HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
DOI 10.1038/nrc3183
Cited by (1,008)
Items 701–800 of 1,008
- The role of hypoxic signalling in metastasis: towards translating knowledge of basic biology into novel anti-tumour strategiesJoaquín Araos Henríquez, Jonathan Paul Sleeman, Boyan K. Garvalov · 2018 · Clinical & Experimental Metastasis
- Metabolic regulation of oxygen and redox homeostasis by p53: Lessons from evolutionary biology?Jie Zhuang, Wenzhe Ma, Cory U. Lago, Paul M. Hwang · 2012 · Free Radical Biology and Medicine
- A novel series of G-quadruplex ligands with selectivity for HIF-expressing osteosarcoma and renal cancer cell linesCaterina M. Lombardo, Sarah Joanne Welsh, Sandra J. Strauss, Aaron G. Dale, Alan K. Todd, Rupesh K. Nanjunda, W. David Wilson, Stephen Neidle · 2012 · Bioorganic & Medicinal Chemistry Letters
- Context-dependent role for chromatin remodeling component PBRM1/BAF180 in clear cell renal cell carcinomaAkiko Murakami, L Wang, S Kalhorn, Peter Schraml, W. Kimryn Rathmell, Aik Choon Tan, Raphael A. Nemenoff, Kurt R. Stenmark, B-H Jiang, Mary E. Reyland et al. · 2017 · Oncogenesis
- Hypoxia-inducible factor-2 alpha up-regulates CD70 under hypoxia and enhances anchorage-independent growth and aggressiveness in cancer cellsShojiro Kitajima, Kian Leong Lee, Masaki Fujioka, Wendi Sun, Jia You, Grace Sushin Chia, Hideki Wanibuchi, Shuhei Tomita, Marito Araki, Hiroyuki Kato et al. · 2018 · Oncotarget
- Acute and chronic hypoxia differentially predispose lungs for metastasesMoritz Reiterer, Renato Colaço, Pardis Emrouznejad, Anders Jensen, Helene Rundqvist, Randall S. Johnson, Cristina M. Branco · 2019 · Scientific Reports
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- ERK signaling controls productive HIF‐1 binding to chromatin and cancer cell adaptation to hypoxia through HIF‐1α interaction with NPM1Kreon Koukoulas, Antonis Giakountis, Angeliki Karagiota, Martina K. Samiotaki, George Panayotou, George Simos, Ilias Mylonis · 2021 · Molecular Oncology
- Hypoxia-Inducible Factor-2α as a Novel Target in Renal Cell CarcinomaWonSeok William Choi, Julia L. Boland, Jianqing Lin · 2021 · Journal of Kidney Cancer and VHL
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- Activity of a first-in-class oral HIF2-alpha inhibitor, PT2385, in patients with first recurrence of glioblastomaRoy Ervin Strowd III, Benjamin M. Ellingson, Catalina Raymond, Jingwen Yao, Patrick Yung Wen, Manmeet Singh Ahluwalia, Anna F. Piotrowski, Arati Suvas Desai, Jennifer Leigh Clarke, Frank Scott Lieberman et al. · 2023 · Journal of Neuro-Oncology
- Beside the MEF2 axis: Unconventional functions of HDAC4Andrea Clocchiatti, Eros Di Giorgio, Francesca Demarchi, Claudio Brancolini · 2012 · Cellular Signalling
- HIF1A-dependent increase in endothelin 2 levels in granulosa cells: role of hypoxia, LH/cAMP, and reactive oxygen speciesRonit Yalu, Adepeju Esther Oyesiji, Iris Eisenberg, Tal Imbar, Rina Meidan · 2014 · Reproduction
- SerpinB3 and Yap Interplay Increases Myc Oncogenic ActivityCristian Turato, Stefania Cannito, Davide Simonato, Gianmarco Villano, Elisabetta Morello, Liliana Terrin, Santina Quarta, Alessandra Biasiolo, Mariagrazia Ruvoletto, Andréa Martini et al. · 2015 · Scientific Reports
- Role of Hypoxia and HIF2α in Development of the Sympathoadrenal Cell Lineage and Chromaffin Cell Tumors with Distinct Catecholamine Phenotypic FeaturesRichter, Susan, Qin, Nan, Pacak, Karel, Eisenhofer, Graeme · 2013 · Advances in Pharmacology
- Deubiquitylase OTUD6B stabilizes the mutated pVHL and suppresses cell migration in clear cell renal cell carcinomaKai Guo, Yinghua Wei, Ze Wang, Xiaoli Zhang, Xin Zhang, Xinxin Liu, Wenyong Wu, Zhengsheng Wu, Lingqiang Zhang, Chun‐Ping Cui · 2022 · Cell Death and Disease
- The Role of Hypoxia-Inducible Factor Isoforms in Breast Cancer and Perspectives on Their Inhibition in TherapyKarolina Kozal, Anna Krześlak · 2022 · Cancers
- The role of HIF in angiogenesis, lymphangiogenesis, and tumor microenvironment in urological cancersLin Shen, Yueyang Chai, Xiangyi Zheng, Xin Xu · 2023 · Molecular Biology Reports
- Hypoxia-associated autophagy flux dysregulation in human cancersJiding Fu, Jie Lin, Zili Dai, Baisheng Lin, Jian Zhang · 2024 · Cancer Letters
- Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone developmentLaura Mangiavini, Christophe Merceron, Elisa Araldi, Richa Khatri, Rita L. Gerard-O’Riley, Tremika LeShan Wilson, Erinn B. Rankin, Amato J. Giaccia, Ernestina Schipani · 2014 · Developmental Biology
- Current views on cell metabolism in SDHx-related pheochromocytoma and paragangliomaAleš Vícha, David Taïeb, Karel Pacák · 2014 · Endocrine Related Cancer
- NECAB3 Promotes Activation of Hypoxia-inducible factor-1 during Normoxia and Enhances Tumourigenicity of Cancer CellsHiroki J. Nakaoka, Toshiro Hara, Seiko Yoshino, Akane Kanamori, Yusuke Matsui, Teppei Shimamura, Hiroshi Sato, Yoshinori Murakami, Motoharu Seiki, Takeharu Sakamoto · 2016 · Scientific Reports
- The hypoxia signalling pathway in haematological malignanciesMarta Irigoyen, Juan Carlos García‐Ruiz, Edurne Berra · 2017 · Oncotarget
- Atovaquone Suppresses Triple-Negative Breast Tumor Growth by Reducing Immune-Suppressive CellsNehal Gupta, Shreyas Ramchandra Gaikwad, Itishree Kaushik, Stephen E. Wright, Maciej M. Markiewski, Sanjay Srivastava · 2021 · International Journal of Molecular Sciences
- Sensitivity of VHL mutant kidney cancers to HIF2 inhibitors does not require an intact p53 pathwayLaura A. Stransky, Sean M. Vigeant, Bofu Huang, Destiny J. West, Thomas Denize, Emily Walton, Sabina Signoretti, William G. Kaelin · 2022 · Proceedings of the National Academy of Sciences
- Effect of chronic intermittent hypoxia-induced HIF-1α/ATAD2 expression on lung cancer stemnessShengyu Hao, Fan Li, Pan Jiang, Jian Gao · 2022 · Cellular & Molecular Biology Letters
- Hypoxia-inducible Factor-2α-dependent Hypoxic Induction of Wnt10b Expression in Adipogenic CellsYoung-Kwon Park, Bongju Park, Seongyeol Lee, Kang Yell Choi, Yunwon Moon, Hyunsung Park · 2013 · Journal of Biological Chemistry
- Proteomic profiling reveals that collismycin A is an iron chelatorMakoto Kawatani, Makoto Muroi, Akira Wada, Gyo Inoue, Yushi Futamura, Harumi Aono, Kenshirou Shimizu, Takeshi Shimizu, Yasuhiro Igarashi, Naoko Takahashi et al. · 2016 · Scientific Reports
- Wild-type IDH2 is a therapeutic target for triple-negative breast cancerJiangjiang Li, T. Semiglazova Yu., Peiting Zeng, Jingyu Tian, Panpan Liu, Shuang Qiao, Shijun Wen, Yumin Hu, Qiao Liu, Wenhua Lu et al. · 2024 · Nature Communications
- Targeting carbonic anhydrase IX improves the anti-cancer efficacy of mTOR inhibitorsSeraina Faes, Anne Planche, Émilie Uldry, Tania Santoro, Catherine Pythoud, Jean‐Christophe Stehle, Janine Horlbeck, Igor Letovanec, Nicolò Riggi, Dipak B. Datta et al. · 2016 · Oncotarget
- RIG-I Resists Hypoxia-Induced Immunosuppression and DedifferentiationChristina Engel, Grethe Brügmann, Silke Lambing, Larissa Helen Mühlenbeck, Samira Marx, Christian Hagen, Dorottya Horváth, Marion Goldeck, János Ludwig, Anna‐Maria Herzner et al. · 2017 · Cancer Immunology Research
- Control of metastatic niche formation by targeting APBA3/Mint3 in inflammatory monocytesToshiro Hara, Hiroki J. Nakaoka, Tetsuro Hayashi, Kouhei Mimura, Daisuke Hoshino, Masahiro Inoue, Fumitaka Nagamura, Yoshinori Murakami, Motoharu Seiki, Takeharu Sakamoto · 2017 · Proceedings of the National Academy of Sciences
- Current Landscape and the Potential Role of Hypoxia-Inducible Factors and Selenium in Clear Cell Renal Cell Carcinoma TreatmentRohan Garje, Josiah An, Kevin G. Sanchez, Austin Greco, Jeffrey M. Stolwijk, Eric Jeffrey Devor, Youcef M. Rustum, Yousef Zakharia · 2018 · International Journal of Molecular Sciences
- The uremic toxin p-cresyl sulfate induces proliferation and migration of clear cell renal cell carcinoma via microRNA-21/ HIF-1α axis signalsTsai-Kun Wu, Chyou-Wei Wei, Ying-Ru Pan, Ren‐Jun Hsu, Chung‐Yi Wu, Yung‐Luen Yu · 2019 · Scientific Reports
- A genetic mouse model of severe iron deficiency anemia reveals tissue-specific transcriptional stress responses and cardiac remodelingAndrew J. Schwartz, Kimber Converso‐Baran, Daniel E. Michele, Yatrik Madhukar Shah · 2019 · Journal of Biological Chemistry
- IDH2 reprograms mitochondrial dynamics in cancer through a HIF‐1α‐regulated pseudohypoxic stateYuan Wang, Ekta Agarwal, Irene Bertolini, Jagadish C. Ghosh, Jae Ho Seo, Dario C. Altieri · 2019 · The FASEB Journal
- Hypoxia favors chemoresistance in T-ALL through an HIF1α-mediated mTORC1 inhibition loopLucine Fahy, Julien Calvo, Sara Chabi, Laurent Renou, Charly Le Maout, Sandrine Poglio, Thierry M Leblanc, Arnaud Petit, André Baruchel, Paola Fabiola Ballerini et al. · 2021 · Blood Advances
- Both Hypoxia-Inducible Factor 1 and MAPK Signaling Pathway Attenuate PI3K/AKT via Suppression of Reactive Oxygen Species in Human Pluripotent Stem CellsPetr Fojtík, Deborah Beckerová, Kateřina Holomková, Martin Šenfluk, Vladimír Rotrekl · 2021 · Frontiers in Cell and Developmental Biology
- Blockade of HIF-1α and STAT3 by hyaluronate-conjugated TAT-chitosan-SPION nanoparticles loaded with siRNA molecules prevents tumor growthHendrik Setia Budi, Sepideh Izadi, Anton Timoshin, Sima Heydarzadeh Asl, Behzad Beyzai, Amir Ghaderpour, Fatemeh Alian, Farzaneh Sadat Eshaghi, Seyedeh Mahboubeh Mousavi, Behnam Rafiee et al. · 2021 · Nanomedicine Nanotechnology Biology and Medicine
- Hypoxia-Inducible Factors in CancerLaura C. Kim, Marie Celeste Simon · 2022 · Cancer Research
- The Hypoxia-Inducible Transcription Factor ZNF395 Is Controlled by IĸB Kinase-Signaling and Activates Genes Involved in the Innate Immune Response and CancerDarko Jordanovski, Christine Herwartz, Anna E. Pawlowski, Stefanie Taute, Peter Frommolt, Gertrud Steger · 2013 · PLoS ONE
- TNFα induces expression of HIF‐1α mRNA and protein but inhibits hypoxic stimulation of HIF‐1 transcriptional activity in airway smooth muscle cellsStamatina Tsapournioti, Ilias Mylonis, Apostolia A. Hatziefthimiou, Μαρία Ιωάννου, Rodopi Stamatiou, Georgios K. Koukoulis, George Simos, Paschalis‐Adam Molyvdas, Efrosyni Paraskeva · 2013 · Journal of Cellular Physiology
- Diverse Mechanisms of Sp1-Dependent Transcriptional Regulation Potentially Involved in the Adaptive Response of Cancer Cells to Oxygen-Deficient ConditionsShiro Koizume, Yohei Miyagi · 2015 · Cancers
- Development of single nanometer-sized ultrafine oxygen bubbles to overcome the hypoxia-induced resistance to radiation therapy via the suppression of hypoxia-inducible factor‑1αMisaki Iijima, Navchaa Gombodorj, Yoshiaki Tachibana, Kohsuke Tachibana, Takehiko Yokobori, Kyoko Honma, Takashi Nakano, Takayuki Asao, Ryusuke Kuwahara, Kazuhiro Aoyama et al. · 2018 · International Journal of Oncology
- Hypoxia drives shared and distinct transcriptomic changes in two invasive glioma stem cell linesValerie J. Marallano, Mary E. Ughetta, Rut Tejero, Sidhanta Nanda, Rohana Ramalingam, Lauren A. Stalbow, Anirudh Sattiraju, Yong Huang, Aarthi Ramakrishnan, Li Shen et al. · 2024 · Scientific Reports
- Chondroitin Sulfate Proteoglycan CSPG4 as a Novel Hypoxia-Sensitive Marker in Pancreatic TumorsShereen Keleg, Titov Alexandr, Anette Heller, Thomas Giese, Christine Tjaden, Sufian S. Ahmad, Matthias M. Gaida, Andrea S. Bauer, Jens Werner, Nathalia A. Giese · 2014 · PLoS ONE
- TRIM2 directly deubiquitinates and stabilizes Snail1 protein, mediating proliferation and metastasis of lung adenocarcinomaZhaoxian Lin, Xing Lin, Lihuan Zhu · 2020 · Cancer Cell International
- Personalized drug testing in human pheochromocytoma/paraganglioma primary culturesKatharina Wang, Ina Schütze, Sebastian Gulde, Nicole Bechmann, Susan Richter, Jana Helm, Michael Lauseker, Julian Maurer, Astrid Reul, Gerald Spoettl et al. · 2022 · Endocrine Related Cancer
- Bafilomycin A1 activates HIF-dependent signalling in human colon cancer cells via mitochondrial uncouplingAlexander V. Zhdanov, Ruslan I. Dmitriev, Dmitri B. Papkovsky · 2012 · Bioscience Reports
- High expression of insulin receptor on tumour‐associated blood vessels in invasive bladder cancer predicts poor overall and progression‐free survivalFilip Roudnicky, Lothar C. Dieterich, Cédric Poyet, Lorenz Buser, Peter Johannes Wild, Dave T. P. Tang, Peter Camenzind, Chien Hsien Ho, Vivianne I. Otto, Michael J. Detmar · 2017 · The Journal of Pathology
- Hypoxia upregulates integrin gene expression in microvascular endothelial cells and promotes their migration and capillary‐like tube formationChristina D. Befani, Panagiotis Liakos · 2017 · Cell Biology International
- Hypoxia-induced Changes in SUMO Conjugation Affect Transcriptional Regulation Under Low OxygenGeorgia Chachami, Nicolas Stankovic‐Valentin, Angeliki Karagiota, Angeliki Basagianni, Uwe Plessmann, Henning Urlaub, Frauke Melchior, George Simos · 2019 · Molecular & Cellular Proteomics
- Zinc finger protein 384 enhances colorectal cancer metastasis by upregulating MMP2Zaihua Yan, Zhou Yu, Yang� Yang, Chongpu Zeng, Peidong Li, Hongpeng Tian, Xuegui Tang, Guangjun Zhang · 2022 · Oncology Reports
- Evolution of the HIF targeted therapy in clear cell renal cell carcinomaBorivoj Golijanin, Kamil Malshy, Sari Safaa Khaleel, Galina Lagos, Ali Amin, Liang Cheng C, Dragan Golijanin, Anthony E. Mega · 2023 · Cancer Treatment Reviews
- Identification and Development of Cyclic Peptide Inhibitors of Hypoxia Inducible Factors 1 and 2 That Disrupt Hypoxia-Response Signaling in Cancer CellsAndrew T. Ball, Soran Mohammed, Cyrielle Doigneaux, Reece M. Gardner, James W. Easton, S. J. Turner, Jonathan W. Essex, Garry Pairaudeau, Ali Tavassoli · 2024 · Journal of the American Chemical Society
- HIF-1α and HIF-2α: Siblings in Promoting Angiogenesis of Residual Hepatocellular Carcinoma after High-Intensity Focused Ultrasound AblationLun Wu, Zhihao Fu, Shiji Zhou, Jianping Gong, Chang An Liu, Zhengrong Qiao, Shengwei Li · 2014 · PLoS ONE · Retracted
- Tumor derived vasculogenesis in von Hippel-Lindau disease-associated tumorsZhengping Zhuang, Jason M Frerich, Kristin Michelle Huntoon, Chunzhang Yang, Marsha J. Merrill, Ziedulla Abdullaev, Svetlana Pack, Sharon B. Shively, Gordon Stamp, Russell R. Lonser · 2014 · Scientific Reports
- Conditional Deletion of Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Gene Reveals Its Essential Role in Chondrocyte Function and Endochondral Bone FormationShaohong Cheng, Weirong Xing, Sheila Pourteymoor, Jan Schulte, Subburaman Mohan · 2015 · Endocrinology
- Regulation and clinical significance of the hypoxia-induced expression of ANGPTL4 in gastric cancerHiroshi Kubo, Yoshihiko Kitajima, Keita Kai, Jun Nakamura, SHUUSUKE MIYAKE, Kazuyoshi Yanagihara, 清人 森戸, Tomokazu Tanaka, Masaaki Shida, Hirokazu Noshirο · 2015 · Oncology Letters
- Prognostic Significance of Hypoxia-Inducible Factor Expression in Renal Cell Carcinoma: A PRISMA-compliant Systematic Review and Meta-AnalysisFan, Yang, Li, Hongzhao, Ma, Xin, Gao, Yu, Chen, Luyao, Li, Xintao, Bao, Xu, Du, Qingshan, Zhang, Yu, Zhang, Xu · 2015 · Medicine
- Dynamic contrast-enhanced MR imaging in predicting progression of enhancing lesions persisting after standard treatment in glioblastoma patients: a prospective studyRoh‐Eul Yoo, Seung Hong Choi, Tae Min Kim, Chul‐Kee Park, Sung‐Hye Park, Jae‐Kyung Won, Il Han Kim, Soon‐Tae Lee, Hye Jeong Choi, Sung‐Hye You et al. · 2016 · European Radiology
- Metabolic Profiling of the Novel Hypoxia-Inducible Factor 2α Inhibitor PT2385 In Vivo and In VitroCen Xie, Xiaoxia Gao, Dongxue Sun, You-Bo Zhang, Kristopher W. Krausz, Xuemei Qin, Frank J. Gonzalez · 2018 · Drug Metabolism and Disposition
- Myeloid Cell Hypoxia-Inducible Factors Promote Resolution of Inflammation in Experimental ColitisNan Lin, Jessica E.S. Shay, Hong Jian Xie, David S.M. Lee, Nicolas Skuli, Qiaosi Tang, Zilu Zhou, Andrew Azzam, Hu Meng, Haichao Wang et al. · 2018 · Frontiers in Immunology
- Transcription Factor HIF-1α Controls Expression of the Cytokine IL-22 in CD4 T CellsScott A Budda, Alanson W. Girton, Jacob G. Henderson, Lauren A. Zenewicz · 2016 · The Journal of Immunology
- Bortezomib attenuates HIF-1- but not HIF-2-mediated transcriptional activationABD-AZIZ, NORAINI, STANBRIDGE, ERIC J., SHAFEE, NORAZIZAH · 2015 · Oncology Letters
- Micro RNA s regulate T‐cell production of interleukin‐9 and identify hypoxia‐inducible factor‐2 α as an important regulator of T helper 9 and regulatory T‐cell differentiationSingh, Yogesh, Garden, Oliver A., Lang, Florian, Cobb, Bradley S. · 2016 · Immunology
- Hypoxia-Induced Signaling in Gut and Liver PathobiologySumeet A. Solanki, Yatrik Madhukar Shah · 2023 · Annual Review of Pathology Mechanisms of Disease
- Hypoxia Inducible Factor pathway proteins in high-altitude mammalsFrank S. Lee · 2023 · Trends in Biochemical Sciences
- The cellular-centered view of hypoxia tumor microenvironment: Molecular mechanisms and therapeutic interventionsTianqi Zhang, Qianyu Lv, Weilin Jin · 2024 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Untuning the tumor metabolic machine: HIF-α: pro- and antitumorigenic?Regina M. Young, Marie Celeste Simon · 2012 · Nature Medicine
- HIF-mediated metabolic switching in bladder outlet obstruction mitigates the relaxing effect of mitochondrial inhibitionMari Ekman, Bengt Uvelius, Sebastian Albinsson, Karl Swärd · 2014 · Laboratory Investigation
- HIG2 promotes colorectal cancer progression via hypoxia-dependent and independent pathwaysSun-Hee Kim, Dingzhi Wang, Yun‐Yong Park, Hiroshi Katoh, Ofer Margalit, Michal Sheffer, Hong Wu, Vijaykumar R. Holla, Ju‐Seog Lee, Raymond N. DuBois · 2013 · Cancer Letters
- Bone Marrow Endosteal Mesenchymal Progenitors Depend on HIF Factors for Maintenance and Regulation of HematopoiesisJlenia Guarnerio, Nadia Coltella, Ugo Ala, Giovanni Tonon, Pier Paolo Pandolfi, Rosa Bernardi · 2014 · Stem Cell Reports
- Hypoxia augments MHC class I antigen presentation via facilitation of ERO1‐α‐mediated oxidative folding in murine tumor cellsToshimitsu Kajiwara, Tsutomu Tanaka, Kazuharu Kukita, Goro Kutomi, Keita Saito, Koichi Okuya, Akari Takaya, Vitaly Kochin, Takayuki Kanaseki, Tomohide Tsukahara et al. · 2016 · European Journal of Immunology
- Hypoxia Inducible Factors Modify Collagen I Fibers in MDA-MB-231 Triple Negative Breast Cancer XenograftsEibhlin S. Goggins, Samata M. Kakkad, Yelena Mironchik, Desmond Jacob, Flonné B. Wildes, Balaji Krishnamachary, Zaver M. Bhujwalla · 2017 · Neoplasia
- TRIM2 downregulation in clear cell renal cell carcinoma affects cell proliferation, migration, and invasion and predicts poor patients’ survivalWen Xiao, Xuegang Wang, Tao Wang, Jinchun Xing · 2018 · Cancer Management and Research
- SENP1-mediated deSUMOylation of USP28 regulated HIF-1α accumulation and activation during hypoxia responseShi-chun Du, Lan Zhu, Yu-xing Wang, Jie Liu, Die Zhang, Yu-lu Chen, Qing Peng, Wei Liu, Bin Liu · 2019 · Cancer Cell International
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- Blood doping: Then and now. A narrative review of the history, science and efficacy of blood doping in elite sportThomas Stewart Atkinson, Marc J. Kahn · 2019 · Blood Reviews
- The up‐regulation of NDRG1 by HIF counteracts the cancer‐promoting effect of HIF in VHL‐deficient clear cell renal cell carcinomaZheng‐Yan Zhang, Shilong Zhang, Hui‐Ling Chen, Yuqin Mao, Zhan‐Ming Li, Chao‐Yue Kong, Bing Han, Jin Zhang, Yonghui Chen, Wei Xue et al. · 2020 · Cell Proliferation
- Phosphorylation of seryl-tRNA synthetase by ATM/ATR is essential for hypoxia-induced angiogenesisYi Shi, Ze Liu, Qian Zhang, Ingrid Vallee, Zhongying Mo, Shuji Kishi, Xiang‐Lei Yang · 2020 · PLoS Biology
- Analyses of the Transcriptome and Metabolome Demonstrate That HIF1α Mediates Altered Tumor Metabolism in Clear Cell Renal Cell CarcinomaDenise R. Minton, Leiping Fu, Qiuying Chen, Brian D. Robinson, Steven S. Gross, David M. Nanus, Lorraine J. Gudas · 2015 · PLoS ONE
- Targeted Identification of Sialoglycoproteins in Hypoxic Endothelial Cells and Validation in Zebrafish Reveal Roles for Proteins in AngiogenesisNicolas Delcourt, Celia Quevedo, Christelle Nonne, Pierre Fons, Donogh P. O'Brien, Denis Loyaux, Maria Espinosa Diez, François Autelitano, Jean-Claude Guillemot, Pascual Ferrara et al. · 2014 · Journal of Biological Chemistry
- Renal cancer: Oxygen meets metabolismVolker H. Haase · 2012 · Experimental Cell Research
- Sodium orthovanadate overcomes sorafenib resistance of hepatocellular carcinoma cells by inhibiting Na+/K+-ATPase activity and hypoxia-inducible pathwaysWenjing Jiang, Guangxin Li, Weidong Li, Ping Wang, Peng Xiu, Xian Li Jiang, Bing Liu, Xueying Sun, Hongchi Jiang · 2018 · Scientific Reports
- Hypoxia, a Targetable Culprit to Counter Pancreatic Cancer Resistance to TherapyRaefa Abou Khouzam, Jean‐Maríe Lehn, Hemma Mayr, Pierre‐Alain Clavien, Michael B. Wallace, Michel Pierre Ducreux, Përparim Limani, Salem Chouaı̈b · 2023 · Cancers
- von-Hippel Lindau and Hypoxia-Inducible Factor at the Center of Renal Cell Carcinoma BiologyNitin H. Shirole, William G. Kaelin · 2023 · Hematology/Oncology Clinics of North America
- Belzutifan plus cabozantinib as first-line treatment for patients with advanced clear-cell renal cell carcinoma (LITESPARK-003): an open-label, single-arm, phase 2 studyToni K. Choueiri, Jaime Rafael Merchan, Robert A. Figlin, David F. McDermott, Edward R. Arrowsmith, Marc Dror Michaelson, Scott S. Tykodi, Elisabeth I. Heath, David Robert Spigel, Anishka D'souza et al. · 2025 · The Lancet Oncology
- Effect of hypoxia on tissue factor pathway inhibitor expression in breast cancerXue Cui, Mari Tinholt, Benedicte Stavik, Anders Erik Astrup Dahm, Sandip M. Kanse, Y. Jin, Sebastian Seidl, Kristine Kleivi Sahlberg, Nina Iversen, Grethe Skretting et al. · 2015 · Journal of Thrombosis and Haemostasis
- Physapubescin selectively induces apoptosis in VHL-null renal cell carcinoma cells through down-regulation of HIF-2α and inhibits tumor growthLixia Chen, Gui‐Yang Xia, Feng Qiu, Chunli Wu, Andria P. Denmon, Xiaolin Zi · 2016 · Scientific Reports
- Differential sub-nuclear distribution of hypoxia-inducible factors (HIF)-1 and -2 alpha impacts on their stability and mobilityS. E. Taylor, James Bagnall, David Y. Mason, Raphaël Lévy, David Garth Fernig, Violaine Sée · 2016 · Open Biology
- Expression of HIF-1α in medullary thyroid cancer identifies a subgroup with poor prognosisLutske Lodewijk, P. J. van Diest, Petra van der Groep, Natalie D. ter Hoeve, Abbey Schepers, Johannes Morreau, Johannes J. Bonenkamp, Adriana C. H. van Engen–van Grunsven, Schelto Kruijff, Bettien M. van Hemel et al. · 2017 · Oncotarget
- HIF signalling: The eyes have itDaniel J. Peet, Thaksaon Kittipassorn, John P. M. Wood, Glyn Chidlow, Robert James Casson · 2017 · Experimental Cell Research
- Fundamental roles for hypoxia signalling in adipose tissue metabolism and inflammation in obesityZoi Michailidou · 2019 · Current Opinion in Physiology
- Engineering strategies to capture the biological and biophysical tumor microenvironment in vitroMatthew L. Tan, Ling Lu, Claudia Fischbach · 2021 · Advanced Drug Delivery Reviews
- Adipocyte HIF2α functions as a thermostat via PKA Cα regulation in beige adipocytesJi Seul Han, Yong Geun Jeon, Minsik Oh, Gung Lee, Hahn Nahmgoong, Sang Mun Han, Jeehye Choi, Ye Young Kim, Kyung Cheul Shin, Jiwon Kim et al. · 2022 · Nature Communications
- Involvement of c-Myc in the proliferation of MCF-7 human breast cancer cells induced by bHLH transcription factor DEC2Yunyan Wu, Hidenobu Sato, Takahiro Suzuki, Tadashi Yoshizawa, Satoko Morohashi, Hiroko Seino, Takeshi Kawamoto, Katsumi Fujimoto, Yukio Kato, Hiroshi Kijima · 2014 · International Journal of Molecular Medicine
- A HIF-1α-driven feed-forward loop augments HIF signalling in Hep3B cells by upregulation of ARNTMarkus Mandl, M-K Lieberum, Reinhard Depping · 2016 · Cell Death and Disease
- Hypoxia inducible factor 1α in hepatocellular carcinoma with cirrhosis: Association with prognosisDan Wang, Xiaojing Zhang, Yapeng Lu, Xueting Wang, Li Zhu · 2018 · Pathology - Research and Practice
- DJ-1 promotes survival of human colon cancer cells under hypoxia by modulating HIF-1α expression through the PI3K-AKT pathwayHong Zheng, Chao Zhou, Xiao Lu, Quanxing Liu, Minqiang Liu, Guoqing Chen, Weigang Chen, Shuai Wang, Yuan Qiu · 2018 · Cancer Management and Research