RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain

Deane, Rashid, Du Yan, Shi, Submamaryan, Ram Kumar, LaRue, Barbara, Jovanovic, Suzana, Hogg, Elizabeth, Welch, Deborah, Manness, Lawrence +15 more·2003·Nature Medicine
DOI 10.1038/nm890

Cited by (135)

Items 101–135 of 135

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  2. Accumulation of intraneuronal Aβ correlates with ApoE4 genotype
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  3. Increased CSF-BACE 1 activity is associated with ApoE-ε4 genotype in subjects with mild cognitive impairment and Alzheimer's disease
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    Origlia, Nicola, Bonadonna, Camilla, Rosellini, Alfredo, Leznik, Elena, Arancio, Ottavio, Yan, Shirley ShiDu, Domenici, Luciano · 2010 · The Journal of Neuroscience
  8. Taxifolin inhibits amyloid-β oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathy
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  9. Endothelin-1 is Elevated in Alzheimer's Disease and Upregulated by Amyloid-β
    Palmer, Jennifer C., Barker, Rachel, Kehoe, Patrick G., Love, Seth · 2012 · Journal of Alzheimer's Disease
  10. Interplay between Brain Pericytes and Endothelial Cells in Dementia
    Procter, Tessa V., Williams, Anna, Montagne, Axel · 2021 · The American Journal of Pathology
  11. APPswe/Aβ regulation of osteoclast activation and RAGE expression in an age-dependent manner
    Cui, Shun, Xiong, Fei, Hong, Yan, Jung, Ji-Ung, Li, Xing-Sheng, Liu, Jian-Zhong, Yan, Riqiang, Mei, Lin, Feng, Xu, Xiong, Wen-Cheng · 2011 · Journal of Bone and Mineral Research
  12. Physiological Roles of Amyloid-?? and Implications for its Removal in Alzheimer???s Disease
    Bishop, Glenda M, Robinson, Stephen R · 2004 · Drugs & Aging
  13. The relationship between amyloid-beta and brain capillary endothelial cells in Alzheimer’s disease
    Su, Qiang, Guo, Jun-Hong, Zhang, Yan-Li, Wang, Juan, Zhang, Zhi-Na · 2022 · Neural Regeneration Research
  14. Mechanism of Neuronal versus Endothelial Cell Uptake of Alzheimer's Disease Amyloid β Protein
    Kandimalla, Karunya K., Scott, Olenych G., Fulzele, Smita, Davidson, Michael W., Poduslo, Joseph F. · 2009 · PLoS ONE
  15. Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow
    Li, Hongmei, Guo, Qinxi, Inoue, Taeko, Polito, Vinicia A, Tabuchi, Katsuhiko, Hammer, Robert E, Pautler, Robia G, Taffet, George E, Zheng, Hui · 2014 · Molecular Neurodegeneration
  16. Abnormal amyloid beta metabolism in systemic abnormalities and Alzheimer’s pathology: Insights and therapeutic approaches from periphery
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  17. Pathological BBB Crossing Melanin-Like Nanoparticles as Metal-Ion Chelators and Neuroinflammation Regulators against Alzheimer’s Disease
    Huang, Qianqian, Jiang, Chaoqing, Xia, Xue, Wang, Yufan, Yan, Chenxing, Wang, Xiaorong, Lei, Ting, Yang, Xiaotong, Yang, Wenqin, Cheng, Guo et al. · 2023 · Research
  18. Amyloid β-interacting partners in Alzheimer's disease: From accomplices to possible therapeutic targets
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  19. Trientine Reduces BACE1 Activity and Mitigates Amyloidosis <i>via</i> the AGE/RAGE/NF-κB Pathway in a Transgenic Mouse Model of Alzheimer's Disease
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  20. Modulation of Amyloid-β1–40 Transport by ApoA1 and ApoJ Across an in vitro Model of the Blood-Brain Barrier
    Merino-Zamorano, Cristina, Fernández-de Retana, Sofía, Montañola, Alex, Batlle, Aina, Saint-Pol, Julien, Mysiorek, Caroline, Gosselet, Fabien, Montaner, Joan, Hernández-Guillamon, Mar · 2016 · Journal of Alzheimer's Disease
  21. Aging alters mRNA expression of amyloid transporter genes at the blood-brain barrier
    Osgood, Doreen, Miller, Miles C., Messier, Arthur A., Gonzalez, Liliana, Silverberg, Gerald D. · 2017 · Neurobiology of Aging
  22. RAGE mediates vascular injury and inflammation after global cerebral ischemia
    Kamide, Tomoya, Kitao, Yasuko, Takeichi, Toshiaki, Okada, Akiko, Mohri, Hiromi, Schmidt, Ann Marie, Kawano, Takayuki, Munesue, Seiichi, Yamamoto, Yasuhiko, Yamamoto, Hiroshi et al. · 2012 · Neurochemistry International
  23. Immunohistochemical analysis of transporters related to clearance of amyloid-β peptides through blood–cerebrospinal fluid barrier in human brain
    Matsumoto, Koichi, Chiba, Yoichi, Fujihara, Ryuji, Kubo, Hiroyuki, Sakamoto, Haruhiko, Ueno, Masaki · 2015 · Histochemistry and Cell Biology
  24. Comparative Epidemiological Investigation of Alzheimer’s Disease and Colorectal Cancer: The Possible Role of Gastrointestinal Conditions in the Pathogenesis of AD
    Zhang, Tianlang, Han, YaRu, Wang, JianYi, Hou, Deren, Deng, Hao, Deng, Yun L., Song, Zhi · 2018 · Frontiers in Aging Neuroscience
  25. When the infectious environment meets the AD brain
    Ganz, Tal, Fainstein, Nina, Ben-Hur, Tamir · 2022 · Molecular Neurodegeneration
  26. Robust neuroinflammation and perivascular pathology in rTg-DI rats, a novel model of microvascular cerebral amyloid angiopathy
    Zhu, Xiaoyue, Hatfield, Joshua, Sullivan, Joseph K., Xu, Feng, Van Nostrand, William E. · 2020 · Journal of Neuroinflammation
  27. Potential of Medicinal Plants as Neuroprotective and Therapeutic Properties Against Amyloid-β-Related Toxicity, and Glutamate-Induced Excitotoxicity in Human Neural Cells
    Lobine, Devina, Sadeer, Nabeelah, Jugreet, Sharmeen, Suroowan, Shanoo, Keenoo, Bibi Sumera, Imran, Muhammad, Venugopala, Katharigatta N., Ibrahim, Faten Mohamed, Zengin, Gokhan, Mahomoodally, Mohamad Fawzi · 2021 · Current Neuropharmacology
  28. Microvascular Contributions to Alzheimer Disease Pathogenesis: Is Alzheimer Disease Primarily an Endotheliopathy?
    Tarawneh, Rawan · 2023 · Biomolecules
  29. Versatile nanomaterials for Alzheimer’s disease: Pathogenesis inspired disease-modifying therapy
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  30. RAGE Does Not Affect Amyloid Pathology in Transgenic ArcAβ Mice
    Vodopivec, Ivana, Galichet, Arnaud, Knobloch, Marlen, Bierhaus, Angelika, Heizmann, Claus W., Nitsch, Roger M. · 2009 · Neurodegenerative Diseases
  31. Multifunctional Nanostructure RAP‐RL Rescues Alzheimer's Cognitive Deficits through Remodeling the Neurovascular Unit
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  32. Ceria nanocluster-based therapy for Alzheimer’s disease through the modulation of activated microglia and attenuation of amyloid-β deposition
    Liu, Hai-Jun, Wang, Mingming, Wang, Yuzhen, Shi, Shanshan, Hu, Xiangxiang, Zhang, Dong-Bo, Fan, Daping, Mintzer, Jacobo, Xu, Peisheng · 2025 · Cell Biomaterials
  33. Reduced expression of membrane-bound (m)RAGE is a biomarker of multiple sclerosis disease progression
    Sternberg, Zohara, Chiotti, Anne, Tario, Joseph, Chichelli, Trevor, Patel, Neel, Chadha, Kailash, Yu, Jinhee, Karmon, Yuval · 2016 · Immunobiology
  34. Beta-amyloid oligomers: recent developments
    Borutaite, Vilmante, Morkuniene, Ramune, Valincius, Gintaras · 2011 · bmc
  35. The Relationship Between the Continuum of Elevated Adiposity, Hyperinsulinemia, and Type 2 Diabetes and Late-onset Alzheimer’s Disease: An Epidemiological Perspective
    Luchsinger, José A. · 2010 · Research and Perspectives in Alzheimer's Disease