The neurocircuitry of addiction: an overview

Feltenstein, M W; See, R E

doi:10.1038/bjp.2008.51

Cited by 422Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesNeuroscience and Neuropharmacology Research

The neurocircuitry of addiction: an overview

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Feltenstein, M W, See, R E·2008·British Journal of Pharmacology

DOI 10.1038/bjp.2008.51PMC PMC2442446

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Abstract

Drug addiction presents as a chronic relapsing disorder characterized by persistent drug-seeking and drug-taking behaviours. Given the significant detrimental effects of this disease both socially and economically, a considerable amount of research has been dedicated to understanding a number of issues in addiction, including behavioural and neuropharmacological factors that contribute to the development, loss of control and persistence of compulsive addictive behaviours. In this review, we will give a broad overview of various theories of addiction, animal models of addiction and relapse, drugs of abuse, and the neurobiology of drug dependence and relapse. Although drugs of abuse possess diverse neuropharmacological profiles, activation of the mesocorticolimbic system, particularly the ventral tegmental area, nucleus accumbens, amygdala and prefrontal cortex via dopaminergic and glutamatergic pathways, constitutes a common pathway by which various drugs of abuse mediate their acute reinforcing effects. However, long-term neuroadaptations in this circuitry likely underlie the transition to drug dependence and cycles of relapse. As further elucidated in more comprehensive reviews of various subtopics on addiction in later sections of this special issue, it is anticipated that continued basic neuroscience research will aid in the development of effective therapeutic interventions for the long-term treatment of drug-dependent individuals.

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The nucleus accumbens is crucially involved in substance abuse and dependence.
“Beyond reward and craving, the nucleus accumbens is crucially involved in substance abuse and dependence (36-38)”
From Effects of dietary glycemic index on brain regions related to reward and craving in men (2013) · cites this paper as [37]

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“Psychoactive drug-use induces dopaminergic activity in the ventral striatum and ventral tegmental area (11), resulting in a robust form of positive reinforcement.”
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Cocaine‐induced neuroadaptations in glutamate transmission
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Deep Brain Stimulation Surgery for Alcohol Addiction
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The Neurobiology of Addictive Disorders
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Extended methamphetamine self-administration enhances reinstatement of drug seeking and impairs novel object recognition in rats
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Levels of Neural Progenitors in the Hippocampus Predict Memory Impairment and Relapse to Drug Seeking as a Function of Excessive Methamphetamine Self-Administration
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No influence of one right-sided prefrontal HF-rTMS session on alcohol craving in recently detoxified alcohol-dependent patients: Results of a naturalistic study
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Reconsolidation of a Cocaine-Associated Stimulus Requires Amygdalar Protein Kinase A
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Neuropeptide S facilitates cue-induced relapse to cocaine seeking through activation of the hypothalamic hypocretin system
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Ceftriaxone upregulates the glutamate transporter in medial prefrontal cortex and blocks reinstatement of methamphetamine seeking in a condition place preference paradigm
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Blockade of 5-HT2A receptors in the medial prefrontal cortex attenuates reinstatement of cue-elicited cocaine-seeking behavior in rats
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Cognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction
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Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine
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A Comparative Study of Factors Associated with Relapse in Alcohol Dependence and Opioid Dependence
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“In addition to the established biopsychosocial model for relapse prevention, recent research has emphasized a gene-environment relationship along with an interaction of biological factors and psychosocial factors making the individual susceptible to relapse.[9,10] Furthermore, craving, self-efficacy, family support, a…”
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Ceftriaxone, a beta-lactam antibiotic, attenuates relapse-like ethanol-drinking behavior in alcohol-preferring rats
Qrunfleh, A. M., Alazizi, A., & Sari, Y. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881113482529 · Cited by 80 · see citing works
Levels of heroin and its metabolites in blood and brain extracellular fluid after i.v. heroin administration to freely moving rats
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Comparison of the reinforcing properties of nicotine and cigarette smoke extract in rats
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Propensity to 'relapse’ following exposure to cocaine cues is associated with the recruitment of specific thalamic and epithalamic nuclei
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Prelimbic Cortex and Ventral Tegmental Area Modulate Synaptic Plasticity Differentially in Nucleus Accumbens During Cocaine-Reinstated Drug Seeking
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Psychosocial factors associated with relapse in men with alcohol or opioid dependence.
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New horizons for therapeutics in drug and alcohol abuse
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Methamphetamine Self-Administration Produces Attentional Set-Shifting Deficits and Alters Prefrontal Cortical Neurophysiology in Rats
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Environmental living conditions introduced during forced abstinence alter cocaine-seeking behavior and Fos protein expression
Thiel, K. J., Pentkowski, N. S., Peartree, N. A., Painter, M. R., & Neisewander, J. L. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.10.001 · Cited by 75 · see citing works
Common neurocircuitry mediating drug and fear relapse in preclinical models
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Discovery of a Novel Site of Opioid Action at the Innate Immune Pattern-Recognition Receptor TLR4 and its Role in Addiction
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Oxytocin in the medial preoptic area facilitates male sexual behavior in the rat
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Environmental enrichment counters cocaine abstinence‐induced stress and brain reactivity to cocaine cues but fails to prevent the incubation effect
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DBS of nucleus accumbens on heroin seeking behaviors in self-administering rats
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Molecular Mechanism: ERK Signaling, Drug Addiction, and Behavioral Effects
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Oxytocin and Rodent Models of Addiction
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Influence of Music Therapy on Coping Skills and Anger Management in Forensic Psychiatric Patients
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Authors: Feltenstein, M. W., & See, R. E.
Affiliations: Medical University of South Carolina (US)
Corresponding author: Feltenstein, M W
Venue: British Journal of Pharmacology
Publisher: Wiley
Published: 2008-05
Volume: 154
Issue: 2
Pages: 261-274
ISSN: 0007-1188 (ISSN-L)
1476-5381
DOI: 10.1038/bjp.2008.51
PMC: PMC2442446
OpenAlex: W1867555087
Cited by: 421
References: 265
Citations by year: 2026: 8 · 2025: 14 · 2024: 12 · 2023: 13 · 2022: 14 · 2021: 18 · 2020: 16 · 2019: 21 · 2018: 19 · 2017: 18 · 2016: 28 · 2015: 22 · 2014: 28 · 2013: 41 · 2012: 40
FWCI: 3.02
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 273 d)
Locations: British Journal of Pharmacology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1c06rr015455-01a1, DA016511, DA015369)
National Institute on Drug Abuse (DA016511, DA07288, R01DA010462, DA 015369, P50DA015369, P50DA016511, DA010462, T32DA007288)
National Center for Research Resources (C06 RR-015455)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: drug addiction, neurocircuitry, relapse, mesocorticolimbic system, ventral tegmental area, nucleus accumbens, amygdala, prefrontal cortex, dopaminergic pathways, glutamatergic pathways, neural adaptation, animal models of addiction, drugs of abuse, addiction theory, compulsive drug seeking
MeSH terms: Animals, Behavior, Animal, Central Nervous System Agents, Dopamine, Humans, Limbic System, Models, Psychological, Neural Pathways, Recurrence, Substance Withdrawal Syndrome, Behavior, Addictive, Neurotransmitter Agents, Glutamic Acid, Substance-Related Disorders, Models, Animal

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