Sex differences in social interaction in rats: role of the immediate-early gene Zif268
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Given both the high prevalence of anxiety disorders in women and the fact that little is known about the mechanisms of gender differences in anxiety, our primary aim in this study was to investigate the neurobiological mechanisms underlying sex differences in social anxiety-like behavior in rats. Through the use of zif268 antisense oligodeoxynucleotides (zif ASO), we induced a temporary downregulation of zif268 expression in the medial prefrontal cortex of male and female rats and found that zif268 ASO male rats show more social anxiety-like behaviors when compared with control male rats in the social interaction test. In fact, zif268 ASO males displayed social anxiety-like behaviors, which were similar to control females, thus downregulation of zif268 expression in the mPFC of male rats eliminated sex differences previously found in the social anxiety-like behavior tests. Interestingly, zif268 ASO in female rats had no effect on their social interaction. Our novel findings have led us to ascertain that sexually dimorphic zif268 expression in the mPFC is a key molecular factor in mediating sex-specific anxiety-like behavior in the social interaction test.
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Male rats tend to spend more time interacting with an unfamiliar, same-sex conspecific than do females.
“male rats tend to spend more time interacting with an unfamiliar, same-sex conspecific than do females (Carrier and Kabbaj, 2012; Slamberová et al., 2011; Stack et al., 2010).”
From The effects of prenatal PCBs on adult social behavior in rats (2015) · cites this paper as Stack et al., 2010
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- Authors
- Stack, A., Carrier, N., Dietz, D., Hollis, F., Sorenson, J., & Kabbaj, M.
- Affiliations
- Florida State University (US)
- Corresponding author
- Kabbaj, Mohamed
- Venue
- Neuropsychopharmacology
- Published
- 2009-10-21
- Volume
- 35
- Issue
- 2
- Pages
- 570-580
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC2795084
- OpenAlex
- W2018228062
- Cited by
- 113
- References
- 42
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 10 · 2023: 5 · 2022: 11 · 2021: 10 · 2020: 10 · 2019: 8 · 2018: 5 · 2017: 7 · 2016: 5 · 2015: 5 · 2014: 9 · 2013: 2 · 2012: 8
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH087583)
- National Institute on Drug Abuse (R03DA021554)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- sex differences, Zif268, immediate early genes, antisense oligodeoxynucleotides, medial prefrontal cortex, sexually dimorphic gene expression, social interaction test
- MeSH terms
- Analysis of Variance, Animals, Behavior, Animal, Dose-Response Relationship, Drug, Estradiol, Estrogens, Exploratory Behavior, Female, Gene Expression Regulation, Interpersonal Relations, Male, Oligodeoxyribonucleotides, Ovariectomy, RNA, Messenger, Sex Characteristics, Stress, Psychological, Vaginal Smears, Rats, Sprague-Dawley, Prefrontal Cortex, Estrous Cycle, Rats, Early Growth Response Protein 1
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