Reward processing in unipolar and bipolar depression: A functional MRI study

Redlich, Ronny; Dohm, Katharina; Grotegerd, Dominik; Opel, Nils; Zwitserlood, Pienie; Heindel, Walter; Arolt, Volker; Kugel, Harald; Dannlowski, Udo

doi:10.1038/npp.2015.110

Cited by 164Bipolar Disorder and TreatmentNeural and Behavioral Psychology StudiesTreatment of Major Depression

Reward processing in unipolar and bipolar depression: A functional MRI study

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Redlich, Ronny, Dohm, Katharina, Grotegerd, Dominik, Opel, Nils, Zwitserlood, Pienie, Heindel, Walter, Arolt, Volker, Kugel, Harald +1 more·2015·Neuropsychopharmacology

DOI 10.1038/npp.2015.110PMC PMC4569953

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Abstract

Differentiating bipolar disorders (BD) from unipolar depression (UD) remains a major clinical challenge. The identification of neurobiological markers may help to differentiate these disorders, particularly during depressive episodes. This cross-sectional study, including 33 patients with UD, 33 patients with BD, and 34 healthy controls, is one of the first to directly compare UD and BD with respect to reward processing. A card-guessing paradigm was employed and brain activity associated with reward processing was investigated by means of fMRI. A 3 (group) × 2 (condition: reward>control, loss>control) ANOVA was conducted using the nucleus accumbens (NAcc) as ROI. Furthermore, a whole-brain approach was applied. A functional connectivity analysis was performed to characterize diagnosis-related alterations in the functional coupling between the NAcc and other brain areas. The ANOVA revealed higher activity for healthy controls (HCs) than for BD and UD in the NAcc during reward processing. Moreover, UD showed a higher functional connectivity between the NAcc and the VTA than HC. The patients groups could be differentiated in that BD showed a decreased activation, in the reward condition, of the NAcc, caudate nucleus, thalamus, putamen, insula, and prefrontal areas compared with UD. These results may help to refine the understanding of neural correlates of reward processing in both disorders, and to understand the neural underpinnings of anhedonia, a core symptom of depressive episodes.

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Reduced activation during consummatory phase of reward in NAc and caudate in MDD vs HCs.
“Furthermore, reduced activation during the consummatory phase of reward was shown for the NAc and caudate in MDD patients compared with HCs (Pizzagalli et al., 2009; Redlich et al., 2015).”
From Circuit Mechanisms of Reward, Anhedonia, and Depression (2019) · cites this paper as Redlich et al., 2015
Increased connectivity between the NAc and the VTA in MDD patients vs HCs was described during reward processing in an fMRI task focusing on reward feedback.
“Furthermore, increased connectivity between the NAc and the VTA in MDD patients vs HCs was described during reward processing in an fMRI task focusing on reward feedback (Redlich et al., 2015).”
From Circuit Mechanisms of Reward, Anhedonia, and Depression (2019) · cites this paper as Redlich et al., 2015

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Authors: Redlich, R., Dohm, K., Grotegerd, D., Opel, N., Zwitserlood, P., Heindel, W., Arolt, V., Kugel, H., & Dannlowski, U.
Affiliations: University of Münster (DE)
Philipps University of Marburg (DE)
Corresponding author: Dannlowski, Udo
ORCID: Redlich, Ronny
Dohm, Katharina
Grotegerd, Dominik
Opel, Nils
Zwitserlood, Pienie
Heindel, Walter
Arolt, Volker
Kugel, Harald
Dannlowski, Udo
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2015-04-16
Volume: 40
Issue: 11
Pages: 2623-2631
ISSN: 0893-133X (ISSN-L)
1740-634X
DOI: 10.1038/npp.2015.110
PMC: PMC4569953
OpenAlex: W1976921288
Cited by: 164
References: 62
Citations by year: 2026: 10 · 2025: 13 · 2024: 5 · 2023: 8 · 2022: 14 · 2021: 32 · 2020: 16 · 2019: 16 · 2018: 15 · 2017: 13 · 2016: 16 · 2015: 6
FWCI: 13.51
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.springer.com/tdm (tdm)
Locations: Neuropsychopharmacology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft (DA1151/5-1, FOR 2107)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords: reward processing, major depressive disorder, bipolar disorder, nucleus accumbens, ventral tegmental area, functional connectivity, anhedonia, neural correlates of depression, differential diagnosis of depression, caudate nucleus, thalamus, insula, prefrontal cortex
MeSH terms: Adult, Analysis of Variance, Bipolar Disorder, Brain, Brain Mapping, Cross-Sectional Studies, Depressive Disorder, Diagnosis, Differential, Female, Humans, Magnetic Resonance Imaging, Male, Mental Processes, Neural Pathways, Neuropsychological Tests, Reward, Signal Processing, Computer-Assisted

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Reward processing in unipolar and bipolar depression: A functional MRI study

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