Anhedonia requires MC4R-mediated synaptic adaptations in nucleus accumbens

Production of glycoprotein-deleted rabies viruses for monosynaptic tracing and high-level gene expression in neurons

Wickersham, I. R., Sullivan, H., & Seung, H. (2010) · Nature Protocols · doi:10.1038/nprot.2009.248 · Cited by 4,905 · see citing works

Central nervous system control of food intake and body weight

Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., & Schwartz, M. W. (2006) · Nature · doi:10.1038/nature05026 · Cited by 2,503 · see citing works

The mesolimbic dopamine reward circuit in depression

Nestler, E. J., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.018 · Cited by 2,059 · see citing works

Animal models of neuropsychiatric disorders

Nestler, E. J., & Hyman, S. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2647 · Cited by 2,023 · see citing works

Dissecting components of reward: ‘liking’, ‘wanting’, and learning

Berridge, K. C., Robinson, T. E., & Aldridge, J. W. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.12.014 · Cited by 1,942 · see citing works

Anatomy and regulation of the central melanocortin system

Cone, R. D. (2005) · Nature Neuroscience · doi:10.1038/nn1455 · Cited by 1,583 · see citing works

The Neuroscience of Natural Rewards: Relevance to Addictive Drugs

Kelley, A. E., & Berridge, K. C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03306.2002 · Cited by 1,465 · see citing works

Reward, dopamine and the control of food intake: implications for obesity

Volkow, N. D., Wang, G.-J., & Baler, R. D. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.11.001 · Cited by 1,400 · see citing works

Synaptic plasticity and addiction

Kauer, J. A., & Malenka, R. C. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2234 · Cited by 1,397 · see citing works

Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning

Tsai, H.-C., Zhang, F., Adamantidis, A., Stuber, G. D., Bonci, A., de Lecea, L., & Deisseroth, K. (2009) · Science · doi:10.1126/science.1168878 · Cited by 1,266 · see citing works

Conditioned place preference: what does it add to our preclinical understanding of drug reward?

Bardo, M. T., & Bevins, R. A. (2000) · Psychopharmacology · doi:10.1007/s002130000569 · Cited by 1,233 · see citing works

The patterns of afferent innervation of the core and shell in the “Accumbens” part of the rat ventral striatum: Immunohistochemical detection of retrogradely transported fluoro‐gold

Brog, J. S., Salyapongse, A., Deutch, A. Y., & Zahm, D. S. (1993) · Journal of Comparative Neurology · doi:10.1002/cne.903380209 · Cited by 1,102 · see citing works

Striatal Plasticity and Basal Ganglia Circuit Function

Kreitzer, A. C., & Malenka, R. C. (2008) · Neuron · doi:10.1016/j.neuron.2008.11.005 · Cited by 1,009 · see citing works

The cell biology of synaptic plasticity: AMPA receptor trafficking

Shepherd, J. D., & Huganir, R. L. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123516 · Cited by 978 · see citing works

Targeting Cre recombinase to specific neuron populations with bacterial artificial chromosome constructs

Gong, S., Doughty, M., Harbaugh, C. R., Cummins, A., Hatten, M. E., Heintz, N., & Gerfen, C. R. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2707-07.2007 · Cited by 977 · see citing works

Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward

Lobo, M. K., Covington, H. E., Chaudhury, D., Friedman, A. K., Sun, H., Damez-Werno, D., Dietz, D. M., Zaman, S., Koo, J. W., Kennedy, P. J., et al. (2010) · Science · doi:10.1126/science.1188472 · Cited by 880 · see citing works

The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity

Isaac, J. T. R., Ashby, M. C., & McBain, C. J. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.001 · Cited by 802 · see citing works

Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving

Conrad, K. L., Tseng, K. Y., Uejima, J. L., Reimers, J. M., Heng, L.-J., Shaham, Y., Marinelli, M., & Wolf, M. E. (2008) · Nature · doi:10.1038/nature06995 · Cited by 790 · see citing works

Rodent Models of Depression: Forced Swim and Tail Suspension Behavioral Despair Tests in Rats and Mice

Castagné, V., Moser, P., Roux, S., & Porsolt, R. D. (2011) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0810as55 · Cited by 702 · see citing works

In Vitro and In Vivo Gene Therapy Vector Evolution via Multispecies Interbreeding and Retargeting of Adeno-Associated Viruses

Grimm, D., Lee, J. S., Wang, L., Desai, T., Akache, B., Storm, T. A., & Kay, M. A. (2008) · Journal of Virology · doi:10.1128/jvi.00254-08 · Cited by 696 · see citing works

Retrograde neuronal tracing with a deletion-mutant rabies virus

Wickersham, I. R., Finke, S., Conzelmann, K., & Callaway, E. M. (2006) · Nature Methods · doi:10.1038/nmeth999 · Cited by 686 · see citing works

Synaptic potentiation onto habenula neurons in the learned helplessness model of depression

Li, B., Piriz, J., Mirrione, M., Chung, C., Proulx, C. D., Schulz, D., Henn, F., & Malinow, R. (2011) · Nature · doi:10.1038/nature09742 · Cited by 634 · see citing works

Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine

Thomas, M. J., Beurrier, C., Bonci, A., & Malenka, R. C. (2001) · Nature Neuroscience · doi:10.1038/nn757 · Cited by 629 · see citing works

Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex

Covington, H. E., Lobo, M. K., Maze, I., Vialou, V., Hyman, J. M., Zaman, S., LaPlant, Q., Mouzon, E., Ghose, S., Tamminga, C. A., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1731-10.2010 · Cited by 621 · see citing works

A FLEX Switch Targets Channelrhodopsin-2 to Multiple Cell Types for Imaging and Long-Range Circuit Mapping

Atasoy, D., Aponte, Y., Su, H. H., & Sternson, S. M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1954-08.2008 · Cited by 614 · see citing works

Distinct Roles of Synaptic Transmission in Direct and Indirect Striatal Pathways to Reward and Aversive Behavior

Hikida, T., Kimura, K., Wada, N., Funabiki, K., & Nakanishi, S. (2010) · Neuron · doi:10.1016/j.neuron.2010.05.011 · Cited by 592 · see citing works

Epac proteins: multi-purpose cAMP targets

Bos, J. L. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.10.002 · Cited by 532 · see citing works

Drug-induced conditioned place preference and aversion in mice

Cunningham, C. L., Gremel, C. M., & Groblewski, P. A. (2006) · Nature Protocols · doi:10.1038/nprot.2006.279 · Cited by 461 · see citing works

Clathrin adaptor AP2 and NSF interact with overlapping sites of GluR2 and play distinct roles in AMPA receptor trafficking and hippocampal LTD

Lee, S. H., Liu, L., Wang, Y. T., & Sheng, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)01024-3 · Cited by 441 · see citing works

Reversal of cocaine-evoked synaptic potentiation resets drug-induced adaptive behaviour

Pascoli, V., Turiault, M., & Lüscher, C. (2011) · Nature · doi:10.1038/nature10709 · Cited by 419 · see citing works

Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization

Ferguson, S. M., Eskenazi, D., Ishikawa, M., Wanat, M. J., Phillips, P. E. M., Dong, Y., Roth, B. L., & Neumaier, J. F. (2011) · Nature Neuroscience · doi:10.1038/nn.2703 · Cited by 418 · see citing works

Transition to Addiction Is Associated with a Persistent Impairment in Synaptic Plasticity

Kasanetz, F., Deroche‐Gamonet, V., Berson, N., Balado, É., Lafourcade, M., Manzoni, O. J., & Piazza, P. V. (2010) · Science · doi:10.1126/science.1187801 · Cited by 364 · see citing works

Postsynaptic TRPV1 triggers cell type–specific long-term depression in the nucleus accumbens

Grueter, B. A., Brasnjo, G., & Malenka, R. C. (2010) · Nature Neuroscience · doi:10.1038/nn.2685 · Cited by 353 · see citing works

Neurobiology of Feeding and Energy Expenditure

Gao, Q., & Horvath, T. L. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094324 · Cited by 346 · see citing works

Differential Expression of the Small-Conductance, Calcium-Activated Potassium Channel SK3 Is Critical for Pacemaker Control in Dopaminergic Midbrain Neurons

Wolfart, J., Neuhoff, H., Franz, O., & Roeper, J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-10-03443.2001 · Cited by 345 · see citing works

D2R striatopallidal neurons inhibit both locomotor and drug reward processes

Durieux, P. F., Bearzatto, B., Guiducci, S., Buch, T., Waisman, A., Zoli, M., Schiffmann, S. N., & de Kerchove d'Exaerde, A. (2009) · Nature Neuroscience · doi:10.1038/nn.2286 · Cited by 297 · see citing works

Nucleus Accumbens Long-Term Depression and the Expression of Behavioral Sensitization

Brebner, K., Wong, T. P., Liu, L., Liu, Y., Campsall, P. A., Gray, S. L., Phelps, L., Phillips, A. G., & Wang, Y. T. (2005) · Science · doi:10.1126/science.1116894 · Cited by 289 · see citing works

Budding of Rabies Virus Particles in the Absence of the Spike Glycoprotein

Mebatsion, T., König, M., & Conzelmann, K. (1996) · Cell · doi:10.1016/s0092-8674(00)81072-7 · Cited by 288 · see citing works

Drd1a-tdTomato BAC Transgenic Mice for Simultaneous Visualization of Medium Spiny Neurons in the Direct and Indirect Pathways of the Basal Ganglia

Shuen, J. A., Chen, M., Gloss, B. R., & Calakos, N. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5492-07.2008 · Cited by 231 · see citing works

Rodent Models of Depression: Forced Swimming and Tail Suspension Behavioral Despair Tests in Rats and Mice

Porsolt, R. D., Brossard, G., Hautbois, C., & Roux, S. (2001) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0810as14 · Cited by 217 · see citing works

Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines

Woolfrey, K. M., Srivastava, D. P., Photowala, H., Yamashita, M., Barbolina, M. V., Cahill, M. E., Xie, Z., Jones, K. A., Quilliam, L. A., Prakriya, M., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2386 · Cited by 161 · see citing works

Structure, function and regulation of the melanocortin receptors

Yang, Y. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.12.020 · Cited by 141 · see citing works

The Melanocortinergic Pathway Is Rapidly Recruited by Emotional Stress and Contributes to Stress-Induced Anorexia and Anxiety-Like Behavior

Liu, J., Garza, J. C., Truong, H. V., Henschel, J., Zhang, W., & Lu, X.-Y. (2007) · Endocrinology · doi:10.1210/en.2007-0745 · Cited by 141 · see citing works

Involvement of melanocortin-4 receptor in anxiety and depression

Chaki, S., & Okuyama, S. (2005) · Peptides · doi:10.1016/j.peptides.2004.11.029 · Cited by 116 · see citing works

Blockade of melanocortin transmission inhibits cocaine reward

Hsu, R., Taylor, J. R., Newton, S. S., Alvaro, J. D., Haile, C. N., Han, G. U., Hruby, V. J., Nestler, E. J., & Duman, R. S. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04038.x · Cited by 94 · see citing works

Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents

Chaki, S., Ogawa, S., Toda, Y., Funakoshi, T., & Okuyama, S. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)02033-8 · Cited by 86 · see citing works

Expression of Mutant NMDA Receptors in Dopamine D1Receptor-Containing Cells Prevents Cocaine Sensitization and Decreases Cocaine Preference

Heusner, C. L., & Palmiter, R. D. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1474-05.2005 · Cited by 65 · see citing works

The brain reward circuitry in mood disorders

Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870 · see citing works

Long-range and local circuits for top-down modulation of visual cortex processing

Zhang, S., Xu, M., Kamigaki, T., Hoang Do, J. P., Chang, W.-C., Jenvay, S., Miyamichi, K., Luo, L., & Dan, Y. (2014) · Science · doi:10.1126/science.1254126 · Cited by 804 · see citing works

Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation

Moda-Sava, R. N., Murdock, M. H., Parekh, P. K., Fetcho, R. N., Huang, B. S., Huynh, T. N., Witztum, J., Shaver, D. C., Rosenthal, D. L., Alway, E. J., et al. (2019) · Science · doi:10.1126/science.aat8078 · Cited by 643 · see citing works

Pathogenesis of depression: Insights from human and rodent studies

Ménard, C., Hodes, G. E., & Russo, S. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.053 · Cited by 593 · see citing works

Prefrontal cortical regulation of brainwide circuit dynamics and reward-related behavior

Ferenczi, E. A., Zalocusky, K. A., Liston, C., Grosenick, L., Warden, M. R., Amatya, D., Katovich, K., Mehta, H., Patenaude, B., Ramakrishnan, C., et al. (2016) · Science · doi:10.1126/science.aac9698 · Cited by 535 · see citing works

Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression

Bagot, R. C., Parise, E. M., Peña, C. J., Zhang, H.-X., Maze, I., Chaudhury, D., Persaud, B., Cachope, R., Bolaños-Guzmán, C. A., Cheer, J. F., et al. (2015) · Nature Communications · doi:10.1038/ncomms8062 · Cited by 491 · see citing works

Dendritic Spines in Depression: What We Learned from Animal Models

Qiao, H., Li, M.-X., Xu, C. S., Chen, H.-B., An, S.-C., & Ma, X. (2016) · Neural Plasticity · doi:10.1155/2016/8056370 · Cited by 442 · see citing works

Stress and the dopaminergic reward system

Baik, J. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00532-4 · Cited by 446 · see citing works

βCaMKII in Lateral Habenula Mediates Core Symptoms of Depression

Li, K., Zhou, T., Liao, L., Yang, Z., Wong, C., Henn, F., Malinow, R., Yates, J. R., & Hu, H. (2013) · Science · doi:10.1126/science.1240729 · Cited by 411 · see citing works

Nucleus Accumbens Medium Spiny Neuron Subtypes Mediate Depression-Related Outcomes to Social Defeat Stress

Francis, T. C., Chandra, R., Friend, D. M., Finkel, E., Dayrit, G., Miranda, J., Brooks, J. M., Iñiguez, S. D., O’Donnell, P., Kravitz, A., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.07.021 · Cited by 379 · see citing works

A thalamic input to the nucleus accumbens mediates opiate dependence

Zhu, Y., Wienecke, C. F. R., Nachtrab, G. T., & Chen, X. (2016) · Nature · doi:10.1038/nature16954 · Cited by 386 · see citing works

The current state of the neurogenic theory of depression and anxiety

Miller, B. R., & Hen, R. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.08.012 · Cited by 386 · see citing works

Activating positive memory engrams suppresses depression-like behaviour

Ramirez, S., Liu, X., MacDonald, C. J., Moffa, A., Zhou, J. Y., Redondo, R. L., & Tonegawa, S. (2015) · Nature · doi:10.1038/nature14514 · Cited by 373 · see citing works

GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine

Miller, O. H., Yang, L., Wang, C.-C., Hargroder, E. A., Zhang, Y., Delpire, E., & Hall, B. J. (2014) · eLife · doi:10.7554/elife.03581 · Cited by 358 · see citing works

Melanocortin-4 receptor–regulated energy homeostasis

Krashes, M. J., Lowell, B. B., & Garfield, A. S. (2016) · Nature Neuroscience · doi:10.1038/nn.4202 · Cited by 359 · see citing works

Accumbal D1R Neurons Projecting to Lateral Hypothalamus Authorize Feeding

O’Connor, E. C., Kremer, Y., Lefort, S., Harada, M., Pascoli, V., Rohner, C., & Lüscher, C. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.038 · Cited by 308 · see citing works

Reward behaviour is regulated by the strength of hippocampus–nucleus accumbens synapses

LeGates, T. A., Kvarta, M. D., Tooley, J. R., Francis, T. C., Lobo, M. K., Creed, M. C., & Thompson, S. M. (2018) · Nature · doi:10.1038/s41586-018-0740-8 · Cited by 290 · see citing works

Chronic stress and glucocorticoids: From neuronal plasticity to neurodegeneration

Vyas, S., Rodrigues, A. J., Silva, J. M., Tronche, F., Almeida, O. F. X., Sousa, N., & Sotiropoulos, I. (2016) · Neural Plasticity · doi:10.1155/2016/6391686 · Cited by 297 · see citing works

A Motivational and Neuropeptidergic Hub: Anatomical and Functional Diversity within the Nucleus Accumbens Shell

Castro, D. C., & Bruchas, M. R. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.003 · Cited by 287 · see citing works

Neuroplasticity Underlying the Comorbidity of Pain and Depression

Doan, L., Manders, T. R., & Wang, J. (2015) · Neural Plasticity · doi:10.1155/2015/504691 · Cited by 284 · see citing works

An excitatory synapse hypothesis of depression

Thompson, S. M., Kallarackal, A. J., Kvarta, M. D., Van Dyke, A. M., LeGates, T. A., & Cai, X. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.03.003 · Cited by 265 · see citing works

Frontostriatal salience network expansion in individuals in depression

Lynch, C. J., Elbau, I., Ng, T. H. B., Ayaz, A., Zhu, S., Wolk, D., Manfredi, N., Johnson, M. A., Chang, M., Chou, J., et al. (2024) · Nature · doi:10.1038/s41586-024-07805-2 · Cited by 311 · see citing works

Decreased motivation during chronic pain requires long-term depression in the nucleus accumbens

Schwartz, N., Temkin, P., Jurado, S., Lim, B. K., Heifets, B. D., Polepalli, J. S., & Malenka, R. C. (2014) · Science · doi:10.1126/science.1253994 · Cited by 278 · see citing works

Distinct Ventral Pallidal Neural Populations Mediate Separate Symptoms of Depression

Knowland, D., Lilascharoen, V., Pacia, C. P., Shin, S., Wang, E. H.-J., & Lim, B. K. (2017) · Cell · doi:10.1016/j.cell.2017.06.015 · Cited by 273 · see citing works

Reward and aversion

Hu, H. (2016) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070815-014106 · Cited by 253 · see citing works

Organization of long-range inputs and outputs of frontal cortex for top-down control

Zhang, S., Xu, M., Chang, W.-C., Ma, C., Hoang Do, J. P., Jeong, D., Lei, T., Fan, J. L., & Dan, Y. (2016) · Nature Neuroscience · doi:10.1038/nn.4417 · Cited by 242 · see citing works

Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression

Francis, T. C., & Lobo, M. K. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.09.007 · Cited by 230 · see citing works

A rapidly acting glutamatergic ARC→PVH satiety circuit postsynaptically regulated by α-MSH

Fenselau, H., Campbell, J. N., Verstegen, A. M. J., Madara, J. C., Xu, J., Shah, B. P., Resch, J. M., Yang, Z., Mandelblat-Cerf, Y., Livneh, Y., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4442 · Cited by 233 · see citing works

Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation

Leng, L., Zhuang, K., Liu, Z., Huang, C., Gao, Y., Chen, G., Lin, H. Z., Hu, Y., Wu, D., Shi, M., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.08.031 · Cited by 233 · see citing works

Cellular and molecular basis for stress-induced depression

Seo, J.-S., Wei, J., Qin, L., Kim, Y., Yan, Z., & Greengard, P. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.118 · Cited by 235 · see citing works

Sex differences in antidepressant efficacy

LeGates, T. A., Kvarta, M. D., & Thompson, S. M. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0156-z · Cited by 225 · see citing works

The molecular and cellular mechanisms of depression: a focus on reward circuitry

Fox, M. E., & Lobo, M. K. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0415-3 · Cited by 232 · see citing works

Essential Role of Mesolimbic Brain-Derived Neurotrophic Factor in Chronic Social Stress–Induced Depressive Behaviors

Wook Koo, J., Labonté, B., Engmann, O., Calipari, E. S., Juarez, B., Lorsch, Z., Walsh, J. J., Friedman, A. K., Yorgason, J. T., Han, M.-H., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.12.009 · Cited by 231 · see citing works

Homeostasis Meets Motivation in the Battle to Control Food Intake

Ferrario, C. R., Labouèbe, G., Liu, S., Nieh, E. H., Routh, V. H., Xu, S., & O’Connor, E. C. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2338-16.2016 · Cited by 213 · see citing works

Two cellular hypotheses explaining the initiation of ketamine's antidepressant actions: Direct inhibition and disinhibition

Miller, O. H., Moran, J. T., & Hall, B. J. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.07.028 · Cited by 200 · see citing works

Genetically distinct parallel pathways in the entopeduncular nucleus for limbic and sensorimotor output of the basal ganglia

Wallace, M. L., Saunders, A., Huang, K. W., Philson, A. C., Goldman, M., Macosko, E. Z., McCarroll, S. A., & Sabatini, B. L. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.017 · Cited by 205 · see citing works

Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression

Descalzi, G., Mitsi, V., Purushothaman, I., Gaspari, S., Avrampou, K., Loh, Y.-H. E., Shen, L., & Zachariou, V. (2017) · Science Signaling · doi:10.1126/scisignal.aaj1549 · Cited by 188 · see citing works

FosB differentially modulates nucleus accumbens direct and indirect pathway function

Grueter, B. A., Robison, A. J., Neve, R. L., Nestler, E. J., & Malenka, R. C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221742110 · Cited by 191 · see citing works

POMC neuronal heterogeneity in energy balance and beyond: an integrated view

Quarta, C., Claret, M., Zeltser, L. M., Williams, K. W., Yeo, G. S. H., Tschöp, M. H., Diano, S., Brüning, J. C., & Cota, D. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00345-3 · Cited by 189 · see citing works

Chronic Stress Induces a Selective Decrease in AMPA Receptor-Mediated Synaptic Excitation at Hippocampal Temporoammonic-CA1 Synapses

Kallarackal, A. J., Kvarta, M. D., Cammarata, E., Jaberi, L., Cai, X., Bailey, A. M., & Thompson, S. M. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2588-13.2013 · Cited by 181 · see citing works

Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression

Cai, X., Kallarackal, A. J., Kvarta, M. D., Goluskin, S., Gaylor, K., Bailey, A. M., Lee, H.-K., Huganir, R. L., & Thompson, S. M. (2013) · Nature Neuroscience · doi:10.1038/nn.3355 · Cited by 180 · see citing works

Single-Cell mRNA Profiling Reveals Cell-Type-Specific Expression of Neurexin Isoforms

Fuccillo, M. V., Földy, C., Gökçe, Ö., Rothwell, P. E., Sun, G. L., Malenka, R. C., & Südhof, T. C. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.028 · Cited by 173 · see citing works

Distinct Cortical-Thalamic-Striatal Circuits through the Parafascicular Nucleus

Mandelbaum, G., Taranda, J., Haynes, T. M., Hochbaum, D. R., Huang, K. W., Hyun, M., Venkataraju, K. U., Straub, C., Wang, W., Robertson, K., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.02.035 · Cited by 177 · see citing works

Serotonin receptors in depression: from A to B

Nautiyal, K. M., & Hen, R. (2017) · F1000Research · doi:10.12688/f1000research.9736.1 · Cited by 173 · see citing works

Nucleus Accumbens Modulation in Reward and Aversion

Klawonn, A. M., & Malenka, R. C. (2018) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2018.83.037457 · Cited by 163 · see citing works

Gene deficiency and pharmacological inhibition of caspase-1 confers resilience to chronic social defeat stress via regulating the stability of surface AMPARs

Li, M., Zheng, H.-L., Luo, Y., He, J.-G., Wang, W., Han, J., Zhang, L., Wang, X., Ni, L., Zhou, H.-Y., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.76 · Cited by 162 · see citing works

Anhedonia as a central factor in depression: Neural mechanisms revealed from preclinical to clinical evidence

Wang, S., Leri, F., & Rizvi, S. J. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110289 · Cited by 164 · see citing works

Melanocortin-4 Receptor in Energy Homeostasis and Obesity Pathogenesis

Hinney, A., Volckmar, A., & Knoll, N. (2013) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-386933-3.00005-4 · Cited by 160 · see citing works

SIRT1 Mediates Depression-Like Behaviors in the Nucleus Accumbens

Kim, H.-D., Hesterman, J., Call, T., Magazu, S., Keeley, E., Armenta, K., Kronman, H., Neve, R. L., Nestler, E. J., & Ferguson, D. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0212-16.2016 · Cited by 158 · see citing works

Neural control of affiliative touch in prosocial interaction

Wu, Y. E., Dang, J., Kingsbury, L., Zhang, M., Sun, F., Hu, R. K., & Hong, W. (2021) · Nature · doi:10.1038/s41586-021-03962-w · Cited by 153 · see citing works

Synaptic plasticity in neuronal circuits regulating energy balance

Zeltser, L. M., Seeley, R. J., & Tschöp, M. H. (2012) · Nature Neuroscience · doi:10.1038/nn.3219 · Cited by 147 · see citing works

Are We Getting Closer to Valid Translational Models for Major Depression?

Berton, O., Hahn, C.-G., & Thase, M. E. (2012) · Science · doi:10.1126/science.1222940 · Cited by 148 · see citing works

Myelination of the brain in Major Depressive Disorder: An in vivo quantitative magnetic resonance imaging study

Sacchet, M. D., & Gotlib, I. H. (2017) · Scientific Reports · doi:10.1038/s41598-017-02062-y · Cited by 145 · see citing works

Neuronal Correlates of Depression

Chaudhury, D., Liu, H., & Han, M.-H. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2044-6 · Cited by 139 · see citing works

Mitofusin-2 in the Nucleus Accumbens Regulates Anxiety and Depression-like Behaviors Through Mitochondrial and Neuronal Actions

Gebara, E., Zanoletti, O., Ghosal, S., Grosse, J., Schneider, B. L., Knott, G. W., Astori, S., & Sandi, C. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.003 · Cited by 144 · see citing works

Calcium-Permeable AMPA Receptors in the Nucleus Accumbens Regulate Depression-Like Behaviors in the Chronic Neuropathic Pain State

Goffer, Y., Xu, D., Eberle, S. E., D’amour, J. A., Lee, M., Tukey, D. S., Froemke, R. C., Ziff, E. B., & Wang, J. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2454-13.2013 · Cited by 142 · see citing works

Molecular Profiling of Neurons Based on Connectivity

Ekstrand, M. I., Nectow, A. R., Knight, Z. A., Latcha, K. N., Pomeranz, L. E., & Friedman, J. M. (2014) · Cell · doi:10.1016/j.cell.2014.03.059 · Cited by 137 · see citing works

Molecular Pharmacology and Neurobiology of Rapid-Acting Antidepressants

Gould, T. D., Zarate, C. A., & Thompson, S. M. (2019) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010617-052811 · Cited by 133 · see citing works

Activation of Mammalian Target of Rapamycin and Synaptogenesis: Role in the Actions of Rapid-Acting Antidepressants

Dwyer, J. M., & Duman, R. S. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.11.011 · Cited by 134 · see citing works

Stress-induced anhedonia is associated with hypertrophy of medium spiny neurons of the nucleus accumbens

Bessa, J. M., Morais, M., Marques, F., Pinto, L., Palha, J. A., Almeida, O. F. X., & Sousa, N. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.39 · Cited by 130 · see citing works

Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABAA Receptors

Fischell, J., Van Dyke, A. M., Kvarta, M. D., LeGates, T. A., & Thompson, S. M. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.112 · Cited by 122 · see citing works

From Gene to Behavior: L-Type Calcium Channel Mechanisms Underlying Neuropsychiatric Symptoms

Kabir, Z. D., Martínez-Rivera, A., & Rajadhyaksha, A. M. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0532-0 · Cited by 125 · see citing works

mGluR5 in the nucleus accumbens is critical for promoting resilience to chronic stress

Shin, S., Kwon, O., Kang, J. I., Kwon, S., Oh, S., Choi, J., Kim, C. H., & Kim, D. G. (2015) · Nature Neuroscience · doi:10.1038/nn.4028 · Cited by 125 · see citing works

Distinct neural mechanisms for the prosocial and rewarding properties of MDMA

Heifets, B. D., Salgado, J. S., Taylor, M. D., Hoerbelt, P., Cardozo Pinto, D. F., Steinberg, E. E., Walsh, J. J., Sze, J. Y., & Malenka, R. C. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw6435 · Cited by 120 · see citing works

From Stress to Anhedonia: Molecular Processes through Functional Circuits

Stanton, C. H., Holmes, A. J., Chang, S. W. C., & Joormann, J. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.09.008 · Cited by 120 · see citing works

Stress effects on the neural substrates of motivated behavior

Hollon, N. G., Burgeno, L. M., & Phillips, P. E. M. (2015) · Nature Neuroscience · doi:10.1038/nn.4114 · Cited by 118 · see citing works

In vivo fiber photometry reveals signature of future stress susceptibility in nucleus accumbens

Muir, J., Lorsch, Z. S., Ramakrishnan, C., Deisseroth, K., Nestler, E. J., Calipari, E. S., & Bagot, R. C. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.122 · Cited by 116 · see citing works

Role of Mesolimbic Brain-Derived Neurotrophic Factor in Depression

Koo, J. W., Chaudhury, D., Han, M.-H., & Nestler, E. J. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.05.020 · Cited by 112 · see citing works

HCN2 Channels in Cholinergic Interneurons of Nucleus Accumbens Shell Regulate Depressive Behaviors

Cheng, J., Umschweif, G., Leung, J., Sagi, Y., & Greengard, P. (2019) · Neuron · doi:10.1016/j.neuron.2018.12.018 · Cited by 110 · see citing works

Unraveling the Central Proopiomelanocortin Neural Circuits

Mercer, A. J., Hentges, S. T., Meshul, C. K., & Low, M. J. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00019 · Cited by 112 · see citing works

Anhedonia in depression symptomatology: appetite dysregulation and defective brain reward processing

Coccurello, R. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112041 · Cited by 106 · see citing works

A negative allosteric modulator for α5 subunit-containing GABA receptors exerts a rapid and persistent antidepressant-like action without the side effects of the NMDA receptor antagonist ketamine in mice

Zanos, P., Nelson, M. E., Highland, J. N., Krimmel, S. R., Georgiou, P., Gould, T. D., & Thompson, S. M. (2017) · eNeuro · doi:10.1523/eneuro.0285-16.2017 · Cited by 106 · see citing works

Synaptic Mechanisms Regulating Mood State Transitions in Depression

Parekh, P. K., Johnson, S. B., & Liston, C. (2022) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-110920-040422 · Cited by 101 · see citing works

Cognition and Reward Circuits in Schizophrenia: Synergistic, Not Separate

Robison, A. J., Thakkar, K. N., & Diwadkar, V. A. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.09.021 · Cited by 101 · see citing works

Dendritic remodeling of D1 neurons by RhoA/Rho-kinase mediates depression-like behavior

Fox, M. E., Chandra, R., Menken, M. S., Larkin, E. J., Nam, H., Engeln, M., Francis, T. C., & Lobo, M. K. (2020) · Molecular Psychiatry · doi:10.1038/s41380-018-0211-5 · Cited by 100 · see citing works

Expression of C1ql3 in Discrete Neuronal Populations Controls Efferent Synapse Numbers and Diverse Behaviors

Martinelli, D. C., Chew, K. S., Rohlmann, A., Lum, M. Y., Ressl, S., Hattar, S. S., Brünger, A. T., Missler, M., & Südhof, T. C. (2016) · Neuron · doi:10.1016/j.neuron.2016.07.002 · Cited by 98 · see citing works

Sucrose withdrawal induces depression and anxiety-like behavior by Kir2.1 upregulation in the nucleus accumbens

Kim, S., Shou, J., Abera, S., & Ziff, E. B. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.11.041 · Cited by 103 · see citing works

Progress in understanding mood disorders: optogenetic dissection of neural circuits

Lammel, S., Tye, K. M., & Warden, M. R. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12049 · Cited by 98 · see citing works

Hunger and Satiety Gauge Reward Sensitivity

Cassidy, R. M., & Tong, Q. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00104 · Cited by 93 · see citing works

Molecular basis of dendritic atrophy and activity in stress susceptibility

Francis, T. C., Chandra, R., Gaynor, A., Konkalmatt, P., Metzbower, S. R., Evans, B., Engeln, M., Blanpied, T. A., & Lobo, M. K. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.178 · Cited by 89 · see citing works

An endogenous opioid circuit determines state-dependent reward consumption

Castro, D. C., Oswell, C. S., Zhang, E. T., Pedersen, C. E., Piantadosi, S. C., Rossi, M. A., Hunker, A. C., Guglin, A., Morón, J. A., Zweifel, L. S., et al. (2021) · Nature · doi:10.1038/s41586-021-04013-0 · Cited by 95 · see citing works

Corticosterone mediates the synaptic and behavioral effects of chronic stress at rat hippocampal temporoammonic synapses

Kvarta, M. D., Bradbrook, K. E., Dantrassy, H. M., Bailey, A. M., & Thompson, S. M. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00359.2015 · Cited by 86 · see citing works

Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling

Israeli, H., Degtjarik, O., Fierro, F., Chunilal, V., Gill, A. K., Roth, N. J., Botta, J. A., Prabahar, V., Peleg, Y., Chan, L. F., et al. (2021) · Science · doi:10.1126/science.abf7958 · Cited by 91 · see citing works

Synaptic changes induced by melanocortin signalling

Caruso, V., Lagerström, M. C., Olszewski, P. K., Fredriksson, R., & Schiöth, H. B. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3657 · Cited by 89 · see citing works

Divergent pallidal pathways underlying distinct Parkinsonian behavioral deficits

Lilascharoen, V., Wang, E. H., Do, N., Pate, S., Tran, A. N., Yoon, C. D., Choi, J.-H., Wang, X.-Y., Pribiag, H., Park, Y.-G., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00810-y · Cited by 71 · see citing works

Circuit-based frameworks of depressive behaviors: The role of reward circuitry and beyond

Knowland, D., & Lim, B. K. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.12.010 · Cited by 85 · see citing works

GSK3β: a master player in depressive disorder pathogenesis and treatment responsiveness

Duda, P., Hajka, D., Wójcicka, O., Rakus, D., & Gizak, A. (2020) · Cells · doi:10.3390/cells9030727 · Cited by 84 · see citing works

Gender-Specific Roles for the Melanocortin-3 Receptor in the Regulation of the Mesolimbic Dopamine System in Mice

Lippert, R. N., Ellacott, K. L. J., & Cone, R. D. (2014) · Endocrinology · doi:10.1210/en.2013-2049 · Cited by 82 · see citing works

Nucleus Accumbens Dopamine Signaling Regulates Sexual Preference for Females in Male Mice

Beny, Y., Zilkha, N., Lavi‐Avnon, Y., Bezalel, N., Rogachev, I., Brandis, A. S., Dayan, M., & Kimchi, T. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.11.062 · Cited by 82 · see citing works

Lipopolysaccharide-Induced Depressive-Like Behavior is Associated with α1-Adrenoceptor Dependent Downregulation of the Membrane GluR1 Subunit in the Mouse Medial Prefrontal Cortex and Ventral Tegmental Area

Sekio, M., & Seki, K. (2015) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu005 · Cited by 75 · see citing works

Negative Affect and Excessive Alcohol Intake Incubate during Protracted Withdrawal from Binge-Drinking in Adolescent, But Not Adult, Mice

Lee, K. M., Coehlo, M. A., Solton, N. R., & Szumlinski, K. K. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.01128 · Cited by 72 · see citing works

Therapeutic mechanisms of psychedelics and entactogens

Heifets, B. D., & Olson, D. E. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01666-5 · Cited by 67 · see citing works

Non-Motor Symptoms of Parkinson’s Disease: The Neurobiology of Early Psychiatric and Cognitive Dysfunction

Hussein, A., Guevara, C. A., Valle, P. D., Gupta, S., Benson, D. L., & Huntley, G. W. (2021) · The Neuroscientist · doi:10.1177/10738584211011979 · Cited by 73 · see citing works

Propofol exerts anti-anhedonia effects via inhibiting the dopamine transporter

Zhu, X., Li, J., Qiu, G., Wang, L., Lu, C., Guo, Y., Yang, K., Cai, F., Xu, T., Yuan, T., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.02.017 · Cited by 71 · see citing works

Targeting the central melanocortin system for the treatment of metabolic disorders

Sweeney, P., Gimenez, L. E., Hernández, C. C., & Cone, R. D. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00855-y · Cited by 66 · see citing works

Regulation of the mesocorticolimbic and mesostriatal dopamine systems by α-melanocyte stimulating hormone and agouti-related protein

Roseberry, A. G., West, K. S., & Dunigan, A. I. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.06.020 · Cited by 67 · see citing works

Toll-like receptor 4 deficiency alters nucleus accumbens synaptic physiology and drug reward behavior

Kashima, D. T., & Grueter, B. A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705974114 · Cited by 66 · see citing works

Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding

Christoffel, D. J., Walsh, J. J., Heifets, B. D., Hoerbelt, P., Neuner, S., Sun, G., Ravikumar, V. K., Wu, H., Halpern, C. H., & Malenka, R. C. (2021) · Nature Communications · doi:10.1038/s41467-021-22430-7 · Cited by 65 · see citing works

Stress relief as a natural resilience mechanism against depression-like behaviors

Dong, Y., Li, Y., Xiang, X., Xiao, Z.-C., Hu, J., Li, Y., Li, H., & Hu, H. (2023) · Neuron · doi:10.1016/j.neuron.2023.09.004 · Cited by 69 · see citing works

Functional Organization of Neuronal and Humoral Signals Regulating Feeding Behavior

Schwartz, G. J., & Zeltser, L. M. (2013) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161125 · Cited by 67 · see citing works

Anhedonia requires MC4 receptor-mediated synaptic adaptations in nucleus accumbens

Lim, B. K., Huang, K. W., Grueter, B. A., Rothwell, P. E., & Robert, C. (2016)

Stress-induced anhedonia is associated with hypertrophy of medium spiny neurons of the nucleus accumbens

Bessa, J. M., Morais, M., Marques, F., Pinto, L., Palha, J. A., Almeida, O. F. X., & Sousa, N. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.39 · Cited by 130 · see citing works

Stress-induced Neuroplastic Changes in the Nucleus Accumbens are Reverted by Antidepressants: Implications for Anhedonic Behaviour

Nuno, S. (2009) · Frontiers in Neuroscience · doi:10.3389/conf.neuro.01.2009.11.107

A thalamic circuit facilitates stress susceptibility via melanocortin 4 receptor‐mediated activation of nucleus accumbens shell

Deng, Q., Zhang, S.-Q., Yang, P., Dong, W., Wang, J., Chen, J., Wang, F., & Long, L. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14046 · Cited by 7 · see citing works

Synaptotagmin-4 induces anhedonic responses to chronic stress via BDNF signaling in the medial prefrontal cortex

Kim, J., Seol, S., Kim, T., Lee, J. L., Koo, J. W., & Kang, H. J. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01156-8 · Cited by 11 · see citing works