Cited by 244Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Redefining the serotonergic system by genetic lineage

Open access

Jensen, Patricia, Farago, Anna F, Awatramani, Rajeshwar B, Scott, Michael M, Deneris, Evan S, Dymecki, Susan M·2008·Nature Neuroscience

DOI 10.1038/nn2050PMC PMC2897136

Open this paper in CoChat — free account

Abstract

Central serotonin-producing neurons are heterogeneous-differing in location, morphology, neurotoxin sensitivity and associated clinical disorders-but the underpinnings of this heterogeneity are largely unknown, as are the markers that distinguish physiological subtypes of serotonergic neurons. Here we redefined serotonergic subtypes on the basis of genetic programs that are differentially enacted in progenitor cells. We uncovered a molecular framework for the serotonergic system that, having genetic lineages as its basis, is likely to have physiological relevance and will permit access to genetically defined subtypes for manipulation.

Integrity signals

Registry

Crossref · 10.1038/nn2050

Cites

15 of 15 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Patterning the Vertebrate Neuraxis
Lumsden, A., & Krumlauf, R. K. (1996) · Science · doi:10.1126/science.274.5290.1109 · Cited by 1,142
The neurobiology of autism
Pardo, C. A., & Eberhart, C. G. (2007) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00102.x · Cited by 514
Multiple Serotonergic Brainstem Abnormalities in Sudden Infant Death Syndrome
Paterson, D. S., Trachtenberg, F. L., Thompson, E. G., Belliveau, R. A., Beggs, A. H., Darnall, R., Chadwick, A. E., Krous, H. F., & Kinney, H. C. (2006) · JAMA · doi:10.1001/jama.296.17.2124 · Cited by 503
An immunohistochemical study of serotonin neuron development in the rat: Ascending pathways and terminal fields
Lidov, H. G. W., & Molliver, M. E. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90077-6 · Cited by 483
Two lineage boundaries coordinate vertebrate apical ectodermal ridge formationPreprint
Kimmel, R. A., Turnbull, D. H., Blanquet, V., Wurst, W., Loomis, C. A., & Joyner, A. L. (2000) · Genes & Development · doi:10.1101/gad.14.11.1377 · Cited by 341
Cell Behaviors and Genetic Lineages of the Mesencephalon and Rhombomere 1
Zervas, M., Millet, S., Ahn, S., & Joyner, A. L. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.010 · Cited by 292
Assembly of the Brainstem Cochlear Nuclear Complex Is Revealed by Intersectional and Subtractive Genetic Fate Maps
Farago, A. F., Awatramani, R. B., & Dymecki, S. M. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.014 · Cited by 228
Cryptic boundaries in roof plate and choroid plexus identified by intersectional gene activation
Awatramani, R., Soriano, P., Rodriguez, C., Mai, J. J., & Dymecki, S. M. (2003) · Nature Genetics · doi:10.1038/ng1228 · Cited by 215
Self-citation
Molecular Neuroanatomy's “Three Gs”: A Primer
Dymecki, S. M., & Kim, J. C. (2007) · Neuron · doi:10.1016/j.neuron.2007.03.009 · Cited by 111
serotonin immunocytochemistry in the adult and developing rat brain: Methodological and pharmacological considerations
Wallace, J. A., Petrusz, P., & Lauder, J. M. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90127-7 · Cited by 102

Show all 15 references

Sorted by citations

A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex
Taniguchi, H., He, M., Wu, P., Kim, S., Paik, R., Sugino, K., Kvitsani, D., Fu, Y., Lu, J., Lin, Y., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.026 · Cited by 1,828
A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure
Yadav, V. K., Oury, F., Suda, N., Liu, Z.-W., Gao, X.-B., Confavreux, C., Klemenhagen, K. C., Tanaka, K. F., Gingrich, J. A., Guo, X. E., et al. (2009) · Cell · doi:10.1016/j.cell.2009.06.051 · Cited by 661
Neural Control of Breathing and CO2 Homeostasis
Guyenet, P. G., & Bayliss, D. A. (2015) · Neuron · doi:10.1016/j.neuron.2015.08.001 · Cited by 468
Serotonin neurons in the dorsal raphe nucleus encode reward signals
Li, Y., Zhong, W., Wang, D., Feng, Q., Liu, Z., Zhou, J., Jia, C., Hu, F., Zeng, J., Guo, Q., et al. (2016) · Nature Communications · doi:10.1038/ncomms10503 · Cited by 440
Mapping projections of molecularly defined dopamine neuron subtypes using intersectional genetic approaches
Poulin, J.-F., Caronia, G., Hofer, C., Cui, Q., Helm, B., Ramakrishnan, C., Chan, C. S., Dombeck, D. A., Deisseroth, K., & Awatramani, R. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0203-4 · Cited by 423
Serotonin in Affective Control
Dayan, P., & Huys, Q. J. M. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135607 · Cited by 381
Impaired Respiratory and Body Temperature Control Upon Acute Serotonergic Neuron Inhibition
Ray, R. S., Corcoran, A. E., Brust, R. D., Kim, J. C., Richerson, G. B., Nattie, E., & Dymecki, S. M. (2011) · Science · doi:10.1126/science.1205295 · Cited by 363
Defining midbrain dopaminergic neuron diversity by single-cell gene expression profiling
Poulin, J.-F., Zou, J., Drouin-Ouellet, J., Kim, K.-Y. A., Cicchetti, F., & Awatramani, R. B. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.008 · Cited by 352
Self-citation
Embracing diversity in the 5-HT neuronal system
Okaty, B. W., Commons, K. G., & Dymecki, S. M. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0151-3 · Cited by 319
The Brainstem and Serotonin in the Sudden Infant Death Syndrome
Kinney, H. C., Richerson, G. B., Dymecki, S. M., Darnall, R. A., & Nattie, E. (2009) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092322 · Cited by 311
Single-cell transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and median raphe nuclei
Ren, J., Isakova, A., Friedmann, D., Zeng, J., Grutzner, S. M., Pun, A., Zhao, G. Q., Kolluru, S. S., Wang, R., Lin, R., et al. (2019) · eLife · doi:10.7554/elife.49424 · Cited by 304
“By contrast, we could not discern obvious difference in spatial distributions among the four MR types, despite the fact that MR serotonin neurons have heterogenous developmental origin (Jensen et al., 2008).”
BackgroundMethodInfluential
Conditional anterograde tracing reveals distinct targeting of individual serotonin cell groups (B5-B9) to the forebrain and brainstem
Muzerelle, A., Scotto-Lomassese, S., Bernard, J. F., Soiza-Reilly, M., & Gaspar, P. (2016) · Brain Structure and Function · doi:10.1007/s00429-014-0924-4 · Cited by 303
Regulation of Breathing and Autonomic Outflows by Chemoreceptors
Guyenet, P. G. (2014) · Comprehensive physiology · doi:10.1002/cphy.c140004 · Cited by 325
Enhancing the precision of genetic lineage tracing using dual recombinases
He, L., Li, Y., Li, Y., Pu, W., Huang, X., Tian, X., Wang, Y., Zhang, H., Liu, Q., Zhang, L., et al. (2017) · Nature Medicine · doi:10.1038/nm.4437 · Cited by 275
C1 neurons: the body's EMTs
Guyenet, P. G., Stornetta, R. L., Bochorishvili, G., DePuy, S. D., Burke, P. G. R., & Abbott, S. B. G. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00054.2013 · Cited by 269
A developmental ontology for the mammalian brain based on the prosomeric model
Puelles, L., Harrison, M. L., Paxinos, G., & WATSON, C. R. R. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.06.004 · Cited by 268
Molecular and anatomical organization of the dorsal raphe nucleus
Huang, K. W., Ochandarena, N. E., Philson, A. C., Hyun, M., Birnbaum, J. E., Cicconet, M., & Sabatini, B. L. (2019) · eLife · doi:10.7554/elife.46464 · Cited by 267
Developmental origins of central norepinephrine neuron diversity
Robertson, S. D., Plummer, N. W., de Marchena, J., & Jensen, P. (2013) · Nature Neuroscience · doi:10.1038/nn.3458 · Cited by 249
Central respiratory chemoreception
Guyenet, P. G., Stornetta, R. L., & Bayliss, D. A. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22435 · Cited by 249
Functional topography of midbrain and pontine serotonergic systems: implications for synaptic regulation of serotonergic circuits
Hale, M. W., & Lowry, C. A. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2089-z · Cited by 254
Central Chemoreceptors: Locations and Functions
Nattie, E., & Li, A. (2012) · Comprehensive physiology · doi:10.1002/cphy.c100083 · Cited by 282
How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems
Murphy, D. L., Fox, M. A., Timpano, K. R., Moya, P. R., Ren‐Patterson, R. F., Andrews, A. M., Holmes, A., Lesch, K., & Wendland, J. R. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.08.034 · Cited by 237
Multi-Scale molecular deconstruction of the serotonin neuron system
Okaty, B. W., Freret, M. E., Rood, B. D., Brust, R. D., Hennessy, M. L., deBairos, D., Kim, J. C., Cook, M. N., & Dymecki, S. M. (2015) · Neuron · doi:10.1016/j.neuron.2015.10.007 · Cited by 217
The Habenulo-Raphe Serotonergic Circuit Encodes an Aversive Expectation Value Essential for Adaptive Active Avoidance of Danger
Amo, R., Fredes, F., Kinoshita, M., Aoki, R., Aizawa, H., Agetsuma, M., Aoki, T., Shiraki, T., Kakinuma, H., Matsuda, M., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.035 · Cited by 217
Parasympathetic ganglia derive from Schwann cell precursors
Espinosa-Medina, I., Outin, E., Picard, C., Chettouh, Z., Dymecki, S. M., Consalez, G. G., Coppola, E., & Brunet, J. (2014) · Science · doi:10.1126/science.1253286 · Cited by 211
Stress-related Serotonergic Systems: Implications for Symptomatology of Anxiety and Affective Disorders
Hale, M. W., Shekhar, A., & Lowry, C. A. (2012) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-012-9827-1 · Cited by 220
Genetic Approaches to Neural Circuits in the Mouse
Josh Huang, Z., & Zeng, H. (2013) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062012-170307 · Cited by 200
Activity of Raphé serotonergic neurons controls emotional behaviors
Teissier, A., Chemiakine, A., Inbar, B., Bagchi, S., Ray, R. S., Palmiter, R. D., Dymecki, S. M., Moore, H., & Ansorge, M. S. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.10.061 · Cited by 197
Probing the diversity of serotonin neurons
Gaspar, P., & Lillesaar, C. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0378 · Cited by 210
Projections and interconnections of genetically defined serotonin neurons in mice
Bang, S. J., Jensen, P., Dymecki, S. M., & Commons, K. G. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07936.x · Cited by 181
Comprehensive Dual- and Triple-Feature Intersectional Single-Vector Delivery of Diverse Functional Payloads to Cells of Behaving Mammals
Fenno, L. E., Ramakrishnan, C., Kim, Y. S., Evans, K. E., Lo, M., Vesuna, S. S., Inoue, M., Cheung, K. Y. M., Yuen, E., Pichamoorthy, N., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.06.003 · Cited by 180
Gut enterochromaffin cells drive visceral pain and anxiety
Bayrer, J. R., Castro, J., Venkataraman, A., Touhara, K. K., Rossen, N. D., Morrie, R. D., Maddern, J., Hendry, A., Braverman, K. N., Garcia‐Caraballo, S., et al. (2023) · Nature · doi:10.1038/s41586-023-05829-8 · Cited by 176
Split-Cre Complementation Indicates Coincident Activity of Different Genes In Vivo
Hirrlinger, J., Scheller, A., Hirrlinger, P. G., Kellert, B., Tang, W., Wehr, M. C., Goebbels, S., Reichenbach, A., Sprengel, R., Rossner, M. J., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004286 · Cited by 151
An improved Flp deleter mouse in C57Bl/6 based on Flpo recombinase
Kranz, A., Fu, J., Duerschke, K., Weidlich, S., Naumann, R., Stewart, A. F., & Anastassiadis, K. (2010) · genesis · doi:10.1002/dvg.20641 · Cited by 153
Role of Parafacial Nuclei in Control of Breathing in Adult Rats
Huckstepp, R. T. R., Cardoza, K. P., Henderson, L. E., & Feldman, J. L. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2953-14.2015 · Cited by 149
Transient inhibition and long-term facilitation of locomotion by phasic optogenetic activation of serotonin neurons
Correia, P. A., Lottem, E., Banerjee, D., Machado, A. S., Carey, M. R., & Mainen, Z. F. (2017) · eLife · doi:10.7554/elife.20975 · Cited by 138
A Genetically Defined Morphologically and Functionally Unique Subset of 5-HT Neurons in the Mouse Raphe Nuclei
Kiyasova, V., Fernández, S. P., Lainé, J., Stankovski, L., Muzerelle, A., Doly, S., & Gaspar, P. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4080-10.2011 · Cited by 148
Functional topography of serotonergic systems supports the Deakin/Graeff hypothesis of anxiety and affective disorders
Paul, E. D., & Lowry, C. A. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881113490328 · Cited by 139
Linking Genetically Defined Neurons to Behavior through a Broadly Applicable Silencing Allele
Kim, J. C., Cook, M. N., Carey, M. R., Shen, C., Regehr, W. G., & Dymecki, S. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.07.010 · Cited by 138
A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting
Han, X., Zhang, Z., He, L., Zhu, H., Li, Y., Pu, W., Han, M., Zhao, H., Liu, K., Li, Y., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.01.007 · Cited by 132
Functional and Developmental Identification of a Molecular Subtype of Brain Serotonergic Neuron Specialized to Regulate Breathing Dynamics
Brust, R. D., Corcoran, A. E., Richerson, G. B., Nattie, E., & Dymecki, S. M. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.11.027 · Cited by 131
Lateral habenula and the rostromedial tegmental nucleus innervate neurochemically distinct subdivisions of the dorsal raphe nucleus in the rat
Sego, C., Gonçalves, L., Lima, L. B., Furigo, I. C., Donato, J., & Metzger, M. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23533 · Cited by 132
Serotonergic transcriptional networks and potential importance to mental health
Deneris, E. S., & Wyler, S. C. (2012) · Nature Neuroscience · doi:10.1038/nn.3039 · Cited by 132
Islet1 Derivatives in the Heart Are of Both Neural Crest and Second Heart Field Origin
Engleka, K. A., Manderfield, L. J., Brust, R. D., Li, L., Cohen, A. H., Dymecki, S. M., & Epstein, J. A. (2012) · Circulation Research · doi:10.1161/circresaha.112.266510 · Cited by 121
A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons
Okaty, B. W., Sturrock, N., Lozoya, Y. E., Chang, Y., Senft, R. A., Lyon, K. A., Alekseyenko, O. V., & Dymecki, S. M. (2020) · eLife · doi:10.7554/elife.55523 · Cited by 122
Spatiotemporally separable Shh domains in the midbrain define distinct dopaminergic progenitor pools
Joksimovic, M., Anderegg, A., Roy, A., Campochiaro, L., Yun, B., Kittappa, R., McKay, R., & Awatramani, R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904285106 · Cited by 121
5-HT modulation of a medial septal circuit tunes social memory stability
Wu, X., Morishita, W., Beier, K. T., Heifets, B. D., & Malenka, R. C. (2021) · Nature · doi:10.1038/s41586-021-03956-8 · Cited by 116
Direct conversion of human fibroblasts to induced serotonergic neurons
Xu, Z., Jiang, H., Zhong, P., Yan, Z., Chen, S., & Feng, J. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.101 · Cited by 116
Development of the serotonergic cells in murine raphe nuclei and their relations with rhombomeric domains
Alonso, A., Merchán, P., Sandoval, J. E., Sánchez-Arrones, L., Garcia-Cazorla, A., Artuch, R., Ferrán, J. L., Martínez-de-la-Torre, M., & Puelles, L. (2013) · Brain Structure and Function · doi:10.1007/s00429-012-0456-8 · Cited by 113
Identification of serotonergic neuronal modules that affect aggressive behavior
Niederkofler, V., Asher, T. E., Okaty, B. W., Rood, B. D., Narayan, A., Hwa, L. S., Beck, S. G., Miczek, K. A., & Dymecki, S. M. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.063 · Cited by 113
Expanding the power of recombinase-based labeling to uncover cellular diversity
Plummer, N. W., Evsyukova, I. Y., Robertson, S. D., de Marchena, J., Tucker, C. J., & Jensen, P. (2015) · Development · doi:10.1242/dev.129981 · Cited by 112
Rethinking 5-HT 1A Receptors: Emerging Modes of Inhibitory Feedback of Relevance to Emotion-Related Behavior
Altieri, S. C., Garcia‐García, Á. L., Leonardo, E. D., & Andrews, A. M. (2012) · ACS Chemical Neuroscience · doi:10.1021/cn3002174 · Cited by 115
MASTR: A Technique for Mosaic Mutant Analysis with Spatial and Temporal Control of Recombination Using Conditional Floxed Alleles in Mice
Lao, Z., Raju, G. P., Bai, C. B., & Joyner, A. L. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.07.004 · Cited by 108
Serotonin neuron development: shaping molecular and structural identities
Deneris, E. S., & Gaspar, P. (2017) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.301 · Cited by 120
Mapping cell fate and function using recombinase-based intersectional strategies
Dymecki, S. M., Ray, R. S., & Kim, J. C. (2010) · Methods in Enzymology · doi:10.1016/s0076-6879(10)77011-7 · Cited by 104
Distinct transcriptomes define rostral and caudal serotonin neurons
Wylie, C. J., Hendricks, T. J., Zhang, B., Wang, L., Lu, P., Leahy, P., Fox, S., Maeno, H., & Deneris, E. S. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4656-09.2010 · Cited by 104
Self-citation
cKit + cardiac progenitors of neural crest origin
Hatzistergos, K. E., Takeuchi, L. M., Saur, D., Seidler, B., Dymecki, S. M., Jia, J., White, I. A., Balkan, W., Kanashiro‐Takeuchi, R. M., Schally, A. V., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1517201112 · Cited by 102
Multiscale single-cell analysis reveals unique phenotypes of raphe 5-HT neurons projecting to the forebrain
Fernandez, S. P., Cauli, B., Cabezas, C., Muzerelle, A., Poncer, J.-C., & Gaspar, P. (2016) · Brain Structure and Function · doi:10.1007/s00429-015-1142-4 · Cited by 100
Of rodents and humans: A comparative review of the neurobehavioral effects of early life SSRI exposure in preclinical and clinical research
Glover, M. E., & Clinton, S. M. (2016) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2016.04.008 · Cited by 109
Development of raphe serotonin neurons from specification to guidance
Kiyasova, V., & Gaspar, P. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07910.x · Cited by 105
Sox6 expression distinguishes dorsally and ventrally biased dopamine neurons in the substantia nigra with distinctive properties and embryonic origins
Luppi, M. P., Azcorra, M., Caronia, G., Poulin, J.-F., Gaertner, Z. A., Gatica, S., Moreno-Ramos, O. A., Nouri, N., Dubois, M., Ma, Y. C., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109975 · Cited by 103
Ferreting out stem cells from their niches
Fuchs, E. V., & Horsley, V. (2011) · Nature Cell Biology · doi:10.1038/ncb0511-513 · Cited by 87
Molecular heterogeneity of midbrain dopaminergic neurons – Moving toward single cell resolution
Anderegg, A., Poulin, J.-F., & Awatramani, R. B. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.10.022 · Cited by 86
Serotonin homeostasis and serotonin receptors as actors of cortical construction: special attention to the 5-HT3A and 5-HT6 receptor subtypes
Vitalis, T., Ansorge, M. S., & Dayer, A. G. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00093 · Cited by 90
Julius H. Comroe, Jr., Distinguished Lecture: Central chemoreception: then … and now
Nattie, E. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01061.2010 · Cited by 81
The Elusive Progenitor Cell in Cardiac Regeneration
Cai, C., & Molkentin, J. D. (2017) · Circulation Research · doi:10.1161/circresaha.116.309710 · Cited by 81
Increased Serotonin-1A (5-HT1A) Autoreceptor Expression and Reduced Raphe Serotonin Levels in Deformed Epidermal Autoregulatory Factor-1 (Deaf-1) Gene Knock-out Mice
Czesak, M., François, B. L., Millar, A., Deria, M., Daigle, M., Visvader, J. E., Anisman, H., & Albert, P. R. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.293027 · Cited by 82
Role of mast cells and basophils in pruritus
Steinhoff, M. S., Buddenkotte, J., & Lerner, E. A. (2018) · Immunological Reviews · doi:10.1111/imr.12635 · Cited by 78
Chapter 5 Hox Genes in Neural Patterning and Circuit Formation in the Mouse Hindbrain
Narita, Y., & Rijli, F. M. (2009) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(09)88005-8 · Cited by 76
Diversification of C. elegans Motor Neuron Identity via Selective Effector Gene Repression
Kerk, S. Y., Kratsios, P., Hart, M. P., Mourao, R., & Hobert, O. (2017) · Neuron · doi:10.1016/j.neuron.2016.11.036 · Cited by 70
Theory and Practice of Lineage Tracing
Hsu, Y. (2015) · Stem Cells · doi:10.1002/stem.2123 · Cited by 75
Functional Interplay between Dopaminergic and Serotonergic Neuronal Systems during Development and Adulthood
Niederkofler, V., Asher, T. E., & Dymecki, S. M. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00021 · Cited by 75
Ascending serotonin neuron diversity under two umbrellas
Commons, K. G. (2016) · Brain Structure and Function · doi:10.1007/s00429-015-1176-7 · Cited by 75
The Serotonin Brainstem Hypothesis for the Sudden Infant Death Syndrome
Kinney, H. C., & Haynes, R. L. (2019) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlz062 · Cited by 72
The serotonergic anatomy of the developing human medulla oblongata: Implications for pediatric disorders of homeostasis
Kinney, H. C., Broadbelt, K. G., Haynes, R. L., Rognum, I. J., & Paterson, D. S. (2011) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2011.05.004 · Cited by 69
The Presynaptic Component of the Serotonergic System is Required for Clozapine's Efficacy
Yadav, P. N., Abbas, A. I., Farrell, M. S., Setola, V., Sciaky, N., Huang, X., Kroeze, W. K., Crawford, L. K., Piel, D., Keiser, M. J., et al. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.195 · Cited by 65
Genetic lineage tracing with multiple DNA recombinases: A user's guide for conducting more precise cell fate mapping studies
Liu, K., Jin, H., & Zhou, B. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.011631 · Cited by 69
Serotonin reuptake inhibitors and bone health: A review of clinical studies and plausible mechanisms
Wadhwa, R., Kumar, M., Talegaonkar, S., & Vohora, D. (2017) · Osteoporosis and Sarcopenia · doi:10.1016/j.afos.2017.05.002 · Cited by 65
Single-Channel Kinetic Analysis for Activation and Desensitization of Homomeric 5-HT3A Receptors
Corradi, J., Gumilar, F., & Bouzat, C. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2009.06.018 · Cited by 64
Integrative physiology of depression and antidepressant drug action: Implications for serotonergic mechanisms of action and novel therapeutic strategies for treatment of depression
Hale, M. W., Raison, C. L., & Lowry, C. A. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.09.005 · Cited by 64
Dorsal Raphe Serotonin Neurons in Mice: Immature Hyperexcitability Transitions to Adult State during First Three Postnatal Weeks Suggesting Sensitive Period for Environmental Perturbation
Rood, B. D., Calizo, L. H., Piel, D., Spangler, Z., Campbell, K., & Beck, S. G. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1498-13.2014 · Cited by 64
Mouse Fgf8 ‐Cre‐LacZ lineage analysis defines the territory of the postnatal mammalian isthmus
WATSON, C. R. R., Shimogori, T., & Puelles, L. (2017) · The Journal of Comparative Neurology · doi:10.1002/cne.24242 · Cited by 63
Serotonin Neuron Diversity in the Dorsal Raphe
Andrade, R., & Haj‐Dahmane, S. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn300224n · Cited by 65
The role of serotonin in the control of locomotor movements and strategies for restoring locomotion after spinal cord injury
Sławińska, U., Miazga, K., & Jordan, L. M. (2014) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2014-1983 · Cited by 61
Enteroendocrine cell lineages that differentially control feeding and gut motility
Hayashi, M., Kaye, J. A., Douglas, E., Joshi, N. R., Gribble, F. M., Reimann, F. M., & Liberles, S. D. (2023) · eLife · doi:10.7554/elife.78512 · Cited by 63
How much can the tubule regenerate and who does it? An open question
Lombardi, D., Becherucci, F., & Romagnani, P. (2015) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfv262 · Cited by 60
Essentials of Recombinase-Based Genetic Fate Mapping in Mice
Jensen, P., & Dymecki, S. M. (2014) · Methods in Molecular Biology · doi:10.1007/978-1-60327-292-6_26 · Cited by 54
The use of lineage tracing to study kidney injury and regeneration
Romagnani, P., Rinkevich, Y., & Dekel, B. (2015) · Nature Reviews Nephrology · doi:10.1038/nrneph.2015.67 · Cited by 58
An intersectional gene regulatory strategy defines subclass diversity of C. elegans motor neurons
Kratsios, P., Kerk, S. Y., Catela, C., Liang, J., Vidal, B., Bayer, E. A., Feng, W., Cruz, E. D. D. L., Croci, L., Consalez, G. G., et al. (2017) · eLife · doi:10.7554/elife.25751 · Cited by 53
Firing Properties of Genetically Identified Dorsal Raphe Serotonergic Neurons in Brain Slices
Mlinar, B., Montalbano, A., Piszczek, Ł., Gross, C. T., & Corradetti, R. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00195 · Cited by 58
Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain
Jacob, J., Storm, R., Castro, D. S., Milton, C. I., Pla, P., Guillemot, F., Birchmeier, C., & Briscoe, J. (2009) · Development · doi:10.1242/dev.034546 · Cited by 54
5-HT1AReceptor-Mediated Autoinhibition and the Control of Serotonergic Cell Firing
Andrade, R., Huereca, D., Lyons, J. G., Andrade, E. M., & McGregor, K. M. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00034 · Cited by 52
Optogenetic Recruitment of Dorsal Raphe Serotonergic Neurons Acutely Decreases Mechanosensory Responsivity in Behaving Mice
Dugué, G. P., Lörincz, M. L., Lottem, E., Audero, E., Matias, S., Correia, P. A., Léna, C., & Mainen, Z. F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105941 · Cited by 54
Genetic dissection of rhythmic motor networks in mice
Grossmann, K. S., Giraudin, A., Britz, O., Zhang, J., & Goulding, M. (2010) · Progress in brain research · doi:10.1016/b978-0-444-53613-6.00002-2 · Cited by 55
Cre‐driver lines used for genetic fate mapping of neural crest cells in the mouse: An overview
Debbache, J., Parfejevs, V., & Sommer, L. (2018) · genesis · doi:10.1002/dvg.23105 · Cited by 54
A Phox2b::FLPo transgenic mouse line suitable for intersectional genetics
Hirsch, M., D’Autréaux, F., Dymecki, S. M., Brunet, J., & Goridis, C. (2013) · genesis · doi:10.1002/dvg.22393 · Cited by 53
Medullary serotonin neurons are CO2 sensitive in situ
Iceman, K. E., Richerson, G. B., & Harris, M. B. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00288.2013 · Cited by 52
Cholinergic neurons in the mouse rostral ventrolateral medulla target sensory afferent areas
Stornetta, R. L., Macon, C. J., Nguyen, T. M., Coates, M. B., & Guyenet, P. G. (2012) · Brain Structure and Function · doi:10.1007/s00429-012-0408-3 · Cited by 50
Activity of Tachykinin1 -Expressing Pet1 Raphe Neurons Modulates the Respiratory Chemoreflex
Hennessy, M. L., Corcoran, A. E., Brust, R. D., Chang, Y., Nattie, E., & Dymecki, S. M. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2316-16.2016 · Cited by 51
A dual genetic tracing system identifies diverse and dynamic origins of cardiac valve mesenchyme
Liu, K., Yu, W., Tang, M., Tang, J., Liu, X., Liu, Q., Li, Y., He, L., Zhang, L., Evans, S. M., et al. (2018) · Development · doi:10.1242/dev.167775 · Cited by 51

Authors: Jensen, P., Farago, A. F., Awatramani, R. B., Scott, M. M., Deneris, E. S., & Dymecki, S. M.
Affiliations: Harvard University (US)
Northwestern University (US)
Case Western Reserve University (US)
Corresponding author: Dymecki, Susan M
ORCID: Jensen, Patricia
Farago, Anna F
Awatramani, Rajeshwar B
Deneris, Evan S
Dymecki, Susan M
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2008-03-16
Volume: 11
Issue: 4
Pages: 417-419
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn2050
PMC: PMC2897136
OpenAlex: W2081784716
Cited by: 244
References: 15
Citations by year: 2026: 1 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 10 · 2021: 13 · 2020: 19 · 2019: 15 · 2018: 15 · 2017: 25 · 2016: 14 · 2015: 22 · 2014: 13 · 2013: 18 · 2012: 18
FWCI: 4.71
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R01MH062723)
National Institute on Drug Abuse (R21DA023643)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK067826)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD036379)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: serotonergic system, serotonergic neurons, neuronal heterogeneity, genetic lineages, neural progenitor cells, molecular subtypes, neurogenesis
MeSH terms: Animals, Cell Differentiation, Mice, Transgenic, Neurons, Rhombencephalon, Serotonin, Stem Cells, Biomarkers, Gene Expression Regulation, Developmental, Cell Lineage, Transgenes, Gene Expression Profiling, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Redefining the serotonergic system by genetic lineage

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks