HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

Keith, Brian, Johnson, Randall S., Simon, M. Celeste·2012·Nature Reviews Cancer

DOI 10.1038/nrc3183

Cited by (1,008)

Items 601–700 of 1,008

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Jing Chen, Tao Li, Qilun Liu, Haiyan Jiao, Wenjun Yang, Xiaoxia Liu, Zhenghao Huo · 2014 · PLoS ONE
Positive feedback loop and synergistic effects between hypoxia‐inducible factor‐2α and stearoyl– C o A desaturase‐1 promote tumorigenesis in clear cell renal cell carcinoma
Yujian Zhang, Hui Wang, Jin Zhang, Jianwei Lv, Yong Huang · 2013 · Cancer Science
Activation of HIF-1α does not increase intestinal tumorigenesis
Xiang Xue, Sadeesh Kumar Ramakrishnan, Yatrik Madhukar Shah · 2014 · American Journal of Physiology-Gastrointestinal and Liver Physiology
Hypometabolism as the ultimate defence in stress response: how the comparative approach helps understanding of medically relevant questions
Thomas A. Gorr · 2016 · Acta Physiologica
Monitoring structural modulation of redox-sensitive proteins in cells with MS-CETSA
Wendi Sun, Lingyun Dai, Han Yu, Brenda Puspita, Tianyun Zhao, Feng Li, Justin L. Tan, Yan Ting Lim, Ming Wei Chen, Radoslaw Mikolaj Sobota et al. · 2019 · Redox Biology
RNF4—A Paradigm for SUMOylation‐Mediated Ubiquitination
Ramesh Kumar, Kanaga Sabapathy · 2019 · PROTEOMICS
Role of Hypoxia and Metabolism in the Development of Neointimal Hyperplasia in Arteriovenous Fistulas
Nirvana Sadaghianloo, Julie Contenti, Alan Dardik, Nathalie M. Mazure · 2019 · International Journal of Molecular Sciences
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Vu Hong Loan Nguyen, Chenyang Yue, Kevin Y. Du, Mohamed Salem, Jacob Anderson O’Brien, Chun Peng · 2020 · International Journal of Molecular Sciences
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Zongdong Yu, Jie Zhu, Haibiao Wang, Hong Li, Xiaofeng Jin · 2021 · Oncology Letters
Transcriptional activation of the Prox1 gene by HIF‐1α and HIF‐2α in response to hypoxia
Bisheng Zhou, Wenxia Si, Zhenhong Su, Wenbin Deng, Xin Tu, Qing Kenneth Wang · 2013 · FEBS Letters
HIF-2α drives hepatic Kupffer cell death and proinflammatory recruited macrophage activation in nonalcoholic steatohepatitis
Ishtiaq Jeelani, Jae-Su Moon, Flávia Franco da Cunha, Chanond A. Nasamran, Seokhyun Jeon, Xinhang Zhang, Gautam K. Bandyopadhyay, Katarzyna Dobaczewska, Zbigniew Mikulski, Mojgan Hosseini et al. · 2024 · Science Translational Medicine
Int6/eIF3e Is Essential for Proliferation and Survival of Human Glioblastoma Cells
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Parallel In Vivo and In Vitro Melanoma RNAi Dropout Screens Reveal Synthetic Lethality between Hypoxia and DNA Damage Response Inhibition
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Regulation of miRNA Expression by Low-Level Laser Therapy (LLLT) and Photodynamic Therapy (PDT)
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Responses of Cancer Cells Induced by Photodynamic Therapy
Toshihiro Kushibiki, Takeshi Hirasawa, Shinpei Okawa, Miya Ishihara · 2013 · Journal of Healthcare Engineering
Quantitative Proteomics Profiling of Primary Lung Adenocarcinoma Tumors Reveals Functional Perturbations in Tumor Metabolism
Maria Pernemalm, Luigi De Petris, Rui Mamede Branca, Jenny Forshed, Lena Kanter, Jean‐Charles Soria, Philippe Girard, Pierre Validire, Yudi Pawitan Y, Joost van den Oord et al. · 2013 · Journal of Proteome Research
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HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells
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Targeting Hypoxia-Inducible Factor 1α in a New Orthotopic Model of Glioblastoma Recapitulating the Hypoxic Tumor Microenvironment
Fares Nigim, Jill Cavanaugh, Anoop P. Patel, William T. Curry, Shinichi Esaki, Ekkehard Matthias Kasper, Andrew S. Chi, David N. Louis, Robert L. Martuza, Samuel D. Rabkin et al. · 2015 · Journal of Neuropathology & Experimental Neurology
Mint3 depletion restricts tumor malignancy of pancreatic cancer cells by decreasing SKP2 expression via HIF-1
Akane Kanamori, Daisuke Matsubara, Yurika Saitoh, Yuya Fukui, Noriko Gotoh, Shuichi Kaneko, Motoharu Seiki, Yoshinori Murakami, Jun‐ichiro Inoue, Takeharu Sakamoto · 2020 · Oncogene
The Tumor Suppressor Kinase LKB1: Metabolic Nexus
Mohammed Bourouh, Paola A. Marignani · 2022 · Frontiers in Cell and Developmental Biology
VHL mutation drives human clear cell renal cell carcinoma progression through PI3K/AKT-dependent cholesteryl ester accumulation
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Repression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth
David Vindrieux, Guillaume Devailly, Arnaud Augert, Benjamin Le Calvé, Mylène Ferrand, Pascal Pigny, Lea Francoise Payen, Gerard J. Lambeau, Michaël Perrais, Sébastien Aubert et al. · 2014 · Oncotarget
Down Regulation of Wnt Signaling Mitigates Hypoxia-Induced Chemoresistance in Human Osteosarcoma Cells
Donald J. Scholten, Christine M. Timmer, Jacqueline D. Peacock, Dominic W. Pelle, Bart O. Williams, Matthew R. Steensma · 2014 · PLoS ONE
Context-dependent intravital imaging of therapeutic response using intramolecular FRET biosensors
James R. W. Conway, Sean C. Warren, Paul Timpson · 2017 · Methods
Selenium targets resistance biomarkers enhancing efficacy while reducing toxicity of anti-cancer drugs: preclinical and clinical development
Yousef Zakharia, Arup Bhattacharya, Youcef M. Rustum · 2018 · Oncotarget
PLOD2 as a potential regulator of peritoneal dissemination in gastric cancer
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The intranuclear PEX domain of MMP involves proliferation, migration, and metastasis of aggressive adenocarcinoma cells
Yuka Okusha, Takanori Eguchi, Chiharu Aoki Sogawa, Tatsuo Okui, Keisuke Nakano, Kuniaki Okamoto, Ken‐ichi Kozaki · 2018 · Journal of Cellular Biochemistry
Hypoxia-inducible factor 1α plays a predominantly negative role in regulatory T cell functions
Tzu-Sheng Hsu, Ming‐Zong Lai · 2018 · Journal of Leukocyte Biology
The VHL/HIF Axis in the Development and Treatment of Pheochromocytoma/Paraganglioma
Peng Song, Jun Zhang, Xintao Tan, Yiqiang Huang, Jing Xu, Natalie Silk, Dianzheng Zhang, Qiuli Liu, Jun Jiang · 2020 · Frontiers in Endocrinology
Unlocking mammalian regeneration through hypoxia inducible factor one alpha signaling
Kelsey G. DeFrates, Daniela Franco, Ellen Heber‐Katz, Phillip B. Messersmith · 2021 · Biomaterials
Review of Oxygenation with Nanobubbles: Possible Treatment for Hypoxic COVID-19 Patients
Ronak Afshari, Omid Akhavan, Michael Richard Hamblin, Rajender S. Varma · 2021 · ACS Applied Nano Materials
ASS1 and ASL suppress growth in clear cell renal cell carcinoma via altered nitrogen metabolism
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Prospective Application of Ferroptosis in Hypoxic Cells for Tumor Radiotherapy
Jing Su, Qin Zhao, Zhuangzhuang Zheng, Huanhuan Wang, Chenbin Bian, Lingbin Meng, Ying Xin, Xin Mei Jiang · 2022 · Antioxidants
Nanoscale CaO2 materials for synergistic transarterial chemoembolization in a VX2 orthotopic rabbit liver cancer model
Yingliang Wang, Xuelian He, Chen Zhou, Yaowei Bai, Tongqiang Li, Jia‐Cheng Liu, Shuguang Ju, Chaoyang Wang, Guangya Xiang, Bin Xiong · 2022 · Acta Biomaterialia
The roles of HLH transcription factors in epithelial mesenchymal transition and multiple molecular mechanisms
Yue Teng, Li Xu · 2013 · Clinical & Experimental Metastasis
Oncogenes strike a balance between cellular growth and homeostasis
Bo Qiu, Marie Celeste Simon · 2015 · Seminars in Cell and Developmental Biology
Hypoxia, hypoxia-inducible factors and fibrogenesis in chronic liver diseases.
Stefania Cannito, Claudia Paternostro, Chiara Busletta, Claudia Bocca, Sebastiano Colombatto, Antonella Miglietta, Erica Novo, Maurizio Parola · 2014 · PubMed
Elacridar enhances the cytotoxic effects of sunitinib and prevents multidrug resistance in renal carcinoma cells
Hiromi Sato, Sana Siddig, Miaki Uzu et al. · 2014 · European Journal of Pharmacology
Overexpression of HIF-2α, TWIST, and CXCR4 Is Associated with Lymph Node Metastasis in Papillary Thyroid Carcinoma
Ni Wang, Haojun Luo, Guobing Yin, Chao-ran Dong, Man Xu, George Y. Chen, Zhimin Liu · 2013 · Clinical and Developmental Immunology
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Jolie Kiemlian Kwee · 2014 · BioMed Research International
Hypoxia promotes chemoresistance in acute lymphoblastic leukemia cell lines by modulating death signaling pathways
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Hypoxia‐sensitive pathways in intestinal inflammation
Eric Brown, Cormac T. Taylor · 2017 · The Journal of Physiology
MicroRNA-191, regulated by HIF-2α, is involved in EMT and acquisition of a stem cell-like phenotype in arsenite-transformed human liver epithelial cells
Chao Chen, Qianlei Yang, Dapeng Wang, Fei Luo, Xinlu Liu, Junchao Xue, Ping Yang, Hui Xu, Jiachun Lü, Aihua Zhang et al. · 2017 · Toxicology in Vitro
Regulation of hypoxia-inducible factor functions in the nucleus by sphingosine-1-phosphate
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ZHX2 drives cell growth and migration via activating MEK/ERK signal and induces Sunitinib resistance by regulating the autophagy in clear cell Renal Cell Carcinoma
Liangsong Zhu, Rong Ding, Hao Yan, Jin Zhang, Zongming Lin · 2020 · Cell Death and Disease
Histone demethylase JMJD2D activates HIF1 signaling pathway via multiple mechanisms to promote colorectal cancer glycolysis and progression
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Stephen Childs, Nicolas Haroune, Lee D. Williams, MICHAEL J. GRONOW · 2016 · Journal of Chromatography A
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Renfrow, Jaclyn J, Soike, Michael H, Debinski, Waldemar, Ramkissoon, Shakti H, Mott, Ryan T, Frenkel, Mark B, Sarkaria, Jann N, Lesser, Glenn J, Strowd, Roy E · 2018 · Future Medicinal Chemistry
Oxygen levels regulate the development of human cortical radial glia cells
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Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway
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Ana Paula Francisco, Alexandra Paulo · 2016 · Current Medicinal Chemistry
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HIF-2α not HIF-1α overexpression confers poor prognosis in non–small cell lung cancer
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