Relationship between CRP and depression: A genetically sensitive study in Sri Lanka
Open accessAbstract
Background Previous studies have shown associations between major depression and C-reactive protein (CRP) levels. Few studies have considered the extent to which shared genetic and environmental factors contribute to this association, nor have they considered the relationship outside of European populations. We examined the association between CRP levels and depression and their aetiology in a Sri Lankan population.Methods Data were collected from 2577 twins and 899 singletons in Colombo, Sri Lanka. Depression symptoms were assessed using the revised Beck Depression Inventory (BDI-II). High-sensitive CRP blood levels were assessed using immunoturbidimetry. Linear regressions were performed to test the association between CRP and depression. The heritability of CRP levels was estimated using Structural Equation Modelling.Results CRP was significantly associated with BMI (p < 0.01) but not depression (p > 0.05). In males, variance in CRP levels was explained by shared environment (51% 95%CIs: 13-62) and non-shared environment (45% 95%CIs: 36-54). In contrast, in females, CRP variance was explained by genetic (41% 95%CIs: 10-52) and non-shared environment (56% 95%CIs: 47-67). A genetic correlation between CRP and BMI was observed in females only.Limitations CRP level was based on a single data collection point, longer term data collection would give a more accurate picture of an individual's state of inflammation.Conclusions The lack of association between depression and CRP strengthens the hypothesis that inflammation might contribute to the development of some, but not all types of depression. CRP levels were moderated by the environment, suggesting interventions aimed at reducing CRP levels and risk for inflammatory conditions, particularly in males.
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In males, the variance in CRP levels was explained by shared environment and non-shared environment, while in females it was explained by genetic and non-shared environment.
“Moreover, in males the variance in CRP levels was explained by shared environment and non-shared environment, while in females it was explained by genetic and non-shared environment [75].”
From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [75]
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- Authors
- Zavos, H. M. S., Zunszain, P. A., Jayaweera, K., Powell, T. R., Chatzivasileiadou, M., Harber-Aschan, L., Adikari, A., Pannala, G., Siribaddana, S., Badini, I., Pariante, C. M., Hotopf, M., Sumathipala, A., & Rijsdijk, F.
- Affiliations
- King's College London (GB)
- Institute for Research and Development (LK)
- Rajarata University of Sri Lanka (LK)
- Corresponding author
- Zavos, Helena M.S.
- ORCID
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2022-01
- Volume
- 297
- Pages
- 112-117
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W3205811910
- Cited by
- 15
- References
- 64
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 1 · 2023: 1 · 2022: 2
- FWCI
- 0.33
- Type
- journal article
- Language
- en
- Open access
- green
- kclpure.kcl.ac.uk
- Licence
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion, other-oa)
- Funders
- Wellcome Trust (093206/Z/10/Z)
- National Institute for Health Research
- South London and Maudsley NHS Foundation Trust
- King's College London
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- C-reactive protein, depression, inflammation, heritability, genetic correlation, shared environment, nonshared environment, body mass index, sex differences, Sri Lankan population, twins
- MeSH terms
- Depression, Major Depressive Disorder, Depressive Disorder, Major, Diseases in Twins, Female, Humans, Male, Sri Lanka, Twins
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