HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

Keith, Brian, Johnson, Randall S., Simon, M. Celeste·2012·Nature Reviews Cancer

DOI 10.1038/nrc3183

Cited by (1,008)

Items 301–400 of 1,008

Restricted Expression of miR-30c-2-3p and miR-30a-3p in Clear Cell Renal Cell Carcinomas Enhances HIF2α Activity
Lijoy K. Mathew, S S Lee, Nicolas Skuli, Shilpa J. Rao, Brian Keith, Katherine L. Nathanson, Priti Lal, Marie Celeste Simon · 2013 · Cancer Discovery
MicroRNA-126 Suppresses Mesothelioma Malignancy by Targeting IRS1 and Interfering with the Mitochondrial Function
Marco Tomasetti, Linda Nocchi, Sara Staffolani, Nicola Manzella, Monica Amati, Jacob Goodwin, Katarína Kľučková, Maria Nga Nguyen, Elisabetta Strafella, Martina Bajzíková et al. · 2014 · Antioxidants and Redox Signaling
The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia
Jingwei Sim, Andrew S. Cowburn, Asís Palazón, Basetti Madhu, Petros A. Tyrakis, David Macías, David Bargiela, Sandra Pietsch, Michael Gralla, Colin E. Evans et al. · 2018 · Cell Metabolism
TRIB3 Promotes the Proliferation and Invasion of Renal Cell Carcinoma Cells via Activating MAPK Signaling Pathway
Baoan Hong, Jingcheng Zhou, Kaifang Ma, Jiufeng Zhang, Haibiao Xie, Kenan Zhang, Lei Li, Lin Cai, Ning Zhang, Zhongyuan Zhang et al. · 2019 · International Journal of Biological Sciences
High aldehyde dehydrogenase activity enhances stem cell features in breast cancer cells by activating hypoxia-inducible factor-2α
Ran‐Ju Kim, Jeong-Ran Park, Kyung‐Jin Roh, A-Ram Choi, Soo‐Rim Kim, Pyeung-Hyeun Kim, Jong Han Yu, Jong Won Lee, Sei Hyun Ahn, Gyungyub Gong et al. · 2012 · Cancer Letters
Molecular Crosstalk Between MYC and HIF in Cancer
Yanping Li, Xiao‐Xin Sun, David Z. Qian, Mu‐Shui Dai · 2020 · Frontiers in Cell and Developmental Biology
Molecular Pathways: Emerging Pathways Mediating Growth, Invasion, and Metastasis of Tumors Progressing in an Irradiated Microenvironment
François Kuonen, Chiara Secondini, Curzio Rüegg · 2012 · Clinical Cancer Research
2-Methoxyestradiol synergizes with sorafenib to suppress hepatocellular carcinoma by simultaneously dysregulating hypoxia-inducible factor-1 and -2
Li Ma, Guangxin Li, Huaqiang Zhu, Xuesong Dong, Dali Zhao, Xian Li Jiang, Jie Li, Haiquan Qiao, Shaobin Ni, Xueying Sun · 2014 · Cancer Letters
Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses
Joanna Obacz, Silvia Pastoreková, Borek Vojtesek, Roman Hrstka · 2013 · Molecular Cancer
Novel cancer treatment paradigm targeting hypoxia-induced factor in conjunction with current therapies to overcome resistance
Kao, Ting-Wan, Bai, Geng-Hao, Wang, Tian-Li, Shih, Ie-Ming, Chuang, Chi-Mu, Lo, Chun-Liang, Tsai, Meng-Chen, Chiu, Li-Yun, Lin, Chu-Chien, Shen, Yao-An · 2023 · Journal of Experimental & Clinical Cancer Research
GATA3 interacts with and stabilizes HIF-1α to enhance cancer cell invasiveness
M-C Lin, Jing‐Jer Lin, C-L Hsu, Hsueh‐Fen Juan, Pei‐Jen Lou, M-C Huang · 2017 · Oncogene
Dynamin 2 along with microRNA-199a reciprocally regulate hypoxia-inducible factors and ovarian cancer metastasis
Hemant P. Joshi, Indira V. Subramanian, Erica K. Schnettler, Goutam Ghosh, Rajesha Rupaimoole, Colleen Evans, Manju Saluja, Yawu Jing, Cristina Ivan, Sabita Roy et al. · 2014 · Proceedings of the National Academy of Sciences
Hypoxia and Hypoxia-Inducible Factors in Leukemias
Margaux Deynoux, Nicola J. Sunter, Olivier Hérault, Frédéric Mazurier · 2016 · Frontiers in Oncology
Novel Drugs with High Efficacy against Tumor Angiogenesis
Shiyu Qi, Shoulong Deng, Zhengxing Lian, Kun Yu · 2022 · International Journal of Molecular Sciences
LSD1 sustains pancreatic cancer growth via maintaining HIF1α-dependent glycolytic process
Yi Qin, Wenwei Zhu, Wenyan Xu, Bo Zhang, Si Shi, Shunrong Ji, Jiang Liu, Jiang Long, Chen Liu, Liang Liu et al. · 2014 · Cancer Letters
Hypoxia activates Wnt/β-catenin signaling by regulating the expression of BCL9 in human hepatocellular carcinoma
Xu, Wei, Zhou, Wang, Cheng, Mo, Wang, Jing, Liu, Zhian, He, Shaohui, Luo, Xiangji, Huang, Wending, Chen, Tianrui, Yan, Wangjun et al. · 2017 · Scientific Reports
Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis
X-D Liu, Jun Yao, Durga Nand Tripathi, Z Ding, Yunlong Xu, Mianen Sun, Jinhan Zhang, Shanshan Bai, Péter Germán, Anh G. Hoang et al. · 2014 · Oncogene
A General Framework for Interrogation of mRNA Stability Programs Identifies RNA-Binding Proteins that Govern Cancer Transcriptomes
Gabrielle Perron, Pouria Jandaghi, Shraddha Solanki, Maryam Safisamghabadi, Cristina Storoz, Mehran Karimzadeh, Andreas Ioannis Papadakis, Madeleine Arseneault, Ghislaine Scélo, Rosamonde Elizabeth Banks et al. · 2018 · Cell Reports
Adenylate kinase 4 modulates oxidative stress and stabilizes HIF-1α to drive lung adenocarcinoma metastasis
Yi‐Hua Jan, Tsung‐Ching Lai, Chih‐Jen Yang, Yuan‐Feng Lin, Ming-Shyan Huang, Michael Hsiao · 2019 · Journal of Hematology & Oncology
Modifying the Tumour Microenvironment: Challenges and Future Perspectives for Anticancer Plasma Treatments
Angela Privat‐Maldonado, Charlotta Bengtson, Jamoliddin Razzokov, Evelien Smits, Annemie Bogaerts · 2019 · Cancers
Aging Reprograms the Hematopoietic-Vascular Niche to Impede Regeneration and Promote Fibrosis
Yutian Chen, Qiang Pu, Yongyuan Ma, Hua Zhang, Tinghong Ye, Chengjian Zhao, Xiaojuan Huang, Yafeng Ren, Lina Qiao, Hanmin Liu et al. · 2020 · Cell Metabolism
Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF‐2 pathway
Emma J. Hodson, Lynn G. Nicholls, Philip J. Turner, Ronan Llyr, James W. Fielding, Gillian Douglas, Indrika Ratnayaka, Peter A. Robbins, Christopher William Pugh, Keith J. Buckler et al. · 2015 · The Journal of Physiology
AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms
Antero Salminen, Kai Kaarniranta, Anu Kauppinen · 2016 · Biogerontology
Hypoxia-induced autophagy as an additional mechanism in human osteosarcoma radioresistance
Helin Feng, Jin Wang, Wei Chen, Baoen Shan, Yin Guo, Jianfa Xu, Ling Wang, Peng Guo, Yingze Zhang · 2016 · Journal of bone oncology
Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma
Hu, Junhui, Tan, Ping, Ishihara, Moe, Bayley, Nicholas A., Schokrpur, Shiruyeh, Reynoso, Jeremy G., Zhang, Yangjun, Lim, Raymond J., Dumitras, Camelia, Yang, Lu et al. · 2023 · Signal Transduction and Targeted Therapy
WSB1 promotes tumor metastasis by inducing pVHL degradation
Kim, Jung Jin, Lee, Seung Baek, Jang, Jinsung, Yi, Sang-Yeop, Kim, Sun-Hyun, Han, Sang-Ah, Lee, Jong-Min, Tong, Seo-Yun, Vincelette, Nicole D., Gao, Bowen et al. · 2015 · Genes & Development
Enhanceosomes as integrators of hypoxia inducible factor (HIF) and other transcription factors in the hypoxic transcriptional response
Matthew R. Pawlus, Cheng‐Jun Hu · 2013 · Cellular Signalling
SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer
Chenxia He, Jeanne M. Danes, Peter C. Hart, Yueming Zhu, Yunping Huang, Andre Luelsdorf de Abreu, Joseph O’Brien, Angela Mathison, Binwu Tang, Jonna M. Frasor et al. · 2019 · Proceedings of the National Academy of Sciences
Integrating tumor hypoxic stress in novel and more adaptable strategies for cancer immunotherapy
Raefa Abou Khouzam, Goutham Hassan Venkatesh, Rania Faouzi Zaarour, Ali N. Chamseddine, Amirtharaj Francis, Stéphanie Buart, Stéphane Terry, Salem Chouaı̈b · 2020 · Seminars in Cancer Biology
Lycopene Prevents DEHP-Induced Liver Lipid Metabolism Disorder by Inhibiting the HIF-1α-Induced PPARα/PPARγ/FXR/LXR System
Yi Zhao, De-Xing Ma, Hongguang Wang · 2020 · Journal of Agricultural and Food Chemistry
MYC and HIF in shaping immune response and immune metabolism
JN Rashida Gnanaprakasam, John William Sherman, Ruoning Wang · 2017 · Cytokine & Growth Factor Reviews
Wild-type IDH2 promotes the Warburg effect and tumor growth through HIF1α in lung cancer
Jiangjiang Li, Ya He, Zheqiong Tan, Jingchen Lu, Liling Li, Xin Song, Feng Shi, Longlong Xie, Shuo You, Xiangjian Luo et al. · 2018 · Theranostics
Breast Cancer Heterogeneity and Response to Novel Therapeutics
Mariona Baliu‐Piqué, Atanasio Pandiella, Alberto Ocaña · 2020 · Cancers
Targeting HIF-2α in the Tumor Microenvironment: Redefining the Role of HIF-2α for Solid Cancer Therapy
Davis, Leah, Recktenwald, Matthias, Hutt, Evan, Fuller, Schuyler, Briggs, Madison, Goel, Arnav, Daringer, Nichole · 2022 · Cancers
The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction
Kazuhiko Yamamura, Takehito Uruno, Akira Shiraishi, Yoshihiko Tanaka, Miho Ushijima, Takeshi Nakahara, Mayuki Watanabe, Makiko Kido‐Nakahara, Ikuya Tsuge, Masutaka Furue et al. · 2017 · Nature Communications
Hypoxia and inflammatory bowel disease
Eoin P. Cummins, Daniel Crean · 2016 · Microbes and Infection
Hypoxia-active nanoparticles used in tumor theranostic
Yaqin Wang, Wenting Shang, Meng Niu, Jie Tian, Ke Xu · 2019 · International Journal of Nanomedicine
HIF1α is a regulator of hematopoietic progenitor and stem cell development in hypoxic sites of the mouse embryo
Parisa Imanirad, Parham Solaimani Kartalaei, Mihaela Crisan, Chris Sebastiaan Vink, Tomoko Yamada-Inagawa, Emma de Pater, Dorota Kurek, Polynikis Kaimakis, Reiner van der Linden, Nancy A. Speck et al. · 2013 · Stem Cell Research
Transient HIF2A inhibition promotes satellite cell proliferation and muscle regeneration
Liwei Xie, Amelia Yin, Anna S. Nichenko, Aaron M. Beedle, Jarrod A. Call, Hang Yin · 2018 · Journal of Clinical Investigation
miR-147b-mediated TCA cycle dysfunction and pseudohypoxia initiate drug tolerance to EGFR inhibitors in lung adenocarcinoma
Wen Cai Zhang, Julie M. Wells, Kin-Hoe Chow, He Huang, Min Yuan, Tanvi Saxena, Mary Ann Melnick, Katerina A. Politi, John M. Asara, Daniel Botelho Costa et al. · 2019 · Nature Metabolism
Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming
Bernadette M. M. Zwaans, David B. Lombard · 2014 · Disease Models & Mechanisms
Hypoxia and antitumor CD8+ T cells: An incompatible alliance?
Romain Vuillefroy de Silly, Pierre‐Yves Dietrich, Paul R. Walker · 2016 · OncoImmunology
Hypoxia-inducible factor-1α plays roles in Epstein-Barr virus’s natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter
Richard J. Kraus, Xianming Yu, Blue-leaf A. Cordes, Saraniya Sathiamoorthi, Tawin Iempridee, Dhananjay M. Nawandar, Shidong Ma, James C. Romero-Masters, Kyle McChesney, Zhen Nan Lin et al. · 2017 · PLoS Pathogens
The twisted survivin connection to angiogenesis
Cristobal T. Sanhueza, Sergio Wehinger, J. Bennett, Manuel Valenzuela, Gareth I. Owen, Andrew F. G. Quest · 2015 · Molecular Cancer
Epigenetic regulation of hypoxia‐responsive gene expression: Focusing on chromatin and DNA modifications
Ya‐Ping Tsai, Kou‐Juey Wu · 2013 · International Journal of Cancer
Navigating tumor angiogenesis: therapeutic perspectives and myeloid cell regulation mechanism
Fan Yang, Gloria Lee, Yi Fan · 2024 · Angiogenesis
Mortalin-mediated and ERK-controlled targeting of HIF-1α to mitochondria confers resistance to apoptosis under hypoxia
Ilias Mylonis, Maria Kourti, Martina K. Samiotaki, George Panayotou, George Simos · 2016 · Journal of Cell Science
Metabolic Modulation of Clear-cell Renal Cell Carcinoma with Dichloroacetate, an Inhibitor of Pyruvate Dehydrogenase Kinase
Adam S. Kinnaird, Peter Dromparis, Bruno Saleme, Vikram Gurtu, Kristalee Watson, Roxane Paulin, Sotirios D. Zervopoulos, Trevor H. Stenson, Gopinath Sutendra, Desmond Pink et al. · 2016 · European Urology
Mutations in the Isocitrate Dehydrogenase Genes IDH1 and IDH2 in Tumors
Frank G. Schaap, Pim J. French, Judith V.M.G. Bovée · 2012 · Advances in Anatomic Pathology
RETRACTED ARTICLE: hERG1 channels modulate integrin signaling to trigger angiogenesis and tumor progression in colorectal cancer
Olivia Crociani, Francesca Zanieri, Serena Pillozzi, Elena Lastraioli, Matteo Stefanini, Antonella Fiore, Angelo Fortunato, Massimo D’Amico, Marika Masselli, Emanuele De Lorenzo et al. · 2013 · Scientific Reports · Retracted
NADPH oxidase-mitochondria axis-derived ROS mediate arsenite-induced HIF-1α stabilization by inhibiting prolyl hydroxylases activity
Yingna Li, Miaomiao Xi, Yu C. Guo, Chunxu Hai, Weilin Yang, Xu-Jun Qin · 2013 · Toxicology Letters
Hypoxia inducible factor 2 alpha inhibits hepatocellular carcinoma growth through the transcription factor dimerization partner 3/ E2F transcription factor 1–dependent apoptotic pathway
Hai-Xiang Sun, Yang Xu, Xin‐Rong Yang, Weimin Wang, Haibo Bai, Ruo-Yu Shi, Suresh K. Nayar, Ranjan Prasad Devbhandari, Yi-zhou He, Qin-Feng Zhu et al. · 2012 · Hepatology
Frequent EPAS1/HIF2α exons 9 and 12 mutations in non-familial pheochromocytoma
Jenny Welander, Adam Stenman, Michael Brauckhoff, Martin Bäckdahl, Catharina Larsson, Oliver Gimm, Peter Söderkvist · 2014 · Endocrine Related Cancer
c-Myc-mediated repression of miR-15-16 in hypoxia is induced by increased HIF-2α and promotes tumor angiogenesis and metastasis by upregulating FGF2
G Xue, H-L Yan, ZHANG YI, L Q Hao, X-T Zhu, Qian Mei, S‐H Sun · 2014 · Oncogene
Mitochondrial One-Carbon Metabolism Maintains Redox Balance during Hypoxia
Inmaculada Martínez‐Reyes, Navdeep S. Chandel · 2014 · Cancer Discovery
Extracellular Matrix (ECM) and Fibrosis in Adipose Tissue: Overview and Perspectives
Kai Sun, Xin Li, Philipp E. Scherer · 2023 · Comprehensive physiology
RETRACTED: Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis
Guoxiang Yuan, Yingjie Peng, Vaddi Damodara Reddy, Vladislav V. Makarenko, Jayasri Nanduri, Shakil A. Khan, Joseph A. Garcia, Ganesh K Kumar, Gregg L. Semenza, Nanduri R. Prabhakar · 2013 · Proceedings of the National Academy of Sciences · Retracted
The Response of Macrophages and Neutrophils to Hypoxia in the Context of Cancer and Other Inflammatory Diseases
Antje Egners, Merve Erdem, Thorsten Cramer · 2016 · Mediators of Inflammation
Hypoxia-inducible factor in breast cancer: role and target for breast cancer treatment
Shijiao Zhi, Chen Chen, Hanlin Huang, Zhengfu Zhang, Fancai Zeng, Shujun Zhang · 2024 · Frontiers in Immunology
Hypoxia-Induced WSB1 Promotes the Metastatic Potential of Osteosarcoma Cells
Ji Cao, Yijie Wang, Rong Dong, Guanyu Lin, Ning Zhang, Jing Wang, Nengming Lin, Yongchuan Gu, Ling Ding, Meidan Ying et al. · 2015 · Cancer Research
The growing complexity of HIF-1α’s role in tumorigenesis: DNA repair and beyond
Nadine Rohwer, Christin Zasada, Stefan Kempa, Thorsten Cramer · 2012 · Oncogene
DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumor immunotolerance
Flora D’Anna, Laurien Van Dyck, Jieyi Xiong, Hui Zhao, Rebecca V. Berrens, Junbin Qian, Paweł Bieniasz-Krzywiec, Vikas Chandra, Luc Schoonjans, Jason B. Matthews et al. · 2020 · Genome biology
Metabolic reprogramming of clear cell renal cell carcinoma
Haiyan Zhu, Xin Wang, Shihao Lu, Kongbo Ou · 2023 · Frontiers in Endocrinology
Distinct Phenotypes of Human Prostate Cancer Cells Associate with Different Adaptation to Hypoxia and Pro-Inflammatory Gene Expression
Linda Ravenna, Lorenzo Principessa, Alessandra Verdina, Luisa Salvatori, Matteo Antonio Russo, Elisa Petrangeli · 2014 · PLoS ONE
The Role of Hypoxia-Inducible Factor 1α in Determining the Properties of Castrate-Resistant Prostate Cancers
Weranja K. B. Ranasinghe, Lin Xiao, Suzana Kovac, Mike S. S. Chang, Carine Michiels, Damien Michael Bolton, Arthur Shulkes, Graham S. Baldwin, Oneel Patel · 2013 · PLoS ONE
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Albino Troilo, Irina Alexander, Sarah Mühl, Daniela Jaramillo, Klaus‐Peter Knobeloch, Wilhelm Krek · 2013 · EMBO Reports
Hif-1α and Hif-2α differentially regulate Notch signaling through competitive interaction with the intracellular domain of Notch receptors in glioma stem cells
Yiyang Hu, Luo-an Fu, Sanzhong Li, Yan Chen, Junchang Li, Jun Han, Liang Liang, Liang Li, Chenchen Ji, Min Zheng et al. · 2014 · Cancer Letters
Flavonoid Compound Icariin Activates Hypoxia Inducible Factor-1α in Chondrocytes and Promotes Articular Cartilage Repair
Pengzhen Wang, Fengjie Zhang, Qiling He, Jianqi Wang, Hoi Ting Shiu, Yinglan Shu, Wing Pui Tsang, Shuang A. Liang, Kai Zhao, Chao Wan · 2016 · PLoS ONE
EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance
Cornelia Depner, H. zum Buttel, Nuray Böğürcü, Ángel M. Cuesta, María R. Aburto, Sascha Seidel, Fabian Finkelmeier, Franziska Foss, J. Hofmann, Kerstin Kaulich et al. · 2016 · Nature Communications
Differences in Tolerance to Hypoxia: Physiological, Biochemical, and Molecular-Biological Characteristics
Dzhuliia Sh. Dzhalilova, Olga V. Makarova · 2020 · Biomedicines
Hypoxia-Inducible Factors Modulate the Stemness and Malignancy of Colon Cancer Cells by Playing Opposite Roles in Canonical Wnt Signaling
Paula Santoyo‐Ramos, María Likhatcheva, Eduardo Alberto García-Zepeda, M. Cristina Castañeda‐Patlán, Martha Robles‐Flores · 2014 · PLoS ONE
MUC1 enhances hypoxia-driven angiogenesis through the regulation of multiple proangiogenic factors
Sho Kitamoto, Seiya Yokoyama, M Higashi, Nobuteru Yamada, Sonshin Takao, S Yonezawa · 2012 · Oncogene
Hypoxia-inducible factors enhance glutamate signaling in cancer cells
Hongxia Hu, Naoharu Takano, Lisha Xiang, Daniele M. Gilkes, Weibo Luo, Gregg L. Semenza · 2014 · Oncotarget
Harnessing developmental processes for vascular engineering and regeneration
Kyung Min Park, Sharon Gerecht · 2014 · Development
Lymphangioleiomyomatosis: A Monogenic Model of Malignancy
Vera P. Krymskaya, Francis X. McCormack · 2017 · Annual Review of Medicine
Knockdown of miR-210 decreases hypoxic glioma stem cells stemness and radioresistance
Wei Yang, Jing Wei, Tiantian Guo, Yueming Shen, Fenju Liu · 2014 · Experimental Cell Research
Spatial transcriptomics delineates molecular features and cellular plasticity in lung adenocarcinoma progression
Yan Wang, Bing Liu, Qingjie Min, Xin Yang, Shi Yan, Yuanyuan Ma, Shaolei Li, Jiawen Fan, Yaqi Wang, Bin Dong et al. · 2023 · Cell Discovery
Hypoxia-inducible factor (HIF) network: insights from mathematical models
Miguel A. S. Cavadas, Lan K. Nguyen, Alex Cheong · 2013 · Cell Communication and Signaling
Depletion of Lipid Efflux Pump ABCG1 Triggers the Intracellular Accumulation of Extracellular Vesicles and Reduces Aggregation and Tumorigenesis of Metastatic Cancer Cells
Yuri Namba, Chiharu Aoki Sogawa, Yuka Okusha, Hotaka Kawai, Mami Itagaki, Kisho Ono, Jun Murakami, Eriko Aoyama, Kazumi Ohyama, Jun‐ichi Asaumi et al. · 2018 · Frontiers in Oncology
Energy Metabolism in Cancer: The Roles of STAT3 and STAT5 in the Regulation of Metabolism-Related Genes
Arturo Valle‐Mendiola, Isabel Soto‐Cruz · 2020 · Cancers
Hypoxia signalling manipulation for bone regeneration
Justin Drager, Edward Joseph Harvey, Jake E. Barralet · 2015 · Expert Reviews in Molecular Medicine
Hypoxic Microenvironment and Metastatic Bone Disease
Toru Hiraga · 2018 · International Journal of Molecular Sciences
Metabolic targeting of HIF-1α potentiates the therapeutic efficacy of oxaliplatin in colorectal cancer
Tzu-Tang Wei, Yi‐Ting Lin, Shao-Pu Tang, Cong-Kai Luo, C.-C. Tsai, Chia‐Tung Shun, Ching‐Chow Chen · 2019 · Oncogene
Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth
Michael S. Nakazawa, T.S. Karin Eisinger‐Mathason, Navid Sadri, Joshua D. Ochocki, Terence P.F. Gade, Ruchi Kaushik Amin, Marie Celeste Simon · 2016 · Nature Communications
PI3Kgamma Inhibitor Attenuates Immunosuppressive Effect of Poly( l ‐Glutamic Acid)‐Combretastatin A4 Conjugate in Metastatic Breast Cancer
Hanjiao Qin, Haiyang Yu, Jiyao Sheng, Dawei Zhang, Na Shen, Linlin Liu, Zhaohui Tang, Xuesi Chen · 2019 · Advanced Science
Hypoxia and cancer cell metabolism
De Huang, Chenchen Li, Huafeng Zhang · 2014 · Acta Biochimica et Biophysica Sinica
Targeting Ferroptosis Pathway to Combat Therapy Resistance and Metastasis of Cancer
Xuan Liu, Yiqian Zhang, Xuyi Wu, Fuyan Xu, Hongbo Ma, Meng‐Ling Wu, Yong Xia · 2022 · Frontiers in Pharmacology
Tumour oxygenation: implications for breast cancer prognosis
Helene Rundqvist, Randall S. Johnson · 2013 · Journal of Internal Medicine
Visceral adiposity in gastrointestinal and hepatic carcinogenesis
Roslyn Vongsuvanh, Jacob George, Liang Qiao, David van der Poorten · 2012 · Cancer Letters
Suppressing Mitochondrial Respiration Is Critical for Hypoxia Tolerance in the Fetal Growth Plate
Qing Yao, Mohd Parvez Khan, Christophe Merceron, Edward L. LaGory, Zachary Tata, Laura Mangiavini, Jiarui Hu, Krishna Vemulapalli, Navdeep S. Chandel, Amato J. Giaccia et al. · 2019 · Developmental Cell
m6A methylation regulates hypoxia-induced pancreatic cancer glycolytic metabolism through ALKBH5-HDAC4-HIF1α positive feedback loop
Xiaoyan Liu, Maoxiao Feng, Xiaodong Hao, Zihan Gao, Zhaoxin Wu, Yuli Wang, Lutao Du, Chuanxin Wang · 2023 · Oncogene
Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells
Christina D. Befani, Ilias Mylonis, Ioanna‐Maria Gkotinakou, Panagiotis Georgoulias, Cheng‐Jun Hu, George Simos, Panagiotis Liakos · 2013 · The International Journal of Biochemistry & Cell Biology
Essential role for SphK1/S1P signaling to regulate hypoxia-inducible factor 2α expression and activity in cancer
Pierre Bouquerel, Cécile Gstalder, D Müller, Jennifer Laurent, Leyre Brizuela, Roger Allen Sabbadini, Bernard A. Malavaud, Stéphane Pyronnet, Yvan Martineau, Isabelle Ader et al. · 2016 · Oncogenesis
PHD2: from hypoxia regulation to disease progression
Ben Wielockx, Ana Meneses · 2016 · Hypoxia
Retrospective Analysis of Radiological Recurrence Patterns in Glioblastoma, Their Prognostic Value And Association to Postoperative Infarct Volume
Stefanie J. Bette, Melanie Barz, Thomas S. Huber, Christoph Straube, Friederike Schmidt‐Graf, Stephanie Elisabeth Combs, Claire Delbridge, Julia Gerhardt, Claus Zimmer, Bernhard Meyer et al. · 2018 · Scientific Reports
Expression of HIF-1α is related to a poor prognosis and tamoxifen resistance in contralateral breast cancer
Annika Jögi, Anna Ehinger, Linda Werner Hartman, Sara Alkner · 2019 · PLoS ONE
Inhibition of hypoxia-inducible factors limits tumor progression in a mouse model of colorectal cancer
Jessica E.S. Shay, Hongxia Z. Imtiyaz, Sharanya Sivanand, Amy C. Durham, Nicolas Skuli, Sarah Hsu, Vera Mucaj, T.S. Karin Eisinger‐Mathason, Bryan L. Krock, Dionysios N. Giannoukos et al. · 2014 · Carcinogenesis
NF-κB, Mesenchymal Differentiation and Glioblastoma
Bakhtiar Yamini · 2018 · Cells
HIF-1α promoted vasculogenic mimicry formation in lung adenocarcinoma through NRP1 upregulation in the hypoxic tumor microenvironment
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Elucidating the Molecular Basis of Sorafenib Resistance in HCC: Current Findings and Future Directions
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