HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
Keith, Brian, Johnson, Randall S., Simon, M. Celeste·2012·Nature Reviews Cancer
DOI 10.1038/nrc3183
Cited by (1,008)
Items 101–200 of 1,008
- Ruthenium-Based Photoactivated ChemotherapySylvestre Bonnet · 2023 · Journal of the American Chemical Society
- Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic NeoplasiaKyoung Eun Lee, Michelle Spata, Lauren J. Bayne, Elizabeth L. Buza, Amy C. Durham, David Allman, Robert H. Vonderheide, Marie Celeste Simon · 2015 · Cancer Discovery
- STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cellsMatthew R. Pawlus, L Wang, Cheng‐Jun Hu · 2013 · Oncogene
- The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell CarcinomaAmrita M. Nargund, Can G. Pham, Yiyu Dong, Patricia I. Wang, Hatice U. Osmangeyoglu, Yuchen Xie, Ömer Aras, Song Han, Toshinao Oyama, Shugaku Takeda et al. · 2017 · Cell Reports
- A Clearer View of the Molecular Complexity of Clear Cell Renal Cell CarcinomaIan J. Frew, Holger Moch · 2014 · Annual Review of Pathology Mechanisms of Disease
- HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular ironSinghal, Rashi, Mitta, Sreedhar R., Das, Nupur K., Kerk, Samuel A., Sajjakulnukit, Peter, Solanki, Sumeet, Andren, Anthony, Kumar, Roshan, Olive, Kenneth P., Banerjee, Ruma et al. · 2021 · Journal of Clinical Investigation
- The Meaning, Measurement and Modification of Hypoxia in the Laboratory and the ClinicEster M. Hammond, Marie‐Claude Asselin, Duncan M. Forster, James P.B. O’Connor, Joana M. Senra, Kaye Janine Williams · 2014 · Clinical Oncology
- Acute vs. Chronic vs. Cyclic Hypoxia: Their Differential Dynamics, Molecular Mechanisms, and Effects on Tumor ProgressionKritika Saxena, Mohit Kumar Jolly · 2019 · Biomolecules
- Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritisChenzhi Jing, Tomas Castro‐Dopico, Nathan Richoz, Zewen Kelvin Tuong, John R. Ferdinand, Laurence S. C. Lok, Kevin W. Loudon, Gemma D. Banham, Rebeccah J. Mathews, M. Zaeem Cader et al. · 2020 · Proceedings of the National Academy of Sciences
- AMPK–mTOR Signaling and Cellular Adaptations in HypoxiaYoomi Chun, Joungmok Kim · 2021 · International Journal of Molecular Sciences
- Hypoxia/pseudohypoxia‐mediated activation of hypoxia‐inducible factor‐1α in cancerYoshihiro Hayashi, Asumi Yokota, Hironori Harada, Gang Huang · 2019 · Cancer Science
- USP22 promotes hypoxia-induced hepatocellular carcinoma stemness by a HIF1α/USP22 positive feedback loop upon TP53 inactivationSunbin Ling, Qiaonan Shan, Qifan Zhan, Qianwei Ye, Peng Liu, Shengjun Xu, Xin He, Jian Ma, Jiajia Xiang, Guangjiang Jiang et al. · 2019 · Gut
- Undercover: gene control by metabolites and metabolic enzymesJan A. van der Knaap, C. Peter Verrijzer · 2016 · Genes & Development
- 3-[(1
<i>S</i>
,2
<i>S</i>
,3
<i>R</i>
)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell CarcinomaXu, Rui, Wang, Keshi, Rizzi, James P., Huang, Heli, Grina, Jonas A., Schlachter, Stephen T., Wang, Bin, Wehn, Paul M., Yang, Hanbiao, Dixon, Darryl D. et al. · 2019 · Journal of Medicinal Chemistry
- SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loopChun‐Ping Cui, Carmen Chak‐Lui Wong, Alan Ka‐Lun Kai, Daniel Wai‐Hung Ho, Eunice Yuen-Ting Lau, Yu‐Man Tsui, Lo‐Kong Chan, Tan To Cheung, Ksh Chok, Albert C. Y. Chan et al. · 2017 · Gut
- Hypoxia-Inducible Factors Have Distinct and Stage-Specific Roles during Reprogramming of Human Cells to PluripotencyJulie Mathieu, Wenyu Zhou, Yalan Xing, Henrik Sperber, Amy Ferreccio, Zsuzsa Agoston, Kavitha T. Kuppusamy, Randall T. Moon, Hannele Ruohola‐Baker · 2014 · Cell stem cell
- Mitochondrial Akt Regulation of Hypoxic Tumor ReprogrammingYoung Chan Chae, Valentina Vaira, M. Cecilia Caino, Hsin‐Yao Tang, Jae Ho Seo, Andrew V. Kossenkov, Luisa Ottobrini, Cristina Martelli, Giovanni Lucignani, Irene Bertolini et al. · 2016 · Cancer Cell
- Lipid Droplets: A Key Cellular Organelle Associated with Cancer Cell Survival under Normoxia and HypoxiaShiro Koizume, Yohei Miyagi · 2016 · International Journal of Molecular Sciences
- Hypoxia as a barrier to immunotherapy in pancreatic adenocarcinomaSara K. Daniel, Kevin M. Sullivan, Kevin P. Labadie, Venu Gopal Pillarisetty · 2019 · Clinical and Translational Medicine
- Hypoxia and Inflammation in Cancer, Focus on HIF and NF-κBLaura D’Ignazio, Michael Batie, Sónia Rocha · 2017 · Biomedicines
- Oxygen availability and metabolic reprogramming in cancerHong Jian Xie, Marie Celeste Simon · 2017 · Journal of Biological Chemistry
- HIF-1α signaling: Essential roles in tumorigenesis and implications in targeted therapiesYan Zhao, Cheng Xing, Yating Deng, Can Ye, Hongling Peng · 2023 · Genes & Diseases
- Inherent DNA‐binding specificities of the HIF‐1α and HIF‐2α transcription factors in chromatinSmythies, James A, Sun, Min, Masson, Norma, Salama, Rafik, Simpson, Peter D, Murray, Elizabeth, Neumann, Viviana, Cockman, Matthew E, Choudhry, Hani, Ratcliffe, Peter J et al. · 2019 · The EMBO Reports
- Hypoxia signaling pathways: modulators of oxygen-related organellesMiriam J. Schönenberger · 2015 · Frontiers in Cell and Developmental Biology
- Cancer–stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasisGregg L. Semenza · 2012 · Oncogene
- The IRP1-HIF-2α Axis Coordinates Iron and Oxygen Sensing with Erythropoiesis and Iron AbsorptionAnderson, Sheila A., Nizzi, Christopher P., Chang, Yuan-I., Deck, Kathryn M., Schmidt, Paul J., Galy, Bruno, Damnernsawad, Alisa, Broman, Aimee T., Kendziorski, Christina, Hentze, Matthias W. et al. · 2013 · Cell Metabolism
- Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processesNicolas Skuli, Amar J. Majmundar, Bryan L. Krock, Rickson C. Mesquita, Lijoy K. Mathew, Zachary L. Quinn, Anja Runge, Liping Liu, Meeri N. Kim, Jiaming Liang et al. · 2012 · Journal of Clinical Investigation
- Hypoxia-inducible factors: a central link between inflammation and cancerTriner, Daniel, Shah, Yatrik M. · 2016 · Journal of Clinical Investigation
- Metabolism in tumor microenvironment: Implications for cancer immunotherapyRongchen Shi, Yi‐Quan Tang, Hongming Miao · 2020 · MedComm
- Mechanisms of Taxane ResistanceMaloney, Sara, Spring, Camden, Morejon-Lasso, Lorena, Prosperi, Jenifer · 2020 · Cancers
- Tumor Hypoxia Regulates Immune Escape/Invasion: Influence on Angiogenesis and Potential Impact of Hypoxic Biomarkers on Cancer TherapiesRaefa Abou Khouzam, Klaudia K. Brodaczewska, Aleksandra Filipiak-Duliban, Nagwa Ahmed Zeinelabdin, Stéphanie Buart, Cezary A. Szczylik, Claudine Kiéda, Salem Chouaı̈b · 2021 · Frontiers in Immunology
- Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi’s sarcomaDiego Omar Croci, Mariana Salatino, Natalia Rubinstein, Juan Pablo Cerliani, Lucas E. Cavallin, Howard J. Leung, Jing Ouyang, Juan M. Ilarregui, Marta A. Toscano, Carolina I. Domaica et al. · 2012 · The Journal of Experimental Medicine
- Primary endothelial cell–specific regulation of hypoxia‐inducible factor (HIF)‐1 and HIF‐2 and their target gene expression profiles during hypoxiaBartoszewski, Rafal, Moszyńska, Adrianna, Serocki, Marcin, Cabaj, Aleksandra, Polten, Andreas, Ochocka, Renata, Dell'Italia, Louis, Bartoszewska, Sylwia, Króliczewski, Jarosław, Dąbrowski, Michał et al. · 2019 · The FASEB Journal
- Development of Inhibitors Targeting Hypoxia-Inducible Factor 1 and 2 for Cancer TherapyTianchi Yu, Bo Tang, Xueying Sun · 2017 · Yonsei Medical Journal
- Hypoxia-regulated target genes implicated in tumor metastasisTsai, Ya-Ping, Wu, Kou-Juey · 2012 · Journal of Biomedical Science
- ITGA6 is directly regulated by hypoxia-inducible factors and enriches for cancer stem cell activity and invasion in metastatic breast cancer modelsDanielle L. Peacock Brooks, Luciana P. Schwab, Raisa I. Krutilina, Deanna N. Parke, Aarti Sethuraman, David Hoogewijs, Alexandra Schörg, Lauren Gotwald, Meiyun Fan, Roland H. Wenger et al. · 2016 · Molecular Cancer
- Endothelial Dysfunction Driven by Hypoxia—The Influence of Oxygen Deficiency on NO BioavailabilityAnna Janaszak‐Jasiecka, Anna Siekierzycka, Agata Płoska, Iwona T. Dobrucki, Leszek Kalinowski · 2021 · Biomolecules
- HIF-2α Protects Human Hematopoietic Stem/Progenitors and Acute Myeloid Leukemic Cells from Apoptosis Induced by Endoplasmic Reticulum StressKevin Rouault‐Pierre, Lourdes López-Onieva, Katie Foster, Fernando Anjos‐Afonso, Isabelle Lamrissi‐Garcia, Martin Serrano-Sanchez, Richard Mitter, Zoran Ivanović, Hubert de Verneuil, John G. Gribben et al. · 2013 · Cell stem cell
- Hypoxia-Inducible miR-210 Regulates the Susceptibility of Tumor Cells to Lysis by Cytotoxic T CellsMuhammad Zaeem Noman, Stéphanie Buart, Pedro J. Romero, Sami Ketari, Bassam Janji, Bernard P. Mari, Fathia Mami‐Chouaib, Salem Chouaı̈b · 2012 · Cancer Research
- Breast cancer stem cells: Features, key drivers and treatment optionsJürgen Dittmer · 2018 · Seminars in Cancer Biology
- A Cyclic Peptide Inhibitor of HIF-1 Heterodimerization That Inhibits Hypoxia Signaling in Cancer CellsMiranda, Elena, Nordgren, Ida K., Male, Abigail L., Lawrence, Charlotte E., Hoakwie, Franciane, Cuda, Francesco, Court, William, Fox, Keith R., Townsend, Paul A., Packham, Graham K. et al. · 2013 · Journal of the American Chemical Society
- The Multiple Roles of Exosomes in MetastasisUlrich H. Weidle, Fabian Birzele, Gwen Kollmorgen, Rüdiger Rüger · 2017 · Cancer Genomics & Proteomics
- New horizons in hypoxia signaling pathwaysChristopher William Pugh, Peter John Ratcliffe · 2017 · Experimental Cell Research
- Chromosome 3p Loss–Orchestrated VHL, HIF, and Epigenetic Deregulation in Clear Cell Renal Cell CarcinomaJames J.-D. Hsieh, Valerie H. Le, Toshinao Oyama, Christopher J. Ricketts, Thai H. Ho, Emily H. Y. Cheng · 2018 · Journal of Clinical Oncology
- FOXM1 (Forkhead box M1) in TumorigenesisInken Wierstra · 2013 · Advances in cancer research
- HIF-1α Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell SurvivalSteve Stegen, Nick van Gastel, Guy Eelen, Bart Ghesquière, Flora D’Anna, Bernard Thienpont, Jermaine Goveia, Sophie Torrekens, Riet Van Looveren, Frank P. Luyten et al. · 2016 · Cell Metabolism
- Hypoxia Promotes Tumor Growth in Linking Angiogenesis to Immune EscapeSalem Chouaı̈b, Yosra Messai, Sophie Couvé, Bernard J. Escudier, Meriem Hasmim, Muhammad Zaeem Noman · 2012 · Frontiers in Immunology
- NLRP12 collaborates with NLRP3 and NLRC4 to promote pyroptosis inducing ganglion cell death of acute glaucomaHui Chen, Yang Deng, Xiaoliang Gan, Yonghao Li, Wenyong Huang, Lin Lü, Lai Wei, Lishi Su, Jiawen Luo, Bin Zou et al. · 2020 · Molecular Neurodegeneration
- PD-L1 expression is regulated by hypoxia inducible factor in clear cell renal cell carcinomaRuf, Melanie, Moch, Holger, Schraml, Peter · 2016 · International Journal of Cancer
- Common pitfalls in preclinical cancer target validationKaelin, William G. · 2017 · Nature Reviews Cancer
- HIF1α is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosisYoshiteru Miyauchi, Yuiko Sato, Tami Kobayashi, Shigeyuki Yoshida, Tomoaki Mori, Hiroya Kanagawa, Eri Katsuyama, Atsuhiro Fujie, Wu Hao, Kana Miyamoto et al. · 2013 · Proceedings of the National Academy of Sciences
- LncRNA RP11-89 facilitates tumorigenesis and ferroptosis resistance through PROM2-activated iron export by sponging miR-129-5p in bladder cancerWenjie Luo, Jun Wang, Wenhao Xu, Chunguang Ma, Fangning Wan, Yongqiang Huang, Mengfei Yao, Hailiang Zhang, Yuanyuan Qu, Dingwei Ye et al. · 2021 · Cell Death and Disease
- Ferroptosis: Emerging mechanisms, biological function, and therapeutic potential in cancer and inflammationXin Jin, Jiuren Tang, Xiangyu Qiu, Xiaoya Nie, Shengming Ou, Geyan Wu, Rongxin Zhang, Jinrong Zhu · 2024 · Cell Death Discovery
- Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathwayKomal Qureshi-Baig, Diana Kuhn, Elodie Viry, Vitaly Igorevich Pozdeev, Martine Schmitz, Fabien Rodriguez, Pit Ullmann, Eric Koncina, Martin Nurmik, Sónia Frasquilho et al. · 2019 · Autophagy
- Hypoxia, endoplasmic reticulum stress and chemoresistance: dangerous liaisonsMuhlis Akman, Dimas Carolina Belisario, Iris C. Salaroglio, Joanna Kopecka, Massimo Donadelli, Enrico De Smaele, Chiara Riganti · 2021 · Journal of Experimental & Clinical Cancer Research
- Hypoxia-Inducible Factor Signaling in Pheochromocytoma: Turning the Rudder in the Right DirectionIvana Jochmanová, Chunzhang Yang, Zhengping Zhuang, Karel Pacák · 2013 · JNCI Journal of the National Cancer Institute
- Iron and Cancer: 2020 VisionSuzy V. Torti, Frank M. Torti · 2020 · Cancer Research
- Hypoxia-inducible factors: key regulators of myeloid cells during inflammationLin, Nan, Simon, M. Celeste · 2016 · Journal of Clinical Investigation
- Current Approaches and Recent Developments in the Management of Head and Neck ParagangliomasDavid Taïeb, Alexandre Kaliski, Carsten C. Boedeker, Victoria L. Martucci, Tito Fojo, John R. Adler, Karel Pacák · 2014 · Endocrine Reviews
- Hypoxia promotes glioma-associated macrophage infiltration via periostin and subsequent M2 polarization by upregulating TGF-beta and M-CSFRXiaofan Guo, Hao Xue, Qianqian Shao, Jian Wang, Xing Guo, Xi Chen, Jinsen Zhang, Shugang Xu, Tong Li, Ping Zhang et al. · 2016 · Oncotarget
- Modulation of the tumor vasculature and oxygenation to improve therapySiemann, Dietmar W., Horsman, Michael R. · 2015 · Pharmacology & Therapeutics
- The cancer stem cell niche(s): The crosstalk between glioma stem cells and their microenvironmentAlina Filatova, Till Acker, Boyan K. Garvalov · 2012 · Biochimica et Biophysica Acta (BBA) - General Subjects
- Differential but complementary HIF1α and HIF2α transcriptional regulationDownes, Nicholas L., Laham-Karam, Nihay, Kaikkonen, Minna U., Ylä-Herttuala, Seppo · 2018 · Molecular Therapy
- Boolean Network Model for Cancer Pathways: Predicting Carcinogenesis and Targeted Therapy OutcomesHerman Fialho Fumiã, Marcelo Lobato Martins · 2013 · PLoS ONE
- Hif-2α Promotes Degradation of Mammalian Peroxisomes by Selective AutophagyKatharina Walter, Miriam J. Schönenberger, Martin Trötzmüller, Michael Horn, Hans‐Peter Elsässer, Ann B. Moser, Miriam S. Lucas, Tobias Schwarz, Philipp A. Gerber, Phyllis L. Faust et al. · 2014 · Cell Metabolism
- Genetic and metabolic hallmarks of clear cell renal cell carcinomaDanielle J. Sanchez, Marie Celeste Simon · 2018 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- HIF-2α promotes conversion to a stem cell phenotype and induces chemoresistance in breast cancer cells by activating Wnt and Notch pathwaysYuanyuan Yan, Fangxiao Liu, Li Han, Lin Zhao, Jianjun Chen, Olufunmilayo Ibironke Olopade, Miao He, Minjie Wei · 2018 · Journal of Experimental & Clinical Cancer Research
- Pilot trial of EZN-2968, an antisense oligonucleotide inhibitor of hypoxia-inducible factor-1 alpha (HIF-1α), in patients with refractory solid tumorsJeong, Woondong, Rapisarda, Annamaria, Park, Sook Ryun, Kinders, Robert J., Chen, Alice, Melillo, Giovanni, Turkbey, Baris, Steinberg, Seth M., Choyke, Peter, Doroshow, James H. et al. · 2014 · Cancer Chemotherapy and Pharmacology
- HIF‐prolyl hydroxylases as therapeutic targets in erythropoiesis and iron metabolismVolker H. Haase · 2017 · Hemodialysis International
- Intertwined regulation of angiogenesis and immunity by myeloid cellsLee B. Rivera, Gabriele Bergers · 2015 · Trends in Immunology
- New Syndrome of Paraganglioma and Somatostatinoma Associated With PolycythemiaKarel Pacák, Ivana Jochmanová, Tamara Prodanov, Chunzhang Yang, Maria J. Merino, Tito Fojo, Josef T. Prchal, Arthur S. Tischler, Ronald M. Lechan, Zhengping Zhuang · 2013 · Journal of Clinical Oncology
- Hypoxia and lymphangiogenesis in tumor microenvironment and metastasisRui‐Cheng Ji · 2013 · Cancer Letters
- Pyruvate and metabolic flexibility: illuminating a path toward selective cancer therapiesOlson, Kristofor A., Schell, John C., Rutter, Jared · 2016 · Trends in Biochemical Sciences
- Tumor suppressor functions of FBW7 in cancer development and progressionZhiwei Peter Wang, Hiroyuki Inuzuka, Jiateng Zhong, Lixin Wan, Hidefumi Fukushima, Fazlul H. Sarkar, Wenyi Wei · 2012 · FEBS Letters
- Ferroptosis: a double-edged sword mediating immune tolerance of cancerQin Dang, Ziqi Sun, Yang Wang, Libo Wang, Zaoqu Liu, Xinwei Han · 2022 · Cell Death and Disease
- EML4-ALK enhances programmed cell death-ligand 1 expression in pulmonary adenocarcinoma via hypoxia-inducible factor (HIF)-1α and STAT3Jaemoon Koh, Ji-Young Jang, Bhumsuk Keam, Sehui Kim, Moon‐Young Kim, Heounjeong Go, Tae Min Kim, Dong‐Wan Kim, Chul Woo Kim, Yoon Kyung Jeon et al. · 2015 · OncoImmunology
- The Distinct Role of HIF-1α and HIF-2α in Hypoxia and AngiogenesisMouayad Zuheir Bakleh, Ayman Al Haj Zen · 2025 · Cells
- ALDOA functions as an oncogene in the highly metastatic pancreatic cancerShunrong Ji, Bo Zhang, Jiang Liu, Yi Qin, Chen Liang, Si Shi, Kaizhou Jin, Dingkong Liang, Wenyan Xu, Huaxiang Xu et al. · 2016 · Cancer Letters
- The p53 family and the hypoxia-inducible factors (HIFs): determinants of cancer progressionIvano Amelio, Gerry Melino · 2015 · Trends in Biochemical Sciences
- Obstructive sleep apnea and cognitive impairment: Addressing the blood–brain barrierDiane C Lim, Allan I Pack · 2013 · Sleep Medicine Reviews
- Iron homeostasis and tumorigenesis: molecular mechanisms and therapeutic opportunitiesCaiguo Zhang, Fan Zhang · 2014 · Protein & Cell
- Cancer Drug Development of Carbonic Anhydrase Inhibitors beyond the Active SiteSrishti Singh, Carrie L. Lomelino, Mam Y. Mboge, Susan Cooke Frost, ROBERT V. McKENNA · 2018 · Molecules
- Hypoxia Inducible Factor Signaling Modulates Susceptibility to Mycobacterial Infection via a Nitric Oxide Dependent MechanismPhilip M. Elks, Sabrina Brizee, Michiel van der Vaart, Sarah R. Walmsley, Fredericus J. van Eeden, Stephen A. Renshaw, Annemarie H. Meijer · 2013 · PLoS Pathogens
- HIF1α and HIF2α independently activate SRC to promote melanoma metastasesHanna, Sara C., Krishnan, Bhavani, Bailey, Sean T., Moschos, Stergios J., Kuan, Pei-Fen, Shimamura, Takeshi, Osborne, Lukas D., Siegel, Marni B., Duncan, Lyn M., O’Brien, E. Tim et al. · 2013 · Journal of Clinical Investigation
- Hypoxia-inducible factors: Crosstalk between inflammation and metabolismJessica E.S. Shay, Marie Celeste Simon · 2012 · Seminars in Cell and Developmental Biology
- mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-dependent Foxk1 PhosphorylationHe, Long, Gomes, Ana P., Wang, Xin, Yoon, Sang Oh, Lee, Gina, Nagiec, Michal J., Cho, Sungyun, Chavez, Andre, Islam, Tasnia, Yu, Yonghao et al. · 2018 · Molecular Cell
- Helix–loop–helix proteins and the advent of cellular diversity: 30 years of discoveryCornelis Murre · 2019 · Genes & Development
- The P2X7 receptor is a key modulator of aerobic glycolysisFrancesca Amoroso, Simonetta Falzoni, Elena Adinolfi, Davide Ferrari, Francesco Di Virgilio · 2012 · Cell Death and Disease
- The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instabilityJaśkiewicz, Maciej, Moszyńska, Adrianna, Króliczewski, Jarosław, Cabaj, Aleksandra, Bartoszewska, Sylwia, Charzyńska, Agata, Gebert, Magda, Dąbrowski, Michał, Collawn, James F., Bartoszewski, Rafal · 2022 · Cellular & Molecular Biology Letters
- Hypoxia as a biomarker for radioresistant cancer stem cellsClaudia Peitzsch, Rosalind L. Perrin, Richard Peter Hill, Anna Dubrovska, Ina Kurth · 2014 · International Journal of Radiation Biology
- Hypoxia inducible factor (HIF) in the tumor microenvironment: friend or foe?Yanqing Huang, Daniel Lin, Cullen M. Taniguchi · 2017 · Science China Life Sciences
- Upregulation of HIF-2α induced by sorafenib contributes to the resistance by activating the TGF-α/EGFR pathway in hepatocellular carcinoma cellsDali Zhao, Bo Zhai, Changjun He, Gang Tan, Xian Li Jiang, Shangha Pan, Xuesong Dong, Zheng Wei, Lixin Ma, Haiquan Qiao et al. · 2014 · Cellular Signalling
- Critical Role of Tumor Microenvironment in Shaping NK Cell Functions: Implication of Hypoxic StressMeriem Hasmim, Yosra Messai, Linda Ziani, Jérôme Thiery, Jean-Henri Bouhris, Muhammad Zaeem Noman, Salem Chouaı̈b · 2015 · Frontiers in Immunology
- Hypoxia Pathway Proteins As Central Mediators of Metabolism in the Tumor Cells and Their MicroenvironmentSundary Sormendi, Ben Wielockx · 2018 · Frontiers in Immunology
- Succinate induces synovial angiogenesis in rheumatoid arthritis through metabolic remodeling and HIF-1α/VEGF axisYi Li, Yang Liu, Chen Wang, Wenrui Xia, Jia‐Yi Zheng, Jie Wu Yang, Baolin Liu, Jianqun Liu, Lifang Liu · 2018 · Free Radical Biology and Medicine
- p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progressionIvano Amelio, Mara Mancini, Varvara Petrova, Rob A. Cairns, П. Н. Вихрева, Sara Nicolai, Alberto Marini, Alexey A. Antonov, John P. C. Le Quesne, Juvenal Dario Baena Acevedo et al. · 2018 · Proceedings of the National Academy of Sciences
- Molecular Pathways: Hypoxia-Activated Prodrugs in Cancer TherapyNatalia Baran, Marina Y Konopleva · 2017 · Clinical Cancer Research
- Effects of hypoxia and HIFs on cancer metabolismVera Mucaj, Jessica E.S. Shay, Marie Celeste Simon · 2012 · International Journal of Hematology
- Innate Immune Cells in the Adipose Tissue in Health and Metabolic DiseaseZoi Michailidou, Mario A. Gomez-Salazar, Vasileia Ismini Alexaki · 2021 · Journal of Innate Immunity
- Induction and application of ferroptosis in cancer therapyQing Hua Nie, Yue Hu, Xiao Hong Yu, Xiao Li, Xuedong Fang · 2022 · Cancer Cell International