Phasic dopamine release in appetitive behaviors and drug addiction

Wanat, Matthew; Willuhn, Ingo; Clark, Jeremy; Phillips, Paul

doi:10.2174/1874473710902020195

Cited by 177Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

Phasic dopamine release in appetitive behaviors and drug addiction

Open access

Wanat, Matthew, Willuhn, Ingo, Clark, Jeremy, Phillips, Paul·2009·Current Drug Abuse Reviewse

DOI 10.2174/1874473710902020195PMC PMC2877500

Open this paper in CoChat — free account

Abstract

Although dopamine is implicated in the development of addiction, it is unclear how specific dopamine release patterns are involved with drug seeking. Addictive drugs increase tonic dopamine levels on the order of minutes, as well as phasic dopamine release events that occur on a subsecond time scale. Phasic dopamine release is associated with the initiation of goal-directed behaviors, and has been shown to promote drug seeking. Prior experience with addictive drugs modulates the synaptic and intrinsic properties of dopamine neurons, affects the pattern of dopamine neuron firing and release, and alters dopamine-dependent behaviors related to drug addiction. In this review, we synthesize the known drug-dependent changes to the dopamine system along with the established functions of phasic dopamine release in order to provide a framework for conceptualizing the role of phasic dopamine release in drug addiction. Because drug addiction is commonly thought to involve changes in brain circuits important for natural reinforcement, we first present the role of phasic dopamine release in appetitive and goal-directed behaviors in the context of contemporary theories regarding the function of dopamine. Next, we discuss the known drug-induced changes to dopamine neurons and phasic release in both in vitro and in vivo preparations. Finally, we offer a simple model that chronic drug experience increases the contrast, or 'signal to noise', of phasic dopamine release to basal dopamine levels in response to drug-related stimuli, which could result in aberrant associations between cues and reinforcers that contribute to the development of addiction.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.2174/1874473710902020195

Cites

260 of 260 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

ACh released in the VTA promotes the switch between tonic and phasic DAergic activity that signals reward and salience.
“The cholinergic system exerts a profound effect on DAergic activity as ACh released in the VTA promotes the switch between tonic and phasic activity in DAergic neurons that signals reward and salience [38, 39].”
From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [38]
The rewarding and conditioning effects of drugs are predominantly driven by phasic DA cell firing, which results in large and transient DA increases.
“Overall, it appears that the rewarding and conditioning effects of drugs are predominantly driven by phasic DA cell firing, which result in large and transient DA increases, in contrast to the downstream changes in executive function that occur in addiction that are linked with changes in tonic DA cell firing, which result in lower and more stable DA levels (Grace 2000;Wanat et al 2009).”
From Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction (2011) · cites this paper as Wanat et al 2009
Downstream changes in executive function that occur in addiction are linked with changes in tonic DA cell firing, which result in lower and more stable DA levels.
“in contrast to the downstream changes in executive function that occur in addiction that are linked with changes in tonic DA cell firing, which result in lower and more stable DA levels (Grace 2000;Wanat et al 2009).”
From Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction (2011) · cites this paper as Wanat et al 2009

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388 · see citing works
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733 · see citing works
Dopamine, learning and motivation.
Wise, R. A. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1406 · Cited by 3,379 · cited 4× · see citing works
“Our model is also consistent with theories regarding the role of dopamine in learning [67, 71].”
Influential
NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647 · see citing works
Uncertainty-based competition between prefrontal and dorsolateral striatal systems for behavioral control
Daw, N. D., Niv, Y., & Dayan, P. (2005) · Nature Neuroscience · doi:10.1038/nn1560 · Cited by 2,533 · see citing works
The debate over dopamine’s role in reward: the case for incentive salience
Berridge, K. C. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0578-x · Cited by 2,347 · see citing works
Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine
Ritz, M. C., Lamb, R. J., Goldberg, S. R., & Kuhar, M. J. (1987) · Science · doi:10.1126/science.2820058 · Cited by 2,180 · see citing works
Discrete coding of reward probability and uncertainty by dopamine neurons
Fiorillo, C. D., Tobler, P. N., & Schultz, W. (2003) · Science · doi:10.1126/science.1077349 · Cited by 2,085 · see citing works
A framework for mesencephalic dopamine systems based on predictive Hebbian learning
Montague, P., Dayan, P., & Sejnowski, T. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-05-01936.1996 · Cited by 2,066 · see citing works
The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat
Swanson, L. W. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90145-9 · Cited by 1,718 · see citing works
Addiction and the brain antireward system
Koob, G. F., & Le Moal, M. (2008) · Annual Review of Psychology · doi:10.1146/annurev.psych.59.103006.093548 · Cited by 1,457 · see citing works
Multiple dopamine functions at different time courses
Schultz, W. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135722 · Cited by 1,415 · see citing works
Synaptic plasticity and addiction
Kauer, J. A., & Malenka, R. C. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2234 · Cited by 1,397 · see citing works
Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy
Richardson, N. R., & Roberts, D. C. S. (1996) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(95)00153-0 · Cited by 1,357 · see citing works
Adaptive Coding of Reward Value by Dopamine Neurons
Tobler, P. N., Fiorillo, C. D., & Schultz, W. (2005) · Science · doi:10.1126/science.1105370 · Cited by 1,276 · see citing works
3,4-Dihydroxyphenylalanine and 5-Hydroxytryptophan as Reserpine Antagonists
Carlsson, A., Lindqvist, M., & Magnusson, T. (1957) · Nature · doi:10.1038/1801200a0 · Cited by 1,272 · see citing works
Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement
Dalley, J. W., Fryer, T. D., Brichard, L., Robinson, E. S. J., Theobald, D. E. H., Lääne, K., Peña, Y., Murphy, E. R., Shah, Y., Probst, K., et al. (2007) · Science · doi:10.1126/science.1137073 · Cited by 1,188 · see citing works
Decision-making deficits, linked to a dysfunctional ventromedial prefrontal cortex, revealed in alcohol and stimulant abusers
Bechara, A., Dolan, S. L., Denburg, N. L., Hindes, A. R., Anderson, S. W., & Nathan, P. E. (2001) · Neuropsychologia · doi:10.1016/s0028-3932(00)00136-6 · Cited by 1,168 · see citing works
Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction
Volkow, N. D., Wang, G.-J., Telang, F., Fowler, J. S., Logan, J., Childress, A.-R., Jayne, M., Ma, Y., & Wong, C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1544-06.2006 · Cited by 1,164 · see citing works
Drugs of Abuse and Stress Trigger a Common Synaptic Adaptation in Dopamine Neurons
Saal, D., Dong, Y., Bonci, A., & Malenka, R. C. (2003) · Neuron · doi:10.1016/s0896-6273(03)00021-7 · Cited by 1,147 · see citing works
Subsecond dopamine release promotes cocaine seeking
Phillips, P. E. M., Stuber, G. D., Heien, M. L. A. V., Wightman, R. M., & Carelli, R. M. (2003) · Nature · doi:10.1038/nature01476 · Cited by 1,113 · see citing works
Self-citation
Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons
Ungless, M. A., Whistler, J. L., Malenka, R. C., & Bonci, A. (2001) · Nature · doi:10.1038/35079077 · Cited by 1,106 · see citing works
Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission
Floresco, S. B., West, A. R., Ash, B., Moore, H., & Grace, A. A. (2003) · Nature Neuroscience · doi:10.1038/nn1103 · Cited by 1,106 · see citing works
Dopamine in drug abuse and addiction: results from imaging studies and treatment implications
Volkow, N. D., Fowler, J. S., Wang, G.-J., & Swanson, J. M. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001507 · Cited by 1,101 · see citing works
Cannabinoid and Heroin Activation of Mesolimbic Dopamine Transmission by a Common µ 1 Opioid Receptor Mechanism
Tanda, G., Pontieri, F. E., & Chiara, G. D. (1997) · Science · doi:10.1126/science.276.5321.2048 · Cited by 1,079 · see citing works
Regulation of firing of dopaminergic neurons and control of goal-directed behaviors
Grace, A. A., Floresco, S. B., Goto, Y., & Lodge, D. J. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.003 · Cited by 1,034 · see citing works
Dopamine responses comply with basic assumptions of formal learning theory
Waelti, P., Dickinson, A., & Schultz, W. (2001) · Nature · doi:10.1038/35083500 · Cited by 1,018 · see citing works
Incubation of cocaine craving after withdrawal
Grimm, J. W., Hope, B. T., Wise, R. A., & Shaham, Y. (2001) · Nature · doi:10.1038/35084134 · Cited by 1,003 · see citing works
Addiction: A Disease of Learning and Memory
Hyman, S. E. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.8.1414 · Cited by 980 · see citing works
Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system
Lammel, S., Hetzel, A., Häckel, O., Jones, I., Liss, B., & Roeper, J. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.022 · Cited by 976 · see citing works
Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—1. Identification and characterization
Grace, A. A., & Bunney, B. S. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90135-5 · Cited by 937 · see citing works
Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens
Nicola, S. M., Surmeier, D. J., & Malenka, R. C. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.185 · Cited by 931 · see citing works
Low Level of Brain Dopamine D2 Receptors in Methamphetamine Abusers: Association With Metabolism in the Orbitofrontal Cortex
Volkow, N. D., Chang, L., Wang, G.-J., Fowler, J. S., Ding, Y.-S., Sedler, M., Logan, J., Franceschi, D., Gatley, J., Hitzemann, R., et al. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.12.2015 · Cited by 916 · see citing works
Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects
Volkow, N. D., Wang, G.-J., Fowler, J. S., Logan, J., Gatley, S. J., Hitzemann, R., Chen, A. D., Dewey, S. L., & Pappas, N. (1997) · Nature · doi:10.1038/386830a0 · Cited by 854 · see citing works
Motivational views of reinforcement: implications for understanding the behavioral functions of nucleus accumbens dopamine
Salamone, J. D., & Correa, M. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00282-6 · Cited by 817 · see citing works
Uniform Inhibition of Dopamine Neurons in the Ventral Tegmental Area by Aversive Stimuli
Ungless, M. A., Magill, P. J., & Bolam, J. P. (2004) · Science · doi:10.1126/science.1093360 · Cited by 782 · see citing works
Nicotine activates and desensitizes midbrain dopamine neurons
Pidoplichko, V. I., DeBiasi, M., Williams, J. T., & Dani, J. A. (1997) · Nature · doi:10.1038/37120 · Cited by 769 · see citing works
Dopamine neurons and their role in reward mechanisms
Schultz, W. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80007-4 · Cited by 769 · see citing works
Drug craving and addiction: integrating psychological and neuropsychopharmacological approaches
Franken, I. H. A. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00081-2 · Cited by 765 · see citing works
The short-latency dopamine signal: a role in discovering novel actions?
Redgrave, P., & Gurney, K. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn2022 · Cited by 762 · see citing works
Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic
Zhou, Q.-Y., & Palmiter, R. D. (1995) · Cell · doi:10.1016/0092-8674(95)90145-0 · Cited by 731 · see citing works
Morphology and electrophysiological properties of immunocytochemically identified rat dopamine neurons recorded in vitro
Grace, A., & Onn, S. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-10-03463.1989 · Cited by 720 · see citing works
Long-term potentiation of excitatory inputs to brain reward areas by nicotine
Mansvelder, H. D., & McGehee, D. S. (2000) · Neuron · doi:10.1016/s0896-6273(00)00042-8 · Cited by 720 · see citing works
Dopamine operates as a subsecond modulator of food seeking
Roitman, M. F., Stuber, G. D., Phillips, P. E. M., Wightman, R. M., & Carelli, R. M. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3823-03.2004 · Cited by 718 · see citing works
Self-citation
Associative learning mediates dynamic shifts in dopamine signaling in the nucleus accumbens
Day, J. J., Roitman, M. F., Wightman, R. M., & Carelli, R. M. (2007) · Nature Neuroscience · doi:10.1038/nn1923 · Cited by 710 · see citing works
Amphetamine-induced dopamine release in human ventral striatum correlates with euphoria
Drevets, W. C., Gautier, C., Price, J. C., Kupfer, D. J., Kinahan, P. E., Grace, A. A., Price, J. L., & Mathis, C. A. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01038-6 · Cited by 706 · cited 2× · see citing works
“[232] Drevets WC, Gautier C, Price JC, Kupfer DJ, Kinahan PE, Grace AA, et al.”
Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas
Mansvelder, H. D., Keath, J. R., & McGehee, D. S. (2002) · Neuron · doi:10.1016/s0896-6273(02)00625-6 · Cited by 701 · see citing works
Nonlinear relationship between impulse flow and dopamine released by rat midbrain dopaminergic neurons as studied by in vivo electrochemistry
Gonon, F. G. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90307-7 · Cited by 676 · see citing works
Monitoring Rapid Chemical Communication in the Brain
Robinson, D. L., Hermans, A., Seipel, A. T., & Wightman, R. M. (2008) · Chemical Reviews · doi:10.1021/cr068081q · Cited by 665 · see citing works
BOLD responses reflecting dopaminergic signals in the human ventral tegmental area
D'Ardenne, K., McClure, S. M., Nystrom, L. E., & Cohen, J. D. (2008) · Science · doi:10.1126/science.1150605 · Cited by 661 · see citing works
Stereological estimates of dopaminergic, GABAergic and glutamatergic neurons in the ventral tegmental area, substantia nigra and retrorubral field in the rat
Nair‐Roberts, R. G., Chatelain-Badie, S. D., Benson, E. M., White‐Cooper, H., Bolam, J. P., & Ungless, M. A. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.01.046 · Cited by 653 · see citing works
Relationship between subjective effects of cocaine and dopamine transporter occupancy
Volkow, N. D., Wang, G., Fischman, M. W., Foltin, R. W., Fowler, J. S., Abumrad, N. N., Vitkun, S. A., Logan, J., Gatley, S. J., Pappas, N. R., et al. (1997) · Nature · doi:10.1038/386827a0 · Cited by 646 · see citing works
The addicted human brain viewed in the light of imaging studies: brain circuits and treatment strategies
Volkow, N. D., Fowler, J. S., & Wang, G.-J. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.07.019 · Cited by 616 · see citing works
Dopamine acts on D2 receptors to increase potassium conductance in neurones of the rat substantia nigra zona compacta
Lacey, M. G., Mercuri, N. B., & North, R. A. (1987) · The Journal of Physiology · doi:10.1113/jphysiol.1987.sp016787 · Cited by 614 · see citing works
Brain circuitry and the reinstatement of cocaine-seeking behavior
Kalivas, P., & McFarland, K. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1393-2 · Cited by 613 · see citing works
Decreases in dopamine receptors but not in dopamine transporters in alcoholics
Volkow, N. D., Wang, G., Fowler, J. S., Logan, J., Hitzemann, R., Ding, Y., Pappas, N., Shea, C., & Piscani, K. (1996) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb05936.x · Cited by 612 · see citing works
Detecting Subsecond Dopamine Release with Fast-Scan Cyclic Voltammetry in Vivo
Robinson, D. L., Venton, B. J., Heien, M. L., & Wightman, R. M. (2003) · Clinical Chemistry · doi:10.1373/49.10.1763 · Cited by 602 · see citing works
Nicotine amplifies reward-related dopamine signals in striatum
Rice, M. E., & Cragg, S. J. (2004) · Nature Neuroscience · doi:10.1038/nn1244 · Cited by 594 · see citing works
Time course of nigrostriatal degeneration in parkinson's disease
Riederer, P. F., & Wuketich, S. (1976) · Journal of Neural Transmission · doi:10.1007/bf01249445 · Cited by 577 · see citing works
Afferent projections to the ventral tegmental area of Tsai and interfascicular nucleus: A horseradish peroxidase study in the rat
Phillipson, O. T. (1979) · The Journal of Comparative Neurology · doi:10.1002/cne.901870108 · Cited by 553 · see citing works
Hyperdopaminergic mutant mice have higher "wanting" but not "liking" for sweet rewards
Peciña, S., Cagniard, B., Berridge, K. C., Aldridge, J. W., & Zhuang, X. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-28-09395.2003 · Cited by 551 · see citing works
Addiction as a Computational Process Gone Awry
Redish, A. D. (2004) · Science · doi:10.1126/science.1102384 · Cited by 534 · see citing works
The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons?
Margolis, E. B., Lock, H., Hjelmstad, G. O., & Fields, H. L. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.117069 · Cited by 527 · see citing works
Marked inhibition of mesolimbic dopamine release: a common feature of ethanol, morphine, cocaine and amphetamine abstinence in rats
Rossetti, Z. L., Hmaidan, Y., & GESSA, G. L. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90706-a · Cited by 526 · see citing works
Time course of extracellular dopamine and behavioral sensitization to cocaine. I. Dopamine axon terminals
Kalivas, P., & Duffy, P. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-01-00266.1993 · Cited by 510 · see citing works
A unified framework for addiction: Vulnerabilities in the decision process
Redish, A. D., Jensen, S., & Johnson, A. (2008) · Behavioral and Brain Sciences · doi:10.1017/s0140525x0800472x · Cited by 501 · see citing works
Mesolimbic Functional Magnetic Resonance Imaging Activations during Reward Anticipation Correlate with Reward-Related Ventral Striatal Dopamine Release
Schott, B. H., Minuzzi, L., Krebs, R. M., Elmenhorst, D., Lang, M., Winz, O. H., Seidenbecher, C. I., Coenen, H. H., Heinze, H.-J., Zilles, K., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2058-08.2008 · Cited by 496 · see citing works
Firing modes of midbrain dopamine cells in the freely moving rat
Hyland, B. I., Reynolds, J. N. J., HAY, J. G., Perk, C. G., & Miller, R. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00267-1 · Cited by 487 · see citing works
Glutamatergic Afferents of the Ventral Tegmental Area in the Rat
Geisler, S., Derst, C., Veh, R. W., & Zahm, D. S. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0012-07.2007 · Cited by 486 · see citing works
Relationship between the Appearance of Symptoms and the Level of Nigrostriatal Degeneration in a Progressive 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Lesioned Macaque Model of Parkinson's Disease
Bézard, E., Doveró, S., Prunier, C., Ravenscroft, P., Chalon, S., Guilloteau, D., Crossman, A. R., Bioulac, B. H., Brotchie, J. M., & Gross, C. E. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-17-06853.2001 · Cited by 484 · see citing works
Real-time measurement of dopamine fluctuations after cocaine in the brain of behaving rats
Heien, M. L. A. V., Khan, A. S., Ariansen, J. L., Cheer, J. F., Phillips, P. E. M., Wassum, K. M., & Wightman, R. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504657102 · Cited by 482 · see citing works
Self-citation
PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys
Nader, M. A., Morgan, D., Gage, H. D., Nader, S. H., Calhoun, T. L., Buchheimer, N., Ehrenkaufer, R., & Mach, R. H. (2006) · Nature Neuroscience · doi:10.1038/nn1737 · Cited by 481 · see citing works
Compulsive drug use linked to sensitized ventral striatal dopamine transmission.
Evans, A. H., Pavese, N., Lawrence, A. D., Tai, Y. F., Appel, S., Doder, M., Brooks, D. J., Lees, A. J., & Piccini, P. (2006) · Annals of Neurology · doi:10.1002/ana.20822 · Cited by 473 · see citing works
Burst firing in midbrain dopaminergic neurons
Overton, P. G., & Clark, D. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00039-8 · Cited by 466 · see citing works
Persistent sensitization of dopamine neurotransmission in ventral striatum (nucleus accumbens) produced by prior experience with (+)-amphetamine: a microdialysis study in freely moving rats
Robinson, T. E., Jurson, P. A., Bennett, J. A., & Bentgen, K. M. (1988) · Brain Research · doi:10.1016/0006-8993(88)90549-5 · Cited by 463 · see citing works
Psychological stress, drug-related cues and cocaine craving
Sinha, R., Fuse, T., Aubin, L.-R., & O'Malley, S. S. (2000) · Psychopharmacology · doi:10.1007/s002130000499 · Cited by 463 · see citing works
Anhedonia or anergia? Effects of haloperidol and nucleus accumbens dopamine depletion on instrumental response selection in a T-maze cost/benefit procedure
Salamone, J. D., Cousins, M. S., & Bucher, S. (1994) · Behavioural Brain Research · doi:10.1016/0166-4328(94)90108-2 · Cited by 460 · see citing works
Ethanol self-administration restores withdrawal-associated deficiencies in accumbal dopamine and 5-hydroxytryptamine release in dependent rats
Weiss, F., Parsons, L. H., Schulteis, G., Hyytiä, P., Lorang, M. T., Bloom, F. E., & Koob, G. F. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03474.1996 · Cited by 457 · see citing works
Amphetamine Exposure Enhances Habit Formation
Nelson, A., & Killcross, S. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4305-05.2006 · Cited by 445 · see citing works
Haloperidol and nucleus accumbens dopamine depletion suppress lever pressing for food but increase free food consumption in a novel food choice procedure
Salamone, J. D., Steinpreis, R. E., McCullough, L. D., Smith, P., Grebel, D., & Mahan, K. (1991) · Psychopharmacology · doi:10.1007/bf02245659 · Cited by 436 · see citing works
Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D(2) receptors.
Volkow, N. D., Wang, G.-J., Fowler, J., Logan, J., Gatley, S., Wong, C., Hitzemann, R., & Pappas, N. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35115-8 · Cited by 434 · see citing works
Influence of Reward Delays on Responses of Dopamine Neurons
Kobayashi, S., & Schultz, W. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1600-08.2008 · Cited by 431 · see citing works
Dopamine cells respond to predicted events during classical conditioning: evidence for eligibility traces in the reward-learning network
Pan, W.-X., Schmidt, R., Wickens, J. R., & Hyland, B. I. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1478-05.2005 · Cited by 429 · see citing works
Cocaine triggered AMPA receptor redistribution is reversed in vivo by mGluR-dependent long-term depression
Bellone, C., & Lüscher, C. (2006) · Nature Neuroscience · doi:10.1038/nn1682 · Cited by 429 · see citing works
Activation in Mesolimbic and Visuospatial Neural Circuits Elicited by Smoking Cues: Evidence From Functional Magnetic Resonance Imaging
Due, D. L., Huettel, S. A., HALL, W. G., & Rubin, D. C. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.6.954 · Cited by 429 · see citing works
Effects of chronic cocaine abuse on postsynaptic dopamine receptors
(1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.6.719 · Cited by 421 · see citing works
Correlation Between Dopamine D2 Receptors in the Ventral Striatum and Central Processing of Alcohol Cues and Craving
Heinz, A., Siessmeier, T., Wrase, J., Hermann, D., Klein, S., Grüsser-Sinopoli, S. M., Flor, H., Braus, D. F., Buchholz, H. G., Gründer, G., et al. (2004) · American Journal of Psychiatry · doi:10.1176/ajp.161.10.1783 · Cited by 408 · see citing works
Fluctuations in nucleus accumbens dopamine concentration during intravenous cocaine self-administration in rats
Wise, R. A., Leeb, K., Pocock, D., Newton, P., Burnette, B., & Justice, J. B. (1995) · Psychopharmacology · doi:10.1007/bf02246140 · Cited by 406 · see citing works
I h Channels Contribute to the Different Functional Properties of Identified Dopaminergic Subpopulations in the Midbrain
Neuhoff, H., Neu, A. D., Liss, B., & Roeper, J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-04-01290.2002 · Cited by 400 · see citing works
Dopamine in the nucleus accumbens during cocaine self-administration as studied by in vivo microdialysis
Pettit, H. O., & Justice, J. B. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90291-8 · Cited by 375 · see citing works
Cannabinoids excite dopamine neurons in the ventral tegmentum and substantia nigra
French, E. D., Dillon, K. A., & Wu, X. (1997) · Neuroreport · doi:10.1097/00001756-199702100-00014 · Cited by 374 · see citing works
Phasic Dopamine Release Evoked by Abused Substances Requires Cannabinoid Receptor Activation
Cheer, J. F., Wassum, K. M., Sombers, L. A., Heien, M. L. A. V., Ariansen, J. L., Aragona, B. J., Phillips, P. E. M., & Wightman, R. M. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4152-06.2007 · Cited by 374 · see citing works
Self-citation
Cannabinoids activate mesolimbic dopamine neurons by an action on cannabinoid CB1 receptors
Gessa, G., Melis, M., Muntoni, A., & Diana, M. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01442-8 · Cited by 370 · see citing works
Glutamatergic neurons are present in the rat ventral tegmental area
Yamaguchi, T., Sheen, W., & Morales, M. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05263.x · Cited by 367 · see citing works
Frequency-dependent modulation of dopamine release by nicotine
Zhang, H., & Sulzer, D. (2004) · Nature Neuroscience · doi:10.1038/nn1243 · Cited by 361 · see citing works
Taste reactivity analysis of 6-hydroxydopamine-induced aphagia: Implications for arousal and anhedonia hypotheses of dopamine function.
Berridge, K. C., Venier, I. L., & Robinson, T. E. (1989) · Behavioral Neuroscience · doi:10.1037/0735-7044.103.1.36 · Cited by 356 · see citing works
Cocaine but Not Natural Reward Self-Administration nor Passive Cocaine Infusion Produces Persistent LTP in the VTA
Chen, B. T., Bowers, M. S., Martín, M., Hopf, F. W., Guillory, A. M., Carelli, R. M., Chou, J., & Bonci, A. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.024 · Cited by 353 · see citing works
The laterodorsal tegmentum is essential for burst firing of ventral tegmental area dopamine neurons
Lodge, D. J., & Grace, A. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510715103 · Cited by 349 · see citing works
Real-time chemical responses in the nucleus accumbens differentiate rewarding and aversive stimuli
Roitman, M. F., Wheeler, R. A., Wightman, R. M., & Carelli, R. M. (2008) · Nature Neuroscience · doi:10.1038/nn.2219 · Cited by 343 · see citing works
Cannabinoids Enhance Subsecond Dopamine Release in the Nucleus Accumbens of Awake Rats
Cheer, J. F., Wassum, K. M., Heien, M. L. A. V., Phillips, P. E. M., & Wightman, R. M. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0529-04.2004 · Cited by 343 · see citing works
Self-citation
Amphetamine‐Induced time‐dependent sensitization of dopamine neurotransmission in the dorsal and ventral striatum: A microdialysis study in behaving rats
Paulson, P. E., & Robinson, T. E. (1995) · Synapse · doi:10.1002/syn.890190108 · Cited by 337 · see citing works
Dissociation of dopamine release in the nucleus accumbens from intracranial self-stimulation
Garris, P. A., Kilpatrick, M., Bunin, M. A., Michael, D., Walker, Q. D., & Wightman, R. M. (1999) · Nature · doi:10.1038/18019 · Cited by 327 · see citing works
Basal extracellular dopamine levels in the nucleus accumbens are decreased during cocaine withdrawal after unlimited-access self-administration
Weiss, F., Markou, A., Lorang, M. T., & Koob, G. F. (1992) · Brain Research · doi:10.1016/0006-8993(92)91327-b · Cited by 318 · see citing works
Extracellular Concentrations of Cocaine and Dopamine Are Enhanced During Chronic Cocaine Administration
Pettit, H. O., Pan, H., Parsons, L. H., & Justice, J. B. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb04562.x · Cited by 318 · see citing works
Electrophysiological effects of cocaine in the mesoaccumbens dopamine system: studies in the ventral tegmental area
Einhorn, L., Johansen, P. A., & White, F. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-01-00100.1988 · Cited by 313 · see citing works
Dopaminergic Innervation of the Amygdala Is Highly Responsive to Stress
Inglis, F., & Moghaddam, B. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0721088.x · Cited by 310 · see citing works
Profound decrement of mesolimbic dopaminergic neuronal activity during ethanol withdrawal syndrome in rats: electrophysiological and biochemical evidence
Diana, M., Pistis, M., Carboni, S., Gessa, G. L., & Rossetti, Z. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7966 · Cited by 309 · see citing works
Reward-Predictive Cues Enhance Excitatory Synaptic Strength onto Midbrain Dopamine Neurons
Stuber, G. D., Klanker, M., de Ridder, B., Bowers, M. S., Joosten, R. N. J. M. A., Feenstra, M. G. P., & Bonci, A. (2008) · Science · doi:10.1126/science.1160873 · Cited by 307 · see citing works
Cocaine Dependence and D2 Receptor Availability in the Functional Subdivisions of the Striatum: Relationship with Cocaine-Seeking Behavior
Martinez, D., Broft, A., Foltin, R. W., Slifstein, M., Hwang, D.-R., Huang, Y., Perez, A., Frankel, W. G., Cooper, T., Kleber, H. D., et al. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300420 · Cited by 306 · see citing works
Repeated cocaine exposure in vivo facilitates LTP induction in midbrain dopamine neurons
Liu, Q.-S., Pu, L., & Poo, M. (2005) · Nature · doi:10.1038/nature04050 · Cited by 305 · see citing works
Imaging the Addicted Human Brain
Fowler, J. S., Volkow, N. D., Kassed, C. A., & Chang, L. (2007) · Science & Practice Perspectives · doi:10.1151/spp07324 · Cited by 304 · see citing works
Opioids block long-term potentiation of inhibitory synapses
Nugent, F. S., Penick, E. C., & Kauer, J. A. (2007) · Nature · doi:10.1038/nature05726 · Cited by 297 · see citing works
Hierarchical Control of Dopamine Neuron-Firing Patterns by Nicotinic Receptors
Mameli-Engvall, M., Evrard, A., Pons, S., Maskos, U., Svensson, T. H., Changeux, J.-P., & Faure, P. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.007 · Cited by 296 · see citing works
A direct projection from superior colliculus to substantia nigra for detecting salient visual events
Comoli, E., Coizet, V., Boyes, J., Bolam, J. P., Canteras, N. S., Quirk, R. H., Overton, P. G., & Redgrave, P. (2003) · Nature Neuroscience · doi:10.1038/nn1113 · Cited by 295 · see citing works
Differential involvement of serotonin and dopamine systems in cost-benefit decisions about delay or effort
Denk, F., Walton, M. E., Jennings, K. A., Sharp, T., Rushworth, M. F. S., & Bannerman, D. M. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2059-4 · Cited by 294 · see citing works
Acute and Chronic Cocaine-Induced Potentiation of Synaptic Strength in the Ventral Tegmental Area: Electrophysiological and Behavioral Correlates in Individual Rats
Borgland, S. L., Malenka, R. C., & Bonci, A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1312-04.2004 · Cited by 291 · see citing works
Frequency of dopamine concentration transients increases in dorsal and ventral striatum of male rats during introduction of conspecifics
Robinson, D. L., Heien, M. L. A. V., & Wightman, R. M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10477.2002 · Cited by 290 · see citing works
Dopamine D2 receptor availability in opiate-dependent subjects before and after naloxone-precipitated withdrawal
Wang, G. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00184-4 · Cited by 285 · see citing works
Correlation of Alcohol Craving With Striatal Dopamine Synthesis Capacity and D 2/3 Receptor Availability: A Combined [ 18 F]DOPA and [ 18 F]DMFP PET Study in Detoxified Alcoholic Patients
Heinz, A., Siessmeier, T., Wrase, J., Buchholz, H. G., Gründer, G., Kumakura, Y., Cumming, P., Schreckenberger, M., Smolka, M. N., Rösch, F., et al. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.8.1515 · Cited by 285 · see citing works
Mice with Chronically Elevated Dopamine Exhibit Enhanced Motivation, but not Learning, for a Food Reward
Cagniard, B., Balsam, P. D., Brunner, D., & Zhuang, X. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300966 · Cited by 282 · see citing works
Extracellular Concentration and In Vivo Recovery of Dopamine in the Nucleus Accumbens Using Microdialysis
Parsons, L. H., & Justice, J. B. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09298.x · Cited by 280 · see citing works
SHORT COMMUNICATION Inhibition of GABAergic neurotransmission in the ventral tegmental area by cannabinoids
Szabó, B., Siemes, S., & Wallmichrath, I. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02041.x · Cited by 277 · see citing works
Laterodorsal tegmental stimulation elicits dopamine efflux in the rat nucleus accumbens by activation of acetylcholine and glutamate receptors in the ventral tegmental area
Forster, G. L., & Blaha, C. D. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00250.x · Cited by 271 · see citing works
Electrophysiological effects of cocaine in the mesoaccumbens dopamine system: repeated administration.
Henry, D. J., Greene, M. A., & White, F. (1989) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21086-2 · Cited by 268 · see citing works
Nucleus accumbens opioid, GABAergic, and dopaminergic modulation of palatable food motivation: Contrasting effects revealed by a progressive ratio study in the rat.
Zhang, M., Balmadrid, C., & Kelley, A. E. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.2.202 · Cited by 268 · see citing works
Basal extracellular dopamine is decreased in the rat nucleus accumbens during abstinence from chronic cocaine
Parsons, L. H., Smith, A. D., & Justice, J. B. (1991) · Synapse · doi:10.1002/syn.890090109 · Cited by 260 · see citing works
Differential development of autoreceptor subsensitivity and enhanced dopamine release during amphetamine sensitization.
Wolf, M. E., White, F. J., Nassar, R., Brooderson, R. J., & Khansa, M. R. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10260-7 · Cited by 258 · see citing works
Corticotropin‐releasing factor increases mouse ventral tegmental area dopamine neuron firing through a protein kinase C‐dependent enhancement ofIh
Wanat, M. J., Hopf, F. W., Stuber, G. D., Phillips, P. E. M., & Bonci, A. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.150078 · Cited by 256 · see citing works
Self-citation
Chronic cocaine but not chronic amphetamine use is associated with perseverative responding in humans
Ersche, K. D., Roiser, J. P., Robbins, T. W., & Sahakian, B. J. (2008) · Psychopharmacology · doi:10.1007/s00213-007-1051-1 · Cited by 255 · see citing works
Enhanced Vulnerability to Cocaine Self-Administration Is Associated with Elevated Impulse Activity of Midbrain Dopamine Neurons
Marinelli, M., & White, F. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-23-08876.2000 · Cited by 254 · see citing works
Dopamine gating of forebrain neural ensembles
O’Donnell, P. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02463.x · Cited by 253 · see citing works
Laterodorsal tegmental projections to identified cell populations in the rat ventral tegmental area
Omelchenko, N., & Sesack, S. R. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20417 · Cited by 252 · see citing works
Amphetamine produces sensitized increases in locomotion and extracellular dopamine preferentially in the nucleus accumbens shell of rats administered repeated cocaine.
Pierce, R. C., & Kalivas, P. W. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12090-9 · Cited by 249 · see citing works
Mechanism and Time Course of Cocaine-Induced Long-Term Potentiation in the Ventral Tegmental Area
Argilli, E., Sibley, D. R., Malenka, R. C., England, P. M., & Bonci, A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1001-08.2008 · Cited by 243 · see citing works
Glutamate Receptors on Dopamine Neurons Control the Persistence of Cocaine Seeking
Engblom, D., Bilbao, A., Sanchis‐Segura, C., Dahan, L., Perreau‐Lenz, S., Balland, B., Parkitna, J. M. R., Luján, R., Halbout, B., Mameli, M., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.010 · Cited by 241 · see citing works
Calculating utility: preclinical evidence for cost–benefit analysis by mesolimbic dopamine
Phillips, P. E. M., Walton, M. E., & Jhou, T. C. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0626-6 · Cited by 237 · see citing works
Self-citation
Nucleus accumbens dopamine depletions alter relative response allocation in a T-maze cost/benefit task
Cousins, M. S., Atherton, A., Turner, L., & Salamone, J. D. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00151-4 · Cited by 236 · see citing works
Midbrain Dopamine Neurons: Projection Target Determines Action Potential Duration and Dopamine D 2 Receptor Inhibition
Margolis, E. B., Mitchell, J., Ishikawa, J., Hjelmstad, G. O., & Fields, H. L. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1526-08.2008 · Cited by 232 · see citing works
Particular subpopulations of midbrain and hypothalamic dopamine neurons express vesicular glutamate transporter 2 in the rat brain
Kawano, M., Kawasaki, A., Sakata‐Haga, H., Fukui, Y., Kawano, H., Nogami, H., & Hisano, S. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21054 · Cited by 230 · see citing works
Independent Presynaptic and Postsynaptic Mechanisms Regulate Endocannabinoid Signaling at Multiple Synapses in the Ventral Tegmental Area
Riegel, A. C., & Lupica, C. R. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3695-04.2004 · Cited by 227 · see citing works
Dynamic changes in nucleus accumbens dopamine efflux during the Coolidge effect in male rats
Fiorino, D. F., Coury, A., & Phillips, A. G. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-12-04849.1997 · Cited by 226 · see citing works
Effect of dose on cocaine self-administration behavior and dopamine levels in the nucleus accumbens
Pettit, H. O., & Justice, J. B. (1991) · Brain Research · doi:10.1016/0006-8993(91)90690-w · Cited by 225 · see citing works
Preferential Enhancement of Dopamine Transmission within the Nucleus Accumbens Shell by Cocaine Is Attributable to a Direct Increase in Phasic Dopamine Release Events
Aragona, B. J., Cleaveland, N. A., Stuber, G. D., Day, J. J., Carelli, R. M., & Wightman, R. M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2225-08.2008 · Cited by 225 · see citing works
D1 or D2 antagonism in nucleus accumbens core or dorsomedial shell suppresses lever pressing for food but leads to compensatory increases in chow consumption
Nowend, K. L., Arizzi, M. N., Carlson, B. B., & Salamone, J. D. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00524-x · Cited by 223 · see citing works
Conditioned Dopamine Release in Humans: A Positron Emission Tomography [ 11 C]Raclopride Study with Amphetamine
Boileau, I., Dagher, A., Leyton, M., Welfeld, K., Booij, L., Diksic, M., & Benkelfat, C. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4370-06.2007 · Cited by 222 · see citing works
Rapid dopamine signaling in the nucleus accumbens during contingent and noncontingent cocaine administration
Stuber, G. D., Roitman, M. F., Phillips, P. E. M., Carelli, R. M., & Wightman, R. M. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300619 · Cited by 217 · see citing works
Self-citation
Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—3. Evidence for electrotonic coupling
Grace, A. A., & Bunney, B. S. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90137-9 · Cited by 205 · see citing works
Time course of the development of the enhanced behavioral and biochemical responses to amphetamine after pretreatment with amphetamine
Kolta, M. G., Shreve, P. E., DESOUZA, V., & Uretsky, N. J. (1985) · Neuropharmacology · doi:10.1016/0028-3908(85)90032-2 · Cited by 199 · see citing works
Hyperpolarization-Activated Cation Current ( I h ) Is an Ethanol Target in Midbrain Dopamine Neurons of Mice
Okamoto, T., Harnett, M. T., & Morikawa, H. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00682.2005 · Cited by 197 · see citing works
Long-Lasting Potentiation of GABAergic Synapses in Dopamine Neurons after a SingleIn VivoEthanol Exposure
Melis, M., Camarini, R., Ungless, M. A., & Bonci, A. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-06-02074.2002 · Cited by 196 · see citing works
In vivo microdialysis reveals a diminished amphetamine-induced DA response corresponding to behavioral sensitization produced by repeated amphetamine pretreatment
Segal, D. S., & Kuczenski, R. T. (1992) · Brain Research · doi:10.1016/0006-8993(92)90672-v · Cited by 193 · see citing works
Real‐Time Measurement of Electrically Evoked Extracellular Dopamine in the Striatum of Freely Moving Rats
Garris, P. A., Christensen, J. R. C., Rebec, G. V., & Wightman, R. M. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68010152.x · Cited by 192 · see citing works
Elevations of nucleus accumbens dopamine and DOPAC levels during intravenous heroin self‐administration
Wise, R. A., Leone, P., Rivest, R., & Leeb, K. (1995) · Synapse · doi:10.1002/syn.890210207 · Cited by 190 · see citing works
Effects of Dopamine Antagonists and Accumbens Dopamine Depletions on Time-Constrained Progressive-Ratio Performance
Aberman, J., Ward, S. J., & Salamone, J. D. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00112-9 · Cited by 190 · see citing works
Differential Autoreceptor Control of Somatodendritic and Axon Terminal Dopamine Release in Substantia Nigra, Ventral Tegmental Area, and Striatum
Cragg, S. J., & Greenfield, S. A. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-15-05738.1997 · Cited by 184 · see citing works
An ultrastructural analysis of tissue surrounding a microdialysis probe
Clapp-Lilly, K. L., Roberts, R. C., Duffy, L. K., Irons, K. P., Hu, Y. S., & Drew, K. L. (1999) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(99)00064-3 · Cited by 181 · see citing works
Restraint increases dopaminergic burst firing in awake rats
Anstrom, K. K., & Woodward, D. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300730 · Cited by 181 · see citing works
Repeated cocaine administration induces behavioral sensitization and corresponding decreased extracellular dopamine responses in caudate and accumbens
Segal, D. S., & Kuczenski, R. T. (1992) · Brain Research · doi:10.1016/0006-8993(92)90297-m · Cited by 181 · see citing works
Pedunculopontine tegmental stimulation evokes striatal dopamine efflux by activation of acetylcholine and glutamate receptors in the midbrain and pons of the rat
Forster, G. L., & Blaha, C. D. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02511.x · Cited by 175 · see citing works
Nucleus accumbens dopamine depletions in rats affect relative response allocation in a novel cost/benefit procedure
Cousins, M. S., & Salamone, J. D. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90460-x · Cited by 174 · see citing works
Dynamic Gain Control of Dopamine Delivery in Freely Moving Animals
Montague, P. R., McClure, S. M., Baldwin, P. R., Phillips, P. E. M., Budygin, E. A., Stuber, G. D., Kilpatrick, M., & Wightman, R. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4279-03.2004 · Cited by 174 · see citing works
Self-citation
Microdialysis of dopamine interpreted with quantitative model incorporating probe implantation trauma
Bungay, P. M., Newton‐Vinson, P., Isele, W., Garris, P. A., & Justice, J. B. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01904.x · Cited by 173 · see citing works
Different effects of nucleus accumbens and ventrolateral striatal dopamine depletions on instrumental response selection in the rat
Cousins, M. S., Sokolowski, J. D., & Salamone, J. D. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90226-j · Cited by 172 · see citing works
Profound decrease of mesolimbic dopaminergic neuronal activity in morphine withdrawn rats.
Diana, M., Pistis, M., Muntoni, A. L., & Gessa, G. L. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24484-6 · Cited by 170 · see citing works
Extinction of Cocaine Self-Administration Reveals Functionally and Temporally Distinct Dopaminergic Signals in the Nucleus Accumbens
Stuber, G. D., Wightman, R. M., & Carelli, R. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.036 · Cited by 168 · see citing works
A subset of ventral tegmental area neurons is inhibited by dopamine, 5-hydroxytryptamine and opioids
Cameron, D., Wessendorf, M. W., & Williams, J. T. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00444-7 · Cited by 163 · see citing works
Role of extracellular dopamine in the initiation and long-term expression of behavioral sensitization to cocaine.
Heidbreder, C. A., Thompson, A. C., & Shippenberg, T. S. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20628-0 · Cited by 163 · see citing works
Activity of A9 and A10 dopaminergic neurons in unrestrained rats: further characterization and effects of apomorphine and cholecystokinin
Freeman, A. S., & Bunney, B. S. (1987) · Brain Research · doi:10.1016/0006-8993(87)90988-7 · Cited by 162 · see citing works
The ability of the mesocortical dopamine system to operate in distinct temporal modes
Lapish, C. C., Kroener, S., Durstewitz, D., Lavı́n, A., & Seamans, J. K. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0527-8 · Cited by 153 · see citing works
Effects of morphine and haloperidol on the electrical activity of rat nigrostriatal neurons.
Iwatsubo, K., & Clouet, D. H. (1977) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)30973-0 · Cited by 151 · see citing works
Electrophysiological properties of mouse dopamine neurons: In vivo and in vitro studies
Sanghera, M. K., Trulson, M. E., & German, D. C. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90171-4 · Cited by 150 · see citing works
Pimozide Does Not Shift Palatability: Separation of Anhedonia from Sensorimotor Suppression by Taste Reactivity
Peciña, S. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00044-0 · Cited by 148 · see citing works
Dopamine Fluctuations in the Nucleus Accumbens during Maintenance, Extinction, and Reinstatement of Intravenous d-Amphetamine Self-Administration
Ranaldi, R., Pocock, D., Zereik, R., & Wise, R. A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-10-04102.1999 · Cited by 148 · see citing works
Sub-second changes in accumbal dopamine during sexual behavior in male rats
Robinson, D. L., Phillips, P. E. M., Budygin, E. A., Trafton, B. J., Garris, P. A., & Wightman, R. M. (2001) · Neuroreport · doi:10.1097/00001756-200108080-00051 · Cited by 147 · see citing works
Self-citation
Cocaine Enhances NMDA Receptor-Mediated Currents in Ventral Tegmental Area Cells via Dopamine D5Receptor-Dependent Redistribution of NMDA Receptors
Schilström, B., Yaka, R., Argilli, E., Suvarna, N. U., Schumann, J., Chen, B. T., Carman, M., Singh, V., Mailliard, W. S., Dorit Ron, A., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5179-05.2006 · Cited by 147 · see citing works
Increases in extracellular dopamine in the nucleus accumbens by cocaine are inversely related to basal levels: effects of acute and repeated administration
Weiss, F., Paulus, M. P., Lorang, M. T., & Koob, G. F. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-11-04372.1992 · Cited by 146 · see citing works
Dynamic changes in accumbens dopamine correlate with learning during intracranial self-stimulation
Owesson-White, C., Cheer, J. F., Beyene, M., Carelli, R. M., & Wightman, R. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803896105 · Cited by 144 · see citing works
Heterogeneous subregional binding patterns of 3H-WIN 35,428 and 3H-GBR 12,935 are differentially regulated by chronic cocaine self- administration
Wilson, J., Nobrega, J., Carroll, M., Niznik, H. B., Shannak, K. S., Lac, S., Pristupa, Z. B., Dixon, L., & Kish, S. J. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-05-02966.1994 · Cited by 143 · see citing works
Simultaneous dopamine and single-unit recordings reveal accumbens GABAergic responses: implications for intracranial self-stimulation
Cheer, J. F., Heien, M. L. A. V., Garris, P. A., Carelli, R. M., & Wightman, R. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509607102 · Cited by 143 · see citing works
Excitability of Dopamine Neurons: Modulation and Physiological Consequences
White, F., Hu, X., Marinelli, M., & Rudick, C. N. (2006) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152706784111542 · Cited by 136 · see citing works
Behavioral and neurochemical sensitization following cocaine self-administration
Hooks, M. S., Duffy, P., Striplin, C. D., & Kalivas, P. W. (1994) · Psychopharmacology · doi:10.1007/bf02244782 · Cited by 132 · see citing works
Lasting reduction in mesolimbic dopamine neuronal activity after morphine withdrawal
Diana, M., Muntoni, A. L., Pistis, M., Melis, M., & Gessa, G. L. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00488.x · Cited by 132 · see citing works
Ethanol Facilitates Glutamatergic Transmission to Dopamine Neurons in the Ventral Tegmental Area
Xiao, C., Shao, X. M., Olive, M. F., Griffin, W. C., Li, K.-Y., Krnjević, K., Zhou, C., & Ye, J. H. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.99 · Cited by 129 · see citing works
Actions of cocaine on rat dopaminergic neuronesin vitro
Lacey, M. G., Mercuri, N. B., & North, R. A. (1990) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1990.tb12998.x · Cited by 127 · see citing works
Apparent synaptic dopamine deficiency induced by withdrawal from chronic cocaine treatment
Robertson, M. W., Leslie, C. A., & Bennett, J. P. (1991) · Brain Research · doi:10.1016/0006-8993(91)90451-z · Cited by 123 · see citing works
An Escalating Dose “Binge” Model of Amphetamine Psychosis: Behavioral and Neurochemical Characteristics
Segal, D. S., & Kuczenski, R. T. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02551.1997 · Cited by 122 · see citing works
Cocaine craving, euphoria, and self-administration: A preliminary study of the effect of catecholamine precursor depletion.
Leyton, M., Casey, K. F., Delaney, J. S., Kolivakis, T., & Benkelfat, C. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.6.1619 · Cited by 120 · see citing works
Effects of chronic Δ9-tetrahydrocannabinol on rat midbrain dopamine neurons: an electrophysiological assessment
Wu, X., & French, E. D. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(99)00140-9 · Cited by 116 · see citing works
Different mechanisms for dopaminergic excitation induced by opiates and cannabinoids in the rat midbrain
Melis, M., Gessa, G. L., & Diana, M. (2000) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(00)00119-6 · Cited by 112 · see citing works
Dopamine and glutamate release in the nucleus accumbens and ventral tegmental area of rat following lateral hypothalamic self-stimulation
You, Z. ‐., Chen, Y., & Wise, R. A. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00379-7 · Cited by 112 · see citing works
Real-Time Measurements of Phasic Changes in Extracellular Dopamine Concentration in Freely Moving Rats by Fast-Scan Cyclic Voltammetry
Phillips, P. E. M., Robinson, D. L., Stuber, G. D., Carelli, R. M., & Wightman, R. M. (2003) · Humana Press eBooks · doi:10.1385/1-59259-358-5:443 · Cited by 112 · see citing works
Self-citation
Effect of Acute Ethanol on Striatal Dopamine Neurotransmission in Ambulatory Rats
Budygin, E. A., Phillips, P. E. M., Robinson, D. L., Kennedy, A. P., Gainetdinov, R. R., & Wightman, R. M. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29507-0 · Cited by 110 · see citing works
Self-citation
Critical guidelines for validation of the selectivity of in-vivo chemical microsensors
Phillips, P. E. M., & Wightman, R. M. (2003) · TrAC Trends in Analytical Chemistry · doi:10.1016/s0165-9936(03)00907-5 · Cited by 110 · see citing works
Self-citation
Emotion-based decision-making in healthy subjects: short-term effects of reducing dopamine levels
Sevy, S. M., Hassoun, Y., Bechara, A., Yechiam, E., Napolitano, B. A., Burdick, K. E., Delman, H., & Malhotra, A. K. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0450-z · Cited by 110 · see citing works
Daily cocaine treatment produces a persistent reduction of [3H]dopamine uptake in vitro in rat nucleus accumbens but not in striatum
Izenwasser, S., & Cox, B. M. (1990) · Brain Research · doi:10.1016/0006-8993(90)90797-f · Cited by 109 · see citing works
Withdrawal of repeated cocaine decreases autoradlographic [3H]mazindol-labelling of dopamine transporter In rat nucleus aecumbens
Sharpe, L. G., Pilotte, N. S., Mitchell, W. M., & Souza, E. B. D. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90804-y · Cited by 107 · see citing works
Heterogeneity of ventral tegmental area neurons: Single-unit recording and iontophoresis in awake, unrestrained rats
Kiyatkin, E. A., & Rebec, G. V. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00054-2 · Cited by 107 · see citing works
Enhanced appetitive conditioning following repeated pretreatment with d-amphetamine
Harmer, C. J., & Phillips, G. D. (1998) · Behavioural Pharmacology · doi:10.1097/00008877-199807000-00001 · Cited by 107 · see citing works
‘Passive stabilization’ of striatal extracellular dopamine across the lesion spectrum encompassing the presymptomatic phase of Parkinson's disease: a voltammetric study in the 6‐OHDA‐lesioned rat
Bergstrom, B. P., & Garris, P. A. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02104.x · Cited by 107 · see citing works
Long-term Outcome of Chronic Drug Use: The Amsterdam Cohort Study among Drug Users
Termorshuizen, F. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi035 · Cited by 106 · see citing works

Flagged first, then by citations

Sorted by citations

Addiction: Beyond dopamine reward circuitry
Volkow, N. D., Wang, G.-J., Fowler, J. S., Tomasi, D., & Telang, F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010654108 · Cited by 959 · see citing works
Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction
Volkow, N. D., Wang, G. J., Fowler, J. S., Tomasi, D., & Baler, R. (2011) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2011_169 · Cited by 525 · see citing works
Model-based and model-free Pavlovian reward learning: Revaluation, revision, and revelation
Dayan, P., & Berridge, K. C. (2014) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-014-0277-8 · Cited by 357 · see citing works
Natural rewards, neuroplasticity, and non-drug addictions
Olsen, C. M. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.03.010 · Cited by 339 · see citing works
An integrative perspective on the role of dopamine in schizophrenia
Maia, T. V., & Frank, M. J. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.05.021 · Cited by 293 · see citing works
New developments in brain research of internet and gaming disorder
Weinstein, A., Livny, A., & Weizman, A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.040 · Cited by 257 · see citing works
A multistep general theory of transition to addiction
Piazza, P. V., & Deroche-Gamonet, V. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3224-4 · Cited by 227 · see citing works
Aversive Stimuli Differentially Modulate Real-Time Dopamine Transmission Dynamics within the Nucleus Accumbens Core and Shell
Badrinarayan, A., Wescott, S. A., Vander Weele, C. M., Saunders, B. T., Couturier, B. E., Maren, S., & Aragona, B. J. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3557-12.2012 · Cited by 225 · see citing works
Multiple roles for orexin/hypocretin in addiction
Mahler, S. V., Smith, R. J., Moorman, D. E., Sartor, G. C., & Aston-Jones, G. (2012) · Progress in Brain Research · doi:10.1016/b978-0-444-59489-1.00007-0 · Cited by 215 · see citing works
Dopamine signaling in the nucleus accumbens of animals self-administering drugs of abuse
Willuhn, I., Wanat, M. J., Clark, J. J., & Phillips, P. E. M. (2010) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2009_27 · Cited by 193 · see citing works
Self-citation
Dopaminergic modulation of incentive motivation in adolescence: age-related changes in signaling, individual differences, and implications for the development of self-regulation
Luciana, M., Wahlstrom, D., Porter, J. N., & Collins, P. F. (2012) · Developmental Psychology · doi:10.1037/a0027432 · Cited by 156 · see citing works
Mechanistic insights into nicotine withdrawal
Paolini, M., & De Biasi, M. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.07.075 · Cited by 66 · see citing works
Catechol‐O‐methyltransferase gene methylation and substance use in adolescents: the <scp>TRAILS</scp> study
van der Knaap, L. J., Schaefer, J. M., Franken, I. H. A., Verhulst, F. C., van Oort, F. V. A., & Riese, H. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12147 · Cited by 38 · see citing works
A mechanistic model of ADHD as resulting from dopamine phasic/tonic imbalance during reinforcement learning
Véronneau-Veilleux, F., Robaey, P., Ursino, M., & Nekka, F. (2022) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2022.849323 · Cited by 32 · see citing works

Authors: Wanat, M., Willuhn, I., Clark, J., & Phillips, P.
Affiliations: University of Washington (US)
Corresponding author: Wanat, Matthew
ORCID: Wanat, Matthew
Willuhn, Ingo
Clark, Jeremy
Phillips, Paul
Venue: Current Drug Abuse Reviewse
Publisher: Bentham Science Publishers Ltd.
Published: 2009-05-01
Volume: 2
Issue: 2
Pages: 195-213
ISSN: 1874-4737 (ISSN-L)
DOI: 10.2174/1874473710902020195
PMC: PMC2877500
OpenAlex: W2433064467
Cited by: 177
References: 260
Citations by year: 2026: 5 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 12 · 2021: 5 · 2020: 15 · 2019: 13 · 2018: 14 · 2017: 10 · 2016: 14 · 2015: 17 · 2014: 16 · 2013: 12 · 2012: 19
FWCI: 4.15
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Current Drug Abuse Reviews (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism (T32AA009455, T32AA007455)
National Institute of Mental Health (R01MH079292)
National Institute on Drug Abuse (F32DA024540, R21DA021793)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: phasic dopamine release, drug addiction, drug-seeking behavior, appetitive behavior, goal-directed behavior, dopaminergic neurons, signal-to-noise ratio, natural reinforcement, chronic drug exposure
MeSH terms: Animals, Appetitive Behavior, Central Nervous System Depressants, Cues, Dopamine, Dose-Response Relationship, Drug, Humans, Recurrence, Reinforcement, Psychology, Substance Withdrawal Syndrome, Substance-Related Disorders

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Phasic dopamine release in appetitive behaviors and drug addiction

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks