p53 and metabolism

On the origin of cancer cells

Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088

Development by Self-Digestion

Levine, B., & Klionsky, D. J. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00099-1 · Cited by 3,728

Blinded by the Light: The Growing Complexity of p53

Vousden, K. H., & Prives, C. (2009) · Cell · doi:10.1016/j.cell.2009.04.037 · Cited by 3,163

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Christofk, H. R., Vander Heiden, M. G., Harris, M. H., Ramanathan, A., Gerszten, R. E., Wei, R., Fleming, M. D., Schreiber, S. L., & Cantley, L. C. (2008) · Nature · doi:10.1038/nature06734 · Cited by 2,820

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622

A model for p53-induced apoptosis

Polyak, K., Xia, Y., Zweier, J. L., Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/38525 · Cited by 2,500

Cancer cell metabolism: warburg and beyond

Hsu, P. P., & Sabatini, D. M. (2008) · Cell · doi:10.1016/j.cell.2008.08.021 · Cited by 2,452

p53 in health and disease

Vousden, K. H., & Lane, D. P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2147 · Cited by 2,351

p53-TP53-Induced Glycolysis Regulator Mediated Glycolytic Suppression Attenuates DNA Damage and Genomic Instability in Fanconi Anemia Hematopoietic Stem Cells

Li, X., Wu, L., Zopp, M., Kopelov, S., & Du, W. (2019) · Stem Cells · doi:10.1002/stem.3015 · Cited by 20

Review: apoptotic mechanisms in bacterial infections of the central nervous system

Parthasarathy, G., & Philipp, M. T. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00306 · Cited by 20

Targeted Knockdown of the Kinetochore Protein D40/Knl-1 Inhibits Human Cancer in a p53 Status-Independent Manner

Urata, Y. N., Takeshita, F., Tanaka, H., Ochiya, T., & Takimoto, M. (2015) · Scientific Reports · doi:10.1038/srep13676 · Cited by 20

Focal adhesion kinase/Src family kinase axis-mediated tyrosine phosphorylation of metabolic enzymes facilitates tumor metastasis

Chen, J., Zhang, J., Zhu, Y., Zhu, Y., Pang, J., Wu, Q., Wang, Y., & Zhan, Q. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02395-5 · Cited by 19

Human cellular mitochondrial remodelling is governed by miR-2909 RNomics

Malik, D., & Kaul, D. (2018) · PLoS ONE · doi:10.1371/journal.pone.0203614 · Cited by 19

Anti-miR-135/SPOCK1 axis antagonizes the influence of metabolism on drug response in intestinal/colon tumour organoids

Babaei‐Jadidi, R., Kashfi, H., Alelwani, W., Bakhtiari, A. K., Kattan, S. W., Mansouri, O. A., Mukherjee, A., Lobo, D. N., & Nateri, A. S. (2022) · Oncogenesis · doi:10.1038/s41389-021-00376-1 · Cited by 20

p53 Orchestrates Cancer Metabolism: Unveiling Strategies to Reverse the Warburg Effect

Abukwaik, R., Vera-Sigüenza, E., Tennant, D. A., & Spill, F. (2024) · Bulletin of Mathematical Biology · doi:10.1007/s11538-024-01346-5 · Cited by 19

Mild Electrical Stimulation at 0.1-ms Pulse Width Induces p53 Protein Phosphorylation and G2 Arrest in Human Epithelial Cells

Fukuda, R., Suico, M. A., Koyama, K., Omachi, K., Kai, Y., Matsuyama, S., Mitsutake, K., Taura, M., Morino‐Koga, S., Shuto, T., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.442442 · Cited by 19

Effects of diet and arginine treatment during the luteal phase on ovarian NO/PGC-1α signaling in ewes

Guo, Y., Nie, H., Sun, L., Zhang, G., Deng, K., Fan, Y., & Wang, F. (2017) · Theriogenology · doi:10.1016/j.theriogenology.2017.03.028 · Cited by 19

Acetylation of TIP60 at K104 is essential for metabolic stress-induced apoptosis in cells of hepatocellular cancer

Fang, X., Lu, G., Ha, K., Lin, H., Ye, D., Zuo, Q., Fu, Y., Zou, C., & Zhang, P. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.11.028 · Cited by 19

Grail is involved in adipocyte differentiation and diet-induced obesity

Liu, P., Hsieh, P., Lin, H., Liu, T.-J., Wu, H., Chen, C.-C., & Chen, Y. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0596-8 · Cited by 19

Expression of the Alternative Oxidase Influences Jun N-Terminal Kinase Signaling and Cell Migration

Andjelković, A., Mordas, A., Bruinsma, L., Ketola, A. E., Cannino, G., Giordano, L., Dhandapani, P. K., Szibor, M., Dufour, É., & Jacobs, H. T. (2018) · Molecular and Cellular Biology · doi:10.1128/mcb.00110-18 · Cited by 20

Inhibition of Kv10.1 Channels Sensitizes Mitochondria of Cancer Cells to Antimetabolic Agents

Hernández‐Reséndiz, I., Pacheu‐Grau, D., Sánchez, A., & Pardo, L. A. (2020) · Cancers · doi:10.3390/cancers12040920 · Cited by 19

Enhanced O-GlcNAc modification induced by the RAS/MAPK/CDK1 pathway is required for SOX2 protein expression and generation of cancer stem cells

Shimizu, M., Shibuya, H., & Tanaka, N. (2022) · Scientific Reports · doi:10.1038/s41598-022-06916-y · Cited by 18

Targeted Degradation Technologies Utilizing Autophagy

Zhou, Z., Liang, J., Cheng, B., Li, Y., Zhou, W., Tian, H., Shi, W., Liu, K., Fang, L., Li, H., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146576 · Cited by 19

Tumor Protein p63/Nuclear Factor κB Feedback Loop in Regulation of Cell Death

Sen, T., Sen, N., Huang, Y., Sinha, D., Luo, Z., Ratovitski, E. A., & Sidransky, D. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.257105 · Cited by 18

Prognostic significance of p53 expression in malignant bone tumors: a meta-analysis

Jiang, L., Cheng, T., & Ai-yong, H. (2013) · Tumor Biology · doi:10.1007/s13277-012-0643-5 · Cited by 18

A ROS-Responsive nanoparticle for nuclear gene delivery and autophagy restoration in Parkinson's disease therapy

Zhai, L., Gao, Y., Yang, H., Wang, H., Liao, B., Cheng, Y., Liu, C., Che, J., Xia, K., Zhang, L., et al. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123345 · Cited by 18

Protective role of fenofibrate in sepsis-induced acute kidney injury in BALB/c mice

Pei, Z., Deng, S., Xie, D., Lv, M., Guo, W., Liu, D., Zheng, Z., & Long, X. (2018) · RSC Advances · doi:10.1039/c8ra00488a · Cited by 18

Tailoring Chemotherapy for the African-Centric S47 Variant of TP53

Barnoud, T., Budina-Kolomets, A., Basu, S., Leu, J. I.-J., Good, M., Kung, C.-P., Liu, J., Liu, Q., Villanueva, J., Zhang, R., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-1327 · Cited by 17

Proteins moonlighting in tumor metabolism and epigenetics

Lv, L., & Lei, Q. (2021) · Frontiers of Medicine · doi:10.1007/s11684-020-0818-1 · Cited by 18

Reprogramming Carbohydrate Metabolism in Cancer and Its Role in Regulating the Tumor Microenvironment

Adhikari, S., Guha, D., Mohan, C., Mukherjee, S., Tyler, J. K., & Das, C. (2022) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-07634-3_1 · Cited by 19

Mutant p53 gain-of-function stimulates canonical Wnt signaling via PI3K/AKT pathway in colon cancer

Alvarado-Ortiz, E., Ortíz-Sánchez, E., Sarabia-Sánchez, M. Á., de la Cruz-López, K. G., García-Carrancá, A. M., & Robles‐Flores, M. (2023) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-023-00793-4 · Cited by 18

The Emerging Role of p21 in Diabetes and Related Metabolic Disorders

ElMitwalli, O. S., Darwish, R., Al-Jabery, L., Algahiny, A. T., Roy, S., Butler, A. E., & Hasan, A. S. H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252313209 · Cited by 17

The Role of the Gut Microbiota in Modulating Signaling Pathways and Oxidative Stress in Glioma Therapies

Krawczyk, A. E., Sladowska, G. E., & Strzałka‐Mrozik, B. (2025) · Cancers · doi:10.3390/cancers17050719 · Cited by 17

Effect of testosterone on the regulation of p53 and p66Shc during oxidative stress damage in C2C12 cells

Pronsato, L., & Milanesi, L. M. (2015) · Steroids · doi:10.1016/j.steroids.2015.12.007 · Cited by 17

MDM2 oligomers: antagonizers of the guardian of the genome

Leslie, P. L., & Zhang, Y. (2016) · Oncogene · doi:10.1038/onc.2016.88 · Cited by 18

Mathematical Modeling of p53 Pathways

Kim, E., Kim, J.-Y., & Lee, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205179 · Cited by 17

Potency and Selectivity Optimization of Tryptophanol‐Derived Oxazoloisoindolinones: Novel p53 Activators in Human Colorectal Cancer

Barcherini, V., Almeida, J., Lopes, E. A., Wang, M., Silva, D., Mori, M., Wang, S., Saraiva, L., & Santos, M. M. M. (2020) · ChemMedChem · doi:10.1002/cmdc.202000522 · Cited by 17

Sulfonamide-Derived Dithiocarbamate Gold(I) Complexes Induce the Apoptosis of Colon Cancer Cells by the Activation of Caspase 3 and Redox Imbalance

Quero, J., Royo, J. C., Fodor, B., Gimeno, M. C., Osada, J., Rodriguez‐Yoldi, M. J., & Cerrada, E. (2022) · Biomedicines · doi:10.3390/biomedicines10061437 · Cited by 17

The p53 Family in Brain Disease

Agostini, M., Melino, G., & Bernassola, F. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7302 · Cited by 19

Roles of microRNA in prostate cancer cell metabolism

Kasomva, K., Sen, A., Paulraj, M. G., Sailo, S. L., Raphael, V., Puro, K.-U., Assumi, S. R., & Savarimuthu Ignacimuthu, S. J. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2018.07.003 · Cited by 17

Pathology and Genetics

Ornellas, A. A., Alves, G., & Schwindt, A. B. D. S. (2014) · Springer eBooks · doi:10.1007/978-1-4939-0461-7_4 · Cited by 17

Death-ision: the link between cellular resilience and cancer resistance to treatments

Baldassarre, G., de la Serna, I. L., & Vallette, F. M. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02339-1 · Cited by 17

MicroRNA-26a targets the mdm2/p53 loop directly in response to liver regeneration

Zhou, J., Li, Z., Huang, Y., Ju, W., Wang, D., Zhu, X., & He, X. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4282 · Cited by 16

Breast Cancer Cell Subtypes Display Different Metabolic Phenotypes That Correlate with Their Clinical Classification

Ripoll, C., Roldán, M., Ruedas-Rama, M. J., Orte, Á., & Martı́n, M. (2021) · Biology · doi:10.3390/biology10121267 · Cited by 16

Gundelia tournefortii inhibits hepatocellular carcinoma progression by lowering gene expression of the cell cycle and hepatocyte proliferation in immunodeficient mice

Amer, J., Salhab, A., Jaradat, N. A., Abdallah, S., Abu-Rass, H., Hattab, S., Ghanim, M. A., & Alqub, M. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113885 · Cited by 17

Internal environment in cancer patients and proposal that carcinogenesis is adaptive response of glycolysis to overcome adverse internal conditions

Watanabe, M., Miyajima, K., Matsui, I., Tomiyama‐Miyaji, C., Kainuma, E., Inoue, M., Matsumoto, H., Kuwano, Y., & Abo, T. (2010) · Health · doi:10.4236/health.2010.27118 · Cited by 16

Global Changes in Lipid Profiles of Mouse Cortex, Hippocampus, and Hypothalamus Upon p53 Knockout

Lee, S. T., Lee, J. C., Kim, J. W., Cho, S. Y., Seong, J. K., & Moon, M. H. (2016) · Scientific Reports · doi:10.1038/srep36510 · Cited by 16

Pilot Study Assessing Tolerability and Metabolic Effects of Metformin in Patients With Li-Fraumeni Syndrome

Walcott, F. L., Wang, P., Bryla, C., Huffstutler, R. D., Singh, N., Pollak, M., Khincha, P. P., Savage, S. A., Mai, P. L., Dodd, K. W., et al. (2020) · JNCI Cancer Spectrum · doi:10.1093/jncics/pkaa063 · Cited by 19

p53-dependent glutamine usage determines susceptibility to oxidative stress in radioresistant head and neck cancer cells

Chang, H. W., Lee, M., Lee, Y. S., Kim, S. H., Lee, J. C., Park, J. J., Nam, H. Y., Kim, M. R., Han, M. W., Kim, S. W., et al. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109820 · Cited by 16

p62 Promotes the Mitochondrial Localization of p53 through Its UBA Domain and Participates in Regulating the Sensitivity of Ovarian Cancer Cells to Cisplatin

Kong, Q., Yan, X., Cheng, M., Jiang, X. M., Xu, L., Shen, L., Yu, H., & Sun, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063290 · Cited by 16

Introduction of Mutant TP53 Related Genes in Metabolic Pathways and Evaluation Their Correlation with Immune Cells, Drug Resistance and Sensitivity

Motlagh, A. V., Mahdevar, M., Mirzaei, S., Entezari, M., Hashemi, M., Hushmandi, K., & Peymani, M. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120650 · Cited by 16

Protein of a thousand faces: The tumor-suppressive and oncogenic responses of p53

Marques, M. A., de Andrade, G. C., Silva, J. L., & de Oliveira, G. A. P. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.944955 · Cited by 16

Prazosin induces p53-mediated autophagic cell death in H9C2 cells

Yang, Y., Wu, C., Chen, W., Chen, Y., & Su, M. (2011) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-011-0657-3 · Cited by 16

Metabolic surgery and intestinal gene expression: Digestive tract and diabetes evolution considerations

Rodrigues, M. R. D. S., Santo, M. A., Fávero, G. M., Vieira, E. C., Artoni, R. F., Nogaroto, V., de Moura, E. G., Lisboa, P. C., & Milléo, F. Q. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i22.6990 · Cited by 16

Associations of TP53 codon 72 polymorphism with complications and comorbidities in patients with type 1 diabetes

Słomiński, B., Skrzypkowska, M. W., Ryba-Stanisławowska, M. E., Myśliwiec, M., & Trzonkowski, P. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-020-02035-1 · Cited by 17

The human ΔNp53 isoform triggers metabolic and gene expression changes that activate mTOR and alter mitochondrial function

Lin, S., Karoly, E. D., & Taatjes, D. J. (2013) · Aging Cell · doi:10.1111/acel.12108 · Cited by 16

p53-mediated autophagy adjustment is involved in the protection of silibinin against murine dermal inflammation and epidermal apoptosis induced by UVB irradiation

Wang, Q., Liu, W., Zeng, H. M., Xie, X., Zang, G., Ye, Y., Tashiro, S., Onodera, S., Jiang, S., & Ikejima, T. (2013) · Journal of Asian Natural Products Research · doi:10.1080/10286020.2012.739616 · Cited by 16

Uridine–cytidine kinase 2 potentiates the mutagenic influence of the antiviral β-d-N4-hydroxycytidine

Xu, Z., Flensburg, C., Bilardi, R. A., & Majewski, I. J. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad1002 · Cited by 15

Emerging Metabolic Targets in the Therapy of Hematological Malignancies

Leni, Z., Parakkal, G., & Arcaro, A. (2013) · BioMed Research International · doi:10.1155/2013/946206 · Cited by 17

Serum Omega-3 and Omega-6 Fatty Acids and Cutaneous p53 Expression in an Australian Population

van der Pols, J. C., Xu, C., Boyle, G. M., Hughes, M. C. B., Carr, S. J., Parsons, P. G., & Green, A. C. (2011) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-10-0961 · Cited by 15

p53 regulates the transcription of the anti-inflammatory molecule developmental endothelial locus-1 (Del-1)

Kim, H., Lee, S. H., Lee, M.-N., Oh, G. T., Choi, K., & Choi, E. Y. (2013) · Oncotarget · doi:10.18632/oncotarget.1318 · Cited by 15

Application of electronic nose technology in the diagnosis of gastrointestinal diseases: a review

Ma, T., Chang, Z., Zhang, N., & Xu, H. (2024) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-024-05925-w · Cited by 14

Determination of lung cancer exhaled breath biomarkers using machine learning-a new analysis framework

Setlhare, T. C., Mpolokang, A. G., Emmanuel Flahaut, B., & Chimowa, G. (2025) · Scientific Reports · doi:10.1038/s41598-025-11365-4 · Cited by 14

An NF-κB/OVOL2 circuit regulates glucose import and cell survival in non-small cell lung cancer

Zhang, R., Geng, G., Guo, J., Mi, Y., Zhu, X., Li, N., Liu, H., Jun-feng, L., Wang, J.-W., Zhao, G. S., et al. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-022-00845-z · Cited by 14

Clinicogenomic Landscape of Metastatic Thymic Epithelial Tumors

Ardeshir‐Larijani, F., Schneider, B. P., Althouse, S. K., Radovich, M., Masood, A., Perna, F., Salman, H., & Loehrer, P. J. (2023) · JCO Precision Oncology · doi:10.1200/po.22.00465 · Cited by 14

Metabolic symbiosis between oxygenated and hypoxic tumour cells: An agent-based modelling study

Jayathilake, P. G., Victori, P., Pavillet, C. E., Lee, C. H., Voukantsis, D., Miar, A., Arora, A., Harris, A. L., Morten, K., & Buffa, F. M. (2024) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1011944 · Cited by 14

Proteomics and metabolomics in cancer drug development

D’Alessandro, A., & Zolla, L. (2013) · Expert Review of Proteomics · doi:10.1586/14789450.2013.840440 · Cited by 14

Modulation of Autophagy-Like Processes by Tumor Viruses

Mack, H. I. D., & Münger, K. (2012) · Cells · doi:10.3390/cells1030204 · Cited by 14

Dynamic regulation of histone H3 lysine (K) acetylation and deacetylation during prolonged oxygen deprivation in a champion anaerobe

Wijenayake, S., & Storey, K. B. (2020) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-020-03848-x · Cited by 16

Biallelic and gene-wide genomic substitution for endogenous intron and retroelement mutagenesis in human cells

Ohno, T., Akase, T., Kono, S., Kurasawa, H., Takashima, T., Kaneko, S., & Aizawa, Y. (2022) · Nature Communications · doi:10.1038/s41467-022-31982-1 · Cited by 14

Mitochondria Protection with Ginkgolide B-Loaded Polymeric Nanocapsules Prevents Diethylnitrosamine-Induced Hepatocarcinoma in Rats

Ghosh, S., Dungdung, S. R., Choudhury, S. T., Chakraborty, S., & Das, N. (2013) · Nanomedicine · doi:10.2217/nnm.13.56 · Cited by 14

A new paradigm of genetic testing for hereditary breast/ovarian cancers

Kwong, A., Chen, J. W., & Shin, V. Y. (2016) · Hong Kong Medical Journal · doi:10.12809/hkmj154634 · Cited by 17

Apoptosis and Other Alternate Mechanisms of Cell Death

Kumar, R., Pate, S. K., Reddy, B. V. R., Bhatt, M., Karthik, K., Gandham, R. K., Mali, Y. S., & Dhama, K. (2015) · Asian Journal of Animal and Veterinary Advances · doi:10.3923/ajava.2015.646.668 · Cited by 17

Good Guy or Bad Guy? The Duality of Wild-Type p53 in Hormone-Dependent Breast Cancer Origin, Treatment, and Recurrence

McGowan, E. M., Lin, Y., & Hatoum, D. (2018) · Cancers · doi:10.3390/cancers10060172 · Cited by 14

Inverted mirror image molecular beacon-based three concatenated logic gates to detect p53 tumor suppressor gene

Xue, C., Xiao, S., Ouyang, C., Li, C., Gao, Z., Shen, Z., & Wu, Z. (2018) · Analytica Chimica Acta · doi:10.1016/j.aca.2018.11.029 · Cited by 14

Disulfidptosis: a new target for central nervous system disease therapy

Chang, J., Liu, D., Xiao, Y., Tan, B., Deng, J., Mei, Z., & Liao, J. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1514253 · Cited by 13

Dual-upregulation of p53 for self-sensitized cuproptosis via microwave dynamic and NO gas therapy

Wang, Y., Wu, Q., Guo, W., Chen, Z., Tan, L., Fu, C., Ren, X., Zhang, J., Meng, X., & Gu, B. (2025) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2025.137421 · Cited by 13

Oxidative pentose phosphate pathway inhibition is a key determinant of antimalarial induced cancer cell death

Salas, E., Roy, S., Marsh, T., Rubin, B. P., & Debnath, J. (2015) · Oncogene · doi:10.1038/onc.2015.348 · Cited by 14

The Metabolic Relationship Between Viral Infection and Cancer

Mullen, P. J., & Christofk, H. R. (2021) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-070120-090423 · Cited by 14

An Update on the Metabolic Landscape of Oncogenic Viruses

Gaballah, A. H., & Bartosch, B. (2022) · Cancers · doi:10.3390/cancers14235742 · Cited by 13

Mutational Status of CDKN2A and TP53 Genes in Laryngeal Squamous Cell Carcinoma

Todorova, T. A., Jordanov, S. H., Stancheva, G. S., Chalakov, I. J., Melnicharov, M. B., Kŭnev, K., Mitev, V., Kaneva, R. P., & Goranova, T. (2014) · Pathology & Oncology Research · doi:10.1007/s12253-014-9836-0 · Cited by 13

Dual Role of Dextran Sulfate 5000 Da as Anti-Apoptotic and Pro-Autophagy Agent

Menvielle, J. P., Safini, N., Tisminetzky, S. G., & Skoko, N. (2012) · Molecular Biotechnology · doi:10.1007/s12033-012-9620-x · Cited by 13

Wheel running, skeletal muscle aerobic capacity and 1-methyl-1-nitrosourea induced mammary carcinogenesis in the rat

Mann, P. B., Jiang, W., Zhu, Z., Wolfe, P., McTiernan, A., & Thompson, H. J. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq063 · Cited by 13

Characterization of the 5’-flanking region of the humanTP53gene and its response to the natural compound, Resveratrol

Uchiumi, F., Shoji, K., Sasaki, Y., Sasaki, M., Sasaki, Y., Oyama, T., Sugisawa, K., & Tanuma, S.-I. (2015) · The Journal of Biochemistry · doi:10.1093/jb/mvv126 · Cited by 13

Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer

Blackhall, F. H. (2015) · Annals of Oncology · doi:10.1093/annonc/mdv089.5 · Cited by 13

Reduced expression of NR4A1 activates glycolytic pathway in acute promyelocytic leukemia cells

Corrocher, F. A., de Paiva, L. B., Duarte, A. S. S., Ferro, K. P., Silveira, L. D. R., de Lima, T. I., Saad, S. T. O., & Lazarini, M. (2017) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2017.1387900 · Cited by 13

Release of volatile organic compounds (VOCs) from colorectal cancer cell line LS174T

Liu, M., Li, Y., Wang, G., Guo, N., Liu, D., Li, D., Guo, L., Zheng, X., Yu, K., Yu, K., et al. (2019) · Analytical Biochemistry · doi:10.1016/j.ab.2019.06.011 · Cited by 13

Inhibition of p53 by Adenovirus Type 12 E1B-55K Deregulates Cell Cycle Control and Sensitizes Tumor Cells to Genotoxic Agents

Li, Q., Zhao, L., Zheng, Z., Yang, H., Santiago, A., & Liao, D. (2011) · Journal of Virology · doi:10.1128/jvi.00492-11 · Cited by 13

Sestrin 2 protects against metabolic stress in a p53-independent manner

Wang, J.-M., Liu, B.-Q., Li, C. R., Du, Z., Sun, J. T., Yan, J. Y., Jiang, J., & Wang, H. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.04.072 · Cited by 13

The combination of calreticulin-targeting L-ASNase and anti-PD-L1 antibody modulates the tumor immune microenvironment to synergistically enhance the antitumor efficacy of radiotherapy

Zhang, Y., Akhil, V., Seo, H. S., Park, H., Kim, S. H., You, S.-H., Liu, Z., Kim, S., Sultonova, R. D., Min, J., et al. (2024) · Theranostics · doi:10.7150/thno.90376 · Cited by 12

Landscape of metabolic alterations and treatment strategies in breast cancer

Wu, X., Tan, X., Bao, Y., Yan, W., & Zhang, Y. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101521 · Cited by 13

Spermidine Enhances Mitochondrial Function and Mitigates Aortic Valve Calcification

Song, N., Ji, E., Yu, J. E., Choi, K., Kim, D., Song, J., Kang, D., Song, J., Yu, J., Kim, K., et al. (2025) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2024.11.011 · Cited by 12

Magnesium Deficiency Results in Oxidation and Fragmentation of DNA, Down Regulation of Telomerase Activity, and Ceramide Release in Cardiovascular Tissues and Cells: Potential Relationship to Atherogenesis, Cardiovascular Diseases and Aging

Altura, B. M., Nc, S., Shah, G. J., Perez-Albela, J. L., Instituto Bien de Salud, L., & Altura, B. T. (2016) · International Journal of Diabetology & Vascular Disease Research · doi:10.19070/2328-353x-1600011e · Cited by 12

Methyl pyruvate protects a normal lung fibroblast cell line from irinotecan-induced cell death: Potential use as adjunctive to chemotherapy

Monchusi, B. A., & Ntwasa, M. M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182789 · Cited by 12

Deletion of the p53 tumor suppressor gene improves neuromotor function but does not attenuate regional neuronal cell loss following experimental brain trauma in mice

Tomasevic, G., Raghupathi, R., Scherbel, U., Wieloch, T. W., & McIntosh, T. K. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22491 · Cited by 12

The IGF-1R/AKT pathway has opposing effects on Nutlin-3a-induced apoptosis

Davaadelger, B., Perez, R. E., Zhou, Y., Duan, L., Gitelis, S., & Maki, C. G. (2017) · Cancer Biology & Therapy · doi:10.1080/15384047.2017.1345397 · Cited by 12

The histone demethylase JMJD2B is critical for p53-mediated autophagy and survival in Nutlin-treated cancer cells

Duan, L., Perez, R. E., Lai, X., Chen, L., & Maki, C. G. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.007122 · Cited by 12

Loss of Rb Cooperates with Ras to Drive Oncogenic Growth in Mammalian Cells

Collins, M. J., Napoli, I., Ribeiro, S., Roberts, S., & Lloyd, A. C. (2012) · Current Biology · doi:10.1016/j.cub.2012.07.040 · Cited by 12

Cell Competition: Pirates on the Tangled Bank

Green, D. R. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.03.006 · Cited by 12

The role of mitochondrial bioenergetics and reactive oxygen species in coronary collateral growth

Pung, Y. F., Sam, W. J., Hardwick, J. P., Yin, L., Ohanyan, V. A., Logan, S. J., DiVincenzo, L., & Chilian, W. M. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00077.2013 · Cited by 12

AMPK/PGC-1α and p53 modulate VDAC1 expression mediated by reduced ATP level and metabolic oxidative stress in neuronal cells

Wang, Z., Tingting, X., Sun, Y., Zhang, X., & Wang, X. (2024) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2024012 · Cited by 11

O-GlcNAcylation: Crosstalk between Hemostasis, Inflammation, and Cancer

Martínez, I. P. V., Pérez‐Campos, E., Mayoral, L. P.-C., Cruz-Luis, H., Pina-Canseco, M. D. S., Zenteno, E., Salinas, I. L. B., Cruz, M. M., Mayoral, E. P., & Hernández‐Huerta, M. T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25189896 · Cited by 11

The role and research progress of serine metabolism in tumor cells

Lyu, H., Bao, S., Cai, L., Wang, M., Liu, Y., Sun, Y., & Hu, X. S. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1509662 · Cited by 13

High-dose vitamin C promotes mitochondrial biogenesis in HCT116 colorectal cancer cells by regulating the AMPK/PGC-1α signaling pathway

Hong, R., Min, S., Huang, J., Zou, M., Zhou, D., & Liang, Y. (2025) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-025-06211-z · Cited by 11

p53-Mediated regulation of hepatic lipid metabolism: Forging links between metabolism, atherogenesis, and cancer

Stratton, S. A., & Barton, M. C. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.10.009 · Cited by 11

Neuronal IL-17 controls Caenorhabditis elegans developmental diapause through CEP-1/p53

Godthi, A., Min, S., Das, S., Cruz-Corchado, J., Deonarine, A., Misel‐Wuchter, K., Issuree, P. D. A., & Prahlad, V. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2315248121 · Cited by 11

Chemotherapy mediates intestinal injury via p53/p53 upregulated modulator of apoptosis ( PUMA ) signaling pathway

Zhan, Y., Tan, S., Mao, W., Jiang, J., Liu, H. L., & Wu, B. (2014) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12157 · Cited by 11

Tumor suppressor p53 and its mutants in cancer metabolism

Liu, J., Zhang, C., Hu, W., & Feng, Z. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.12.025 · Cited by 276

The latest research progress on P53 and tumor metabolism

ZHAI Haihui, L. Y. (2023) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.19401/j.cnki.1007-3639.2023.11.009

Taking up the reins of power: metabolic functions of p53

Humpton, T. J., & Vousden, K. H. (2019) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjz065 · Cited by 29

Metabolic regulation by p53: Implications for cancer therapy

Koo, K. Y., Moon, K., He, S., & Lee, M.-S. (2025) · Molecules and Cells · doi:10.1016/j.mocell.2025.100198 · Cited by 45

Emerging Roles of the Tumor Suppressor p53 in Metabolism

Yu, L., Wu, M. Y., Zhu, G., & Xu, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.762742 · Cited by 49