AP-1: a double-edged sword in tumorigenesis

AP-1 as a regulator of cell life and death

Shaulian, E., & Karin, M. (2002) · Nature Cell Biology · doi:10.1038/ncb0502-e131 · Cited by 2,961

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

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The promise of retinoids to fight against cancer

Altucci, L., & Gronemeyer, H. (2001) · Nature Reviews Cancer · doi:10.1038/35106036 · Cited by 773

DNA Damaging Agents Induce Expression of Fas Ligand and Subsequent Apoptosis in T Lymphocytes via the Activation of NF-κB and AP-1

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The EGF Receptor Provides an Essential Survival Signal for SOS-Dependent Skin Tumor Development

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Cellular Transformation and Malignancy Induced by ras Require c-jun

Johnson, R., Spiegelman, B., Hanahan, D., & Wisdom, R. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.8.4504 · Cited by 282

JunB can substitute for Jun in mouse development and cell proliferation

Passegué, E., Jochum, W., Behrens, A., Ricci, R., & Wagner, E. F. (2002) · Nature Genetics · doi:10.1038/ng790 · Cited by 162

Immunity, Inflammation, and Cancer

Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755

Oxidative Stress in Cancer

Hayes, J. D., Dinkova-Kostova, A. T., & Tew, K. D. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.06.001 · Cited by 2,654

Mechanisms of Hippo pathway regulation

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The molecular understanding of osteoclast differentiation

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Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

Zanconato, F., Forcato, M., Battilana, G., Azzolin, L., Quaranta, E., Bodega, B., Rosato, A., Bicciato, S., Cordenonsi, M., & Piccolo, S. (2015) · Nature Cell Biology · doi:10.1038/ncb3216 · Cited by 1,219

Understanding MAPK Signaling Pathways in Apoptosis

Yue, J., & López, J. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072346 · Cited by 1,245

S100A8 and S100A9 in inflammation and cancer

Gebhardt, C., Németh, J., Angel, P., & Hess, J. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.05.017 · Cited by 696

Activity-Regulated Transcription: Bridging the Gap between Neural Activity and Behavior

Yap, E.-L., & Greenberg, M. E. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.013 · Cited by 706

Inflammation as a Tumor Promoter in Cancer Induction

Philip, M., Rowley, D. A., & Schreiber, H. (2004) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2004.06.006 · Cited by 640

A Molecular Web: Endoplasmic Reticulum Stress, Inflammation, and Oxidative Stress

Chaudhari, N., Talwar, P., Parimisetty, A., Lefebvre d’Hellencourt, C., & Ravanan, P. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00213 · Cited by 600

The ERK Cascade: Distinct Functions within Various Subcellular Organelles

Wortzel, I., & Seger, R. (2011) · Genes & Cancer · doi:10.1177/1947601911407328 · Cited by 563

Fos/AP‐1 proteins in bone and the immune system

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The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer

Chakraborty, S., Kaur, S., Guha, S., & Batra, S. K. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.03.008 · Cited by 503

AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection

Vierbuchen, T., Ling, E., Cowley, C. J., Couch, C. H., Wang, X., Harmin, D. A., Roberts, C. W. M., & Greenberg, M. E. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.11.026 · Cited by 455

Loss of Cell Polarity Drives Tumor Growth and Invasion through JNK Activation in Drosophila

Igaki, T., Pagliarini, R. A., & Xu, T. (2006) · Current Biology · doi:10.1016/j.cub.2006.04.042 · Cited by 370

Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins

Lockwood, W. W., Zejnullahu, K., Bradner, J. E., & Varmus, H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216363109 · Cited by 327

Static and Dynamic DNA Loops form AP-1-Bound Activation Hubs during Macrophage Development

Phanstiel, D. H., Van Bortle, K., Spacek, D., Hess, G. T., Shamim, M. S., Machol, I., Love, M. I., Aiden, E. L., Bassik, M. C., & Snyder, M. P. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.08.006 · Cited by 299

Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases

Beck, I. M. E., Vanden Berghe, W., Vermeulen, L., Yamamoto, K. R., Haegeman, G., & De Bosscher, K. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0013 · Cited by 298

Potential role of mesenchymal stem cells (MSCs) in the breast tumour microenvironment: stimulation of epithelial to mesenchymal transition (EMT)

Martin, F. T., Dwyer, R. M., Kelly, J., Khan, S., Murphy, J. M., Curran, C., Miller, N., Hennessy, E., Dockery, P., Barry, F. P., et al. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-0734-1 · Cited by 290

c-Jun activation is associated with proliferation and angiogenesis in invasive breast cancer

Vleugel, M. M., Greijer, A. E., Bos, R., van der Wall, E., & van Diest, P. J. (2006) · Human Pathology · doi:10.1016/j.humpath.2006.01.022 · Cited by 250

MAPK signaling in inflammation-associated cancer development

Huang, P., Han, J., & Hui, L. (2010) · Protein & Cell · doi:10.1007/s13238-010-0019-9 · Cited by 273

An autoregulatory loop mediated by miR-21 and PDCD4 controls the AP-1 activity in RAS transformation

Talotta, F., Cimmino, A., Matarazzo, M. R., Casalino, L., De Vita, G., D'Esposito, M., Di Lauro, R., & Verde, P. (2009) · Oncogene · doi:10.1038/onc.2008.370 · Cited by 242

Negative regulation of inflammation by SIRT1

Xie, J., Zhang, X., & Zhang, L. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.10.010 · Cited by 234

The c‐myc Promoter: Still MysterY and Challenge

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Cancer cell signaling pathways targeted by spice-derived nutraceuticals

Sung, B., Prasad, S., Yadav, V. R., & Aggarwal, B. B. (2012) · Nutrition and Cancer · doi:10.1080/01635581.2012.630551 · Cited by 204

Molecular Mechanisms and Genetics of Oxidative Stress in Alzheimer’s Disease

Cioffi, F., Adam, R. H. I., & Broersen, K. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190863 · Cited by 204

Cyr61 Expression Confers Resistance to Apoptosis in Breast Cancer MCF-7 Cells by a Mechanism of NF-κB-dependent XIAP Up-Regulation

Lin, M.-T., Chang, C.-C., Chen, S.-T., Chang, H.-L., Su, J.-L., Chau, Y.-P., & Kuo, M.-L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402305200 · Cited by 194

Single-cell biological network inference using a heterogeneous graph transformer

Ma, A., Wang, X., Li, J., Wang, C., Xiao, T., Liu, Y., Cheng, H., Wang, J., Li, Y., Chang, Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36559-0 · Cited by 184

Protein kinases and transcription factors activation in response to UV-radiation of skin: implications for carcinogenesis

López-Camarillo, C., Aréchaga Ocampo, E., López Casamichana, M., Pérez-Plasencia, C., Álvarez-Sánchez, E., & Marchat, L. A. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms13010142 · Cited by 165

Reduction-oxidation pathways involved in cancer development: a systematic review of literature reviews

Gào, X., & Schöttker, B. (2017) · Oncotarget · doi:10.18632/oncotarget.17128 · Cited by 147

In vivo and ex vivo comparative transcriptional profiling of invasive and non‐invasive Candida albicans isolates identifies genes associated with tissue invasion

Thewes, S., Kretschmar, M., Park, H., Schaller, M., Filler, S. G., & Hube, B. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05614.x · Cited by 140

Natural Withanolides in the Treatment of Chronic Diseases

White, P. T., Subramanian, C., Motiwala, H. F., & Cohen, M. S. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-41334-1_14 · Cited by 139

Activation and function of immediate-early genes in the nervous systemThis paper is one of a selection of papers in a Special Issue entitled 31st Annual International Asilomar Chromatin and Chromosomes Conference, and has undergone the Journal’s usual peer review process.

Pérez-Cadahía, B., Drobic, B., & Davie, J. R. (2011) · Biochemistry and Cell Biology · doi:10.1139/o10-138 · Cited by 137

Dual effect of oxidative stress on leukemia cancer induction and treatment

Udensi, U. K., & Tchounwou, P. B. (2014) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-014-0106-5 · Cited by 135

The transcription factor c-Jun/AP-1 promotes liver fibrosis during non-alcoholic steatohepatitis by regulating Osteopontin expression

Schulien, I., Hockenjos, B., Schmitt-Graeff, A., Perdekamp, M. G., Follo, M., Thimme, R., & Hasselblatt, P. (2019) · Cell Death & Differentiation · doi:10.1038/s41418-018-0239-8 · Cited by 111

Epigenetic regulation of miR-21 in colorectal cancer: ITGB4 as a novel miR-21 target and a three-gene network (miR-21-ITGΒ4-PDCD4) as predictor of metastatic tumor potential

Ferraro, A., Kontos, C. K., Boni, T., Bantounas, I., Siakouli, D., Kosmidou, V., Vlassi, M., Spyridakis, Y., Tsipras, I., Zografos, G., et al. (2014) · Epigenetics · doi:10.4161/epi.26842 · Cited by 111

Inflammation and Cancer: Is the Link as Simple as We Think?

Nickoloff, B. J., Ben-Neriah, Y., & Pikarsky, E. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23724.x · Cited by 110

CellOracle: Dissecting cell identity via network inference and in silico gene perturbation

Kamimoto, K., Hoffmann, C. M., & Morris, S. A. (2020) · doi:10.1101/2020.02.17.947416 · Cited by 81

Interplay among transcription factors Ets21c, Fos and Ftz-F1 drives JNK-mediated tumor malignancy

Külshammer, E., Mundorf, J., Kilinc, M., Frommolt, P., Wagle, P., & Uhlirova, M. (2015) · Disease Models & Mechanisms · doi:10.1242/dmm.020719 · Cited by 65

TIRAP in the Mechanism of Inflammation

Rajpoot, S., Wary, K. K., Ibbott, R., Liu, D., Saqib, U., Thurston, T. L. M., & Baig, M. S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.697588 · Cited by 79

Involvement of matrix metalloproteinase-13 in stromal-cell-derived factor 1α-directed invasion of human basal cell carcinoma cells

Chu, C.-Y., Cha, S.-T., Chang, C.-C., Hsiao, C.-H., Tan, C.-T., Lu, Y.-C., Jee, S.-H., & Kuo, M.-L. (2007) · Oncogene · doi:10.1038/sj.onc.1210040 · Cited by 78

Inhibitory effects of fucoidan on activation of epidermal growth factor receptor and cell transformation in JB6 Cl41 cells

Lee, N. Y., Ermakova, S. P., Zvyagintseva, T. N., Kang, K. W., Dong, Z., & Choi, H. S. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2008.01.025 · Cited by 75

Human T-Cell Leukemia Virus Type 1 (HTLV-1) bZIP Factor Requires Cellular Transcription Factor JunD To Upregulate HTLV-1 Antisense Transcription from the 3′ Long Terminal Repeat

Gazon, H., Lemasson, I., Polakowski, N., Césaire, R., Matsuoka, M., Barbeau, B., Mesnard, J.-M., & Peloponese, J.-M. (2012) · Journal of Virology · doi:10.1128/jvi.00661-12 · Cited by 73

The Fra-2 transgenic mouse model of systemic sclerosis

Maurer, B., Distler, J. H. W., & Distler, O. (2013) · Vascular Pharmacology · doi:10.1016/j.vph.2012.12.001 · Cited by 71

DNA‐Binding Small Molecules as Inhibitors of Transcription Factors

Leung, C., Chan, D. S., Ma, V. P., & Ma, D. (2013) · Medicinal Research Reviews · doi:10.1002/med.21266 · Cited by 58

GENA-LM: A Family of Open-Source Foundational DNA Language Models for Long Sequences

Fishman, V., Kuratov, Y., Shmelev, A., Petrov, M., Penzar, D., Shepelin, D., Chekanov, N., Kardymon, O., & Burtsev, M. (2023) · doi:10.1101/2023.06.12.544594 · Cited by 137

c-Fos overexpression increases the proliferation of human hepatocytes by stabilizing nuclear Cyclin D1

Güller, M., Toualbi-Abed, K., Legrand, A., Michel, L., Mauviel, A., Bernuau, D., & Daniel, F. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.6339 · Cited by 52

Activation of peroxisome proliferator-activated receptor δ inhibits human macrophage foam cell formation and the inflammatory response induced by very low-density lipoprotein

Bojic, L. A., Sawyez, C. G., Telford, D. E., Edwards, J. Y., Hegele, R. A., & Huff, M. W. (2012) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.112.255208 · Cited by 51

Regulation of αβ/γδ T Cell Development by the Activator Protein 1 Transcription Factor c-Jun

Riera-Sans, L., & Behrens, A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.9.5690 · Cited by 47

Gene regulatory network reconfiguration in direct lineage reprogramming

Kamimoto, K., Adil, M. T., Jindal, K., Hoffmann, C. M., Kong, W., Yang, X., & Morris, S. A. (2023) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.11.010 · Cited by 42

Targeting c-Jun inhibits fatty acid oxidation to overcome tamoxifen resistance in estrogen receptor-positive breast cancer

Jiang, C., Zhu, Y., Chen, H., Lin, J., Xie, R., Li, W., Xue, J., Chen, L., Chen, X., & Xu, S. (2023) · Cell Death & Disease · doi:10.1038/s41419-023-06181-5 · Cited by 36

Phosphorylation of the Transcription Factor Ets-1 by ERK2: Rapid Dissociation of ADP and Phospho-Ets-1

Callaway, K., Waas, W. F., Rainey, M. A., Ren, P., & Dalby, K. N. (2010) · Biochemistry · doi:10.1021/bi100199q · Cited by 32

PAX2 protein induces expression of cyclin D1 through activating AP-1 protein and promotes proliferation of colon cancer cells

Zhang, H.-S., Yan, B., Li, X.-B., Fan, L., Zhang, Y.-F., Wu, G.-H., Li, M., & Fang, J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.401521 · Cited by 32

Enkephalin downregulation in the nucleus accumbens underlies chronic stress-induced anhedonia

Poulin, J.-F., Laforest, S., & Drolet, G. (2014) · Stress · doi:10.3109/10253890.2013.850669 · Cited by 22

Increased matrix stiffness promotes fibrogenesis of hepatic stellate cells through AP-1-induced chromatin priming

Zhao, W., Yuan, W., Dong, T., Qi, W., Feng, Z., Li, C., & Sun, Y. (2025) · Communications Biology · doi:10.1038/s42003-025-08160-2 · Cited by 16

The role of Wnt/β-catenin signaling pathway in the pathogenesis and treatment of multiple myeloma (review).

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IRF2BP2 counteracts the ATF7/JDP2 AP-1 heterodimer to prevent inflammatory overactivation in acute myeloid leukemia (AML) cells

Fischer, S., Weber, L. M., Stielow, B., Frech, M., Simon, C., Geller, M., Könnecke, J., Finkernagel, F., Forné, I., Nist, A., et al. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae437 · Cited by 10

Synthetic gene circuits that selectively target RAS-driven cancers

Senn, G. V., Nissen, L., & Benenson, Y. (2026) · eLife · doi:10.7554/elife.104320 · Cited by 2