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In Vivo Fiber Photometry Reveals Signature of Future Stress Susceptibility in Nucleus Accumbens
Open accessAbstract
Recognizing why chronic stress causes only a subset of individuals to become depressed is critical to understanding depression on a basic level and, also, to developing treatments that increase resilience. Stress-induced alterations in the activity of reward-related brain regions, such as the nucleus accumbens (NAc), are linked to the pathophysiology of depression. However, it has been difficult to determine if differences in stress susceptibility are pre-existing or merely an effect of chronic stress. The NAc consists largely of medium spiny neurons (MSNs), distinguished by their predominant expression of either D1 or D2 dopamine receptors. Mice that develop depressive-like symptoms after chronic social defeat stress show distinct changes in the activity of these two cell subtypes. Until now it has not been possible to determine whether such effects are merely a consequence of stress or in fact precede stress and, thus, have utility in pre-identifying stress-susceptible individuals. The goal of this study was to define a cell-type specific signature of stress susceptibility and resilience. Using fiber photometry calcium imaging, we recorded calcium transients in NAc D1- and D2-MSNs in awake behaving mice and found that D1-MSN activity is a predictive marker of depression susceptibility: prior to stress, mice that will later become resilient had increased baseline D1- MSN activity, and increased calcium transients specific to social interaction. Differences in D2- MSN activity were not specific to social interaction. Our findings identify a pre-existing mechanism of stress-induced susceptibility, creating the potential to target preventative interventions to the most relevant populations.
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“No statistical power estimation analyses were used to predetermine sample sizes, which instead were chosen to match previous publications (2, 11, 26-28).”
From Social Interaction Elicits Activity in Glutamatergic Neurons in the Posterior Intralaminar Complex of the Thalamus (2024) · cites this paper as [28]
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Cites
Dopamine, learning and motivation.
Wise, R. A. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1406 · Cited by 3,379 · cited 1×
“The nucleus accumbens (NAc) is an important structure in motivation and reward (Schultz, 2006; Wise, 2004).”
BackgroundCausal Relationship Between Stressful Life Events and the Onset of Major Depression
Kendler, K. S., Karkowski, L. M., & Prescott, C. A. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.6.837 · Cited by 2,566
Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307
Self-citationEssential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129
Self-citationTHE EFFECTS OF STRESSFUL LIFE EVENTS ON DEPRESSION
Kessler, R. C. (1997) · Annual Review of Psychology · doi:10.1146/annurev.psych.48.1.191 · Cited by 2,111 · cited 1×
“Epidemiological studies highlight the importance of stress in the etiology of depression (Kendler et al, 1999; Kessler, 1997).”
BackgroundModulation of Striatal Projection Systems by Dopamine
Gerfen, C. R., & Surmeier, D. J. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113641 · Cited by 1,700
Behavioral Theories and the Neurophysiology of Reward
Schultz, W. (2006) · Annual Review of Psychology · doi:10.1146/annurev.psych.56.091103.070229 · Cited by 1,637
A standardized protocol for repeated social defeat stress in mice
Golden, S. A., Covington, H. E., Berton, O., & Russo, S. J. (2011) · Nature Protocols · doi:10.1038/nprot.2011.361 · Cited by 1,581
Natural neural projection dynamics underlying social behavior
Gunaydin, L. A., Grosenick, L., Finkelstein, J. C., Kauvar, I. V., Fenno, L. E., Adhikari, A., Lammel, S., Mirzabekov, J. J., Airan, R. D., Zalocusky, K. A., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.017 · Cited by 1,389
Self-citationRapid regulation of depression-related behaviours by control of midbrain dopamine neurons
Chaudhury, D., Walsh, J. J., Friedman, A. K., Juarez, B., Ku, S. M., Koo, J. W., Ferguson, D., Tsai, H.-C., Pomeranz, L., Christoffel, D. J., et al. (2013) · Nature · doi:10.1038/nature11713 · Cited by 1,156
Self-citationDopamine neurons modulate neural encoding and expression of depression-related behaviour
Tye, K. M., Mirzabekov, J. J., Warden, M. R., Ferenczi, E. A., Tsai, H.-C., Finkelstein, J., Kim, S.-Y., Adhikari, A., Thompson, K. R., Andalman, A. S., et al. (2013) · Nature · doi:10.1038/nature11740 · Cited by 1,073
Self-citationDistinct roles for direct and indirect pathway striatal neurons in reinforcement
Kravitz, A. V., Tye, L. D., & Kreitzer, A. C. (2012) · Nature Neuroscience · doi:10.1038/nn.3100 · Cited by 972
Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward
Lobo, M. K., Covington, H. E., Chaudhury, D., Friedman, A. K., Sun, H., Damez-Werno, D., Dietz, D. M., Zaman, S., Koo, J. W., Kennedy, P. J., et al. (2010) · Science · doi:10.1126/science.1188472 · Cited by 880
Self-citationAntidepressant effect of optogenetic stimulation of the medial prefrontal cortex
Covington, H. E., Lobo, M. K., Maze, I., Vialou, V., Hyman, J. M., Zaman, S., LaPlant, Q., Mouzon, E., Ghose, S., Tamminga, C. A., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1731-10.2010 · Cited by 621
Self-citationDopamine Signaling in reward-related behaviors
Baik, J. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00152 · Cited by 568
Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression
Bagot, R. C., Parise, E. M., Peña, C. J., Zhang, H.-X., Maze, I., Chaudhury, D., Persaud, B., Cachope, R., Bolaños-Guzmán, C. A., Cheer, J. F., et al. (2015) · Nature Communications · doi:10.1038/ncomms8062 · Cited by 491
Self-citationΔFosB in brain reward circuits mediates resilience to stress and antidepressant responses
Vialou, V., Robison, A. J., LaPlant, Q. C., Covington, H. E., Dietz, D. M., Ohnishi, Y. N., Mouzon, E., Rush, A. J., Watts, E. L., Wallace, D. L., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2551 · Cited by 479
Self-citationFrancis, T. C., Chandra, R., Friend, D. M., Finkel, E., Dayrit, G., Miranda, J., Brooks, J. M., Iñiguez, S. D., O’Donnell, P., Kravitz, A., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.07.021 · Cited by 379
Anhedonia requires MC4R-mediated synaptic adaptations in nucleus accumbens
Lim, B. K., Huang, K. W., Grueter, B. A., Rothwell, P. E., & Malenka, R. C. (2012) · Nature · doi:10.1038/nature11160 · Cited by 368
In vivo imaging identifies temporal signature of D1 and D2 medium spiny neurons in cocaine reward
Calipari, E. S., Bagot, R. C., Purushothaman, I., Davidson, T. J., Yorgason, J. T., Peña, C. J., Walker, D. M., Pirpinias, S. T., Guise, K. G., Ramakrishnan, C., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521238113 · Cited by 317
Self-citationLobo, M. K., Zaman, S., Damez-Werno, D. M., Koo, J. W., Bagot, R. C., DiNieri, J. A., Nugent, A., Finkel, E., Chaudhury, D., Chandra, R., et al. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1875-13.2013 · Cited by 245
Self-citationβ-catenin mediates stress resilience through Dicer1/microRNA regulation
Dias, C., Feng, J., Sun, H., Shao, N. Y., Mazei-Robison, M. S., Damez-Werno, D., Scobie, K., Bagot, R., LaBonté, B., Ribeiro, E., et al. (2014) · Nature · doi:10.1038/nature13976 · Cited by 240
Self-citationWook Koo, J., Labonté, B., Engmann, O., Calipari, E. S., Juarez, B., Lorsch, Z., Walsh, J. J., Friedman, A. K., Yorgason, J. T., Han, M.-H., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.12.009 · Cited by 231
Self-citationValenti, O., Gill, K. M., & Grace, A. A. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08038.x · Cited by 131
Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress
Christoffel, D. J., Golden, S. A., Walsh, J. J., Guise, K. G., Heshmati, M., Friedman, A. K., Dey, A., Smith, M., Rebusi, N., Pfau, M., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4034 · Cited by 101
Self-citationACF chromatin-remodeling complex mediates stress-induced depressive-like behavior
Sun, H., Damez-Werno, D. M., Scobie, K. N., Shao, N.-Y., Dias, C., Rabkin, J., Koo, J. W., Korb, E., Bagot, R. C., Ahn, F. H., et al. (2015) · Nature Medicine · doi:10.1038/nm.3939 · Cited by 91
Self-citation
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The molecular and cellular mechanisms of depression: a focus on reward circuitry
Fox, M. E., & Lobo, M. K. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0415-3 · Cited by 232
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Pisano, F., Pisanello, M., Lee, S. J., Lee, J., Maglie, E., Balena, A., Sileo, L., Spagnolo, B., Bianco, M., Hyun, M., et al. (2019) · Nature Methods · doi:10.1038/s41592-019-0581-x · Cited by 162
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Willmore, L., Cameron, C., Yang, J., Witten, I. B., & Falkner, A. L. (2022) · Nature · doi:10.1038/s41586-022-05328-2 · Cited by 149
Metadata
- Authors
- Muir, J., Lorsch, Z. S., Ramakrishnan, C., Deisseroth, K., Nestler, E. J., Calipari, E. S., & Bagot, R. C.
- Affiliations
- McGill University (CA)
- Icahn School of Medicine at Mount Sinai (US)
- Stanford University (US)
- Ludmer Centre for Neuroinformatics and Mental Health (CA)
- Corresponding author
- Bagot, Rosemary C
- ORCID
- Venue
- Neuropsychopharmacology
- Published
- 2017-06-07
- Volume
- 43
- Issue
- 2
- Pages
- 255-263
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC5729554
- OpenAlex
- W2624524674
- Cited by
- 116
- References
- 26
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 12 · 2023: 16 · 2022: 15 · 2021: 17 · 2020: 17 · 2019: 14 · 2018: 12 · 2017: 1
- FWCI
- 5.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institute of Mental Health (F30MH110073, P50MH096890, R01MH051399)
- National Institute on Drug Abuse (K99DA042111, R00DA042111, R01DA014133)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- stress vulnerability, depression, chronic social defeat stress, nucleus accumbens, medium spiny neurons, dopamine D1 receptor, dopamine D2 receptor, calcium transients, fiber photometry, resilience, social interaction, predictive biomarkers
- MeSH terms
- Animals, Behavior, Animal, Calcium, Depression, Disease Models, Animal, Disease Susceptibility, Male, Mice, Inbred C57BL, Nucleus Accumbens, Photometry, Social Behavior, Stress, Psychological, Receptors, Dopamine D1, Receptors, Dopamine D2, Mice, GABAergic Neurons
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