteogenic signaling on silk-based matrices

Midha, S., Murab, S., & Ghosh, S. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.04.020 · Cited by 116

Mechanism of Action of Bortezomib and the New Proteasome Inhibitors on Myeloma Cells and the Bone Microenvironment: Impact on Myeloma-Induced Alterations of Bone Remodeling

Accardi, F., Toscani, D., Bolzoni, M., Palma, B. D., Aversa, F., & Giuliani, N. (2015) · BioMed Research International · doi:10.1155/2015/172458 · Cited by 113

The Pathology of Bone Tissue during Peri-Implantitis

Schminke, B., Orde, F. V., Gruber, R., Schliephake, H., Bürgers, R., & Miosge, N. (2014) · Journal of Dental Research · doi:10.1177/0022034514559128 · Cited by 113

Inhibitory Role of Notch1 in Calcific Aortic Valve Disease

Acharya, A., Hans, C. P., Koenig, S. N., Nichols, H. A., Galindo, C. L., Garner, H. R., Merrill, W. H., Hinton, R. B., & Garg, V. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027743 · Cited by 116

Thrombospondin-2 and SPARC/osteonectin are critical regulators of bone remodeling

Delany, A. M., & Hankenson, K. D. (2009) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-009-0076-0 · Cited by 119

Bone Marrow–Derived Mesenchymal Stem Cells Obtained During Arthroscopic Rotator Cuff Repair Surgery Show Potential for Tendon Cell Differentiation After Treatment With Insulin

Mazzocca, A. D., McCarthy, M. B., Chowaniec, D. M., Cote, M. P., Judson, C. H., Apostolakos, J. M., Solovyova, O., Beitzel, K., & Arciero, R. A. (2011) · Arthroscopy The Journal of Arthroscopic and Related Surgery · doi:10.1016/j.arthro.2011.06.029 · Cited by 111

Notch signaling and the bone marrow hematopoietic stem cell niche

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Notch Signaling in Osteocytes Differentially Regulates Cancellous and Cortical Bone Remodeling

CANALIS, E. M., Adams, D. J., Boskey, A. L., Parker, K., Kranz, L., & Zanotti, S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.470492 · Cited by 111

A Dual Role for NOTCH Signaling in Joint Cartilage Maintenance and Osteoarthritis

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Notch signaling enhances osteogenic differentiation while inhibiting adipogenesis in primary human bone marrow stromal cells

Ugarte, F., Ryser, M., Thieme, S., Fierro, F. A., Navratiel, K., Bornhäuser, M., & Brenner, S. (2009) · Experimental Hematology · doi:10.1016/j.exphem.2009.03.007 · Cited by 109

The role of microRNAs in bone remodeling

Jing, D., Hao, J., Shen, Y., Tang, G., Li, M., Huang, S.-H., & Zhao, Z. (2015) · International Journal of Oral Science · doi:10.1038/ijos.2015.22 · Cited by 108

Notch signaling suppresses glucose metabolism in mesenchymal progenitors to restrict osteoblast differentiation

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Vegfa regulates perichondrial vascularity and osteoblast differentiation in bone development

Duan, X., Murata, Y., Liu, Y., Nicolae, C. M., Olsen, B. R., & Berendsen, A. D. (2015) · Development · doi:10.1242/dev.117952 · Cited by 102

Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development

Kohn, A., Dong, Y., Mirando, A. J., Jesse, A. M., Honjo, T., Zuscik, M. J., O’Keefe, R. J., & Hilton, M. J. (2012) · Development · doi:10.1242/dev.070649 · Cited by 102

Bone Notches

Foley, J. F. (2008) · Science Signaling · doi:10.1126/stke.110ec90

Notch signaling suppresses glucose metabolism in mesenchymal progenitors to restrict osteoblast differentiation

Lee, S.-Y., & Long, F. (2018) · Journal of Clinical Investigation · doi:10.1172/jci96221 · Cited by 106

Osteogenic differentiation of the mesenchymal progenitor cells, Kusa is suppressed by Notch signaling

Shindo, K., Kawashima, N., Sakamoto, K., Yamaguchi, A., Umezawa, A., Takagi, M., Katsube, K., & Suda, H. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00349-5 · Cited by 72

Physiological Notch Signaling Maintains Bone Homeostasis via RBPjk and Hey Upstream of NFATc1

Tu, X., Chen, J., Lim, J., Karner, C. M., Lee, S.-Y., Heisig, J., Wiese, C., Surendran, K., Kopan, R., Gessler, M., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002577 · Cited by 98

Effect of Notch signaling pathway in the differentiation of bone marrow mesenchymal stem cellderived osteoblasts

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