The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory
Abstract
Dopamine (DA) D1 receptor (D1R) stimulation in prefrontal cortex (PFC) produces an 'inverted-U' dose-response, whereby either too little or too much D1R stimulation impairs spatial working memory. This response has been observed across species, including genetic linkages with human cognitive abilities, PFC activation states and DA synthesis. The cellular basis for the inverted U has long been sought, with in vitro intracellular recordings supporting a variety of potential mechanisms. The current study demonstrates that the D1R agonist inverted-U response can be observed in PFC neurons of behaving monkeys: low levels of D1R stimulation enhance spatial tuning by suppressing responses to nonpreferred directions, whereas high levels reduce delay-related firing for all directions, eroding tuning. These sculpting actions of D1R stimulation are mediated in monkeys and rats by cyclic AMP intracellular signaling. The evidence for an inverted U at the cellular level in behaving animals promises to bridge in vitro molecular analyses with human cognitive experience.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Dopaminergic stimulation of D1-receptors opens ion channels on a set of dendritic spines that receive inputs irrelevant to focused working memory and attention. Opening channels on these spines weakens irrelevant network connections, reducing noisy input to the neuron and enhancing the efficiency of PFC function.”
From Catecholamine influences on prefrontal cortical function: Relevance to treatment of attention deficit/hyperactivity disorder and related disorders (2011) · cites this paper as Vijayraghavan et al., 2007
In the citing paper
“In the PFC, DA plays a role complementary to that of NE, decreasing PFC neuronal activity in response to irrelevant stimuli. (Vijayraghavan et al., 2007).”
From Catecholamine influences on prefrontal cortical function: Relevance to treatment of attention deficit/hyperactivity disorder and related disorders (2011) · cites this paper as Vijayraghavan et al., 2007
In the citing paper
“D1-receptors have fundamental excitatory effects on PFC function, but also modify inputs to pyramidal cells (Vijayraghavan et al., 2007).”
From Catecholamine influences on prefrontal cortical function: Relevance to treatment of attention deficit/hyperactivity disorder and related disorders (2011) · cites this paper as Vijayraghavan et al., 2007
In the citing paper
“As a result, PFC neurons require a specific amount of DA to function optimally (Arnsten et al., 2009; Vijayraghavan et al., 2007).”
From Catecholamine influences on prefrontal cortical function: Relevance to treatment of attention deficit/hyperactivity disorder and related disorders (2011) · cites this paper as Vijayraghavan et al., 2007
In the citing paper
“Similar results are observed at the cellular level, whereby Sp-cAMPS, high doses of D1 agonist or a phosphodiesterase inhibitor all suppress neuronal firing in monkeys performing a working memory task, whereas inhibition of cAMP or gentle blockade of HCN channels restores normal firing patterns60,68.”
From Stress signalling pathways that impair prefrontal cortex structure and function (2009) · cites this paper as [68]
In the citing paper
“Conversely, we propose that in an ODR task, D1 receptors suppress neuronal responses to non-preferred directions by increasing cAMP production68 and opening HCN channels on spines that receive network inputs from cells that are tuned to these other directions (FIG. 4a).”
From Stress signalling pathways that impair prefrontal cortex structure and function (2009) · cites this paper as [68]
In the citing paper
“The impairment in working memory that is induced by stress exposure or excessive D1 receptor stimulation can be prevented by blocking cAMP activity or HCN channels in the PFC60,68 (A.F.T.A., unpublished observations) or can be mimicked by administering the cAMP analogue Sp-cAMPS96.”
From Stress signalling pathways that impair prefrontal cortex structure and function (2009) · cites this paper as [68]
In the citing paper
“The inverted U-shaped relationship can also be observed at the cellular level (FIG. 2b), where an optimal level of D1 receptor stimulation enhances spatial tuning by suppressing delay-related firing to the neurons’ non-preferred directions in the ODR task68.”
From Stress signalling pathways that impair prefrontal cortex structure and function (2009) · cites this paper as [68]
In the citing paper
“Conversely, dopamine acts at D1 receptors to narrow spatial tuning, sculpting network inputs to decrease noise (i.e., stabilization of the representation).”
From Catecholamine Influences on Dorsolateral Prefrontal Cortical Networks (2011) · cites this paper as [109]
In the citing paper
“Thus, DA and NE have complementary roles: NE α2A receptor stimulation enhances network firing for shared, preferred inputs (i.e., increasing signals [57]), whereas D1 receptor stimulation sculpts neuronal firing by decreasing firing to nonpreferred inputs (i.e., decreasing noise [109]).”
From Catecholamine Influences on Dorsolateral Prefrontal Cortical Networks (2011) · cites this paper as [109]
In the citing paper
“This inverted U-shaped relationship can be observed at the cellular level (Figure 3B), where an optimal level of D1/5 receptor stimulation enhances spatial tuning by suppressing delay-related firing to the neurons’ nonpreferred directions (109).”
From Catecholamine Influences on Dorsolateral Prefrontal Cortical Networks (2011) · cites this paper as [109]
In the citing paper
“In contrast to moderate D1/5 receptor stimulation, high doses of D1/5 agonist suppress all neuronal firing (Figure 3B, right side of curve).”
From Catecholamine Influences on Dorsolateral Prefrontal Cortical Networks (2011) · cites this paper as [109]
In the citing paper
“Conversely, inhibition of Ca2+–PKC or cAMP–PKA signaling, or blockade of HCN channels, can rescue PFC delay-cell firing and working memory functions57,60,62.”
From Stress weakens prefrontal networks: molecular insults to higher cognition (2015) · cites this paper as [60]
In the citing paper
“Norepinephrine α1-ARs activate Ca2+–protein kinase C (PKC) signaling, which reduces delay-cell firing in the primate dlPFC57, while high levels of dopamine D1R stimulation reduce dlPFC delay-cell firing by increasing cAMP–protein kinase A (PKA) signaling60.”
From Stress weakens prefrontal networks: molecular insults to higher cognition (2015) · cites this paper as [60]
In the citing paper
“As is the case with selective attention, dopamine D1 receptors also appear to modulate visuo-spatial working memory-related activity in the monkey PFC (e.g. [19])”
From Linking ADHD to the Neural Circuitry of Attention (2017) · cites this paper as [19]
In the citing paper
“With nonhuman primates we can, for example, interrogate how catecholaminergic circuits in the prefrontal cortex contribute to ADHD-linked behaviors (e.g. [19,47])”
From Linking ADHD to the Neural Circuitry of Attention (2017) · cites this paper as [19]
In the citing paper
“Dopaminergic signalling has a role in the top-down regulation of spatial attention, and D1 dopaminergic receptors modulate response amplitude and selectivity in the dorsolateral prefrontal cortex for preferred spatial locations during working memory tasks204,205.”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [204]
In the citing paper
“Dopaminergic signalling has a role in the top-down regulation of spatial attention, and D1 dopaminergic receptors modulate response amplitude and selectivity in the dorsolateral prefrontal cortex for preferred spatial locations during working memory tasks204,205.”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [204]
In the citing paper
“Dopamine effects on behavior follow an inverted U-shaped dose-response curve, with both deficient and excessive amounts of dopamine activity predicting poor cognitive tasks performance (24,25).”
From Influence of the COMT genotype on working memory and brain activity changes during development (2011) · cites this paper as [24]
In the citing paper
“PFC functioning and WM performance have been suggested to follow an inverted-U curve function of dopamine levels (24), with adult rs4680 Met/Met individuals near the apex of this curve (2).”
From Influence of the COMT genotype on working memory and brain activity changes during development (2011) · cites this paper as [24]
Citations
Cites
Cellular basis of working memory
Goldman-Rakic, P. S. (1995) · Neuron · doi:10.1016/0896-6273(95)90304-6 · Cited by 2,663
McDonald-McGinn, D. M., Sullivan, K. E., Marino, B., Philip, N., Swillen, A., Vorstman, J. A. S., Zackai, E. H., Emanuel, B. S., Vermeesch, J. R., Morrow, B. E., et al. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.71 · Cited by 2,236
Modulation of memory fields by dopamine Dl receptors in prefrontal cortex
Williams, G. V., & Goldman-Rakic, P. S. (1995) · Nature · doi:10.1038/376572a0 · Cited by 1,593
Self-citationThe principal features and mechanisms of dopamine modulation in the prefrontal cortex
Seamans, J. K., & Yang, C. R. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.006 · Cited by 1,592
Schultz, W., Apicella, P., & Ljungberg, T. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-03-00900.1993 · Cited by 1,291
Mattay, V. S., Goldberg, T. E., Fera, F., Hariri, A. R., Tessitore, A., Egan, M. F., Kolachana, B., Callicott, J. H., & Weinberger, D. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0931309100 · Cited by 893
Zahrt, J., Taylor, J. R., Mathew, R. G., & Arnsten, A. F. T. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08528.1997 · Cited by 796
Self-citationCallicott, J. H. (1999) · Cerebral Cortex · doi:10.1093/cercor/9.1.20 · Cited by 771
Mehta, M. A., Owen, A. M., Sahakian, B. J., Mavaddat, N., Pickard, J. D., & Robbins, T. W. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-06-j0004.2000 · Cited by 608 · cited 1×
“The reduction in processing of 'noise' by D1R stimulation seen in the current study is consonant with results observed in imaging studies of human subjects performing working memory tasks, whereby cognition-enhancing doses of stimulant medication actually reduce the area of PFC activated by task demands, thus enhancin…”
ResultExecutive Subprocesses in Working Memory
Goldberg, T. E., Egan, M. F., Gscheidle, T., Coppola, R., Weickert, T. W., Kolachana, B. S., Goldman, D. A., & Weinberger, D. R. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.9.889 · Cited by 586
Cited by
Sorted by citations
Items 201–300 of 997
Comprehensive review: Computational modelling of schizophrenia
Valton, V., Romaniuk, L., Steele, J. D., Lawrie, S. M., & Seriès, P. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.08.022 · Cited by 82
Dopaminergic Mechanisms Underlying Normal Variation in Trait Anxiety
Berry, A. S., White, R. L., Furman, D. J., Naskolnakorn, J. R., Shah, V. D., D’Esposito, M., & Jagust, W. J. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2382-18.2019 · Cited by 83
Dopamine, working memory, and training induced plasticity: Implications for developmental research.
Söderqvist, S., Nutley, S. B., Peyrard‐Janvid, M., Matsson, H., Humphreys, K., Kere, J., & Klingberg, T. (2011) · Developmental Psychology · doi:10.1037/a0026179 · Cited by 80
Effect of the tools of the mind kindergarten program on children’s social and emotional development
Blair, C., McKinnon, R. D., & Daneri, M. P. (2018) · Early Childhood Research Quarterly · doi:10.1016/j.ecresq.2018.01.002 · Cited by 99
Dopamine vs Noradrenaline: Inverted-U Effects and ADHD Theories
Lévy, F. (2009) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/00048670802607238 · Cited by 78
Morar, B., Dragović, M., Waters, F., Chandler, D., Kalaydjieva, L. V., & Jablensky, A. V. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.70 · Cited by 77
Xu, T., Sotnikova, T. D., Liang, C., Zhang, J., Jung, J. U., Spealman, R. D., Gainetdinov, R. R., & Yao, W. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0974-09.2009 · Cited by 80
Dopamine D 1 signaling organizes network dynamics underlying working memory
Roffman, J. L., Tanner, A. S., Eryilmaz, H., Rodriguez-Thompson, A., Silverstein, N. J., Ho, N. F., Nitenson, A. Z., Chonde, D. B., Greve, D. N., Abi‐Dargham, A., et al. (2016) · Science Advances · doi:10.1126/sciadv.1501672 · Cited by 76
Soltani, A., Noudoost, B., & Moore, T. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221236110 · Cited by 73
Psychostimulants Act Within the Prefrontal Cortex to Improve Cognitive Function
Spencer, R. C., Klein, R. M., & Berridge, C. W. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.12.002 · Cited by 74
Prefrontal Dopamine Levels Determine the Balance between Cognitive Stability and Flexibility
Fallon, S. J., Williams‐Gray, C. H., Barker, R., Owen, A. M., & Hampshire, A. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs025 · Cited by 82
Paradoxical effects of stress and an executive task on decisions under risk.
Pabst, S., Schoofs, D., Pawlikowski, M., Brand, M., & Wolf, O. T. (2013) · Behavioral Neuroscience · doi:10.1037/a0032334 · Cited by 74
Masana, M., Bortolozzi, A. A., & Artigas, F. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000908 · Cited by 78
Functional connectivity change as shared signal dynamics
Cole, M. W., Yang, G. J., Murray, J. D., Repovš, G., & Anticevic, A. (2016) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2015.11.011 · Cited by 60
Catecholamine/Serotonin Interactions
Hensler, J. G., Artigas, F., Bortolozzi, A., Daws, L. C., De Deurwaerdère, P., Milan, L., Navailles, S., & Koek, W. (2013) · Advances in Pharmacology · doi:10.1016/b978-0-12-411512-5.00009-9 · Cited by 73
Epistatic interaction between COMT and DTNBP1 modulates prefrontal function in mice and in humans
Papaleo, F., Burdick, M., Callicott, J. H., & Weinberger, D. R. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.133 · Cited by 73
He, B. J., & Zempel, J. M. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003348 · Cited by 75
Distinct manifestations of executive dysfunction in aged rats
Beas, B. S., Setlow, B., & Bizon, J. L. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.03.019 · Cited by 74
Castañé, A., Santana, N., & Artigas, F. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3946-6 · Cited by 71
Dopamine, cognitive function, and gamma oscillations: role of D4 receptors
Furth, K. E., Mastwal, S. S., Wang, K. H., Buonanno, A., & Vullhorst, D. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00102 · Cited by 74
Morin, B., Nichols, L. A., Zalasky, K. M., Davis, J. W., Manthey, J. A., & Holland, L. J. (2008) · Journal of Nutrition · doi:10.1093/jn/138.7.1274 · Cited by 72
Söderqvist, S., Matsson, H., Peyrard‐Janvid, M., Kere, J., & Klingberg, T. (2013) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00478 · Cited by 78
Computational models of reinforcement learning: the role of dopamine as a reward signal
Samson, R. D., Frank, M. J., & Fellous, J. (2010) · Cognitive Neurodynamics · doi:10.1007/s11571-010-9109-x · Cited by 75
Dopaminergic Suppression of Brain Deactivation Responses during Sequence Learning
Árgyelán, M., Carbon, M., Ghilardi, M. F., Feigin, A., Mattis, P. J., Tang, C., DHAWAN, V. M., & Eidelberg, D. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2933-08.2008 · Cited by 70
Reducing substance use during adolescence: a translational framework for prevention
Stanis, J. J., & Andersen, S. L. (2014) · Psychopharmacology · doi:10.1007/s00213-013-3393-1 · Cited by 75
Ng, J., Rashid, A. J., So, C. H., O’Dowd, B. F., & George, S. R. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.10.017 · Cited by 69
Molecular mechanisms of working memory
Khan, Z. U., & Muly, E. C. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.12.039 · Cited by 79
Imaging the genetics of executive function
Greene, C. M., Braet, W., Johnson, K. A., & Bellgrove, M. A. (2007) · Biological Psychology · doi:10.1016/j.biopsycho.2007.11.009 · Cited by 76
Seshadri, S., Faust, T. E., Ishizuka, K., Delevich, K. M., Chung, Y., Kim, S.-H., Cowles, M. W., Niwa, M., Jaaro-Peled, H., Tomoda, T., et al. (2015) · Nature Communications · doi:10.1038/ncomms10118 · Cited by 67
Investigating the mechanism(s) underlying switching between states in bipolar disorder
Young, J. W., & Dulcis, D. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.019 · Cited by 68
Schroll, H., Vitay, J., & Hamker, F. H. (2011) · Neural Networks · doi:10.1016/j.neunet.2011.10.008 · Cited by 70
Linking neurogenetics and individual differences in language learning: the dopamine hypothesis.
Wong, P. C. M., Morgan-Short, K., Ettlinger, M., & Zheng, J. (2012) · Cortex · doi:10.1016/j.cortex.2012.03.017 · Cited by 67
Fallon, S. J., van der Schaaf, M. E., ter Huurne, N., & Cools, R. (2016) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01065 · Cited by 70
Gratton, C., Yousef, S., Aarts, E., Wallace, D. L., D’Esposito, M., & Silver, M. A. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2405-16.2017 · Cited by 63
Dopamine activates astrocytes in prefrontal cortex via α1-adrenergic receptors
Pittolo, S., Yokoyama, S., Willoughby, D. D., Taylor, C. R., Reitman, M. E., Tse, V., Wu, Z., Etchenique, R., Li, Y., & Poskanzer, K. E. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111426 · Cited by 70
Holmes, J., Gathercole, S. E., & Dunning, D. L. (2010) · Advances in Child Development and Behavior · doi:10.1016/b978-0-12-374748-8.00001-9 · Cited by 66
McMorris, T., Hale, B. J., Corbett, J., Robertson, K. M., & Hodgson, C. I. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.01.010 · Cited by 69
Dopamine Regulates Two Classes of Primate Prefrontal Neurons That Represent Sensory Signals
Jacob, S. N., Ott, T., & Nieder, A. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0210-13.2013 · Cited by 70
A computational neuroscience approach to schizophrenia and its onset
Rolls, E. T., & Deco, G. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.09.001 · Cited by 67
Perez, S. M., Shah, A., Asher, A. M., & Lodge, D. J. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712001344 · Cited by 66
Holmboe, K., Nemoda, Z., Fearon, P. R. M., Csibra, G., Sasvári‐Székely, M., & Johnson, M. H. (2010) · Developmental Psychology · doi:10.1037/a0018180 · Cited by 69
Bach, M. E., Simpson, E. H., Kahn, L. W., Marshall, J. J., Kandel, E. R., & Kellendonk, C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807746105 · Cited by 65
Alavash, M., Lim, S.-J., Thiel, C. M., Sehm, B., Deserno, L., & Obleser, J. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.01.048 · Cited by 70
Blot, K., Kimura, S.-I., Bai, J., Kemp, A., Manahan-Vaughan, D., Giros, B., Tzavara, E., & Otani, S. (2015) · Cerebral Cortex · doi:10.1093/cercor/bht329 · Cited by 58
Function and developmental origin of a mesocortical inhibitory circuit
Kabanova, A., Pabst, M., Lorkowski, M., Braganza, O., Boehlen, A., Nikbakht, N., Pothmann, L., Vaswani, A. R., Musgrove, R., Di Monte, D. A., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4020 · Cited by 61
Aging magnifies the effects of dopamine transporter and D2 receptor genes on backward serial memory
Li, S., Papenberg, G., Nagel, I. E., Preuschhof, C., Schröder, J., Nietfeld, W., Bertram, L., Heekeren, H. R., Lindenberger, U., & Bäckman, L. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.08.001 · Cited by 64
Girgis, R. R., Snellenberg, J. X. V., Glass, A., Kegeles, L. S., Thompson, J. L., Wall, M. M., Cho, R. Y., Carter, C. S., Slifstein, M., Abi‐Dargham, A., et al. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116636120 · Cited by 63
Ni, H., Shang, C., Gau, S. S., Lin, Y., Huang, H., & Yang, L.-K. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000357 · Cited by 63
Friedman, J. I., Carpenter, D. M., Lü, J., Jin, F., Tang, C. Y., WHITE, L. E., Parrella, M. J., Bowler, S., Elbaz, Z. S., Flanagan, L., et al. (2008) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318161318f · Cited by 61
Pardey, M. C., Kumar, N. N., Goodchild, A. K., & Cornish, J. L. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881112465497 · Cited by 61
Dose-response effects of d-amphetamine on effort-based decision-making and reinforcement learning
Soder, H. E., Cooper, J. A., Lopez-Gamundi, P., Hoots, J. K., Nunez, C., Lawlor, V. M., Lane, S. D., Treadway, M. T., & Wardle, M. C. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-020-0779-8 · Cited by 61
Bertolino, A., & Blasi, G. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.04.038 · Cited by 63
Clock Speed as a Window into Dopaminergic Control of Emotion and Time Perception
Cheng, R., Tipples, J., Narayanan, N. S., & Meck, W. H. (2016) · Timing & Time Perception · doi:10.1163/22134468-00002064 · Cited by 71
Moore, D., Jung, M., Hillman, C. H., Kang, M., & Loprinzi, P. D. (2022) · Psychophysiology · doi:10.1111/psyp.14014 · Cited by 60
Striatal Dopamine Influences the Default Mode Network to Affect Shifting between Object Features
Dang, L. C., Donde, A., Madison, C. M., O’Neil, J. P., & Jagust, W. J. (2012) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00252 · Cited by 61
Yang, L., Cao, Q., Shuai, L., Li, H., Chan, R. C. K., & Wang, Y. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001490 · Cited by 63
Braskie, M. N., Landau, S. M., Wilcox, C. E., Taylor, S. D., O’Neil, J. P., Baker, S. L., Madison, C. M., & Jagust, W. J. (2010) · Human Brain Mapping · doi:10.1002/hbm.21081 · Cited by 60
Attention-Deficit/Hyperactivity Phenotype in Mice Lacking the Cyclin-Dependent Kinase 5 Cofactor p35
Drerup, J. M., Hayashi, K., Cui, H., Mettlach, G., Long, M. A., Marvin, M. A., Sun, X., Goldberg, M. S., Lutter, M. L., & Bibb, J. A. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.016 · Cited by 58
Cognitive Activation by Central Thalamic Stimulation: The Yerkes-Dodson Law Revisited
Mair, R. G., Onos, K. D., & Hembrook‐Short, J. R. (2010) · Dose-Response · doi:10.2203/dose-response.10-017.mair · Cited by 65
Maltese, M., March, J. R., Bashaw, A. G., & Tritsch, N. X. (2021) · eLife · doi:10.7554/elife.68041 · Cited by 62
Bisagno, V., González, B., & Urbano, F. J. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.01.013 · Cited by 59
The prefrontal cortex: a target for antipsychotic drugs
Artigas, F. (2009) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2009.01455.x · Cited by 57
Davis, C. M., DeCicco-Skinner, K. L., & Hienz, R. D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144556 · Cited by 56
Dopamine Modulates the Efficiency of Sensory Evidence Accumulation During Perceptual Decision Making
Beste, C., Adelhöfer, N., Gohil, K., Passow, S., Roessner, V., & Li, S. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy019 · Cited by 56
Chu, H., & Zhen, X. (2010) · Acta Pharmacologica Sinica · doi:10.1038/aps.2010.105 · Cited by 56
The ethics of elective psychopharmacology
Mohamed, A. D., & Sahakian, B. J. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114571100037x · Cited by 56
Reilly, J. L., & Sweeney, J. A. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu013 · Cited by 56
Guanfacine Extended Release: A New Pharmacological Treatment Option in Europe
Huß, M., Chen, W., & Ludolph, A. G. (2015) · Clinical Drug Investigation · doi:10.1007/s40261-015-0336-0 · Cited by 60
The cost of dopamine for dynamic cognitive control
Cools, R. (2015) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2015.05.007 · Cited by 79
Galloway, E. M., Woo, N. H., & Lu, B. (2008) · Progress in brain research · doi:10.1016/s0079-6123(07)00015-5 · Cited by 57
Pharmacological and therapeutic directions in ADHD: Specificity in the PFC
Lévy, F. (2008) · Behavioral and Brain Functions · doi:10.1186/1744-9081-4-12 · Cited by 58
Steullet, P., Cabungcal, J.-H., Cuénod, M., & Do, K. Q. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00244 · Cited by 49
Long-term learning transforms prefrontal cortex representations during working memory
Miller, J. A., Tambini, A., Kiyonaga, A., & D’Esposito, M. (2022) · Neuron · doi:10.1016/j.neuron.2022.09.019 · Cited by 63
Working Memory Is Complex and Dynamic, Like Your Thoughts
Buschman, T. J., & Miller, E. K. (2022) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01940 · Cited by 55
Personalized learning: From neurogenetics of behaviors to designing optimal language training
Wong, P. C. M., Vuong, L. C., & Liu, K. (2016) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2016.10.002 · Cited by 59
Wellman, C. L., Bollinger, J. L., & Moench, K. M. (2019) · International review of neurobiology · doi:10.1016/bs.irn.2019.11.007 · Cited by 53
HCN Channel Targets for Novel Antidepressant Treatment
Ku, S. M., & Han, M.-H. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0538-7 · Cited by 54
See, R. E. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709000054 · Cited by 54
Duan, T., Tan, J., Yuan, Q., Cao, J., Zhou, Q., & Xu, L. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3048-2 · Cited by 60
The COMT Val158Met polymorphism modulates working memory performance under acute stress
Buckert, M., Kudielka, B. M., Reuter, M., & Fiebach, C. J. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.014 · Cited by 60
Neural response to working memory load varies by dopamine transporter genotype in children
Stollstorff, M., Foss‐Feig, J. H., Cook, E. H., Stein, M. A., Gaillard, W. D., & Vaidya, C. J. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.104 · Cited by 58
Zhong, P., & Yan, Z. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu190 · Cited by 56
Drug addiction: An affective-cognitive disorder in need of a cure
Fattore, L., & Diana, M. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.04.006 · Cited by 58
Glausier, J. R., Khan, Z. U., & Muly, E. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn212 · Cited by 58
Vijayraghavan, S., Major, A. J., & Everling, S. (2018) · Neuron · doi:10.1016/j.neuron.2018.05.027 · Cited by 51
Self-citationMcCracken, J. T., McGough, J. J., Loo, S. K., Levitt, J., Del’Homme, M., Cowen, J., Sturm, A., Whelan, F., Hellemann, G., Sugar, C., et al. (2016) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2016.05.015 · Cited by 57
Dendritic integration in pyramidal neurons during network activity and disease
Palmer, L. M. (2013) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2013.09.010 · Cited by 56
Retinal dysfunction of contrast processing in major depression also apparent in cortical activity
Bubl, E., Kern, E., Ebert, D., Riedel, A., van Elst, L. T., & Bach, M. (2015) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-014-0573-x · Cited by 56
Barnes, S. A., Young, J. W., & Neill, J. C. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2460-8 · Cited by 55
COMT as a Drug Target for Cognitive Functions and Dysfunctions
Scheggia, D., Sannino, S., Scattoni, M. L., & Papaleo, F. (2012) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152712800672481 · Cited by 51
Sun, Y., Yang, Y., Galvin, V. C., Yang, S., Arnsten, A. F. T., & Wang, M. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0364-17.2017 · Cited by 55
Self-citationWang, M., Datta, D., Enwright, J. F., Galvin, V. C., Yang, S., Paspalas, C. D., Kozak, R., Gray, D. L., Lewis, D. A., & Arnsten, A. F. T. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.03.001 · Cited by 55
Self-citationBerman, R. F., Pessah, I. N., Mouton, P. R., Mav, D., & Harry, J. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm265 · Cited by 52
Implications of synaptic biophysics for recurrent network dynamics and active memory
Durstewitz, D. (2009) · Neural Networks · doi:10.1016/j.neunet.2009.07.016 · Cited by 55
Prefrontal dopamine and the dynamic control of human long-term memory
Wimber, M., Schott, B. H., Wendler, F., Seidenbecher, C. I., Behnisch, G., Macharadze, T., Bäuml, K.-H. T., & Richardson‐Klavehn, A. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.15 · Cited by 51
Bonaventure, P., Aluisio, L. E., Shoblock, J. R., Boggs, J. D., Fraser, I. C., Lord, B., Lovenberg, T. W., & Galici, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020210 · Cited by 51
Wang, Y., Zhang, H., Cui, J., Zhang, J., Yin, F., Guo, H., Lai, J., & Xing, B. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0068-y · Cited by 50
Arnsten, A. F. T., & Wang, M. (2016) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010715-103617 · Cited by 50
Self-citationRanganath, A., & Jacob, S. N. (2015) · The Neuroscientist · doi:10.1177/1073858415602850 · Cited by 52
Parker, K. L., Ruggiero, R. N., & Narayanan, N. S. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00294 · Cited by 52
Metadata
- Authors
- Vijayraghavan, S., Wang, M., Birnbaum, S. G., Williams, G. V., & Arnsten, A. F. T.
- Affiliations
- Yale University (US)
- Venue
- Nature Neuroscience
- Published
- 2007-02-04
- Volume
- 10
- Issue
- 3
- Pages
- 376-384
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2046835548
- Cited by
- 1,013
- References
- 50
- Citations by year
- 2026: 29 · 2025: 27 · 2024: 55 · 2023: 53 · 2022: 48 · 2021: 50 · 2020: 53 · 2019: 49 · 2018: 47 · 2017: 50 · 2016: 58 · 2015: 69 · 2014: 61 · 2013: 73 · 2012: 68
- FWCI
- 22.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (P50MH068789)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dopamine D1 receptor, prefrontal cortex, spatial working memory, neuronal firing patterns, spatial tuning, cAMP signaling, monkeys, rats
- MeSH terms
- Action Potentials, Cyclic AMP, Analysis of Variance, Animals, Behavior, Animal, Dose-Response Relationship, Drug, Drug Interactions, Iontophoresis, Macaca mulatta, Male, Memory, Short-Term, Neurons, Neuropsychological Tests, Sensitivity and Specificity, Thionucleotides, Dopamine Agents, Rats, Sprague-Dawley, Prefrontal Cortex, Receptors, Dopamine D1, Maze Learning, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
