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The Therapeutic Potential of Psychedelic Drugs: Past, Present, and Future
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Plant-based psychedelics, such as psilocybin, have an ancient history of medicinal use. After the first English language report on LSD in 1950, psychedelics enjoyed a short-lived relationship with psychology and psychiatry. Used most notably as aids to psychotherapy for the treatment of mood disorders and alcohol dependence, drugs such as LSD showed initial therapeutic promise before prohibitive legislature in the mid-1960s effectively ended all major psychedelic research programs. Since the early 1990s, there has been a steady revival of human psychedelic research: last year saw reports on the first modern brain imaging study with LSD and three separate clinical trials of psilocybin for depressive symptoms. In this circumspective piece, RLC-H and GMG share their opinions on the promises and pitfalls of renewed psychedelic research, with a focus on the development of psilocybin as a treatment for depression.
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“Classic psychedelics, such as synthetic LSD and psilocybin, which is found in certain mushrooms, have shown promise as aids in psychotherapy e.g., for mood disorders and substance dependence [1, 5, 33].”
From Mindfulness meditation and psychedelics: potential synergies and commonalities (2023) · cites this paper as [1]
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“In contrast, classical psychedelics are not generally considered to be addictive (Carhart-Harris and Goodwin, 2017;Nichols et al., 2017) as animals will not readily self-administer these compounds (Fantegrossi et al., 2008).”
From Psychedelics and Neural Plasticity: Therapeutic Implications (2022) · cites this paper as Carhart-Harris and Goodwin, 2017
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“See Carhart-Harris and Goodwin (2017) for a review of historical and recent trials with psychedelics.”
BackgroundInfluentialSelf-citationRoseman, L., Nutt, D. J., & Carhart-Harris, R. L. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00974 · Cited by 808
“Given the growing evidence favoring the therapeutic value of psychedelics (dos Santos et al., 2016; Rucker et al., 2016; Carhart-Harris and Goodwin, 2017), it is timely that we better understand their therapeutic mechanisms.”
BackgroundSelf-citation
Metadata
- Authors
- Carhart-Harris, R. L., & Goodwin, G. M.
- Affiliations
- Imperial College London (GB)
- Oxford Health NHS Foundation Trust (GB)
- Corresponding author
- Carhart-Harris, Robin L
- Venue
- Neuropsychopharmacology
- Published
- 2017-04-26
- Volume
- 42
- Issue
- 11
- Pages
- 2105-2113
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC5603818
- OpenAlex
- W2610144880
- Cited by
- 706
- References
- 86
- Citations by year
- 2026: 107 · 2025: 129 · 2024: 96 · 2023: 81 · 2022: 76 · 2021: 59 · 2020: 75 · 2019: 30 · 2018: 38 · 2017: 12
- FWCI
- 6.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Spiral (Imperial College London) (submittedVersion)
- Funders
- Strong
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Health › Religion, Spirituality, and Psychology
- Keywords
- psychedelics, psilocybin, LSD, depression treatment, mood disorders, alcoholism, psychedelic drug regulation
- MeSH terms
- Animals, Mental Disorders, Hallucinogens, Humans, Psilocybin, History, 20th Century, History, 21st Century
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