A direct projection from superior colliculus to substantia nigra for detecting salient visual events
Abstract
Midbrain dopaminergic neurons respond to unexpected and biologically salient events, but little is known about the sensory systems underlying this response. Here we describe, in the rat, a direct projection from a primary visual structure, the midbrain superior colliculus (SC), to the substantia nigra pars compacta (SNc) where direct synaptic contacts are made with both dopaminergic and non-dopaminergic neurons. Complementary electrophysiological data reveal that short-latency visual responses in the SNc are abolished by ipsilateral lesions of the SC and increased by local collicular stimulation. These results show that the tectonigral projection is ideally located to relay short-latency visual information to dopamine-containing regions of the ventral midbrain. We conclude that it is within this afferent sensory circuitry that the critical perceptual discriminations that identify stimuli as both unpredicted and biologically salient are made.
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It is unclear how NAc dopamine release encodes the properties and/or emotional valence of arousing visual stimuli, such as visual threats.
“While many previous studies have reported phasic firing of dopaminergic neurons in response to light flashes in laboratory animals (Horvitz et al., 1997; Comoli et al., 2003; Dommett et al., 2005), it is unclear how NAc dopamine release encodes the properties and/or emotional valence of arousing visual stimuli, such as visual threats.”
From Ventral striatum dopamine release encodes unique properties of visual stimuli in mice (2023) · cites this paper as Comoli et al., 2003
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- Authors
- Comoli, E., Coizet, V., Boyes, J., Bolam, J. P., Canteras, N. S., Quirk, R. H., Overton, P. G., & Redgrave, P.
- Affiliations
- University of Sheffield (GB)
- University of Oxford (GB)
- Universidade de São Paulo (BR)
- Corresponding author
- Redgrave, Peter
- Venue
- Nature Neuroscience
- Published
- 2003-08-17
- Volume
- 6
- Issue
- 9
- Pages
- 974-980
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2153330378
- Cited by
- 295
- References
- 44
- Citations by year
- 2026: 8 · 2025: 15 · 2024: 7 · 2023: 13 · 2022: 8 · 2021: 13 · 2020: 16 · 2019: 12 · 2018: 9 · 2017: 7 · 2016: 9 · 2015: 17 · 2014: 16 · 2013: 16 · 2012: 13
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- superior colliculus, substantia nigra pars compacta, dopaminergic neurons, unexpected events, midbrain
- MeSH terms
- Animals, Female, Male, Neural Pathways, Photic Stimulation, Substantia Nigra, Superior Colliculi, Synapses, Visual Pathways, Visual Perception, Rats, Sprague-Dawley, Rats
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