HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

Keith, Brian, Johnson, Randall S., Simon, M. Celeste·2012·Nature Reviews Cancer

DOI 10.1038/nrc3183

Cited by (1,008)

Items 801–900 of 1,008

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William J. Fredericks, Hankun Yin, Priti Lal, Puthiyaveettil N. Raghunath, S. Bruce Malkowicz, Nathaniel Fredericks, John Tomaszewski, Frank J. Rauscher, S. Bruce Malkowicz · 2013 · International Journal of Oncology
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Klotho negatively regulated aerobic glycolysis in colorectal cancer via ERK/HIF1α axis
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Hayriye Tatlı Doğan, Merve Meryem Kıran, Burak Bi̇lgi̇n, Aydan Kılıçarslan, Mehmet Alı Nahıt Şendur, Bülent Yalçın, A. Ardıçoğlu, Ali Fuat Atmaca, Berrak Gümüşkaya · 2018 · Diagnostic Pathology
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PLGA–Nano-Encapsulated Disulfiram Inhibits Hypoxia-Induced NF-κB, Cancer Stem Cells, and Targets Glioblastoma In Vitro and In Vivo
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HIF2α activation and mitochondrial deficit due to iron chelation cause retinal atrophy
Yang Kong, Pei‐Kang Liu, Yao Li, Nicholas David Nolan, Peter M. J. Quinn, Chun‐Wei Hsu, Laura A. Jenny, Jin Zhao, Xuan Cui, Ya‐Ju Chang et al. · 2023 · EMBO Molecular Medicine
14-3-3σ-NEDD4L axis promotes ubiquitination and degradation of HIF-1α in colorectal cancer
Sicheng Liu, Rui Guo, Xu Hui, Jinneng Yang, Haidan Luo, Sai‐Ching J. Yeung, Kai Li, Mong‐Hong Lee, Runxiang Yang · 2023 · Cell Reports
The expression of the BPIFB4 and CXCR4 associates with sustained health in long-living individuals from Cilento-Italy
Gaia Spinetti, Elena Sangalli, Claudia Specchia, Francesco Villa, Chiara Spinelli, Rita Pipolo, Albino Carrizzo, Simona Greco, Christine Voellenkle, Carmine Vecchione et al. · 2017 · Aging
Sanguinarine disrupts the colocalization and interaction of HIF‐1α with tyrosine and serine phosphorylated‐STAT3 in breast cancer
Qi Su, Jingjing Wang, Mengying Fan, Mohsin Ahmad Ghauri, Asmat Ullah, Bo Wang, Bingling Dai, Yingzhuan Zhan, Dongdong Zhang, Yanmin Zhang · 2020 · Journal of Cellular and Molecular Medicine
Trends in Bone Metastasis Modeling
Roberta Laranga, Serena Duchi, Toni Ibrahim, Ania Naila Guerrieri, Davide María Donati, Enrico Lucarelli · 2020 · Cancers
Targeting glycolytic pathway in fibroblast-like synoviocytes for rheumatoid arthritis therapy: challenges and opportunities
Qianwei Li, Yuehong Chen, Huan Liu, Yunru Tian, Geng Yin, Qibing Xie · 2023 · Inflammation Research
Long non-coding RNA lung cancer-associated transcript-1 promotes glioblastoma progression by enhancing Hypoxia-inducible factor 1 alpha activity
Haidong Huang, Hariti Shah, Hao Jing, Jianhong Lin, Richard A. Prayson, Liangqi Xie, Shideng Bao, Abhishek A. Chakraborty, Eckhard Jankowsky, Jianjun Zhao et al. · 2024 · Neuro-Oncology
Moderate, chronic ethanol feeding exacerbates carbon tetrachloride–induced hepatic fibrosis via hepatocyte‐specific hypoxia‐inducible factor 1α
Sanjoy Roychowdhury, Dian Jung Chiang, Megan R. McMullen · 2014 · Pharmacology Research & Perspectives
Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation
Fu, Chenglai, Tyagi, Richa, Chin, Alfred C., Rojas, Tomas, Li, Ruo-Jing, Guha, Prasun, Bernstein, Isaac A., Rao, Feng, Xu, Risheng, Cha, Jiyoung Y. et al. · 2018 · Circulation Research
Hypoxia and Hormone-Mediated Pathways Converge at the Histone Demethylase KDM4B in Cancer
Jun Yang, Adrian Llewellyn Harris, Andrew M. Davidoff · 2018 · International Journal of Molecular Sciences
Controlling the Phenotype of Tumor-Infiltrating Macrophages via the PHD-HIF Axis Inhibits Tumor Growth in a Mouse Model
Shunji Nishide, Shinji Matsunaga, Masayuki Shiota, Takehiro Yamaguchi, Shojiro Kitajima, Yoichi Maekawa, Norihiko Takeda, Michio Tomura, Junji Uchida, Katsuyuki Miura et al. · 2019 · iScience
SerpinB3 Differently Up-Regulates Hypoxia Inducible Factors -1α and -2α in Hepatocellular Carcinoma: Mechanisms Revealing Novel Potential Therapeutic Targets
Stefania Cannito, Beatrice Foglia, Gianmarco Villano, Cristian Turato, Teresa C. Delgado, Elisabetta Morello, Fabrizio Pin, Erica Novo, Lucia Napione, Santina Quarta et al. · 2019 · Cancers
Monocytes and Macrophages in Cancer: Unsuspected Roles
Sofia Gouveia-Fernandes · 2020 · Advances in experimental medicine and biology
Metabolic modulation during intestinal fibrosis
Simon Bos, Debby Laukens · 2020 · Journal of Digestive Diseases
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Magdelyn Mei-Theng Wong, Hui-Yin Chan, Norazlin Abdul Aziz, Thamil Selvee Ramasamy, Jan Jin Bong, Ewe Seng Ch’ng, Subasri Armon, Suat‐Cheng Peh, Sin‐Yeang Teow · 2021 · Molecular Biology Reports
Hypoxia-Mediated Complement 1q Binding Protein Regulates Metastasis and Chemoresistance in Triple-Negative Breast Cancer and Modulates the PKC-NF-κB-VCAM-1 Signaling Pathway
Hao Wu, Yijun Chu, Shanshan Sun, Guozheng Li, Shouping Xu, Xianyu Zhang, Yongdong Jiang, Song Gao, Qin Wang, Jian Zhang et al. · 2021 · Frontiers in Cell and Developmental Biology
Autophagy in adipogenesis: Molecular mechanisms and regulation by bioactive compounds
Faizullah Khan, Haroon Zaman Khan, Ajmal Khan, Masao Yamasaki, Naïma Moustaïd‐Moussa, Ahmed Al-Harrasi, Shaikh Mizanoor Rahman · 2022 · Biomedicine & Pharmacotherapy
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WonSeok William Choi, Julia L. Boland, Akshar Kalola, Jianqing Lin · 2023 · Current Oncology Reports
Pheochromocytoma: Gasping for Air
Ivana Jochmanová, Zhengping Zhuang, Karel Pacák · 2015 · Hormones and Cancer
Patterning hypoxic multicellular spheroids in a 3D matrix – a promising method for anti‐tumor drug screening
Jingyun Ma, Xu Zhang, Yang Liu, Haibo Yu, Lianqing Liu, Yang Shi, Yanfeng Li, Jianhua Qin · 2015 · Biotechnology Journal
Effect of hypoxia-inducible factors in normal and leukemic stem cell regulation and their potential therapeutic impact
Kevin Rouault‐Pierre, Ashley Hamilton, Dominique A. Bonnet · 2015 · Expert Opinion on Biological Therapy
Regulation of glucose metabolism by p62/SQSTM1 through HIF1α
Ke Chen, Jin Zeng, Haibing Xiao, Chunhua Huang, Junhui Hu, Weimin Yao, Yu Gan, Wei Xiao, Hua Xu, Zhangqun Ye · 2016 · Journal of Cell Science
Gene network analysis reveals a novel 22-gene signature of carbon metabolism in hepatocellular carcinoma
Jinqiang Zhang, Melody Baddoo, Chang Han, Michael J. Strong, Jennifer Cvitanovic, Krzysztof Moroz, Srikanta Dash, Erik K. Flemington, Tong Wu · 2016 · Oncotarget
Correlation of c-MET Expression with PD-L1 Expression in Metastatic Clear Cell Renal Cell Carcinoma Treated by Sunitinib First-Line Therapy
Solène‐Florence Kammerer‐Jacquet, Sarah Médane, Karim Bensalah, Jean‐Christophe Bernhard, Mokrane Yacoub, Frantz Dupuis, Alain Ravaud, Grégory Verhoest, Romain Mathiéu, B. Peyronnet et al. · 2017 · Targeted Oncology
Hypoxia-induced suppression of c-Myc by HIF-2α in human pulmonary endothelial cells attenuates TFAM expression
Ali J. Zarrabi, Derrick D. Kao, Dustin T. Nguyen, Joseph Loscalzo, Diane E. Handy · 2017 · Cellular Signalling
Hepatocyte-specific HIF-1α ablation improves obesity-induced glucose intolerance by reducing first-pass GLP-1 degradation
Yun Sok Lee, Matthew Riopel, Pedro Cabrales, Guatam K. Bandyopadhyay · 2019 · Science Advances
Multiple Faces of the Glioblastoma Microenvironment
Șovrea, Alina Simona, Boșca, Bianca, Melincovici, Carmen Stanca, Constantin, Anne-Marie, Crintea, Andreea, Mărginean, Mariana, Dronca, Eleonora, Jianu, Mihaela Elena, Suflețel, Rada, Gonciar, Diana et al. · 2022 · International Journal of Molecular Sciences
Hypoxia in Skin Cancer: Molecular Basis and Clinical Implications
Sungmi Jeon, Miyeon Jeon, Sanga Choi, Seongkyeong Yoo, Soo-Hyun Park, Mingyu Lee, Iljin Kim · 2023 · International Journal of Molecular Sciences
Longitudinal dynamics of the tumor hypoxia response: From enzyme activity to biological phenotype
Sandy Che-Eun S. Lee, Andrea Hye An Pyo, Marianne Koritzinsky · 2023 · Science Advances
MED15 is upregulated by HIF-2α and promotes proliferation and metastasis in clear cell renal cell carcinoma via activation of SREBP-dependent fatty acid synthesis
Xiaoliang Hua, Shengdong Ge, Li Zhang, Qing Yan Jiang, Juan Chen, Haibing Xiao, Chang Yin Liang · 2024 · Cell Death Discovery
Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges
Martin Schneider, Jonathan M. Harnoss, Moritz J. Strowitzki, Praveen Radhakrishnan, Lisa Katharina Platzer, Julian Camill Harnoss, Thomas P. Hank, Jun Cai, Alexis B. Ulrich · 2015 · Hypoxia
Hypoxia-Inducible Factor1-Α (HIF1α) and Vascular Endothelial Growth Factor-A (VEGF-A) Expression in De Novo AML Patients
Mohammad Jabari, Mehdi Allahbakhshian Farsani, Sina Salari, Mohsen Hamidpour, Vahid Amiri, Mohammad Hossein Mohammadi · 2019 · Asian Pacific Journal of Cancer Prevention
von Hippel-Lindau mutants in renal cell carcinoma are regulated by increased expression of RSUME
Lucas Tedesco, Belén Elguero, David Gonilski‐Pacin, Sergio A. Senin, Cora Pollak, Patricio Aitor García Marchiñena, Alberto M. Jurado, Mariana Isola, Maria Jose Labanca, Martín Palazzo et al. · 2019 · Cell Death and Disease
NRF 2/ ABCB 1‐mediated efflux and PARP 1‐mediated dampening of DNA damage contribute to doxorubicin resistance in chronic hypoxic HepG2 cells
Xiangwen Xia, Qi Wang, Tianhe Ye · 2019 · Fundamental and Clinical Pharmacology
A stroma‐related lncRNA panel for predicting recurrence and adjuvant chemotherapy benefit in patients with early‐stage colon cancer
Rui Zhou, Huiying Sun, Siting Zheng, Jingwen Zhang, Dongqiang Zeng, Jianhua Wu, Zhenhua Huang, Xiaoxiang Rong, Jianping Bin, Yulin Liao et al. · 2020 · Journal of Cellular and Molecular Medicine
Seasonal and regional changes in temperature projections over the Arabian Peninsula based on the CMIP5 multi-model ensemble dataset
Mansour Almazroui, M. Salman Khalid, M. Nazrul Islam, Sajjad Saeed · 2020 · Atmospheric Research
Calcitriol Suppresses HIF-1 and HIF-2 Transcriptional Activity by Reducing HIF-1/2α Protein Levels via a VDR-Independent Mechanism
Ioanna‐Maria Gkotinakou, Eleni Kechagia, Kalliopi Pazaitou‐Panayiotou, Ilias Mylonis, Panagiotis Liakos, Andreas K. Tsakalof · 2020 · Cells
Vadadustat for anemia in chronic kidney disease patients on peritoneal dialysis: A phase 3 open‐label study in Japan
Masaomi Nangaku, Kazuoki Kondo, Souichirou Takabe, Kiichiro Ueta, Genki Kaneko, Makiko Otsuka, Yutaka Kawaguchi, Yasuhiro Komatsu · 2020 · Therapeutic Apheresis and Dialysis
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Mutian Lian, Maria Mortoglou, Pinar Uysal Onganer · 2023 · Current Issues in Molecular Biology
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Ahmed Haddad, Vitaly Margulis · 2015 · Nature Reviews Urology
Regulation of CLL survival by hypoxia‐inducible factor and its target genes
Idit Shachar, Sivan Cohen, Ayelet Marom, Shirly Becker-Herman · 2012 · FEBS Letters
Hypoxia targeted bifunctional suicide gene expression enhances radiotherapy in vitro and in vivo
Xiaorong Sun, Ligang Xing, Xuelong Deng · 2012 · Radiotherapy and Oncology
Reprogramming the Transcriptional Response to Hypoxia with a Chromosomally Encoded Cyclic Peptide HIF-1 Inhibitor
Ishna N. Mistry, Ali Tavassoli · 2016 · ACS Synthetic Biology
Mint3-mediated L1CAM expression in fibroblasts promotes cancer cell proliferation via integrin α5β1 and tumour growth
Hiroki J. Nakaoka, Zen‐ichi Tanei, Toshiro Hara, J S Weng, Akane Kanamori, Tomoatsu Hayashi, Hiroshi Sato, Akira Orimo, Kazutaka Otsuji, Keiichiro Tada et al. · 2017 · Oncogenesis
BMPR2 and HIF1-α overexpression in resected osteosarcoma correlates with distant metastasis and patient survival
Shidong Wang, Tingting Ren, Yi Huang, Xing Bao, Kunkun Sun, Danhua Shen, Wei Guo · 2017 · Chinese Journal of Cancer Research
The evaluation of potent antitumor activities of shikonin coumarin-carboxylic acid, PMMB232 through HIF-1α-mediated apoptosis
Hongwei Han, Chao-Sai Zheng, So Jeong Chu, Wenxue Sun, Lujing Han, Rongwu Yang, Jinliang Qi, Guihua Lu, Xiaoming Wang, Yonghua Yang · 2017 · Biomedicine & Pharmacotherapy
Reactive Oxygen Species Signaling Promotes Hypoxia-Inducible Factor 1 α Stabilization in Sonic Hedgehog-Driven Cerebellar Progenitor Cell Proliferation
Nicholas W. Eyrich, Chad R. Potts, M. Hope Robinson, Victor D Maximov, Anna Marie Kenney · 2019 · Molecular and Cellular Biology
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David F. Adams, Mark S. Watkins, Luc Durette, Josée Laliberté, Félix Goulet, Elaine Debien, Kendall S. Frazier, Nacéra Mellal, Liangfu Chen, Wei Shi et al. · 2019 · Toxicologic Pathology
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Miaomiao Wu, Lidong Sun, Tanjing Song · 2024 · Frontiers in Molecular Biosciences
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Aziz Eftekhari, Usman Sabir, Takhar Kasumov · 2025 · Pharmacology & Therapeutics
Glioblastoma Multiforme and Adult Neurogenesis in the Ventricular‐Subventricular Zone: A Review
Claudia Capdevila, Lucía Rodríguez‐Vázquez, Joaquı́n Martı́ · 2016 · Journal of Cellular Physiology
FoxM1 is regulated by both HIF-1α and HIF-2α and contributes to gastrointestinal stromal tumor progression
Chenguang Bai, Xiaohong Liu, Cen Qiu, Jianming Zheng · 2018 · Gastric Cancer
ERO1L promotes pancreatic cancer cell progression through activating the Wnt/catenin pathway
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Manqing Cao, Junrong Gao, Hongyuan Zhou, Jiafei Huang, A‐Bin You, Zhigui Guo, Feng Fang, Wei Zhang, Tianqiang Song, Ti Zhang · 2015 · Tumor Biology
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Isabella Spinello, Maria Teresa Quaranta, Rosa Paolillo, Elvira Pelosi, Annamaria Cerio, Ernestina Saulle, F. L. Coco, Ugo Testa, Catherine Labbaye · 2015 · Haematologica
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Aya Yoshimura, Shinichi Nishimura, Saori Otsuka, Akira Hattori, Hideaki Kakeya · 2015 · Organic Letters
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Chunyan Li, Tao Liu, Alexandr V. Bazhin, Yuhui Yang · 2016 · Journal of Cellular Physiology
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Zhengang Yu, Bing‐Zhe Wang, Zhaozhong Cheng · 2017 · The Kaohsiung Journal of Medical Sciences
Translational repression of HIF2α expression in mice with Chuvash polycythemia reverses polycythemia
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Yanmei Liu, Shenpeng Ying, Ying-Rui Huang, Yin Pan, Weijun Chen, Lingqin Ni, Jinye Xu, Qinyan Shen, Yong Liang · 2015 · World Journal of Surgical Oncology
The NOTCH1-dependent HIF1α/VGLL4/IRF2BP2 oxygen sensing pathway triggers erythropoiesis terminal differentiation
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P4HA2 ‐mediated HIF ‐1α stabilization promotes erdafitinib‐resistance in FGFR3 ‐alteration bladder cancer
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NNT‐induced tumor cell “slimming” reverses the pro‐carcinogenesis effect of HIF2a in tumors
Zhiyong Xiong, Wei Xiong, Wen Xiao, Changfei Yuan, Jian Shi, Yu Huang, Cheng Wang, Xiangui Meng, Zhixian Chen, Hongmei Yang et al. · 2021 · Clinical and Translational Medicine
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Kuzuoglu-Ozturk, Duygu, Nguyen, Hao G., Xue, Lingru, Figueredo, Emma, Subramanyam, Vishvak, Liu, Isabelle, Bonitto, Kenya, Noronha, Ashish, Dabrowska, Adrianna, Cowan, Janet E. et al. · 2025 · Cancer Cell
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Shaopeng Wang, Yu‐Dong Cai · 2017 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
The von Hippel–Lindau Tumor Suppressor Protein
William G. Kaelin · 2018 · Annual Review of Cancer Biology
Hypoxia-induced USP22-BMI1 axis promotes the stemness and malignancy of glioma stem cells via regulation of HIF-1α
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