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The microbiome and cancer
Open accessAbstract
Microbiota and host form a complex 'super-organism' in which symbiotic relationships confer benefits to the host in many key aspects of life. However, defects in the regulatory circuits of the host that control bacterial sensing and homeostasis, or alterations of the microbiome, through environmental changes (infection, diet or lifestyle), may disturb this symbiotic relationship and promote disease. Increasing evidence indicates a key role for the bacterial microbiota in carcinogenesis. In this Opinion article, we discuss links between the bacterial microbiota and cancer, with a particular focus on immune responses, dysbiosis, genotoxicity, metabolism and strategies to target the microbiome for cancer prevention.
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“The microbial microenvironment is primarily comprised of intestinal and intra-tumoral microorganisms and their metabolites, which possess the ability to either facilitate or inhibit tumor progression and impact the effectiveness and toxicity of cancer treatments.329–332”
From Drug repurposing for cancer therapy (2024) · cites this paper as [332]
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“Exposure to broad-spectrum antibiotic (ATB) therapy may adversely influence outcomes of ICI therapy 2 through modulation of intestinal microbiota, 3 a key host determinant of response to ICIs known to precondition cancer-specific immunity.4”
From Association of Prior Antibiotic Treatment With Survival and Response to Immune Checkpoint Inhibitor Therapy in Patients With Cancer (2019) · cites this paper as [4]
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“In particular, the regulation of such therapeutic outcome is tightly connected with the ability of the gut microbiota to metabolize anti-tumoral compounds, as well as to modulate host’s immune response and inflammation pathways [164].”
From Gut Microbiota and Cancer: From Pathogenesis to Therapy (2019) · cites this paper as [164]
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Metadata
- Authors
- Schwabe, R. F., & Jobin, C.
- Affiliations
- Columbia University (US)
- University of Florida Health (US)
- Corresponding author
- Schwabe, Robert F.
- Jobin, Christian
- Venue
- Nature Reviews Cancer
- Published
- 2013-10-17
- Volume
- 13
- Issue
- 11
- Pages
- 800-812
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- PMC
- PMC3986062
- OpenAlex
- W2016853666
- Cited by
- 1,689
- References
- 205
- Citations by year
- 2026: 87 · 2025: 123 · 2024: 135 · 2023: 141 · 2022: 207 · 2021: 214 · 2020: 150 · 2019: 138 · 2018: 146 · 2017: 103 · 2016: 110 · 2015: 77 · 2014: 54
- FWCI
- 7.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (R01AA020211)
- National Cancer Institute (U54CA163111)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK047700, R01DK073338, R01DK076920)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
- Keywords
- gut microbiota, carcinogenesis, dysbiosis, host-microbe symbiosis, bacterial sensing, immune response, genotoxicity, host metabolism, cancer prevention, microbiome-targeted therapy
- MeSH terms
- Animals, Bacteria, Diet, Humans, Immune System, Mutagens, Neoplasms, Symbiosis, Gene Expression Regulation, Bacterial, Gene Expression Regulation, Neoplastic, Virulence Factors, Mice, Carcinogenesis, Microbiota
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