The DOI matches its Crossref record; 134 of the 134 references it cites were found in a registry or an index.
p53 and metabolism
Abstract
Although metabolic alterations have been observed in cancer for almost a century, only recently have the mechanisms underlying these changes been identified and the importance of metabolic transformation realized. p53 has been shown to respond to metabolic changes and to influence metabolic pathways through several mechanisms. The contributions of these activities to tumour suppression are complex and potentially rather surprising: some reflect the function of basal p53 levels that do not require overt activation and others might even promote, rather than inhibit, tumour progression.
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“Target genes directly regulated by p53 participate in multiple metabolic pathways.194, 195”
From Census and evaluation of p53 target genes (2017) · cites this paper as [194]
In the citing paper
“P53 is a crucial protein that regulates the cell cycle and acts as a tumor suppressor.”
From Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials (2023) · cites this paper as [205]
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Metadata
- Authors
- Vousden, K. H., & Ryan, K. M.
- Affiliations
- Cancer Research UK Scotland Institute (GB)
- Venue
- Nature Reviews Cancer
- Published
- 2009-09-17
- Volume
- 9
- Issue
- 10
- Pages
- 691-700
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W1991510903
- Cited by
- 959
- References
- 134
- Citations by year
- 2026: 23 · 2025: 39 · 2024: 37 · 2023: 36 · 2022: 49 · 2021: 46 · 2020: 44 · 2019: 39 · 2018: 49 · 2017: 52 · 2016: 60 · 2015: 78 · 2014: 84 · 2013: 97 · 2012: 82
- FWCI
- 6.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Funders
- Cancer Research UK
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- p53, cancer metabolism, tumor suppression, tumor progression, metabolic pathways, cancer cells
- MeSH terms
- Autophagy, Cell Transformation, Neoplastic, Glycolysis, Humans, Neoplasms, Tumor Suppressor Protein p53, Oxidative Stress, Cell Proliferation
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