Cited by 1,689Gut microbiota and healthOral microbiology and periodontitis researchBacterial Cancer Therapy

The DOI matches its Crossref record; 206 of the 206 references it cites were found in a registry or an index.

The microbiome and cancer

Open access

Schwabe, Robert F., Jobin, Christian·2013·Nature Reviews Cancer

Open this paper in CoChat — free account

Abstract

Microbiota and host form a complex 'super-organism' in which symbiotic relationships confer benefits to the host in many key aspects of life. However, defects in the regulatory circuits of the host that control bacterial sensing and homeostasis, or alterations of the microbiome, through environmental changes (infection, diet or lifestyle), may disturb this symbiotic relationship and promote disease. Increasing evidence indicates a key role for the bacterial microbiota in carcinogenesis. In this Opinion article, we discuss links between the bacterial microbiota and cancer, with a particular focus on immune responses, dysbiosis, genotoxicity, metabolism and strategies to target the microbiome for cancer prevention.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nrc3610

Cites

206 of 206 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
Immunity, Inflammation, and Cancer
Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
Inflammation and cancer: back to Virchow?
Balkwill, F., & Mantovani, A. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04046-0 · Cited by 7,746
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277
Metagenomic Analysis of the Human Distal Gut Microbiome
Gill, S. R., Pop, M., DeBoy, R. T., Eckburg, P. B., Turnbaugh, P. J., Samuel, B. S., Gordon, J. I., Relman, D. A., Fraser-Liggett, C. M., & Nelson, K. E. (2006) · Science · doi:10.1126/science.1124234 · Cited by 4,699

Show all 205 references

Research works printed but not linked: 2

Koch, R. in Tenth International Congress of Medicine 1 (August Hirschwald, Berlin, 1891).
Laqueur, G. L., Matsumoto, H. & Yamamoto, R. S. Comparison of the carcinogenicity of methylazoxymethanol-β-D-glucosiduronic acid in conventional and germfree Sprague-Dawley rats. J. Natl Cancer Inst. 67, 1053–1055 (1981).

Sorted by citations

Items 901–1,000 of 1,001

Variations in cervico-vaginal microbiota among HPV-positive and HPV-negative asymptomatic women in Peru
Carrillo‐Ng, H., Becerra-Goicochea, L., Tarazona-Castro, Y., Pinillos-Vilca, L., del Valle, L. J., Aguilar-Luis, M. Á., Tinco-Valdez, C., Silva-Caso, W. G., Martins-Luna, J., Peña-Tuesta, I., et al. (2021) · BMC Research Notes · doi:10.1186/s13104-020-05422-6 · Cited by 18
Impact of the ileal microbiota on colon cancer
Roberti, M. P., Rauber, C., Kroemer, G., & Zitvogel, L. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.09.016 · Cited by 18
Antibiotic therapy is associated with an increased incidence of cancer
Roderburg, C., Loosen, S. H., Jördens, M. S., Demir, M., Luedde, T., & Kostev, K. (2022) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-03998-z · Cited by 18
Diet, Microbes, and Cancer Across the Tree of Life: a Systematic Review
Kapsetaki, S. E., Alcaraz, G. M., Maley, C. C., Whisner, C. M., & Aktipis, A. (2022) · Current Nutrition Reports · doi:10.1007/s13668-022-00420-5 · Cited by 19
Opisthorchiasis and the Microbiome
Saltykova, I. V., Петров, В. А., & Brindley, P. J. (2018) · Advances in Parasitology/Advances in parasitology · doi:10.1016/bs.apar.2018.07.001 · Cited by 18
Probiotics Evaluation in Oncological Surgery: A Systematic Review of 36 Randomized Controlled Trials Assessing 21 Diverse Formulations
Cogo, E., Elsayed, M., Liang, V., Cooley, K., Guerin, C., Psihogios, A., & Papadogianis, P. (2021) · Current Oncology · doi:10.3390/curroncol28060435 · Cited by 17
Gut Microbiota and Therapy in Metastatic Melanoma: Focus on MAPK Pathway Inhibition
Guardamagna, M., Berciano‐Guerrero, M., González, B. V., Pérez-Ruiz, E., Oliver, J., Lavado-Valenzuela, R., Rueda‐Domínguez, A., Barragán, I., & Queipo‐Ortuño, M. I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911990 · Cited by 17
Oral microbiota may predict the presence of esophageal squamous cell carcinoma
Jiang, Z., Wang, J., Qian, X., Zhang, Z., & Wang, S. (2022) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-04393-4 · Cited by 17
Association between vaginal microbiota and the progression of ovarian cancer
Li, C., Feng, Y., Yang, C., Wang, D., Zhang, D., Luo, X., Zhang, H., Huang, H., Zhang, H., Jiang, Y., et al. (2023) · Journal of Medical Virology · doi:10.1002/jmv.28898 · Cited by 17
Eating away cancer: the potential of diet and the microbiome for shaping immunotherapy outcome
Nguyen, N.-T. A., Jiang, Y., & McQuade, J. L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1409414 · Cited by 19
Associations of antibiotic use with risk of primary liver cancer in the Clinical Practice Research Datalink
Yang, B., Hagberg, K. W., Chen, J., Sahasrabuddhe, V. V., Graubard, B. I., Jick, S. S., & McGlynn, K. A. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.148 · Cited by 17
Manipulation of the Microbiota Using Probiotics
Grimm, V., & Riedel, C. U. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-31248-4_8 · Cited by 17
Research Strategies for Nutritional and Physical Activity Epidemiology and Cancer Prevention
Mahabir, S., Willett, W. C., Friedenreich, C. M., Lai, G. Y., Boushey, C. J., Matthews, C. E., Sinha, R. R., Colditz, G. A., Rothwell, J. A., Reedy, J., et al. (2017) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-17-0509 · Cited by 17
Novel human microbe-disease associations inference based on network consistency projection
Zou, S., Zhang, J., & Zhang, Z. (2018) · Scientific Reports · doi:10.1038/s41598-018-26448-8 · Cited by 17
Elemental Ratios Link Environmental Change and Human Health
Paseka, R. E., Bratt, A. R., MacNeill, K. L., Burian, A., & See, C. R. (2019) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2019.00378 · Cited by 18
Composition and consistence of the bacterial microbiome in upper, middle and lower esophagus before and after Lugol’s iodine staining in the esophagus cancer screening
Yin, J., Dong, L., Zhao, J., Shao, D., Li, J., Li, J., Yu, A., Wei, W., & Chen, W. (2020) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2020.1839961 · Cited by 17
Revealing the composition of the eukaryotic microbiome of oyster spat by CRISPR-Cas Selective Amplicon Sequencing (CCSAS)
Zhong, K. X., Cho, A., Deeg, C., Chan, A. M., & Suttle, C. A. (2021) · Microbiome · doi:10.1186/s40168-021-01180-0 · Cited by 17
Evolutionary dynamics in Barrett oesophagus: implications for surveillance, risk stratification and therapy
Schmidt, M., HACKETT, R. J., Baker, A., McDonald, S. A. C., Quante, M., & Graham, T. A. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00531-4 · Cited by 17
The Machine-Learning-Mediated Interface of Microbiome and Genetic Risk Stratification in Neuroblastoma Reveals Molecular Pathways Related to Patient Survival
Li, X., Wang, X., Huang, R., Stucky, A., Chen, X., Sun, L. P., Wen, Q., Zeng, Y., Fletcher, H. M., Wang, C., et al. (2022) · Cancers · doi:10.3390/cancers14122874 · Cited by 17
Association between Dietary Fatty Acid Patterns and Colorectal Cancer Risk: A Large-Scale Case-Control Study in China
Tu, K., Ma, T., Zhou, R., Xu, L., Fang, Y., & Zhang, C. (2022) · Nutrients · doi:10.3390/nu14204375 · Cited by 17
Metaproteomic Analysis of an Oral Squamous Cell Carcinoma Dataset Suggests Diagnostic Potential of the Mycobiome
He, S., Chakraborty, R., & Ranganathan, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021050 · Cited by 17
Gut Microbiota as a Positive Potential Therapeutic Factor in Carcinogenesis: an Overview of Microbiota-Targeted Therapy
Joukar, F., Mavaddati, S., Mansour‐Ghanaei, F., & Samadani, A. A. (2019) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-019-00237-6 · Cited by 17
Does microbiome shift play a role in carcinogenesis? A systematic review
Mallika, L., Augustine, D., Rao, R. S., Patil, S., Alamir, A. H., Awan, K. H., Sowmya, S., Haragannavar, V. C., & Prasad, K. (2020) · Translational Cancer Research · doi:10.21037/tcr.2020.02.11 · Cited by 17
Reprogramming of myeloid angiogenic cells byBartonella henselaeleads to microenvironmental regulation of pathological angiogenesis
O’Rourke, F., Mändle, T., Urbich, C., Dimmeler, S., Michaelis, U. R., Brandes, R. P., Floetenmeyer, M., Döring, C., Hansmann, M., Lauber, K., et al. (2015) · Cellular Microbiology · doi:10.1111/cmi.12447 · Cited by 17
Predicting potential microbe-disease associations based on heterogeneous graph attention network and deep sparse autoencoder
Wang, B., Zhao, W., Du, X., Zhang, J., Zhang, C., Wang, L., & He, Y. (2025) · Engineering Applications of Artificial Intelligence · doi:10.1016/j.engappai.2025.110301 · Cited by 16
Predicting healthspan and disease risks through biological age
Li, G., Cheng, L., Wong, I. N., Yin, Y., Chen, J., Liu, L., & Zhang, K. (2025) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2025.10.006 · Cited by 16
Alteration of stomach microbiota compositions in the progression of gastritis induces nitric oxide in gastric cell
Dong, T., Feng, Q., Liu, F., Chang, L. K., Zhou, X., Han, M., Tian, X., Zhong, N., & Liu, S. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4373 · Cited by 16
Human Microbiota in Esophageal Adenocarcinoma: Pathogenesis, Diagnosis, Prognosis and Therapeutic Implications
Dan, W., Peng, L., Yan, B., Li, Z., & Pan, F. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.791274 · Cited by 16
Advanced development of biomarkers for immunotherapy in hepatocellular carcinoma
Peng, X., Gong, C., Zhang, W., & Zhou, A. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2022.1091088 · Cited by 16
The animal's microbiome and cancer: A translational perspective
Aluai‐Cunha, C., Pinto, C. A., Correia, A., Serra, C. R., & Santos, A. A. F. (2023) · Veterinary and Comparative Oncology · doi:10.1111/vco.12892 · Cited by 17
The dynamic crosslinking between gut microbiota and inflammation during aging: reviewing the nutritional and hormetic approaches against dysbiosis and inflammaging
Chaudhary, S., Kaur, P., Singh, T. A., Bano, K. S., Vyas, A., Mishra, A. K., Singh, P., & Mehdi, M. M. (2024) · Biogerontology · doi:10.1007/s10522-024-10146-2 · Cited by 17
Intrinsic association between diet and the gut microbiome: current evidence
Fodor, A. A., & Winglee, K. (2015) · Nutrition and Dietary Supplements · doi:10.2147/nds.s62362 · Cited by 16
A discussion of the gut microbiome’s development, determinants, and dysbiosis in cancers of the esophagus and stomach
Grover, K., Gregory, S., Gibbs, J. F., & Emenaker, N. J. (2021) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo-2019-gi-07 · Cited by 16
The Gut Microbiota Impact Cancer Etiology through “Phase IV Metabolism” of Xenobiotics and Endobiotics
Ervin, S. M., & Redinbo, M. R. (2020) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-20-0155 · Cited by 16
Disparities in Surgical Oncology: Management of Advanced Cancer
Nizam, W., Yeo, H., Obeng‐Gyasi, S., Brock, M. V., & Johnston, F. M. (2021) · Annals of Surgical Oncology · doi:10.1245/s10434-021-10275-9 · Cited by 16
Immune-Onco-Microbiome: A New Revolution for Gynecological Cancers
Tucci, C. D., Vito, I. M., & Muzii, L. (2023) · Biomedicines · doi:10.3390/biomedicines11030782 · Cited by 16
Biological measures to minimize the risk of radiotherapy-associated second cancer: A research perspective
Imaoka, T., Ishii, N., Kawaguchi, I., Homma‐Takeda, S., Doi, K., Daino, K., Nakanishi, I., Tagami, K., Kokubo, T., Morioka, T., et al. (2016) · International Journal of Radiation Biology · doi:10.3109/09553002.2016.1152413 · Cited by 16
A Catalogue of Altered Salivary Proteins Secondary to Invasive Ductal Carcinoma: A Novel In Vivo Paradigm to Assess Breast Cancer Progression
Streckfus, C. F., & Bigler, L. R. (2016) · Scientific Reports · doi:10.1038/srep30800 · Cited by 17
A multicenter, randomized controlled comparison of three renutrition strategies for the management of moderate acute malnutrition among children aged from 6 to 24 months (the MALINEA project)
Vray, M., Hedible, K. G. B., Adam, P., Tondeur, L., Manirazika, A., Randremanana, R. V., Maïnassara, H. B., Briend, A., Artaud, C., Platen, C. V., et al. (2018) · Trials · doi:10.1186/s13063-018-3027-3 · Cited by 17
Cancer immunity thwarted by the microbiome
Hartmann, N., & Kronenberg, M. (2018) · Science · doi:10.1126/science.aat8289 · Cited by 16
Predictive Biomarkers for Immunotherapy in the Treatment of Advanced Urothelial Carcinoma: Where We Stand and Where We Go
Gevaert, T., Cimadamore, A., Eckstein, M., Scarpelli, M., Antonio Lopez-beltran, B., Liang Cheng, C., & Montironi, R. (2019) · Future Oncology · doi:10.2217/fon-2019-0217 · Cited by 16
The bacteria inside human cancer cells: Mainly as cancer promoters
Zhu, W., Wang, J., Liu, Z., & Wei, J. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.897330 · Cited by 16
The Microbiome in PDAC—Vantage Point for Future Therapies?
Pfisterer, N., Lingens, C., Heuer, C., Dang, L., Neeße, A., & Ammer‐Herrmenau, C. (2022) · Cancers · doi:10.3390/cancers14235974 · Cited by 15
Tumor Microbial Communities and Thyroid Cancer Development—The Protective Role of Antioxidant Nutrients: Application Strategies and Future Directions
Gorini, F., & Tonacci, A. (2023) · Antioxidants · doi:10.3390/antiox12101898 · Cited by 16
Buds and Bugs: A Fascinating Tale of Gut Microbiota and Cannabis in the Fight against Cancer
Al-Khazaleh, A. K., Jaye, K. M., Chang, D., Münch, G. W., & Bhuyan, D. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020872 · Cited by 15
Targeting bacterial metabolites in tumor for cancer therapy: An alternative approach for targeting tumor-associated bacteria
Ji, G., Zhao, J., Si, X., & Song, W. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115345 · Cited by 16
The microbial composition of pancreatic ductal adenocarcinoma: a systematic review of 16S rRNA gene sequencing
Merali, N., Chouari, T. A. M., Sweeney, C., Halle-Smith, J. M., Jessel, M.-D., Wang, B., Brien, J. O., Suyama, S., Jiménez, J. I., Roberts, K. J., et al. (2024) · International Journal of Surgery · doi:10.1097/js9.0000000000001762 · Cited by 15
Predictive Value of a Gastric Microbiota Dysbiosis Test for Stratifying Cancer Risk in Atrophic Gastritis Patients
Zaramella, A., Arcidiacono, D., Duci, M., Benna, C., Pucciarelli, S., Fantin, A., Rosato, A., Re, V. D., Cannizzaro, R., Fassan, M., et al. (2024) · Nutrients · doi:10.3390/nu17010142 · Cited by 15
Multi-omics analysis reveals associations between gut microbiota and host transcriptome in colon cancer patients
Qin, Y., Wang, Q., Lin, Q., Liu, F., Pan, X., Wei, C., Chen, J., Huang, T., Fang, M., Yang, W., et al. (2025) · mSystems · doi:10.1128/msystems.00805-24 · Cited by 15
Chronic Inflammation and Carcinogenesis – Emerging Role of Chronic Inflammatory Periodontal Disease
Grover, V., Kapoor, A., Sehgal, K., & Kaur, G. (2016) · Cancer Research Frontiers · doi:10.17980/2016.200 · Cited by 15
Microbiota and cancer: an update
Vallianou, N. G., & Tzortzatou-Stathopoulou, F. F. (2019) · Journal of Chemotherapy · doi:10.1080/1120009x.2018.1541046 · Cited by 15
Prognostic Biomarkers for Melanoma Immunotherapy
Twitty, C., Huppert, L. A., & DAUD, A. I. (2020) · Current Oncology Reports · doi:10.1007/s11912-020-0886-z · Cited by 15
Host Microbiomes in Tumor Precision Medicine: How far are we?
D’Amico, F., Barone, M., Tavella, T., Rampelli, S., Brigidi, P., & Turroni, S. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220105121754 · Cited by 16
Body Microbiota and Its Relationship With Benign and Malignant Breast Tumors: A Systematic Review
Samkari, A., Alsulami, M., Bataweel, L. A., Altaifi, R., Altaifi, A., Saleem, A., Farsi, A., Iskanderani, O. F., Akeel, N. Y., Malibary, N., et al. (2022) · Cureus · doi:10.7759/cureus.25473 · Cited by 15
Understanding the development and function of the gut microbiota in health and inflammation
Selvakumar, D., Evans, D., Coyte, K. Z., McLaughlin, J. T., Brass, A., Hancock, L., & Cruickshank, S. M. (2022) · Frontline Gastroenterology · doi:10.1136/flgastro-2022-102119 · Cited by 15
Nutrition and Microbiome Interactions in Human Cancer
Daschner, P. J., Ross, S., Seifried, H. E., Kumar, A., & Flores, R. (2022) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2022.10.004 · Cited by 15
The Influence of the microbiome on the innate immune microenvironment of solid tumors
Charles, A. M., & Thomas, R. M. (2023) · Neoplasia · doi:10.1016/j.neo.2023.100878 · Cited by 15
Intestinal microbiota: A bridge between intermittent fasting and tumors
Liu, J., Shao, N., Qiu, H., Zhao, J., Chen, C., Wan, J., He, Z., Zhao, X., & Xu, L. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115484 · Cited by 15
An Integrated Outlook on the Metagenome and Metabolome of Intestinal Diseases
Aw, W., & Fukuda, S. (2015) · Diseases · doi:10.3390/diseases3040341 · Cited by 15
How adaptive immunity constrains the composition and fate of large bacterial populations
Bonsma-Fisher, M., Soutière, D., & Goyal, S. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1802887115 · Cited by 15
The New Frontier: the Intestinal Microbiome and Surgery
Skowron, K. B., Shogan, B. D., Rubin, D. T., & Hyman, N. (2018) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-018-3744-7 · Cited by 15
The pro- and antineoplastic effects of deoxycholic acid in pancreatic adenocarcinoma cell models
Schwarcz, S., Kovács, P., Kovàcs, T., Ujlaki, G., Nyerges, P., Uray, K., Bai, P., & Mikó, E. (2023) · Molecular Biology Reports · doi:10.1007/s11033-023-08453-x · Cited by 14
Metagenomic analysis unveils the microbial landscape of pancreatic tumors
Khan, S., Banerjee, G., Setua, S., Jones, D. H., Chauhan, B. V., Dhasmana, A., Banerjee, P., Yallapu, M. M., Behrman, S. W., & Chauhan, S. C. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1275374 · Cited by 14
The Human Gut and Dietary Salt: The Bacteroides/Prevotella Ratio as a Potential Marker of Sodium Intake and Beyond
Fagunwa, O., Davies, K., & Bradbury, J. (2024) · Nutrients · doi:10.3390/nu16070942 · Cited by 14
Encapsulation of probiotics using gelatin and sodium phytate for improvement of viability and antioxidant capacity in gastrointestinal condition
Dadmehr, M., Mansouri, R., & Korouzhdehi, B. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105550 · Cited by 14
Significant Impact ofIL-6-174G/C but Inverse Relation with -634 C/G Polymorphism in Patients with Non-Small Cell Lung Cancer in Kashmiri Population
Bhat, I. A., Qasim, I., Masoodi, K. Z., Paul, S. A., Bhat, B. A., Rasool, R., Aziz, S. A., & Shah, Z. A. (2015) · Immunological Investigations · doi:10.3109/08820139.2015.1004336 · Cited by 14
Tongue-coating microbiome as a cancer predictor: A scoping review
Mohammed, M. M. A., Kawas, S. A., & Al‐Qadhi, G. (2021) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2021.105271 · Cited by 15
Transcriptional Heterogeneity and the Microbiome of Cutaneous T-Cell Lymphoma
Licht, P., & Mailänder, V. (2022) · Cells · doi:10.3390/cells11030328 · Cited by 14
Does Gut-breast Microbiota Axis Orchestrates Cancer Progression?
Marino, M. M., Nastri, B. M., D’Agostino, M., Risolo, R., Angelis, A. D., Settembre, G., Rienzo, M., D’Esposito, V., Abbondanza, C., Formisano, P., et al. (2022) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530322666220331145816 · Cited by 14
Hepatocellular carcinoma and microbiota: Implications for clinical management and treatment
Spanu, D., Pretta, A., Lai, E., Persano, M., Donisi, C., Mariani, S., Dubois, M., Migliari, M., Saba, G., Ziranu, P., et al. (2022) · World Journal of Hepatology · doi:10.4254/wjh.v14.i7.1319 · Cited by 16
Both endogenous and exogenous miR-139–5p inhibit Fusobacterium nucleatum-related colorectal cancer development
Zhao, Y., Tao, Q., Li, S., Zheng, P., Liu, J., & Liang, X. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173459 · Cited by 14
High-dimensional log-error-in-variable regression with applications to microbial compositional data analysis
Shi, P., Zhou, Y., & Zhang, A. R. (2021) · Biometrika · doi:10.1093/biomet/asab020 · Cited by 14
Gastric Cancer and Microbiota: Exploring the Microbiome’s Role in Carcinogenesis and Treatment Strategies
Lazăr, D. C., Chiriac, S. D., Drăghici, G. A., Moacă, E.-A., Faur, A. C., Avram, M. F., Turi, V., Nicolin, M.-R., Goldiș, A., Salehi, M. A., et al. (2025) · Life · doi:10.3390/life15070999 · Cited by 13
Gut Microbiome, a Potent Modulator of Epigenetics in Human Diseases
Kim, J. (2017) · Journal of Bacteriology and Virology · doi:10.4167/jbv.2017.47.2.75 · Cited by 13
Fusobacterium nucleatum—The Cause of Human Colorectal Cancer
Barukčić, I. (2018) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2018.63004 · Cited by 20
Nutraceuticals in the Modulation of the Intestinal Microbiota: Current Status and Future Directions
Spisni, E., Turroni, S., Alvisi, P., Spigarelli, R., Azzinnari, D., Ayala, D., Imbesi, V., & Valerii, M. C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.841782 · Cited by 14
Bladder Cancer and the Urinary Microbiome—New Insights and Future Directions: A Review
Russo, A. E., Memon, A., & Ahmed, S. S. (2024) · Clinical Genitourinary Cancer · doi:10.1016/j.clgc.2023.12.015 · Cited by 13
The characteristics of intratumoral microbial community reflect the development of lung adenocarcinoma
Su, Y., Li, S., Sang, D., & Zhang, Y. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1353940 · Cited by 13
Endometrial Dysbiosis: A Possible Association with Estrobolome Alteration
Scarfò, G., Daniele, S., Chelucci, E., Papini, F., Epifani, F., Ruggiero, M. R., Cela, V., Franzoni, F., & Artini, P. G. (2024) · Biomolecules · doi:10.3390/biom14101325 · Cited by 13
The oral-gut microbiome axis in breast cancer: from basic research to therapeutic applications
Huang, L., Jiang, C., Yan, M., Wan, W., Li, S., Xiang, Z., & Wu, J. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1413266 · Cited by 13
A comprehensive analysis of the uterine microbiome in endometrial cancer patients - identification of Anaerococcus as a potential biomarker and carcinogenic cofactor
Kuźmycz, O., Kowalczyk, A., Bolanowska, A., Drozdzowska, A., Lach, J., Wierzbińska, W., Kluz, T., & Stączek, P. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1511625 · Cited by 13
The role of the urinary microbiome in genitourinary cancers
Lee, S., Sfanos, K. S., & Singla, N. (2025) · Nature Reviews Urology · doi:10.1038/s41585-025-01011-z · Cited by 13
Bone Mechanical Function and the Gut Microbiota
Hernandez, C. J. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-66653-2_12 · Cited by 13
Piceatannol Mediated Modulation of Oxidative Stress and Regeneration in the Liver of Endotoxemic Mice
Kılıç, V. (2019) · Journal of Medicinal Food · doi:10.1089/jmf.2018.0201 · Cited by 13
Analyzing the Association between Candida Prevalence, Species Specificity, and Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis— Candida and OSCC
Patil, S. (2020) · Applied Sciences · doi:10.3390/app10031099 · Cited by 13
Diverse role of gut microbiota on reduction of ascites and intestinal injury in malignant ascites effusion rats treated with Euphorbia kansui stir-fried with vinegar
Guo, S., Jiang, D., Zhang, Q., Zhang, Y., Yao, W., Cao, Y., Bao, B., Tang, Y., An, K., & Li, Z. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113489 · Cited by 13
Tissue-associated microbial detection in cancer using human sequencing data
Rodriguez, R. M., Khadka, V. S., Menor, M., Hernandez, B. Y., & Deng, Y. (2020) · BMC Bioinformatics · doi:10.1186/s12859-020-03831-9 · Cited by 13
Wastewater treatment works change the intestinal microbiomes of insectivorous bats
Mehl, C., Schoeman, M. C., Sanko, T. J., Bezuidenhout, C. C., Mienie, C. M. S., Preiser, W., & Vosloo, D. (2021) · PLoS ONE · doi:10.1371/journal.pone.0247475 · Cited by 13
Bugs as Drugs: Neglected but a Promising Future Therapeutic Strategy in Cancer
Divyashree, M., Prakash, S. K., Aditya, V., Aljabali, A. A. A., Alzahrani, K. J., Azevedo, V., Goés‐Neto, A., Tambuwala, M. M., & Barh, D. (2022) · Future Oncology · doi:10.2217/fon-2021-1137 · Cited by 13
Interaction of cervical microbiome with epigenome of epithelial cells: Significance of inflammation to primary healthcare
Holubeková, V., Kolková, Z., Kašubová, I., Samec, M., Mazuráková, A., Koklesová, L., Kubatka, P., Rokos, T., Kozubík, E., Biringer, K., et al. (2022) · BioMolecular Concepts · doi:10.1515/bmc-2022-0005 · Cited by 13
Bee pollen in zebrafish diet affects intestinal microbiota composition and skin cutaneous melanoma development
Chiacchio, I. M. D., Gómez‐Abenza, E., Paiva, I. M., de Abreu, D. J. M., Rodriguez-Vidal, J. F., Carvalho, E. E. N., Carvalho, S. M., Murgas, L. D. S., & Mulero, V. (2022) · Scientific Reports · doi:10.1038/s41598-022-14245-3 · Cited by 13
Hedgehog blockade remodels the gut microbiota and the intestinal effector CD8+ T cells in a mouse model of mammary carcinoma
Hinshaw, D. C., Swain, C. A., Chen, D., Hanna, A., Molina, P. A., Maynard, C. L., Lee, G., McFarland, B. C., Samant, R. S., & Shevde, L. A. (2022) · Laboratory Investigation · doi:10.1038/s41374-022-00828-1 · Cited by 15
Probiotic immunonutrition impacts on colon cancer immunotherapy and prevention
Nami, Y., Hejazi, S., Geranmayeh, M. H., Shahgolzari, M., & Khosroushahi, A. Y. (2022) · European Journal of Cancer Prevention · doi:10.1097/cej.0000000000000738 · Cited by 13
miR‐203a —A multifaceted regulator modulating cancer hallmarks and therapy response
Biswal, P., Lalruatfela, A., Behera, S. K., Biswal, S., & Mallick, B. (2023) · IUBMB Life · doi:10.1002/iub.2786 · Cited by 13
Mechanistic and Technical Challenges in Studying the Human Microbiome and Cancer Epidemiology
Verma, M. (2016) · Technology in Cancer Research & Treatment · doi:10.1177/1533034616645219 · Cited by 14
Cigarette smoke toxicity modes of action estimated by a bioluminescent bioreporter bacterial panel
Axelrod, T., Eltzov, E., Lerman, M., Harpaz, D., & Marks, R. S. (2021) · Talanta · doi:10.1016/j.talanta.2020.122076 · Cited by 13
3D Organoids: An Untapped Platform for Studying Host–Microbiome Interactions in Esophageal Cancers
Flashner, S. P., Yan, K. S., & Nakagawa, H. (2021) · Microorganisms · doi:10.3390/microorganisms9112182 · Cited by 13
From promotion to management: The wide impact of bacteria on cancer and its treatment
Peréz-Chanona, E., & Jobin, C. (2014) · BioEssays · doi:10.1002/bies.201400015 · Cited by 13
Self-citation
Global Epidemiology of Gastrointestinal Cancers
Dızdar, Ö., & Kılıçkap, S. (2019) · Springer eBooks · doi:10.1007/978-3-030-18890-0_1 · Cited by 14
Editorial on "Cancer and the microbiota" published in Science.
Hamm, A. K., & Weir, T. L. (2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2305-5839.2015.07.16 · Cited by 14

Authors: Schwabe, R. F., & Jobin, C.
Affiliations: Columbia University (US)
University of Florida Health (US)
Corresponding author: Schwabe, Robert F.
Jobin, Christian
ORCID: Schwabe, Robert F.
Jobin, Christian
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2013-10-17
Volume: 13
Issue: 11
Pages: 800-812
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc3610
PMC: PMC3986062
OpenAlex: W2016853666
Cited by: 1,689
References: 205
Citations by year: 2026: 87 · 2025: 123 · 2024: 135 · 2023: 141 · 2022: 207 · 2021: 214 · 2020: 150 · 2019: 138 · 2018: 146 · 2017: 103 · 2016: 110 · 2015: 77 · 2014: 54
FWCI: 7.55
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Alcohol Abuse and Alcoholism (R01AA020211)
National Cancer Institute (U54CA163111)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK047700, R01DK073338, R01DK076920)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
Keywords: gut microbiota, carcinogenesis, dysbiosis, host-microbe symbiosis, bacterial sensing, immune response, genotoxicity, host metabolism, cancer prevention, microbiome-targeted therapy
MeSH terms: Animals, Bacteria, Diet, Humans, Immune System, Mutagens, Neoplasms, Symbiosis, Gene Expression Regulation, Bacterial, Gene Expression Regulation, Neoplastic, Virulence Factors, Mice, Carcinogenesis, Microbiota

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The microbiome and cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks