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Smoothing and Differentiation of Data by Simplified Least Squares Procedures.

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An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis

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Promoting angiogenesis in oxidative diabetic wound microenvironment using a nanozyme-reinforced self-protecting hydrogel

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Kinase inhibitors modulate huntingtin cell localization and toxicity

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Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection

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Uncovering the Selection Criteria for the Emergence of Multi-Building-Block Replicators from Dynamic Combinatorial Libraries

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Peptide lipidation stabilizes structure to enhance biological function

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ProteinSGM: Score-based generative modeling for de novo protein design

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Score-based generative modeling for de novo protein design

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Ceftriaxone Blocks the Polymerization of α-Synuclein and Exerts Neuroprotective Effects in Vitro

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Structural changes associated with the acute thermal instability of Rubisco activase.

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Shark variable new antigen receptor (VNAR) single domain antibody fragments: stability and diagnostic applications

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In Vitro Monitoring Conformational Changes of Polypeptide Monolayers Using Infrared Plasmonic Nanoantennas

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Critical Scaffolding Regions of the Tumor Suppressor Axin1 Are Natively Unfolded

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Hybrid Network Model for “Deep Learning” of Chemical Data: Application to Antimicrobial Peptides

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Design of potent and proteolytically stable oxyntomodulin analogs

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Probing the Interactions of Perfluorocarboxylic Acids of Various Chain Lengths with Human Serum Albumin: Calorimetric and Spectroscopic Investigations

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Emergence of Function and Selection from Recursively Programmed Polymerisation Reactions in Mineral Environments

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Autism-associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses

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ExEnDiff: An Experiment-Guided Diffusion Model for Protein Conformational Ensemble Generation

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Unprotected peptide macrocyclization and stapling via a fluorine-thiol displacement reaction

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Extracellular loop 2 of G protein–coupled olfactory receptors is critical for odorant recognition

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Advances in monitoring and control of refolding kinetics combining PAT and modeling

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Molecular chaperone RAP interacts with LRP1 in a dynamic bivalent mode and enhances folding of ligand-binding regions of other LDLR family receptors

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Conformation-dependent binding and tumor-targeted delivery of siRNA by a designed TRBP2: Affibody fusion protein

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Phase separation of a microtubule plus-end tracking protein into a fluid fractal network

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Accurate quantitation for in vitro refolding of single domain antibody fragments expressed as inclusion bodies by referring the concomitant expression of a soluble form in the periplasms of Escherichia coli

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Secondary structure assessment of formulated bevacizumab in the presence of SDS by deep ultraviolet resonance Raman (DUVRR) spectroscopy

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Conformational stability as a quality attribute for the cell therapy raw material human serum albumin

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Structural and biophysical properties of FopA, a major outer membrane protein of Francisella tularensis

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The intrinsically disordered cytoplasmic tail of a dendrite branching receptor uses two distinct mechanisms to regulate the actin cytoskeleton

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Tidying up the conformational ensemble of a disordered peptide by computational prediction of spectroscopic fingerprints

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Applying Computational Protein Design to Engineer Affibodies for Affinity-controlled Delivery of Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor

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Conformations and sequence determinants in the lipid binding of an adhesive peptide derived from Vibrio cholerae biofilms

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Disordered proteins interact with the chemical environment to tune their protective function during drying

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Transforming a fragile protein helix into an ultrastable scaffold via a hierarchical AI and chemistry framework

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Optimizing Stability in Dynamic Small-Molecule Binding Proteins

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AlphaMut: A Deep Reinforcement Learning Model to Suggest Helix-Disrupting Mutations

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Structural characterization of DNA-binding domain of essential mammalian protein TTF 1

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Phase separation of a microtubule plus-end tracking protein into a fluid fractal network

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Transforming a Fragile Protein Helix into an Ultrastable Scaffold via a Hierarchical AI and Chemistry Framework

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Effects of ultrasonication on structure and gelation of plant proteins at different denaturation states

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Lubricin’s Mucin Domain Has Strong Polyproline Type II Helical Character

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