Cited by 960Cancer-related Molecular PathwaysCancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

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p53 and metabolism

Vousden, Karen H., Ryan, Kevin M.·2009·Nature Reviews Cancer

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Abstract

Although metabolic alterations have been observed in cancer for almost a century, only recently have the mechanisms underlying these changes been identified and the importance of metabolic transformation realized. p53 has been shown to respond to metabolic changes and to influence metabolic pathways through several mechanisms. The contributions of these activities to tumour suppression are complex and potentially rather surprising: some reflect the function of basal p53 levels that do not require overt activation and others might even promote, rather than inhibit, tumour progression.

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Tissue-specific Autophagy Alterations and Increased Tumorigenesis in Mice Deficient in Atg4C/Autophagin-3
Mariño, G., Salvador-Montoliu, N., Fueyo, A., Knecht, E., Mizushima, N., & López-Otı́n, C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701194200 · Cited by 427
Retracted
On the origin of cancer cells
Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425
The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088
Development by Self-Digestion
Levine, B., & Klionsky, D. J. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00099-1 · Cited by 3,728
Blinded by the Light: The Growing Complexity of p53
Vousden, K. H., & Prives, C. (2009) · Cell · doi:10.1016/j.cell.2009.04.037 · Cited by 3,163
Self-citation
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Christofk, H. R., Vander Heiden, M. G., Harris, M. H., Ramanathan, A., Gerszten, R. E., Wei, R., Fleming, M. D., Schreiber, S. L., & Cantley, L. C. (2008) · Nature · doi:10.1038/nature06734 · Cited by 2,820
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622
A model for p53-induced apoptosis
Polyak, K., Xia, Y., Zweier, J. L., Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/38525 · Cited by 2,500
Cancer cell metabolism: warburg and beyond
Hsu, P. P., & Sabatini, D. M. (2008) · Cell · doi:10.1016/j.cell.2008.08.021 · Cited by 2,452
p53 in health and disease
Vousden, K. H., & Lane, D. P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2147 · Cited by 2,351
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Han, C. Y., Patten, D. A., Lee, S. G., Parks, R. J., Chan, D. W., Harper, M., & Tsang, B. K. (2019) · Molecular Carcinogenesis · doi:10.1002/mc.23106 · Cited by 44
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Meller, C. L., Meller, R., Simon, R. P., Culpepper, K. M., & Podrabsky, J. E. (2012) · Journal of Comparative Physiology B · doi:10.1007/s00360-012-0672-9 · Cited by 43
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Dulic, V. (2013) · Methods in Molecular Biology · doi:10.1007/978-1-62703-239-1_2 · Cited by 42
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Authors: Vousden, K. H., & Ryan, K. M.
Affiliations: Cancer Research UK Scotland Institute (GB)
ORCID: Vousden, Karen H.
Ryan, Kevin M.
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2009-09-17
Volume: 9
Issue: 10
Pages: 691-700
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc2715
OpenAlex: W1991510903
Cited by: 959
References: 134
Citations by year: 2026: 23 · 2025: 39 · 2024: 37 · 2023: 36 · 2022: 49 · 2021: 46 · 2020: 44 · 2019: 39 · 2018: 49 · 2017: 52 · 2016: 60 · 2015: 78 · 2014: 84 · 2013: 97 · 2012: 82
FWCI: 6.60
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Funders: Cancer Research UK
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: p53, cancer metabolism, tumor suppression, tumor progression, metabolic pathways, cancer cells
MeSH terms: Autophagy, Cell Transformation, Neoplastic, Glycolysis, Humans, Neoplasms, Tumor Suppressor Protein p53, Oxidative Stress, Cell Proliferation

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