Cited by 960Cancer-related Molecular PathwaysCancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

The DOI matches its Crossref record; 134 of the 134 references it cites were found in a registry or an index.

p53 and metabolism

Vousden, Karen H., Ryan, Kevin M.·2009·Nature Reviews Cancer

Open this paper in CoChat — free account

Abstract

Although metabolic alterations have been observed in cancer for almost a century, only recently have the mechanisms underlying these changes been identified and the importance of metabolic transformation realized. p53 has been shown to respond to metabolic changes and to influence metabolic pathways through several mechanisms. The contributions of these activities to tumour suppression are complex and potentially rather surprising: some reflect the function of basal p53 levels that do not require overt activation and others might even promote, rather than inhibit, tumour progression.

Integrity signals

Registry

Crossref · 10.1038/nrc2715

Cites

134 of 134 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Tissue-specific Autophagy Alterations and Increased Tumorigenesis in Mice Deficient in Atg4C/Autophagin-3
Mariño, G., Salvador-Montoliu, N., Fueyo, A., Knecht, E., Mizushima, N., & López-Otı́n, C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701194200 · Cited by 427
Retracted
On the origin of cancer cells
Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425
The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088
Development by Self-Digestion
Levine, B., & Klionsky, D. J. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00099-1 · Cited by 3,728
Blinded by the Light: The Growing Complexity of p53
Vousden, K. H., & Prives, C. (2009) · Cell · doi:10.1016/j.cell.2009.04.037 · Cited by 3,163
Self-citation
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Christofk, H. R., Vander Heiden, M. G., Harris, M. H., Ramanathan, A., Gerszten, R. E., Wei, R., Fleming, M. D., Schreiber, S. L., & Cantley, L. C. (2008) · Nature · doi:10.1038/nature06734 · Cited by 2,820
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622
A model for p53-induced apoptosis
Polyak, K., Xia, Y., Zweier, J. L., Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/38525 · Cited by 2,500
Cancer cell metabolism: warburg and beyond
Hsu, P. P., & Sabatini, D. M. (2008) · Cell · doi:10.1016/j.cell.2008.08.021 · Cited by 2,452
p53 in health and disease
Vousden, K. H., & Lane, D. P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2147 · Cited by 2,351
Self-citation

Flagged first, then by citations

Show all 134 references

Sorted by citations

Items 901–960 of 960

Yin and Yang of YY1 regulation on tumor metabolic reprogramming
Meliala, I. T. S., Hosea, R., Kasim, V., & Wu, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821909-6.00014-6
The role of NFκB in glucose import and survival of B-cell lymphomas
Sommermann, T. G. (2012) · OPUS FAU (Kooperativer Bibliotheksverbund Berlin-Brandenburg (KOBV), on behalf of the Universitätsbibliothek Erlangen-Nürnberg)
Molecular Docking of the Cardenolides of Asclepias subulata in the Human p53 Protein Reveals an Interaction in the Cleft of the Y220C Mutant
Valenzuela-Chavira, I., Meneses-Sagrero, S. E., Arvizu-Flores, A. A., Hernández-Paredes, J., Rascón-Valenzuela, L. A., Velázquez, C. A., & Robles‐Zepeda, R. E. (2021) · Current Chemical Biology · doi:10.2174/2212796815666211026112056
References and Notes
Ferreri, C., & Chatgilialoglu, C. (2015) · Wiley eBooks · doi:10.1002/9781118683682.bref
Modulation of Host Cell Metabolism by Chlamydia trachomatis
Rother, M., da Costa, A. R. T., Zietlow, R., Meyer, T. F., & Rudel, T. (2020) · John Wiley & Sons, Inc. eBooks · doi:10.1128/9781683670261.ch18
p53
Duncan, A. D., Tsai, W., & Barton, M. C. (2015) · Wiley eBooks · doi:10.1002/9781118663387.ch26
Erratum to: The 2014 Beatson international cancer conference: powering the cancer machine
Kamphorst, J. J., & Murphy, D. J. (2014) · Cancer & Metabolism · doi:10.1186/s40170-014-0127-8
Application of nuclear magnetic resonance spectroscopy for the detection of metabolic changes in blood cells with defective DNA repair
Vanderstichelen, G. (2022) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) · doi:10.21248/gups.68013
An Overview on the Application of Solid Phase Microextraction in the Analysis of Volatile Organic Compounds as Potential Biomarkers of Cancer
Ayazi, Z., & Sarnaghi, S. P. (2022) · ImmunoAnalysis · doi:10.34172/ia.2022.02
p53 at the Crossroads Between Stress Response Signaling and Tumorigenesis: From Molecular Mechanisms to Therapeutic Opportunities
Giono, L. E., Ladelfa, M. F., & Monte, M. (2014) · Springer eBooks · doi:10.1007/978-94-017-9421-3_4
Cross-talk between metabolic alterations and stemness acquisition for the progression, severity and therapy of human breast cancer
Kumari, A., & Mishra, R. (2022) · doi:10.52679/978-81-952885-6-4_3
What can we learn from tumors? Parallels in cell and human behavior
Šmardová, J. (2023) · Masarykova univerzita eBooks · doi:10.5817/cz.muni.m280-0377-2023
Current antioxidant medicinal regime and treatments used to alleviate oxidative stress in infertility issues
Siddique, R., Mehmood, M. H., & Shehzad, M. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18807-7.00018-1
Hirocidins, Cytotoxic Metabolites from Streptomyces hiroshimensis, Induce Mitochondrion‐Mediated Apoptosis
Han, E. J., Jeong, M., Lee, S. R., Sorensen, E. J., & Seyedsayamdost, M. R. (2024) · Angewandte Chemie · doi:10.1002/ange.202405367
Persistent endotoxin exposure in macrophages elicits an immunometabolic profile susceptible to NF-κB and p53 perturbationPreprint
Maduka, C. V., Xie, X., Makela, A. V., Ural, E. E., & Contag, C. H. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.30.651567
p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respirationPreprint
Kumar, R. S., Couly, S., Muys, B. R., Li, X. L., Grammatikakis, I., Singh, R., Guest, M., Wen, X., Tang, W., Ambs, S., et al. (2025) · eLife · doi:10.7554/elife.107538.1
The tumor microenvironment reprograms FAM227A expression: Implications for CRC metastasis and diagnostic biomarker development
Wang, H., Yang, B., Wang, R., Pan, T., & Yao, S. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152853
Differential regulation of autophagy by therapeutic and physiologic glucose restriction under normoxia and hypoxia
Xi, H. (2012)
The study of RAS-induced metabolic reprogramming and the role of the pentose phosphate pathway in tumor metabolism
Mauricio, A. B. (2014) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Additional file 1 of eIF5B regulates the expression of PD-L1 in prostate cancer cells by interacting with Wig1
Li, Q., Xiao, M., Shi, Y., Hu, J., Bi, T., Wang, C., Yan, L., & Li, X. (2021) · Figshare · doi:10.6084/m9.figshare.16625156
Additional file 2 of Cyclosporine A alleviates colitis by inhibiting the formation of neutrophil extracellular traps via the regulating pentose phosphate pathway
Xu, C., Ye, Z., Jiang, W., Wang, S., & Zhang, H. (2024) · Figshare · doi:10.6084/m9.figshare.26653455
Additional file 1 of Apoptosis and autophagy markers predict survival in neoadjuvant treated oesophageal adenocarcinoma patients
El-Mashed, S., O’Donovan, T. R., Kay, E., O’Grady, A., McManus, D., Turkington, R. C., & McKenna, S. L. (2022) · Figshare · doi:10.6084/m9.figshare.20521671
Additional file 1 of Cysteine depletion sensitizes prostate cancer cells to agents that enhance DNA damage and to immune checkpoint inhibition
Saha, A., Zhao, S., Kindall, A., Wilder, C. S., Friedman, C. A., Clark, R., Georgiou, G., Stone, E., Kidane, D., & DiGiovanni, J. (2023) · Figshare · doi:10.6084/m9.figshare.22807626
Additional file 2 of An NF-κB/OVOL2 circuit regulates glucose import and cell survival in non-small cell lung cancer
Zhang, R., 耿国军, Guo, J.-G., Mi, Y.-J., Zhu, X.-L., Li, N., Liu, H.-M., Lin, J.-F., Wang, J., Zhao, G., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19445188
Additional file 1 of p63 orchestrates serine and one carbon metabolism enzymes expression in head and neck cancer
Cappello, A., Tosetti, G., Smirnov, A., Ganini, C., Yang, X., Shi, Y., Wang, Y., Melino, G., Bernassola, F., & Candi, E. (2023) · Figshare · doi:10.6084/m9.figshare.24540560
Additional file 1 of Cyclosporine A alleviates colitis by inhibiting the formation of neutrophil extracellular traps via the regulating pentose phosphate pathway
Xu, C., Ye, Z., Jiang, W., Wang, S., & Zhang, H. (2023) · Figshare · doi:10.6084/m9.figshare.26653452
Additional file 3 of Cyclosporine A alleviates colitis by inhibiting the formation of neutrophil extracellular traps via the regulating pentose phosphate pathway
Xu, C., Ye, Z., Jiang, W., Wang, S., & Zhang, H. (2024) · Figshare · doi:10.6084/m9.figshare.26653458
Collateral Impact of Mannose Supplementation on Metastatic Properties in Osteosarcoma Cell Models
Morita, A., & Hara, T. (2026) · Biology · doi:10.3390/biology15020127
p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respirationPreprint
Kumar, R. S., Couly, S., Muys, B. R., Li, X. L., Grammatikakis, I., Singh, R., Guest, M., Wen, X., Tang, W., Ambs, S., et al. (2026) · eLife · doi:10.7554/elife.107538.2
Reviewer #2 (Public review): p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration
(2026) · eLife · doi:10.7554/elife.107538.2.sa1
Synthèse asymétrique de l’épi-jasmonate de méthyle et de son énantiomère (ent-épi-jasmonate de méthyle) par voie chimique et enzymatique
Deau, E. (2011) · theses.fr (ABES) · doi:10.70675/2507541ezfdaaz4b2fzb15az4676f0f05e81
Etude physiopathologique de l'inflammation et du remodelage bronchique dans l'asthme
Ozier, A. (2011) · theses.fr (ABES) · doi:10.70675/5efabca5z64d3z4f18z9ac3z5b9588577e49
L’autophagie, un mécanisme impliqué dans la physiopathologie de l’infection par le VIH-1
Sagnier, S. (2011) · theses.fr (ABES) · doi:10.70675/e0fd9061z341fz4170z9b0ezfd60e3e061f0
Impact de l’autophagie sur la radiosensibilité tumorale
Ko, A. (2013) · theses.fr (ABES) · doi:10.70675/bb8f00d2ze478z4bbcz883aze4a06af07318
Role of p53 in muscle wasting
de Abreu, P. A. (2016) · theses.fr (ABES) · doi:10.70675/a49b7f77z1189z425fz86b8z8ee9f8fa327a
Identification de l'ostéopontine comme facteur libéré par les cellules vasculaires sénescentes et son implication dans l'hypertension pulmonaire
Saker, M. (2015) · theses.fr (ABES) · doi:10.70675/0c954efczbbd6z4be2zaf9dzd2bf7b273239
Etude de la reprogrammation métabolique de l' adénocarcinome canalaire pancréatique
Olivares, O. (2015) · theses.fr (ABES) · doi:10.70675/ef2c6a2czab6dz4a68z8004z1ade8605dadc
Rôle de E4F1 dans la régulation de l'homéostasie des cellules cancéreuses
Houlès, T. (2015) · theses.fr (ABES) · doi:10.70675/e8fee4b0z4774z4e2cz8af0z6ec05b379c25
Implication de la voie p53 dans les syndromes d'insuffisance médullaire
Toufektchan, E. (2018) · theses.fr (ABES) · doi:10.70675/58dfec7cz94b0z449fz96a6z9051bf80c551
Rôle de la plasticité cellulaire et du métabolisme dans la radiorésistance des cellules de glioblastomes : mise en évidence de nouvelles cibles thérapeutiques potentielles
Dahan, P. (2015) · theses.fr (ABES) · doi:10.70675/515e2aa9z1921z4297zaf7az36c49ac09385
A metabolic crosstalk between liposarcoma and skeletal muscle sustains tumor growth
Romero, J. P. (2020) · theses.fr (ABES) · doi:10.70675/4cf2e124zfd6ez42dazb9baz3a6f801f1847
Rôle de la kinase ATR dans la progression de la stéatose hépatique non alcoolique
Saroul-Aïnama, M. (2022) · theses.fr (ABES) · doi:10.70675/1fc5906az1637z451czab81z7529e034be63
Critical Role for Malic Enzymes in MYC-Mediated Cellular Adaptation to Glutamine Depletion
Si, Y., Li, W., Chen, Y., Yuan, J., Hu, C., Liu, Y., & Li, L. (2026) · Metabolites · doi:10.3390/metabo16040282
Phase separation of tumor suppressor p53 and its family proteins
Paul, A., & Maji, S. K. (2026) · Elsevier eBooks · doi:10.1016/b978-0-323-99507-8.00084-6
The Natural Quassinoid Brusatol Enhances Venetoclax Efficacy and Overcomes Resistance in Myeloid Leukemias
Kawaguchi, S., Sato, K., Izawa, J., Takayama, N., Hayakawa, H., Suzaki, K., Goyama, S., Kato, C., Sakashita, E., Tominaga, K., et al. (2026) · Cancer Science · doi:10.1111/cas.70423
Role of the immune receptor CD47 in mouse model of non-infectious uveitis
Che, Y. (2026) · theses.fr (ABES) · doi:10.70675/7c36bc77zbcf8z4d6ez988dzdd814ec9a952
Global stabilization of the mitochondrial proteome is associated with extreme anoxia tolerance in Austrofundulus limnaeus WS40NE cells
Hughes, C., Corona, M. M., Kültz, D., & Podrabsky, J. E. (2026) · BMC Biology · doi:10.1186/s12915-026-02674-9
Zebrafish frk Gene Knockout Shows Social Impairments Relevant to Autism and Delays Brain Development by Increasing Cell Proliferation
Lin, X., Wu, J., Ying, Y., Yan, B., Wang, J., Zou, J., & Jiang, K. (2026) · Autism Research · doi:10.1002/aur.70310
p53-associated metabolic checkpoint regulation in a tick embryo-derived cell line
Moraes, B., Arcanjo, A. F., Okagawa, T., Nogueira, C. L., Brumana, A., Souza, J. L., Vasconcelos, A. A., Almeida, F. C. L., Pinto, K. G., Filardy, A., et al. (2026) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2026.104633
2-deoxy-d-ribose: A multifaceted player at the crossroads of cancer metabolism
Kersten, M. C., Witt, M., Stiewe, T., Gremke, N., & Taudte, R. V. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119800
PTM-Driven Reshaping of the Peptide Translocation Landscape in Bilayer Graphene Nanopores
Upadhyaya, A., Sur, P., Varma, M. M., & Maiti, P. K. (2026) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.6c02456
Targeting metabolic reprogramming in cancer: Past, present, and future
Kumari, N., Shukla, S. K., & Thakur, R. (2026) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2026.109109
Decoding Sebaceous Gland Biology Through Experimental Models: Progress, Limitations, and Future Directions
Briganti, S., Mosca, S., Ottaviani, M., & Flori, E. (2026) · Cells · doi:10.3390/cells15171591
The p53–p21–Cyclin D2 regulatory axis drives metabolic reprogramming and a distinct senescent macrophage senotype during aging and MASLDPreprint
Torres, G., Salladay-Perez, I. A., Deng, C. Y., Avila, I., Delgado, Y., Tong, G., Muñoz‐Estrada, J., Estrada, L., Dhingra, A., Armstrong, W. R., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.22.753597
The Preferred Apoptotis Pathways in Humans Differ in Case of Prolonged Contact with Low Dose Alpha and Gamma Ionizing Radiation
Korzeneva, I. B., Bakaeva, Z. V., Skorodumova, E. N., Stepanova, E. V., Alekseeva, N. A., Sideltsova, E. I., Samoylova, E. V., Prokhorova, M. V., & Marchenko, G. A. (2026) · Medical Radiology and radiation safety · doi:10.33266/1024-6177-2026-71-5-73-85
BindingDB Entry 50047411: Structure-activity relationship study of 4-substituted piperidines at Leu26 moiety of novel p53-hDM2 inhibitors.
BindingDB (2017) · UC San Diego · doi:10.7270/q28s4rtd
BindingDB Entry 50016713: Phe19 modification of HDM2-p53 PPI inhibitors to alleviate CYP3A4 metabolism/mechanism-based inhibition liability.
BindingDB (2023) · UC San Diego · doi:10.7270/q2862mgn
Mdm2-p53 Signaling in Tissue Homeostasis and the DNA Damage Response: A Dissertation
Gannon, H. (2012) · eScholarship@UMassChan · doi:10.13028/sfjc-xh51
Mechanisms of microenvironmental conditioning in non-Hodgkin’s lymphoma
Zhuang, L. (2012) · ERA
An Overview of Cancer Metabolism
Armitage, E. G., Kotze, H. L., & Williams, K. J. (2014) · SpringerBriefs in systems biology · doi:10.1007/978-1-4939-0615-4_1

Authors: Vousden, K. H., & Ryan, K. M.
Affiliations: Cancer Research UK Scotland Institute (GB)
ORCID: Vousden, Karen H.
Ryan, Kevin M.
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2009-09-17
Volume: 9
Issue: 10
Pages: 691-700
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc2715
OpenAlex: W1991510903
Cited by: 959
References: 134
Citations by year: 2026: 23 · 2025: 39 · 2024: 37 · 2023: 36 · 2022: 49 · 2021: 46 · 2020: 44 · 2019: 39 · 2018: 49 · 2017: 52 · 2016: 60 · 2015: 78 · 2014: 84 · 2013: 97 · 2012: 82
FWCI: 6.60
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Funders: Cancer Research UK
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: p53, cancer metabolism, tumor suppression, tumor progression, metabolic pathways, cancer cells
MeSH terms: Autophagy, Cell Transformation, Neoplastic, Glycolysis, Humans, Neoplasms, Tumor Suppressor Protein p53, Oxidative Stress, Cell Proliferation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

p53 and metabolism

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks