The potential role of lamotrigine in schizophrenia

Large, Charles H.; Webster, Elizabeth L.; Goff, Donald C.

doi:10.1007/s00213-005-0020-9

Cited by 69Schizophrenia research and treatmentTreatment of Major DepressionNeuroscience and Neuropharmacology Research

The potential role of lamotrigine in schizophrenia

Large, Charles H., Webster, Elizabeth L., Goff, Donald C.·2005·Psychopharmacology

DOI 10.1007/s00213-005-0020-9

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Abstract

Rationale Atypical antipsychotic drugs are the drugs of choice for the treatment of schizophrenia. However, despite advances, no treatments have been established for patients who fail to improve with the most effective of these, clozapine. The inhibition of dopamine transmission through blockade of dopamine D2 receptors is considered to be essential for antipsychotic efficacy, but it is postulated that modulation of glutamate transmission may be equally important. In support of this, symptoms similar to schizophrenia can be induced in healthy volunteers using N-methyl-D-aspartate (NMDA) antagonist drugs that are also known to enhance glutamate transmission. Furthermore, lamotrigine, which can modulate glutamate release, may add to or synergise with atypical antipsychotic drugs, some of which may themselves modulate glutamate transmission.Objectives We examine the evidence for the efficacy of lamotrigine. We consider how this fits with a glutamate neuron dysregulation hypothesis of the disorder. We discuss mechanisms by which lamotrigine might influence neuronal activity and glutamate transmission, and possible ways in which the drug might interact with antipsychotic medications.Results Data from four clinical studies support the efficacy of adjunctive lamotrigine in the treatment of schizophrenia. In addition, and consistent with a glutamate neuron dysregulation hypothesis of schizophrenia, lamotrigine can prevent the psychotic symptoms or behavioural disruption induced by NMDA receptor antagonists in healthy volunteers or rodents.Conclusions The efficacy of lamotrigine is most likely explained within the framework of a glutamate neuron dysregulation hypothesis, and may arise primarily through the drugs ability to influence glutamate transmission and neural activity in the cortex. The drug is likely to act through inhibition of voltage-gated sodium channels, though other molecular interactions cannot be ruled out. Lamotrigine may add to or synergise with some atypical antipsychotic drugs acting on glutamate transmission; alternatively, they may act independently on glutamate and dopamine systems to bring about a combined therapeutic effect. We propose new strategies for the treatment of schizophrenia using a combination of anti-dopaminergic and anti-glutamatergic drugs.

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Reducing presynaptic glutamate release has been proposed as compensation for the elevated E/I ratio and behavioral symptoms arising from schizophrenia and NMDAR antagonists.
“Reducing presynaptic glutamate release has been proposed as compensation for the elevated E/I ratio and behavioral symptoms arising from schizophrenia (Large et al. 2005) and NMDAR antagonists (Moghaddam and Adams 1998;Anand et al. 2000;Brody et al. 2003;Krystal et al. 2005).”
From Linking microcircuit dysfunction to cognitive impairment: Effects of disinhibition associated with schizophrenia in a cortical working memory model (2014) · cites this paper as Large et al. 2005

Clozapine for the Treatment-Resistant Schizophrenic: A Double-blind Comparison With Chlorpromazine
Kane, J. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800330013001 · Cited by 4,156 · see citing works
Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans: Psychotomimetic, Perceptual, Cognitive, and Neuroendocrine Responses
Krystal, J. H. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950030035004 · Cited by 3,330 · see citing works
Recent advances in the phencyclidine model of schizophrenia
(1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.10.1301 · Cited by 2,904 · see citing works
Psychosis as a state of aberrant salience: a framework linking biology, phenomenology and pharmacology in schizophrenia
Kapur, S. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.1.13 · Cited by 2,813 · see citing works
Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs
Creese, I., Burt, D. R., & Snyder, S. H. (1976) · Science · doi:10.1126/science.3854 · Cited by 2,220 · see citing works
Dopamine in schizophrenia: a review and reconceptualization
Davis, K. L., Kahn, R. S., Ko, G., & Davidson, M. (1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.11.1474 · Cited by 2,021 · see citing works
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
Harrison, P. J., & Weinberger, D. R. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001558 · Cited by 2,020 · see citing works
Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: A hypothesis for the etiology of schizophrenia
Grace, A. A. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90196-u · Cited by 1,831 · see citing works
Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex
Moghaddam, B., Adams, B., Verma, A., & Daly, D. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02921.1997 · Cited by 1,793 · see citing works
Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies
BRAFF, D. L., Geyer, M. A., & Swerdlow, N. R. (2001) · Psychopharmacology · doi:10.1007/s002130100810 · Cited by 1,701 · see citing works
Glutamate receptor dysfunction and schizophrenia
Olney, J. W. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950240016004 · Cited by 1,685 · see citing works
Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review
Geyer, M. A., Krebs-Thomson, K., Braff, D. L., & Swerdlow, N. R. (2001) · Psychopharmacology · doi:10.1007/s002130100811 · Cited by 1,484 · see citing works
The Neuropsychopharmacology of Phencyclidine: From NMDA Receptor Hypofunction to the Dopamine Hypothesis of Schizophrenia
Jentsch, J., & Roth, R. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00060-8 · Cited by 1,349 · see citing works
Sensorimotor Gating and Schizophrenia
Braff, D. L. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810140081011 · Cited by 1,312 · see citing works
Hyperpolarization-Activated Cation Currents: From Molecules to Physiological Function
Robinson, R. B., & Siegelbaum, S. A. (2003) · Annual Review of Physiology · doi:10.1146/annurev.physiol.65.092101.142734 · Cited by 1,177 · see citing works
The Prodromal Phase of First-episode Psychosis: Past and Current Conceptualizations
Yung, A. R., & McGorry, P. D. (1996) · Schizophrenia Bulletin · doi:10.1093/schbul/22.2.353 · Cited by 1,168 · cited 2× · see citing works
“Very briefly, schizophrenia is widely considered to be a developmental disorder that appears during adolescence (Keshavan and Hogarty 1999) and that is preceded by a prodromal phase (Yung and McGorry 1996).”
Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding
Schotte, A., Janssen, P. F. M., Gommeren, W., Luyten, W. H. M. L., Gompel, P. V., Lesage, A. S., Loore, K. D., & Leysen, J. E. (1996) · Psychopharmacology · doi:10.1007/bf02245606 · Cited by 1,167 · see citing works
Gating and Habituation of the Startle Reflex in Schizophrenic Patients
Braff, D. L. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820030038005 · Cited by 1,027 · see citing works
NMDA receptor hypofunction model of schizophrenia
Olney, J. W., Newcomer, J. W., & Farber, N. B. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(99)00029-1 · Cited by 1,020 · see citing works
Subanesthetic Doses of Ketamine Stimulate Psychosis in Schizophrenia
Lahti, A. C., Koffel, B., LaPorte, D. J., & Tamminga, C. A. (1995) · Neuropsychopharmacology · doi:10.1016/0893-133x(94)00131-i · Cited by 921 · see citing works
The Emerging Role of Glutamate in the Pathophysiology and Treatment of Schizophrenia
GOFF, D. C., & Coyle, J. T. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.9.1367 · Cited by 914 · see citing works
Self-citation
Atypical antipsychotics: Mechanism of action
Seeman, P. (2002) · The Canadian Journal of Psychiatry · doi:10.1177/070674370204700106 · Cited by 899 · see citing works
Mapping adolescent brain change reveals dynamic wave of accelerated gray matter loss in very early-onset schizophrenia
Thompson, P. M., Vidal, C., Giedd, J. N., Gochman, P., Blumenthal, J., Nicolson, R., Toga, A. W., & Rapoport, J. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.201243998 · Cited by 812 · see citing works
Antipsychotic Drug Effects on Brain Morphology in First-Episode Psychosis
Lieberman, J. A. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.4.361 · Cited by 804 · see citing works
Clinical and Theoretical Implications of 5-HT2 and D2 Receptor Occupancy of Clozapine, Risperidone, and Olanzapine in Schizophrenia
Kapur, S., Zipursky, R. B., & Remington, G. J. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.2.286 · Cited by 711 · see citing works
Ketamine-Induced Exacerbation of Psychotic Symptoms and Cognitive Impairment in Neuroleptic-Free Schizophrenics
Malhotra, A. K. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00036-5 · Cited by 681 · see citing works
D-Alanine Added to Antipsychotics for the Treatment of Schizophrenia
Tsai, G. E., Yang, P., Chang, Y., & Chong, M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.06.032 · Cited by 676 · see citing works
Effects of Ketamine in Normal and Schizophrenic Volunteers
Lahti, A. C. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00243-3 · Cited by 674 · see citing works
Basic Pharmacology of Valproate
̈scher, W. L. (2002) · CNS Drugs · doi:10.2165/00023210-200216100-00003 · Cited by 667 · see citing works
Modulation of synaptic transmission and long-term potentiation: effects on paired pulse facilitation and EPSC variance in the CA1 region of the hippocampus
Manabe, T., Wyllie, D. J., Perkel, D. J., & Nicoll, R. A. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.70.4.1451 · Cited by 666 · see citing works
Using an Animal Model of Deficient Sensorimotor Gating to Study the Pathophysiology and New Treatments of Schizophrenia
Swerdlow, N. R., & Geyer, M. A. (1998) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033326 · Cited by 616 · see citing works
Ziconotide: Neuronal Calcium Channel Blocker for Treating Severe Chronic Pain
Miljanich, G. P. (2004) · Current Medicinal Chemistry · doi:10.2174/0929867043363884 · Cited by 611 · see citing works
A Pooled Analysis of 2 Placebo-Controlled 18-Month Trials of Lamotrigine and Lithium Maintenance in Bipolar I Disorder
Goodwin, G. M., Bowden, C. L., Calabrese, J. R., Grunze, H., Kasper, S., White, R., Greene, P., & Leadbetter, R. (2004) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v65n0321 · Cited by 581 · see citing works
D-serine added to antipsychotics for the treatment of schizophrenia
Tsai, G. E., Yang, P., Chung, L.-C., LANGE, N. D., & Coyle, J. T. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00279-0 · Cited by 572 · see citing works
Amphetamine, cocaine, phencyclidine and nomifensine increase extracellular dopamine concentrations preferentially in the nucleus accumbens of freely moving rats
Carboni, E., Impérato, A., Perezzani, L., & Chiara, G. D. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90012-2 · Cited by 560 · see citing works
Longitudinal study of brain morphology in first episode schizophrenia
Lieberman, J. A., Chakos, M., Wu, H., Alvir, J. M., Hoffman, E. B., Robinson, D. G., & Bilder, R. M. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01067-8 · Cited by 554 · see citing works
A Follow-up Magnetic Resonance Imaging Study of Schizophrenia: Relationship of Neuroanatomical Changes to Clinical and Neurobehavioral Measures
Gur, R. E., Cowell, P., Turetsky, B. I., Gallacher, F., Cannon, T., Bilker, W., & Gur, R. C. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.2.145 · Cited by 540 · see citing works
Progressive Structural Brain Abnormalities and Their Relationship to Clinical Outcome
Ho, B., Andreasen, N. C., Nopoulos, P., Arndt, S. V., Magnotta, V. A., & Flaum, M. A. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.6.585 · Cited by 536 · see citing works
Provocative tests with psychostimulant drugs in schizophrenia
Lieberman, J. A., Kane, J. M., & Alvir, J. (1987) · Psychopharmacology · doi:10.1007/bf00216006 · Cited by 535 · see citing works
Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action
Löscher, W. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00075-6 · Cited by 532 · see citing works
NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development
Krystal, J. H., D'Souza, D. C., Mathalon, D., Perry, E., Belger, A., & Hoffman, R. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1582-z · Cited by 530 · see citing works
Central D2-dopamine receptor occupancy in relation to antipsychotic drug effects: A double-blind PET study of schizophrenic patients
Nordström, A., Farde, L., Wiesel, F., Forslund, K., Pauli, S., Halldin, C., & Uppfeldt, G. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90288-o · Cited by 527 · see citing works
Emerging principles of altered neural circuitry in schizophrenia
Benes, F. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00041-7 · Cited by 513 · see citing works
Schizophrenia as a chronic active brain process: a study of progressive brain structural change subsequent to the onset of schizophrenia
DeLisi, L. E., Sakuma, M., Tew, W. P., Kushner, M., Hoff, A. L., & GRIMSON, R. C. (1997) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(97)00012-7 · Cited by 512 · see citing works
DARPP-32: Regulator of the Efficacy of Dopaminergic Neurotransmission
Fienberg, A. A., Hiroi, N., Mermelstein, P. G., Song, W., Snyder, G. L., Nishi, A., Chéramy, A., O'Callaghan, J. P., Miller, D. B., Cole, D. G., et al. (1998) · Science · doi:10.1126/science.281.5378.838 · Cited by 491 · see citing works
Phencyclidine-induced psychosis
Rm, A., & Young, S. J. (1978) · American Journal of Psychiatry · doi:10.1176/ajp.135.9.1081 · Cited by 478 · see citing works
The phenomenology of experimentally induced amphetamine psychosis--preliminary observations.
ANGRIST, B. M., & Gershon, S. (1970) · PubMed · Cited by 477 · see citing works
NMDA-dependent modulation of CA1 local circuit inhibition
Grunze, H., Rainnie, D., Hasselmo, M., Barkai, E., Hearn, E., McCarley, R., & Greene, R. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02034.1996 · Cited by 467 · see citing works
Burst firing in midbrain dopaminergic neurons
Overton, P. G., & Clark, D. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00039-8 · Cited by 466 · see citing works
Dopamine as the wind of the psychotic fire: new evidence from brain imaging studies
Laruelle, M., & Abi-Dargham, A. (1999) · Journal of Psychopharmacology · doi:10.1177/026988119901300405 · Cited by 464 · see citing works
The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions
Rogawski, M. A., & Löscher, W. (2004) · Nature Medicine · doi:10.1038/nm1074 · Cited by 464 · see citing works
Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites
Poolos, N. P., Migliore, M., & Johnston, D. (2002) · Nature Neuroscience · doi:10.1038/nn891 · Cited by 454 · see citing works
Compromised White Matter Tract Integrity in Schizophrenia Inferred From Diffusion Tensor Imaging
Lim, K. O., Hedehus, M., Moseley, M. E., de Crespigny, A. J., Sullivan, E. V., & Pfefferbaum, A. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.4.367 · Cited by 447 · see citing works
Dopamine receptor sequences. Therapeutic levels of neuroleptics occupy D2 receptors, clozapine occupies D4.
Seeman, P. (1992) · PubMed · Cited by 441 · see citing works
The neuropsychology of ventral prefrontal cortex: Decision-making and reversal learning
Clark, L., Cools, R., & Robbins, T. W. (2004) · Brain and Cognition · doi:10.1016/s0278-2626(03)00284-7 · Cited by 439 · see citing works
Glutamate, Dopamine, and Schizophrenia: From Pathophysiology to Treatment
LARUELLE, M., KEGELES, L. S., & ABI‐DARGHAM, A. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.063 · Cited by 437 · see citing works
NMDA receptor hypofunction produces concomitant firing rate potentiation and burst activity reduction in the prefrontal cortex
Jackson, M. E., Homayoun, H., & Moghaddam, B. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308455101 · Cited by 430 · see citing works
Dopamine receptor subtypes colocalize in rat striatonigral neurons.
Surmeier, D. J., Eberwine, J. H., Wilson, C. J., Cao, Y., Stefani, A., & Kitai, S. T. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10178 · Cited by 430 · see citing works
Attenuation of the Neuropsychiatric Effects of Ketamine With Lamotrigine: Support for Hyperglutamatergic Effects ofN-methyl-D-aspartate Receptor Antagonists
Anand, A., Charney, D. S., Oren, D. A., Berman, R. M., Hu, X. S., Cappiello, A., & Krystal, J. H. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.3.270 · Cited by 426 · see citing works
The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine-depleted mice
Carlsson, M., & Carlsson, A. (1989) · Journal of Neural Transmission · doi:10.1007/bf01258633 · Cited by 423 · see citing works
Prefrontal function in schizophrenia: confounds and controversies
Weinberger, D. R., & Berman, K. F. (1996) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1996.0135 · Cited by 414 · see citing works
Modulation of N -methyl- d -aspartate receptor function by glycine transport
Bergeron, R., Meyer, T. M., Coyle, J. T., & Greene, R. W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15730 · Cited by 412 · see citing works
Mood Stabilizer Valproate Promotes ERK Pathway-Dependent Cortical Neuronal Growth and Neurogenesis
Hao, Y., Creson, T. K., Zhang, L., Li, P., Du, F., Yuan, P., Gould, T. D., Manji, H. K., & Chen, G. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5747-03.2004 · Cited by 405 · see citing works
Storage, recall, and novelty detection of sequences by the hippocampus: Elaborating on the SOCRATIC model to account for normal and aberrant effects of dopamine
Lisman, J. E., & Otmakhova, N. A. (2001) · Hippocampus · doi:10.1002/hipo.1071 · Cited by 402 · see citing works
Mechanisms of action of valproate: a commentatory
Johannessen, C. (2000) · Neurochemistry International · doi:10.1016/s0197-0186(00)00013-9 · Cited by 400 · see citing works
Brain Volume Changes in First-Episode Schizophrenia
Cahn, W., Pol, H. E. H., Lems, E. B. T. E., van Haren, N. E. M., Schnack, H. G., van der Linden, J. A., Schothorst, P. F., van Engeland, H., & Kahn, R. S. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.11.1002 · Cited by 398 · see citing works
Corticolimbic Dopamine Neurotransmission Is Temporally Dissociated from the Cognitive and Locomotor Effects of Phencyclidine
Adams, B. W., & Moghaddam, B. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-14-05545.1998 · Cited by 388 · see citing works
Effects of phencyclidine and phencyclidine biologs on sensorimotor gating in the rat*1
Mansbach, R. S. (1989) · Neuropsychopharmacology · doi:10.1016/0893-133x(89)90035-3 · Cited by 380 · see citing works
Serotonin, via 5-HT2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release
Aghajanian, G. K., & Marek, G. J. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01224-x · Cited by 376 · see citing works
Dopamine D1 Receptor-Dependent Trafficking of Striatal NMDA Glutamate Receptors to the Postsynaptic Membrane
Dunah, A. W., & Standaert, D. G. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-15-05546.2001 · Cited by 374 · see citing works
MRI white matter diffusion anisotropy and PET metabolic rate in schizophrenia
Buchsbaum, M., Tang, C. Y., Peled, S., Gudbjartsson, H., Lu, D.-F., Hazlett, E., Downhill, J., Haznedar, M., Fallon, J., & Atlas, S. (1998) · NeuroReport · doi:10.1097/00001756-199802160-00013 · Cited by 369 · see citing works
Neuromodulation of Na+ channels: An unexpected form of cellular platicity
Cantrell, A. R., & Catterall, W. A. (2001) · Nature reviews. Neuroscience · doi:10.1038/35077553 · Cited by 344 · see citing works
Glycine transporter I inhibitor, N-Methylglycine (sarcosine), added to antipsychotics for the treatment of schizophrenia
Tsai, G. E., Lane, H., Yang, P., Chong, M., & LANGE, N. D. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.09.012 · Cited by 343 · see citing works
Comparison of Ketamine-Induced Thought Disorder in Healthy Volunteers and Thought Disorder in Schizophrenia
Adler, C. M., Malhotra, A. K., Elman, I., Goldberg, T. E., Egan, M. F., Pickar, D., & Breier, A. F. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.10.1646 · Cited by 337 · see citing works
Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment
Konradi, C., & Heckers, S. (2003) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00328-5 · Cited by 336 · see citing works
Clozapine antagonizes phencyclidine-induced deficits in sensorimotor gating of the startle response.
Bakshi, V. P., Swerdlow, N. R., & Geyer, M. A. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23831-9 · Cited by 330 · see citing works
Neuropsychopharmacology
Stolerman, I. P. (2010) · Springer eBooks · doi:10.1007/978-3-540-68706-1_4410 · Cited by 322 · see citing works
Cell biology of the hippocampal formation in schizophrenia
Weinberger, D. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00331-x · Cited by 321 · see citing works
Subchronic Phencyclidine Administration Reduces Mesoprefrontal Dopamine Utilization and Impairs Prefrontal Cortical-Dependent Cognition in the Rat
Jentsch, J. D. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00034-1 · Cited by 320 · see citing works
Information-processing deficits and thought disorder in schizophrenia
Perry, W., & BRAFF, D. L. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.3.363 · Cited by 311 · see citing works
Mechanisms of Action of Carbamazepine and Its Derivatives, Oxcarbazepine, BIA 2-093, and BIA 2-024
Ambrósio, A. F., Soares-da-Silva, P., Carvalho, C. M., & Carvalho, A. P. (2002) · Neurochemical Research · doi:10.1023/a:1014814924965 · Cited by 293 · see citing works
ELECTRICAL AND CALCIUM SIGNALING IN DENDRITES OF HIPPOCAMPAL PYRAMIDAL NEURONS
Magee, J. C., Hoffman, D. A., Colbert, C. M., & Johnston, D. (1998) · Annual Review of Physiology · doi:10.1146/annurev.physiol.60.1.327 · Cited by 284 · see citing works
Sodium valproate, but not ethosuximide, produces use- and voltage-dependent limitation of high frequency repetitive firing of action potentials of mouse central neurons in cell culture.
McLean, M. J., & Macdonald, R. L. (1986) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24966-7 · Cited by 274 · see citing works
Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects
Krystal, J. H., Abi-Saab, W., Perry, E., D’Souza, D. C., Liu, N., Gueorguieva, R., McDougall, L., Hunsberger, T., Belger, A., Levine, L., et al. (2005) · Psychopharmacology · doi:10.1007/s00213-004-1982-8 · Cited by 272 · see citing works
Dopamine Enhancement of NMDA Currents in Dissociated Medium-Sized Striatal Neurons: Role of D1 Receptors and DARPP-32
Flores‐Hernández, J., Cepeda, C., Hernández, E., Calvert, C. R., Jokel, E. S., Fienberg, A. A., Greengard, P., & Levine, M. S. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00361.2002 · Cited by 270 · see citing works
Dextroamphetamine
Griffith, J. D. (1972) · Archives of General Psychiatry · doi:10.1001/archpsyc.1972.01750200001001 · Cited by 270 · see citing works
Sensorimotor gating deficits in bipolar disorder patients with acute psychotic mania
Perry, W., Minassian, A., Feifel, D., & Braff, D. L. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01184-2 · Cited by 260 · see citing works
GABAergic local circuit neurons and prefrontal cortical dysfunction in schizophrenia
Lewis, D. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00042-9 · Cited by 257 · see citing works
Interaction of the antiepileptic drug lamotrigine with recombinant rat brain type IIA Na+ channels and with native Na+ channels in rat hippocampal neurones
Xie, X., Lancaster, B., Peakman, T., & Garthwaite, J. (1995) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00373920 · Cited by 248 · see citing works
On the Plausibility of “The Neurodevelopmental Hypothesis” of Schizophrenia
Weinberger, D. R. (1996) · Neuropsychopharmacology · doi:10.1016/0893-133x(95)00199-n · Cited by 245 · see citing works
Interactive effects of subanesthetic ketamine and haloperidol in healthy humans
Krystal, J. H., D’Souza, D. C., Karper, L. P., Bennett, A., Abi‐Dargham, A., Abi‐Saab, D., Cassello, K., Bowers, M. B., Vegso, S., Heninger, G. R., et al. (1999) · Psychopharmacology · doi:10.1007/s002130051049 · Cited by 243 · see citing works
General Pharmacology of Clozapine
Coward, D. M. (1992) · The British Journal of Psychiatry · doi:10.1192/s0007125000296840 · Cited by 242 · see citing works
Emerging experimental therapeutics for bipolar disorder: insights from the molecular and cellular actions of current mood stabilizers
Gould, T. D., Quiroz, J. A., Singh, J. B., Zarate, C. A., & Manji, H. K. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001518 · Cited by 238 · see citing works
Sensorimotor Gating and Thought Disturbance Measured in Close Temporal Proximity in Schizophrenic Patients
Perry, W., Geyer, M. A., & BRAFF, D. L. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.3.277 · Cited by 238 · see citing works
Glycogen synthase kinase‐3β, mood stabilizers, and neuroprotection
Li, X., Bijur, G. N., & Jope, R. S. (2002) · Bipolar Disorders · doi:10.1034/j.1399-5618.2002.40201.x · Cited by 238 · see citing works
Effect of Divalproex Combined with Olanzapine or Risperidone in Patients with an Acute Exacerbation of Schizophrenia
Casey, D. E., Daniel, D. G., Wassef, A. A., Tracy, K. A., Wozniak, P., & Sommerville, K. W. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300023 · Cited by 232 · see citing works
Examination of drug-induced and isolation-induced disruptions of prepulse inhibition as models to screen antipsychotic drugs
Varty, G. B., Higgins, G. A., & Higgins, G. A. (1995) · Psychopharmacology · doi:10.1007/bf02246437 · Cited by 231 · see citing works
Voltage clamp analysis of the inhibitory actions of diphenylhydantoin and carbamazepine on voltage-sensitive sodium channels in neuroblastoma cells.
Willow, M., Gonoi, T., & Catterall, W. A. (1985) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)12546-7 · Cited by 229 · see citing works
d- Serine Added to Clozapine for the Treatment of Schizophrenia
Tsai, G. E., Yang, P., Chung, L.-C., Tsai, I.-C., Tsai, C.-W., & Coyle, J. T. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.11.1822 · Cited by 227 · see citing works
Blockade of phencyclidine-induced hyperlocomotion by olanzapine, clozapine and serotonin receptor subtype selective antagonists in mice
Gleason, S. D., & Shannon, H. E. (1997) · Psychopharmacology · doi:10.1007/s002130050165 · Cited by 216 · see citing works
A Common Anticonvulsant Binding Site for Phenytoin, Carbamazepine, and Lamotrigine in Neuronal Na+ Channels
Kuo, C. (1998) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)13073-8 · Cited by 214 · see citing works
Glutamatergic drugs for schizophrenia: a systematic review and meta-analysis
Tuominen, H. J., Tiihonen, J., & Wahlbeck, K. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.05.005 · Cited by 209 · see citing works
Dysfunctional brain dopamine systems induced by psychotomimetic NMDA-receptor antagonists and the effects of antipsychotic drugs.
Svensson, T. (2000) · Brain research. Brain research reviews · doi:10.1016/s0165-0173(99)00048-x · Cited by 207 · see citing works
Effective neuroleptic medication removes prepulse inhibition deficits in schizophrenia patients
Weike, A. I., Bauer, U., & Hamm, A. O. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00229-2 · Cited by 206 · see citing works
Differential effects of chronic antipsychotic drug treatment on extracellular glutamate and dopamine concentrations
Yamamoto, B., & Cooperman, M. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-07-04159.1994 · Cited by 203 · see citing works
Brain maturational processes and delayed onset in schizophrenia
Keshavan, M. S., & Hogarty, G. E. (1999) · Development and Psychopathology · doi:10.1017/s0954579499002199 · Cited by 202 · see citing works
Lamotrigine inhibits Ca2+ currents in cortical neurons: functional implications
Stefani, A., Spadoni, F., Siniscalchi, A., & Bernardi, G. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00265-8 · Cited by 200 · see citing works
Clozapine Blunts N-Methyl-d-Aspartate Antagonist-Induced Psychosis: A Study with Ketamine
Malhotra, A. K., Adler, C. M., Kennison, S. D., Elman, I., Pickar, D., & Breier, A. F. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00546-x · Cited by 200 · see citing works
BDNF‐mediated signal transduction is modulated by GSK3β and mood stabilizing agents
Mai, L., Jope, R. S., & Li, X. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00939.x · Cited by 195 · see citing works
Lamotrigine in treatment-resistant schizophrenia: a randomized placebo-controlled crossover trial
Tiihonen, J., Hallikainen, T., Ryynänen, O., Repo‐Tiihonen, E., Kotilainen, I., Eronen, M., Toivonen, P., Wahlbeck, K., & Putkonen, A. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00524-9 · Cited by 191 · see citing works
Valproate for schizophrenia
Wang, Y., Xia, J., Helfer, B., Li, C., & Leucht, S. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004028.pub4 · Cited by 188 · see citing works
Interactive effects of subanesthetic ketamine and subhypnotic lorazepam in humans
Krystal, J. H., Karper, L. P., Bennett, A., D’Souza, D. C., Abi‐Dargham, A., Morrissey, K., Abi‐Saab, D., Bremner, J. D., Bowers, M. B., Suckow, R. F., et al. (1998) · Psychopharmacology · doi:10.1007/s002130050503 · Cited by 184 · see citing works
Dissociation of ketamine effects on rule acquisition and rule implementation: possible relevance to NMDA receptor contributions to executive cognitive functions
Krystal, J. H., Bennett, A., Abi‐Saab, D., Belger, A., Karper, L. P., D’Souza, D. C., Lipschitz, D. S., Abi‐Dargham, A., & Charney, D. S. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00097-9 · Cited by 183 · see citing works
A placebo-controlled crossover trial of d-cycloserine added to clozapine in patients with schizophrenia
GOFF, D. C., Henderson, D. C., Evins, A. E., & AMICO, E. T. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00367-9 · Cited by 178 · see citing works
Self-citation
Modulation of cerebral GABA by topiramate, lamotrigine, and gabapentin in healthy adults
Kuzniecky, R., Ho, S., Pan, J. W., Martin, R. C., Gilliam, F. G., Faught, E., & Hetherington, H. P. (2002) · Neurology · doi:10.1212/wnl.58.3.368 · Cited by 174 · see citing works
The Dopamine D2, but not D3or D4, Receptor Subtype is Essential for the Disruption of Prepulse Inhibition Produced by Amphetamine in Mice
Ralph, R. J., Varty, G. B., Kelly, M. A., Wang, Y.-M., Caron, M. G., Rubinstein, M., Grandy, D. K., Low, M. J., & Geyer, M. A. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04627.1999 · Cited by 174 · see citing works
Neuropathology of Schizophrenia: Cortex, Thalamus, Basal Ganglia, and Neurotransmitter-specific Projection Systems
Heckers, S. (1997) · Schizophrenia Bulletin · doi:10.1093/schbul/23.3.403 · Cited by 173 · see citing works
Placebo-Controlled Trial of Glycine Added to Clozapine in Schizophrenia
Evins, A. E., Fitzgerald, S. M., Wine, L., Rosselli, R., & GOFF, D. C. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.5.826 · Cited by 172 · see citing works
Self-citation
Comparative distribution of voltage-gated sodium channel proteins in human brain
Whitaker, W. R. J., Faull, R. L. M., Waldvogel, H. J., Plumpton, C., Emson, P. C., & Clare, J. J. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00289-8 · Cited by 165 · see citing works
The anticonvulsant, lamotrigine decreases spontaneous glutamate release but increases spontaneous GABA release in the rat entorhinal cortex in vitro
Cunningham, M. O., & Jones, R. S. G. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00051-4 · Cited by 163 · see citing works
Clozapine and Haloperidol Modulate N-Methyl-d-aspartate- and Non-N-Methyl-d-aspartate Receptor-Mediated Neurotransmission in Rat Prefrontal Cortical Neurons In Vitro
Arvanov, V. L., Liang, X., Schwartz, J. E., Grossman, S. D., & Wang, R. Y. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37013-2 · Cited by 162 · see citing works
Stabilization of Mood From Below Versus Above Baseline in Bipolar Disorder: A New Nomenclature
Ketter, T., & Calabrese, J. R. (2002) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v63n0210 · Cited by 161 · see citing works
The in vivo effects of olanzapine and other antipsychotic agents on receptor occupancy and antagonism of dopamine D 1 , D 2 , D 3 , 5HT 2A and muscarinic receptors
Zhang, W., & Bymaster, F. P. (1999) · Psychopharmacology · doi:10.1007/s002130050834 · Cited by 160 · see citing works
Observations on the psychotomimetic effects of sernyl
Bakker, C. B., & Amini, F. B. (1961) · Comprehensive Psychiatry · doi:10.1016/s0010-440x(61)80033-3 · Cited by 159 · see citing works
Equivalent Occupancy of Dopamine D1 and D2 Receptors With Clozapine: Differentiation From Other Atypical Antipsychotics
Tauscher, J., Hussain, T., Agid, O., Verhoeff, N. P. L. G., Wilson, A. A., Houle, S., Remington, G., Zipursky, R. B., & Kapur, S. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.9.1620 · Cited by 159 · see citing works
Modulation of the gamma-aminobutyric acid type A receptor by the antiepileptic drugs carbamazepine and phenytoin.
Granger, P., Biton, B., Faure, C., Vigé, X., Depoortere, H., Graham, D. J. M., Langer, S. Z., Scatton, B., & Avenet, P. (1995) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08760-7 · Cited by 158 · see citing works
Recent Advances in the Neurobiology of Schizophrenia
Miyamoto, S. (2003) · Molecular Interventions · doi:10.1124/mi.3.1.27 · Cited by 156 · see citing works
Working Memory in Schizophrenia: Transient "Online" Storage Versus Executive Functioning
Perry, W., Heaton, R. K., Potterat, E. G., Roebuck, T. M., Minassian, A., & BRAFF, D. L. (2001) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a006854 · Cited by 155 · see citing works
A longitudinal study of hippocampal volume in first episode psychosis and chronic schizophrenia
Wood, S. J., Velakoulis, D., Smith, D. J., Bond, D. J., Stuart, G. W., McGorry, P. D., Brewer, W. J., Bridle, N., Eritaia, J., Desmond, P. M., et al. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00175-x · Cited by 153 · see citing works
Clinical and Sensorimotor Gating Effects of Ketamine in Normals
Duncan, E. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00240-2 · Cited by 150 · see citing works
Utility of the Lethargic (lh/lh) Mouse Model of Absence Seizures in Predicting the Effects of Lamotrigine, Vigabatrin, Tiagabine, Gabapentin, and Topiramate Against Human Absence Seizures
Hosford, D. A., & Wang, Y. (1997) · Epilepsia · doi:10.1111/j.1528-1157.1997.tb01729.x · Cited by 149 · see citing works
The effects of low dose ketamine on sensory gating, neuroendocrine secretion and behavior in healthy human subjects
van Berckel, B. N. M., Oranje, B., van Ree, J. M., Verbaten, M. N., & Kahn, R. S. (1998) · Psychopharmacology · doi:10.1007/s002130050620 · Cited by 148 · see citing works
Brain activation during cognitive stimulation with the Wisconsin Card Sorting Test — a functional MRI study on healthy volunteers and schizophrenics
Volz, H., Christian Gaser, B., Häger, F., Rzanny, R., Mentzel, H., Kreitschmann‐Andermahr, I., Kaiser, W. A., & Sauer, H. (1997) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(97)00053-x · Cited by 147 · see citing works
Effects of MK-801 on spontaneous and amphetamine-stimulated dopamine release in striatum measured with in vivo microdialysis in awake rats
Miller, D. W., & Abercrombie, E. D. (1996) · Brain Research Bulletin · doi:10.1016/0361-9230(95)02144-2 · Cited by 146 · see citing works
Activation of Glutamate Neurotransmission in the Prefrontal Cortex Sustains the Motoric and Dopaminergic Effects of Phencyclidine
Takahata, R., & Moghaddam, B. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300127 · Cited by 140 · see citing works
Effect of Clozapine and Adjunctive High-Dose Glycine in Treatment-Resistant Schizophrenia
Potkin, S. G., Jin, Y., Bunney, B. G., COSTA, J. F., & Gulasekaram, B. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.1.145 · Cited by 139 · see citing works
M100907, a Serotonin 5-HT2A Receptor Antagonist and Putative Antipsychotic, Blocks Dizocilpine-Induced Prepulse Inhibition Deficits in Sprague–Dawley and Wistar Rats
Varty, G. B., Bakshi, V. P., & Geyer, M. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00072-4 · Cited by 137 · see citing works
Inhibition of System A-mediated glycine transport in cortical synaptosomes by therapeutic concentrations of clozapine: implications for mechanisms of action
Javitt, D. C., Duncan, L., Balla, A., & Sershen, H. W. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001552 · Cited by 137 · see citing works
Mesolimbic and mesocortical dopamine activation induced by phencyclidine: contrasting pattern to striatal response
Deutch, A. Y., Tam, S., Freeman, A. S., Bowers, M. B., & Roth, R. H. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90356-6 · Cited by 135 · see citing works
Presynaptic receptors and the control of glutamate exocytosis
Sánchez‐Prieto, J., Budd, D. C., Herrero, I., Vázquez, E., & Nicholls, D. G. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10031-x · Cited by 134 · see citing works
Lithium Protects Rat Cerebellar Granule Cells against Apoptosis Induced by Anticonvulsants, Phenytoin and Carbamazepine
Nonaka, S., Katsube, N. C., & Chuang, D.-M. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37615-3 · Cited by 131 · see citing works
Lamotrigine inhibits monoamine uptake in vitro and modulates 5-hydroxytryptamine uptake in rats
Southam, E., Kirkby, D. L., Higgins, G. A., & Hagan, R. M. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00580-9 · Cited by 129 · see citing works
Cellular and Molecular Actions of Lamotrigine: Possible Mechanisms of Efficacy in Bipolar Disorder
Xie, X., & Hagan, R. M. (1998) · Neuropsychobiology · doi:10.1159/000026527 · Cited by 129 · see citing works
Similar potency of carbamazepine, oxcarbazepine, and lamotrigine in inhibiting the release of glutamate and other neurotransmitters
Waldmeier, P. C., Baumann, P. A., Wicki, P., Feldtrauer, J.-J., Stierlin, C., & Schmutz, M. (1995) · Neurology · doi:10.1212/wnl.45.10.1907 · Cited by 128 · see citing works
Augmenting antipsychotic treatment with lamotrigine or topiramate in patients with treatment-resistant schizophrenia: a naturalistic caseseries outcome study
Dursun, S. M., & Deakin, J. F. W. (2001) · Journal of Psychopharmacology · doi:10.1177/026988110101500409 · Cited by 125 · see citing works
Investigation of the effects of lamotrigine and clozapine in improving reversal-learning impairments induced by acute phencyclidine and d-amphetamine in the rat
Idris, N. F., Repeto, P., Neill, J. C., & Large, C. H. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2058-5 · Cited by 123 · see citing works
Self-citation
Inhibition of N-type calcium currents by lamotrigine in rat amygdalar neurones
Wang, S., Huang, C., Hsu, K., Tsai, J.-J., & Gean, P. (1996) · Neuroreport · doi:10.1097/00001756-199611250-00048 · Cited by 121 · see citing works
Effects of d-amphetamine and phencyclidine on behavior and extracellular concentrations of neurotensin and dopamine in the ventral striatum and the medial prefrontal cortex of the rat
Hertel, P., Mathé, J. M., Nomikos, G. G., Iurlo, M., Mathé, A. A., & Svensson, T. H. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(96)00138-6 · Cited by 121 · see citing works
Partial improvement in negative schizophrenic symptoms after amphetamine
ANGRIST, B. M., Peselow, E. D., Rubinstein, M. E., Corwin, J., & Rotrosen, J. (1982) · Psychopharmacology · doi:10.1007/bf00432248 · Cited by 120 · see citing works
Comparative effects of glycine and d-cycloserine on persistent negative symptoms in schizophrenia: a retrospective analysis
Heresco‐Levy, U., & Javitt, D. C. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00129-4 · Cited by 120 · see citing works
Effect of phenycyclidine on dopamine release in the rat prefrontal cortex; an in vivo microdialysis study
Hondo, H., Yonezawa, Y., Nakahara, T., Nakamura, K., Hirano, M., Uchimura, H., & Tashiro, N. (1994) · Brain Research · doi:10.1016/0006-8993(94)91558-x · Cited by 119 · see citing works
Antiepileptic drugs and agents that inhibit voltage-gated sodium channels prevent NMDA antagonist neurotoxicity
Farber, N. B., Jiang, X.-P., Heinkel, C., & Nemmers, B. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001087 · Cited by 119 · see citing works
Systemic PCP treatment elevates brain extracellular 5-HT
Martin, P., Carlsson, M. L., & Hjorth, S. (1998) · Neuroreport · doi:10.1097/00001756-199809140-00012 · Cited by 118 · see citing works
Actions of clozapine and haloperidol on the extracellular levels of excitatory amino acids in the prefrontal cortex and striatum of conscious rats
Daly, D. A., & Moghaddam, B. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90483-2 · Cited by 117 · see citing works
Lamotrigine
Messenheimer, J. A. (1995) · Epilepsia · doi:10.1111/j.1528-1157.1995.tb06002.x · Cited by 117 · see citing works
Potential Mechanisms of Action of Lamotrigine in the Treatment of Bipolar Disorders
Ketter, T. A., Manji, H. K., & Post, R. M. (2003) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000088915.02635.e8 · Cited by 116 · see citing works
A six-month, placebo-controlled trial of d-cycloserine co-administered with conventional antipsychotics in schizophrenia patients
GOFF, D. C., Herz, L. R., Posever, T. A., Shih, V. E., Tsai, G. E., Henderson, D. C., Freudenreich, O., Evins, A. E., Yovel, I., Zhang, H., et al. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2032-2 · Cited by 116 · see citing works
Self-citation
Altered Cortical Glutamate Neurotransmission in Schizophrenia
Lewis, D. A., Glantz, L. A., Pierri, J. N., & Sweet, R. A. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.007 · Cited by 113 · see citing works
Adjunctive Divalproex and Hostility Among Patients With Schizophrenia Receiving Olanzapine or Risperidone
Citrome, L., Casey, D. E., Daniel, D. G., Wozniak, P., Kochan, L. D., & Tracy, K. A. (2004) · Psychiatric Services · doi:10.1176/appi.ps.55.3.290 · Cited by 111 · see citing works
Interaction of Dopamine D1 and NMDA Receptors Mediates Acute Clozapine Potentiation of Glutamate EPSPs in Rat Prefrontal Cortex
Chen, L., & Yang, C. R. (2002) · Journal of Neurophysiology · doi:10.1152/jn.2002.87.5.2324 · Cited by 108 · see citing works
Placebo-controlled trial of lamotrigine added to conventional and atypical antipsychotics in schizophrenia
Kremer, I., Vass, Á., Gorelik, I., Bar, G., Blanaru, M., Javitt, D. C., & Heresco‐Levy, U. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.06.029 · Cited by 108 · see citing works
Lamotrigine Treatment During Amygdala‐Kindled Seizure Development Fails to Inhibit Seizures and Diminishes Subsequent Anticonvulsant Efficacy
Postma, T., Krupp, E., Li, X. L., Post, R. M., & Weiss, S. R. B. (2000) · Epilepsia · doi:10.1111/j.1499-1654.2000.001514.x · Cited by 107 · see citing works
The role of nucleus accumbens dopamine in the neurochemical and behavioral effects of phencyclidine: a microdialysis and behavioral study
Steinpreis, R. E., & Salamone, J. D. (1993) · Brain Research · doi:10.1016/0006-8993(93)91671-e · Cited by 107 · see citing works
Changes in Use of Valproate and Other Mood Stabilizers for Patients With Schizophrenia From 1994 to 1998
Citrome, L., Levine, J., & Allingham, B. (2000) · Psychiatric Services · doi:10.1176/appi.ps.51.5.634 · Cited by 107 · see citing works
Efficacy and tolerance of D-cycloserine in drug-free schizophrenic patients
van Berckel, B. N. M., Hijman, R., van der Linden, J. A., Westenberg, H. G. M., van Ree, J. M., & Kahn, R. S. (1996) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00311-3 · Cited by 106 · see citing works
Low dose ketamine increases prepulse inhibition in healthy men
Abel, K. M., Allin, M. P. G., Hemsley, D. R., & Geyer, M. A. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00073-x · Cited by 106 · see citing works
Impaired Inhibition of Conditioned Responses Produced by Subchronic Administration of Phencyclidine to Rats
Jentsch, D. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00174-3 · Cited by 104 · see citing works
The serotonin 5-HT2A receptors antagonist M100907 prevents impairment in attentional performance by NMDA receptor blockade in the rat prefrontal cortex
Mirjana, C., Baviera, M., Invernizzi, R. W., & Balducci, C. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300479 · Cited by 102 · cited 4× · see citing works
“As discussed earlier, drugs that negatively modulate glutamate transmission, such as 5-HT2a antagonists (Mirjana et al. 2004; Ceglia et al. 2004) and mGluR2/3 agonists (Schoepp and Marek 2002; Carter et al.”
Influential
Target‐Specific Glutamatergic Regulation of Dopamine Neurons in the Ventral Tegmental Area
Takahata, R., & Moghaddam, B. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751775.x · Cited by 101 · see citing works
Modulation of brain and serum glutamatergic concentrations following a switch from conventional neuroleptics to olanzapine
GOFF, D. C., Hennen, J. A., Lyoo, I. K., Tsai, G. E., Wald, L. L., Evins, A. E., Yurgelun-Todd, D. A., & Renshaw, P. F. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01321-x · Cited by 101 · see citing works
Self-citation
The atypical antipsychotic ziprasidone, but not haloperidol, improves phencyclidine-induced cognitive deficits in a reversal learning task in the rat
Abdul-Monim, Z., Reynolds, G. P., & Neill, J. C. (2003) · Journal of Psychopharmacology · doi:10.1177/0269881103017001700 · Cited by 101 · see citing works
Preclinical Pharmacology of mGlu2 / 3 Receptor Agonists: Novel Agents for Schizophrenia?
Schoepp, D. D., & Marek, G. J. (2002) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007024606177 · Cited by 100 · see citing works
Dextro-amphetamine Diminishes Negative Symptoms in Schizophrenia
KAMMEN, D. P. V., & BORONOW, J. J. (1988) · International Clinical Psychopharmacology · doi:10.1097/00004850-198804000-00002 · Cited by 99 · see citing works
Reversal of phencyclidine-induced effects by glycine and glycine transport inhibitors
Javitt, D. C., Balla, A., Sershen, H. W., & Lajtha, Á. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00237-6 · Cited by 99 · see citing works
Randomized Double‐blind Parallel‐group Study Comparing Cognitive Effects of a Low‐dose Lamotrigine with Valproate and Placebo in Healthy Volunteers
Aldenkamp, A. P., Arends, J. B. A. M., Bootsma, H. P., Diepman, L., Hulsman, J. A. R. J., Lambrechts, D. A. J. E., Leenen, L. A. M., Majoie, M., Schellekens, A., & Vocht, J. D. (2002) · Epilepsia · doi:10.1046/j.1528-1157.2002.29201.x · Cited by 99 · see citing works
Differential interactions of lamotrigine and related drugs with transmembrane segment IVS6 of voltage-gated sodium channels
Liu, G., Yarov-Yarovoy, V. M., Nobbs, M. S., Clare, J. J., Scheuer, T., & Catterall, W. A. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(02)00400-8 · Cited by 99 · see citing works
Phencyclidine-Induced Deficits in Prepulse Inhibition of Startle are Blocked by Prazosin, an Alpha-1 Noradrenergic Antagonist
Bakshi, V. P., & Geyer, M. A. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37049-1 · Cited by 99 · see citing works
Prepulse inhibition of the startle response in risperidone-treated patients: comparison with typical antipsychotics
Kumari, V., Soni, W., & Sharma, T. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00276-6 · Cited by 98 · see citing works
Does carbamazepine-induced reduction of plasma haloperidol levels worsen psychotic symptoms?
Arana, G. W., GOFF, D. C., Friedman, H., Ornsteen, M., Greenblatt, D. J., Black, B., & Shader, R. I. (1986) · American Journal of Psychiatry · doi:10.1176/ajp.143.5.650 · Cited by 97 · see citing works
Self-citation
Prolonged psychosis attributed to phencyclidine: report of three cases
Rainey, J. M., & Crowder, M. K. (1975) · American Journal of Psychiatry · doi:10.1176/ajp.132.10.1076 · Cited by 97 · see citing works
Clozapine Plus Lamotrigine in Treatment-Resistant Schizophrenia
Dursun, S. M., McIntosh, D., & Milliken, H. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.10.950 · Cited by 96 · see citing works
Comparative genome‐ and proteome analysis of cerebral cortex from MK‐801‐treated rats
Paulson, L., Martin, P., Persson, A. I., Nilsson, C. L., Ljung, E., Brinkmalm, A., Eriksson, P. S., Blennow, K., & Davidsson, P. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10509 · Cited by 95 · see citing works
Hypofrontality in neuroleptic-naive schizophrenic patients during the Wisconsin Card Sorting Test - a fMRI study
Riehemann, S., Volz, H., Stützer, P., Smesny, S., Christian Gaser, B., & Sauer, H. (2001) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s004060170055 · Cited by 93 · see citing works
Interleaved Transcranial Magnetic Stimulation/Functional MRI Confirms that Lamotrigine Inhibits Cortical Excitability in Healthy Young Men
Li, X., Tenebäck, C. C., Nahas, Z. H., Kozel, F. A., Large, C. H., Cohn, J., Bohning, D. E., & George, M. S. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300452 · Cited by 91 · see citing works
Self-citation
Evaluation of the effects of lamotrigine, valproate and carbamazepine in a rodent model of mania
Arban, R., Maraia, G., Brackenborough, K. T., Winyard, L. A., Wilson, A. W., Gerrard, P. A., & Large, C. H. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.08.015 · Cited by 91 · see citing works
Self-citation
Comparison of the Effects of Clozapine, Risperidone, and Olanzapine on Ketamine-Induced Alterations in Regional Brain Metabolism
Duncan, G. E., Miyamoto, S., Leipzig, J. N., & Lieberman, J. A. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39197-9 · Cited by 90 · see citing works
Valproate selectively reduces the persistent fraction of Na+ current in neocortical neurons
Taverna, S., Mantegazza, M., Franceschetti, S., & AVANZINI, G. (1998) · Epilepsy Research · doi:10.1016/s0920-1211(98)00060-6 · Cited by 90 · see citing works
Neuroprotective effects of lamotrigine in global ischemia in gerbils. A histological, in vivo microdialysis and behavioral study
Shuaib, A. M., Mahmood, R. H., Wishart, T., Kanthan, R., Murabit, M. A., Ijaz, S., Miyashita, H., & Howlett, W. (1995) · Brain Research · doi:10.1016/0006-8993(95)01048-1 · Cited by 90 · see citing works
Mechanisms of typical and atypical antipsychotic drug action in relation to dopamine and NMDA receptor hypofunction hypotheses of schizophrenia
Duncan, G. E., Zorn, S. J., & Lieberman, J. A. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000581 · Cited by 90 · see citing works
Effects of lamotrigine and levetiracetam on seizure development in a rat amygdala kindling model
Stratton, S. C., Large, C. H., Cox, B. J., Davies, G., & Hagan, R. M. (2003) · Epilepsy Research · doi:10.1016/s0920-1211(02)00254-1 · Cited by 89 · see citing works
Self-citation
D-Cycloserine Increases Positive Symptoms in Chronic Schizophrenic Patients When Administered in Addition to Antipsychotics A Double-Blind, Parallel, Placebo-Controlled Study
van Berckel, B. N. M. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00014-7 · Cited by 89 · see citing works
Lamotrigine Protects Hippocampal CA1 Neurons From Ischemic Damage After Cardiac Arrest
Crumrine, R. C., Bergstrand, K., Cooper, A. T., Faison, W. L., & Cooper, B. R. (1997) · Stroke · doi:10.1161/01.str.28.11.2230 · Cited by 87 · see citing works
Carbamazepine as adjunctive treatment in nonepileptic chronic inpatients with EEG temporal lobe abnormalities.
Vm, N. (1983) · PubMed · Cited by 87 · see citing works
A Systematic Review of the Effects of Lamotrigine on Cognitive Function and Quality of Life
Aldenkamp, A. P., & Baker, G. A. (2001) · Epilepsy & Behavior · doi:10.1006/ebeh.2001.0168 · Cited by 82 · see citing works
GABAB receptors are up-regulated by chronic treatment with lithium or carbamazepine. GABA hypothesis of affective disorders?
Motohashi, N., Ikawa, K., & Kariya, T. (1989) · European Journal of Pharmacology · doi:10.1016/0014-2999(89)90687-0 · Cited by 82 · see citing works
A two-process theory of schizophrenia: Evidence from studies in post-mortem brain
Deakin, J. F. W., & Simpson, M. D. C. (1997) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(96)00042-8 · Cited by 81 · see citing works
Effects of Carbamazepine and Valproate on Haloperidol Plasma Levels and on Psychopathologic Outcome in Schizophrenic Patients
Heßlinger, B., Normann, C., Langosch, J. M., Klose, P., Berger, T., & Walden, J. (1999) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199908000-00005 · Cited by 80 · see citing works
Glutamatergic neurotransmission modulation and the mechanisms of antipsychotic atypicality
Heresco‐Levy, U. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2003.09.007 · Cited by 80 · see citing works
The neuropathology of schizophrenic diseases: historical aspects and present knowledge
Bogerts, B. (1999) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/pl00014181 · Cited by 80 · see citing works
The 5‐HT2A receptor antagonist M100,907 prevents extracellular glutamate rising in response to NMDA receptor blockade in the mPFC
Ceglia, I., Carli, M., Baviera, M., Renoldi, G., Calcagno, E., & Invernizzi, R. W. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02704.x · Cited by 79 · see citing works

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Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial
Patil, S. T., Zhang, L., Martenyi, F., Lowe, S. L., Jackson, K. A., Andreev, B. V., Avedisova, A. S., Bardenstein, L. M., Gurovich, I. Y., Morozova, M. A., et al. (2007) · Nature Medicine · doi:10.1038/nm1632 · Cited by 1,040 · see citing works
Evidence-based guidelines for the pharmacological treatment of schizophrenia: Updated recommendations from the British Association for Psychopharmacology
Barnes, T. R. E., Drake, R., Paton, C., Cooper, S. J., Deakin, J. F. W., Ferrier, I. N., Gregory, C. J., Haddad, P. M., Howes, O. D., Jones, I. R., et al. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881119889296 · Cited by 607 · see citing works
Evidence-based guidelines for the pharmacological treatment of schizophrenia: recommendations from the British Association for Psychopharmacology
Barnes, T. R. E. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881110391123 · Cited by 357 · see citing works
Glutamate and the Neural Basis of the Subjective Effects of Ketamine: A Pharmaco–Magnetic Resonance Imaging Study
Deakin, J. F. W., Lees, J., McKie, S., Hallak, J. E. C., Williams, S. R., & Dursun, S. M. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.37 · Cited by 311 · see citing works
Linking microcircuit dysfunction to cognitive impairment: Effects of disinhibition associated with schizophrenia in a cortical working memory model
Murray, J. D., Anticevic, A., Gancsos, M., Ichinose, M., Corlett, P. R., Krystal, J. H., & Wang, X.-J. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhs370 · Cited by 255 · see citing works
Potential Psychiatric Applications of Metabotropic Glutamate Receptor Agonists and Antagonists
Krystal, J. H., Mathew, S. J., DʼSouza, D. C., Garakani, A., Gunduz-Bruce, H., & Charney, D. S. (2010) · CNS Drugs · doi:10.2165/11533230-000000000-00000 · Cited by 180 · see citing works
Atypical Antipsychotics: CATIE Study, Drug-Induced Movement Disorder and Resulting Iatrogenic Psychiatric-Like Symptoms, Supersensitivity Rebound Psychosis and Withdrawal Discontinuation Syndromes
Chouinard, G., & Chouinard, V.-A. (2008) · Psychotherapy and Psychosomatics · doi:10.1159/000112883 · Cited by 168 · see citing works
Glutamate-mediated excitotoxicity in schizophrenia: a review.
Plitman, E., Nakajima, S., de la Fuente-Sandoval, C., Gerretsen, P., Chakravarty, M., Kobylianskii, J., Chung, J., Caravaggio, F., Iwata, Y., Remington, G., et al. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.07.015 · Cited by 151 · see citing works
Clozapine resistance: Augmentation strategies
Porcelli, S., Balzarro, B., & Serretti, A. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.08.005 · Cited by 139 · see citing works
Lamotrigine as Add-On Therapy in Schizophrenia
GOFF, D. C., Keefe, R. S. E., Citrome, L., Davy, K., Krystal, J. H., Large, C. H., Thompson, T. R., Volavka, J., & Webster, E. L. (2007) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31815abf34 · Cited by 120 · see citing works
Self-citation
Quantifying the Attenuation of the Ketamine Pharmacological Magnetic Resonance Imaging Response in Humans: A Validation Using Antipsychotic and Glutamatergic Agents
Doyle, O., Simoni, S. D., Schwarz, A. J., Brittain, C., O’Daly, O., Williams, S., & Mehta, M. A. (2013) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.201665 · Cited by 117 · see citing works
Differential Effects of Antipsychotic and Glutamatergic Agents on the phMRI Response to Phencyclidine
Gozzi, A., Large, C. H., Schwarz, A. J., Bertani, S., Crestan, V., & Bifone, A. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301547 · Cited by 114 · see citing works
Self-citation
The effect of lamotrigine augmentation of clozapine in a sample of treatment-resistant schizophrenic patients: A double-blind, placebo-controlled study
Zoccali, R. A., Muscatello, M. R. A., Bruno, A., Cambria, R., Micò, U., Spina, E., & Meduri, M. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.02.009 · Cited by 106 · see citing works
Do NMDA receptor antagonist models of schizophrenia predict the clinical efficacy of antipsychotic drugs?
Large, C. H. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881107077712 · Cited by 94 · see citing works
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Glutaminase-deficient mice display hippocampal hypoactivity, insensitivity to pro-psychotic drugs and potentiated latent inhibition: relevance to schizophrenia
Gaisler-Salomon, I., Miller, G. M., Chuhma, N., Lee, S., Zhang, H., Ghoddoussi, F., Lewandowski, N., Fairhurst, S., Wang, Y., Conjard-Duplany, A., et al. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.58 · Cited by 86 · see citing works
Ketamine induces a robust whole-brain connectivity pattern that can be differentially modulated by drugs of different mechanism and clinical profile
Joules, R., Doyle, O., Schwarz, A. J., O’Daly, O., Brammer, M. J., Williams, S., & Mehta, M. A. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3951-9 · Cited by 76 · see citing works
Differential effects produced by ketamine on oscillatory activity recorded in the rat hippocampus, dorsal striatum and nucleus accumbens
Hunt, M. J., Falińska, M., Łęski, S., Wojcik, D. K., & Kasicki, S. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881110362126 · Cited by 70 · see citing works
The Neurobehavioral Pharmacology of Ketamine: Implications for Drug Abuse, Addiction, and Psychiatric Disorders
Trujillo, K. A., Smith, M. L., Sullivan, B., Heller, C. Y., Garcia, C., & Bates, M. L. S. (2011) · ILAR Journal · doi:10.1093/ilar.52.3.366 · Cited by 59 · see citing works
Lamotrigine for schizophrenia
Premkumar, T. S., & Pick, J. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005962.pub2 · Cited by 59 · see citing works
Validation of ketamine as a pharmacological model of thalamic dysconnectivity across the illness course of schizophrenia
Abram, S. V., Roach, B. J., Fryer, S. L., Calhoun, V. D., Preda, A., van Erp, T. G. M., Bustillo, J., Lim, K. O., Loewy, R. L., Stuart, B. K., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01502-0 · Cited by 49 · see citing works
An Investigation of the Efficacy of Mood Stabilizers in Rodent Models of Prepulse Inhibition
Ong, J. C., Brody, S. A., Large, C. H., & Geyer, M. A. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.090845 · Cited by 48 · see citing works
Self-citation
Lamotrigine inhibition of rotenone- or 1-methyl-4-phenylpyridinium-induced mitochondrial damage and cell death
Kim, Y. J., Ko, H. H., Han, E. S., & Lee, C. S. (2007) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2006.12.006 · Cited by 46 · see citing works
Effect of Adjunctive Lamotrigine Treatment on the Plasma Concentrations of Clozapine, Risperidone and Olanzapine in Patients With Schizophrenia or Bipolar Disorder
Spina, E., D’Arrigo, C., Migliardi, G., Santoro, V., Muscatello, M. R. A., Micò, U., D’Amico, G., & Perucca, E. (2006) · Therapeutic Drug Monitoring · doi:10.1097/01.ftd.0000246763.59506.b0 · Cited by 45 · see citing works
Development of psychosis in patients with epilepsy treated with lamotrigine: Report of six cases and review of the literature
Brandt, C., Füratsch, N., Boehme, V., Kramme, C., Pieridou, M., Villagrán, A., Woermann, F. G., & Pohlmann‐Eden, B. (2007) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2007.03.015 · Cited by 42 · see citing works
(±) Ketamine-induced prepulse inhibition deficits of an acoustic startle response in rats are not reversed by antipsychotics
Cilia, J., Hatcher, P. D., Reavill, C., & Jones, D. N. C. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881107077718 · Cited by 41 · see citing works
Cognitive enhancing agents in schizophrenia and bipolar disorder
Vreeker, A., van Bergen, A. H., & Kahn, R. S. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.04.014 · Cited by 35 · see citing works
Lamotrigine in the Immediate Treatment of Outpatients With Depersonalization Disorder Without Psychiatric Comorbidity: Randomized, Double-Blind, Placebo-Controlled Study
Aliyev, N. A., & Aliyev, Z. N. (2011) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31820428e1 · Cited by 28 · see citing works
Retracted
Human Urotensin-II Potentiates the Mitogenic Effect of Mildly Oxidized Low-Density Lipoprotein on Vascular Smooth Muscle Cells: Comparison with Other Vasoactive Agents and Hydrogen Peroxide
Watanabe, T., Takahashi, K., Kanome, T., Hongo, S., Miyazaki, A., Koba, S., Katagiri, T., PAKARA, R., & Benedict, C. R. (2006) · Hypertension Research · doi:10.1291/hypres.29.821 · Cited by 28 · see citing works
Potential drug targets and treatment of schizophrenia
Kumar, A., Yadav, M., Parle, M., Dhingra, S., & Dhull, D. K. (2017) · Inflammopharmacology · doi:10.1007/s10787-017-0340-5 · Cited by 26 · see citing works
Modulatory effects of ketamine, risperidone and lamotrigine on resting brain perfusion in healthy human subjects
Shcherbinin, S., Doyle, O., Zelaya, F. O., Simoni, S. D., Mehta, M. A., & Schwarz, A. J. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4021-z · Cited by 21 · see citing works
Neural network dysfunction in bipolar depression: clues from the efficacy of lamotrigine
Large, C. H., Daniel, E. D., Li, X., & George, M. S. (2009) · Biochemical Society Transactions · doi:10.1042/bst0371080 · Cited by 21 · see citing works
Self-citation
The Efficacy of Sodium Channel Blockers to Prevent Phencyclidine-Induced Cognitive Dysfunction in the Rat: Potential for Novel Treatments for Schizophrenia
Large, C. H., Bison, S., Sartori, I., Read, K. D., Gozzi, A., Quarta, D., Antolini, M., Hollands, E. C., Gill, C. H., Gunthorpe, M. J., et al. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.178475 · Cited by 20 · see citing works
Self-citation
Concomitant use of lamotrigine and aripiprazole increases risk of Stevens–Johnson syndrome?
Shen, Y., Chen, S.-J., Lin, C. C. H., & Chen, C. (2007) · International Clinical Psychopharmacology · doi:10.1097/01.yic.0000224789.21406.81 · Cited by 20 · see citing works
Modulation of high-frequency oscillations associated with NMDA receptor hypofunction in the rodent nucleus accumbens by lamotrigine
Hunt, M. J., Garcia, R., Large, C. H., & Kasicki, S. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.04.009 · Cited by 20 · see citing works
Self-citation
Contributions of Glutamate and GABA Systems to the Neurobiology and Treatment of Schizophrenia
Krystal, J. H., & Moghaddam, B. (2010) · doi:10.1002/9781444327298.ch21 · Cited by 17 · see citing works
Efficacy of Ketamine with and without Lamotrigine in Treatment-Resistant Depression: A Preliminary Report
Joseph, B., Núñez, N. A., Kung, S., Voort, J. L. V., Pazdernik, V., Schak, K. M., Boehm, S. M., Carpenter, B., Johnson, E. K., Malyshev, G., et al. (2023) · Pharmaceuticals · doi:10.3390/ph16081164 · Cited by 14 · see citing works
Recent Advances in Targeting the Ionotropic Glutamate Receptors in Treating Schizophrenia
McCullumsmith, R. E., Hammond, J. C., Funk, A., & Meador‐Woodruff, J. H. (2012) · Current Pharmaceutical Biotechnology · doi:10.2174/138920112800784899 · Cited by 14 · see citing works
Gabapentin adjunctive to risperidone or olanzapine in partially responsive schizophrenia: an open-label pilot study
Gabriel, A. (2010) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s13407 · Cited by 13 · see citing works
Psychotomimetic effects of PCP, LSD, and Ecstasy: pharmacological models of schizophrenia?
Catts, V. S., & Catts, S. V. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511789977.011 · Cited by 12 · see citing works
Lamotrigine, an antiepileptic drug, inhibits 5-HT 3 receptor currents in NCB-20 neuroblastoma cells
Kim, K., Jeun, S. H., & Sung, K.-W. (2017) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2017.21.2.169 · Cited by 12 · see citing works
Anticonvulsants in sports: Ethical considerations
Kaufman, K. R. (2007) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2006.12.004 · Cited by 12 · see citing works
Potentiation of the anticonvulsant efficacy of sodium channel inhibitors by an NK1‐receptor antagonist in the rat
Kalinichev, M., Bradford, A. M., Bison, S., Lucas, A. J., Sartori, I., Garbati, N., Andreetta, F., Bate, S. T., Austin, N. E., Jones, D. N. C., et al. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2009.02482.x · Cited by 11 · see citing works
Self-citation
Lamotrigine, quetiapine and aripiprazole-induced neuroleptic malignant syndrome in a patient with renal failure caused by lithium: a case report
Szota, A. M., Radajewska, I., Grudzka, P., & Araszkiewicz, A. S. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02597-x · Cited by 11 · see citing works
Modulatory Effects of Ketamine and Lamotrigine on Cognition: Emotion Interaction in the Brain
Gärtner, M., Weigand, A., Keicher, C., Meiering, M. S., Weigner, D., Carstens, L., Hertrampf, R., Beckmann, C. F., Mennes, M., Wunder, A., et al. (2023) · Neuropsychobiology · doi:10.1159/000528315 · Cited by 10 · see citing works
Region- and time- specific effects of ketamine on cerebral blood flow: a randomized controlled trial
Gärtner, M., Weigand, A., Meiering, M. S., Weigner, D., Carstens, L., Keicher, C., Hertrampf, R., Beckmann, C. F., Mennes, M., Wunder, A., et al. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01605-4 · Cited by 9 · see citing works
Efficacy of 3,5‐dibromo‐L‐phenylalanine in rat models of stroke, seizures and sensorimotor gating deficit
Cao, W., Shah, H. P., Glushakov, A. V., Mecca, A., Shi, P. D., Sumners, C., Seubert, C. N., & Martynyuk, A. E. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00498.x · Cited by 8 · see citing works
Effects of lamotrigine on PCP-evoked elevations in monoamine levels in the medial prefrontal cortex of freely moving rats
Quarta, D., & Large, C. H. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881110385598 · Cited by 7 · see citing works
Self-citation
On the brink of precision medicine for psychosis: Treating the patient, not the disease
Demjaha, A. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.08.011 · Cited by 6 · see citing works
Low-dose lamotrigine augmentation therapy improves residual symptoms in treatment-resistant schizophrenia: A report of five cases
Ohnuma, T., Takebayashi, Y., Higashiyama, R. I., Shibata, N., & Arai, H. (2013) · Asia-Pacific Psychiatry · doi:10.1111/j.1758-5872.2012.00225.x · Cited by 5 · see citing works
Lamotrigine-associated exacerbation of positive symptoms in paranoid schizophrenia
Konstantakopoulos, G., Oulis, P., Michalopoulou, P. G., Koulouris, G. C., & Masdrakis, V. G. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.08.018 · Cited by 5 · see citing works
Reconnaître les symptômes psychiatriques iatrogènes liés aux antipsychotiques
Demily, C., Chouinard, V., & Chouinard, G. (2010) · L Encéphale · doi:10.1016/j.encep.2010.01.003 · Cited by 4 · see citing works
Pharmacological evaluation of lateral habenula and rostromedial tegmental nucleus in the expression of ethanol-induced place preference
Gakare, S. G., & Ugale, R. R. (2023) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000728 · Cited by 4 · see citing works
Pharmakotherapie bipolarer Störungen im Kindes- und Jugendalter
Vloet, J. A., & Hagenah, U. (2009) · Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie · doi:10.1024/1422-4917.37.1.27 · Cited by 4 · see citing works
Lamotrigine-Induced Neuroleptic Malignant Syndrome Under Risperidone Treatment: A Case Report
Motomura, E., Tanii, H., Usami, A., Ohoyama, K., Nakagawa, M., & Okada, M. (2012) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.11040093 · Cited by 4 · see citing works
Negative emotionality shapes the modulatory effects of ketamine and lamotrigine in subregions of the anterior cingulate cortex
Gärtner, M., Weigand, A., Meiering, M. S., Weigner, D., Carstens, L., Keicher, C., Hertrampf, R., Beckmann, C. F., Mennes, M., Wunder, A., et al. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02977-x · Cited by 3 · see citing works
Lamotrigine enhances the neuroprotective effects of memantine on aluminum chloride-induced behavioral changes in rats
Abdel‐Aal, R. A., Farghaly, H. S. M., & Zakaria, A. (2018) · Journal of Current Medical Research and Practice · doi:10.4103/jcmrp.jcmrp_110_18 · Cited by 2 · see citing works
Development and Validation of Analytical Method for Simultaneous Estimation of Lamotrigine and Clozapine in Synthetic Mixture by Absorbance Correction Method
Atodariya, P. P., Raj, H. A., & Jain, V. C. (2015) · Pharmatutor · Cited by 2 · see citing works
Functional connectivity alterations of the pregenual anterior cingulate cortex by ketamine and the modulation by lamotrigine
Weigner, D., Meiering, M. S., Weigand, A., Carstens, L., Keicher, C., Hertrampf, R., Beckmann, C. F., Mennes, M., Wunder, A., Gärtner, M., et al. (2025) · Journal of Psychopharmacology · doi:10.1177/02698811251346705 · Cited by 1 · see citing works
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Fatemi, S. H. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-252-6_6 · Cited by 1 · see citing works
Modelos fisiopatológicos de la esquizofrenia; de dopamina a glutamato, de glutamato a GABA
Rodrigo Paz, H. (2005) · Revista chilena de neuro-psiquiatría · doi:10.4067/s0717-92272005000400006 · Cited by 1 · see citing works
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Fatemi, S. H., & Folsom, T. D. (2016) · Springer eBooks · doi:10.1007/978-1-4939-2528-5_6 · Cited by 1 · see citing works
Traitement chimiothérapique des schizophrénies
Vandel, P., Haffen, É., & Sechter, D. (2008) · Encyclopédie médico-chirurgicale. Psychiatrie · doi:10.1016/s0246-1072(08)48121-x · Cited by 1 · see citing works
Médicaments non dopaminergiques dans la schizophrénie
Llorca, P. (2006) · L Encéphale · doi:10.1016/s0013-7006(06)76264-9
Reconnaître les symptômes psychiatriques iatrogènes liés aux antipsychotiques Iatrogenic psychiatric-like symptoms recognition
Demily, C., & Chouinard, G. (2010)
Schizophrenia
Balu, D. T., & GOFF, D. C. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9780511980053.005
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Spina, E., Migliardi, G., Pharm, D., Santoro, V., Muscatello, M. R. A., & Perucca, E. (2006)
Current awareness in human psychopharmacology
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Eggers, C., & Röpcke, B. (2011) · Springer eBooks · doi:10.1007/978-3-642-19846-5_16

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Kremer, I., Vass, Á., Gorelik, I., Bar, G., Blanaru, M., Javitt, D. C., & Heresco‐Levy, U. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.06.029 · Cited by 108 · see citing works
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Dursun, S. M., & Deakin, J. F. W. (2001) · Journal of Psychopharmacology · doi:10.1177/026988110101500409 · Cited by 125 · see citing works
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Hasan, A., Malchow, B., Falkai, P., & Schmitt, A. (2014) · Fortschritte der Neurologie · Psychiatrie · doi:10.1055/s-0034-1366571 · Cited by 12 · see citing works
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Heresco‐Levy, U. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2003.09.007 · Cited by 80 · see citing works
The Emerging Role of Glutamate in the Pathophysiology and Treatment of Schizophrenia
GOFF, D. C., & Coyle, J. T. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.9.1367 · Cited by 914 · see citing works
Self-citation

Authors: Large, C. H., Webster, E. L., & Goff, D. C.
Affiliations: GlaxoSmithKline (Italy) (IT)
GlaxoSmithKline (United States) (US)
Massachusetts General Hospital (US)
Corresponding author: Large, Charles H.
ORCID: Large, Charles H.
Webster, Elizabeth L.
Goff, Donald C.
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2005-07-06
Volume: 181
Issue: 3
Pages: 415-436
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/s00213-005-0020-9
OpenAlex: W2039572620
Cited by: 69
References: 282
Citations by year: 2025: 1 · 2024: 1 · 2023: 4 · 2022: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 5 · 2014: 1 · 2013: 2 · 2012: 4
FWCI: 1.09
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: lamotrigine, schizophrenia, glutamatergic neurotransmission, NMDA receptor antagonists, atypical antipsychotics, adjunctive therapy, dopamine D2 receptor, voltage-gated sodium channels, drug synergy
MeSH terms: Lamotrigine, Animals, Anticonvulsants, Brain, Disease Models, Animal, Drug Synergism, Drug Therapy, Combination, Humans, Schizophrenia, Schizophrenic Psychology, Antipsychotic Agents, Triazines, Glutamic Acid, Rats

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The potential role of lamotrigine in schizophrenia

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