HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

Keith, Brian, Johnson, Randall S., Simon, M. Celeste·2012·Nature Reviews Cancer

Cited by (1,008)

Items 701–800 of 1,008

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  5. Hypoxia-inducible factor-2 alpha up-regulates CD70 under hypoxia and enhances anchorage-independent growth and aggressiveness in cancer cells
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  6. Acute and chronic hypoxia differentially predispose lungs for metastases
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  7. Antianemia Drug Roxadustat (FG-4592) Protects Against Doxorubicin-Induced Cardiotoxicity by Targeting Antiapoptotic and Antioxidative Pathways
    Guangfeng Long, Hongbing Chen, Mengying Wu, Yuanyuan Li, Ling Gao, Songming Huang, Yue Zhang, Zhanjun Jia, Weiwei Xia · 2020 · Frontiers in Pharmacology
  8. ERK signaling controls productive HIF‐1 binding to chromatin and cancer cell adaptation to hypoxia through HIF‐1α interaction with NPM1
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  10. MicroRNA-29 Ameliorates Fibro-Inflammation and Insulin Resistance in HIF1α-Deficient Obese Adipose Tissue by Inhibiting Endotrophin Generation
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  11. Activity of a first-in-class oral HIF2-alpha inhibitor, PT2385, in patients with first recurrence of glioblastoma
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  13. HIF1A-dependent increase in endothelin 2 levels in granulosa cells: role of hypoxia, LH/cAMP, and reactive oxygen species
    Ronit Yalu, Adepeju Esther Oyesiji, Iris Eisenberg, Tal Imbar, Rina Meidan · 2014 · Reproduction
  14. SerpinB3 and Yap Interplay Increases Myc Oncogenic Activity
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  15. Role of Hypoxia and HIF2α in Development of the Sympathoadrenal Cell Lineage and Chromaffin Cell Tumors with Distinct Catecholamine Phenotypic Features
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  16. Deubiquitylase OTUD6B stabilizes the mutated pVHL and suppresses cell migration in clear cell renal cell carcinoma
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  17. The Role of Hypoxia-Inducible Factor Isoforms in Breast Cancer and Perspectives on Their Inhibition in Therapy
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  18. The role of HIF in angiogenesis, lymphangiogenesis, and tumor microenvironment in urological cancers
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  19. Hypoxia-associated autophagy flux dysregulation in human cancers
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  20. Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development
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  21. Current views on cell metabolism in SDHx-related pheochromocytoma and paraganglioma
    Aleš Vícha, David Taïeb, Karel Pacák · 2014 · Endocrine Related Cancer
  22. NECAB3 Promotes Activation of Hypoxia-inducible factor-1 during Normoxia and Enhances Tumourigenicity of Cancer Cells
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  23. The hypoxia signalling pathway in haematological malignancies
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  25. Sensitivity of VHL mutant kidney cancers to HIF2 inhibitors does not require an intact p53 pathway
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  26. Effect of chronic intermittent hypoxia-induced HIF-1α/ATAD2 expression on lung cancer stemness
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  27. Hypoxia-inducible Factor-2α-dependent Hypoxic Induction of Wnt10b Expression in Adipogenic Cells
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  29. Wild-type IDH2 is a therapeutic target for triple-negative breast cancer
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  31. RIG-I Resists Hypoxia-Induced Immunosuppression and Dedifferentiation
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  33. Current Landscape and the Potential Role of Hypoxia-Inducible Factors and Selenium in Clear Cell Renal Cell Carcinoma Treatment
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  34. The uremic toxin p-cresyl sulfate induces proliferation and migration of clear cell renal cell carcinoma via microRNA-21/ HIF-1α axis signals
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  35. A genetic mouse model of severe iron deficiency anemia reveals tissue-specific transcriptional stress responses and cardiac remodeling
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  36. IDH2 reprograms mitochondrial dynamics in cancer through a HIF‐1α‐regulated pseudohypoxic state
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  37. Hypoxia favors chemoresistance in T-ALL through an HIF1α-mediated mTORC1 inhibition loop
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  38. Both Hypoxia-Inducible Factor 1 and MAPK Signaling Pathway Attenuate PI3K/AKT via Suppression of Reactive Oxygen Species in Human Pluripotent Stem Cells
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  40. Hypoxia-Inducible Factors in Cancer
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  42. TNFα induces expression of HIF‐1α mRNA and protein but inhibits hypoxic stimulation of HIF‐1 transcriptional activity in airway smooth muscle cells
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  43. Diverse Mechanisms of Sp1-Dependent Transcriptional Regulation Potentially Involved in the Adaptive Response of Cancer Cells to Oxygen-Deficient Conditions
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  44. Development of single nanometer-sized ultrafine oxygen bubbles to overcome the hypoxia-induced resistance to radiation therapy via the suppression of hypoxia-inducible factor‑1α
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  45. Hypoxia drives shared and distinct transcriptomic changes in two invasive glioma stem cell lines
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  46. Chondroitin Sulfate Proteoglycan CSPG4 as a Novel Hypoxia-Sensitive Marker in Pancreatic Tumors
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  47. TRIM2 directly deubiquitinates and stabilizes Snail1 protein, mediating proliferation and metastasis of lung adenocarcinoma
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  55. Identification and Development of Cyclic Peptide Inhibitors of Hypoxia Inducible Factors 1 and 2 That Disrupt Hypoxia-Response Signaling in Cancer Cells
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