Cited by 1,689Gut microbiota and healthOral microbiology and periodontitis researchBacterial Cancer Therapy

The DOI matches its Crossref record; 206 of the 206 references it cites were found in a registry or an index.

The microbiome and cancer

Open access

Schwabe, Robert F., Jobin, Christian·2013·Nature Reviews Cancer

Open this paper in CoChat — free account

Abstract

Microbiota and host form a complex 'super-organism' in which symbiotic relationships confer benefits to the host in many key aspects of life. However, defects in the regulatory circuits of the host that control bacterial sensing and homeostasis, or alterations of the microbiome, through environmental changes (infection, diet or lifestyle), may disturb this symbiotic relationship and promote disease. Increasing evidence indicates a key role for the bacterial microbiota in carcinogenesis. In this Opinion article, we discuss links between the bacterial microbiota and cancer, with a particular focus on immune responses, dysbiosis, genotoxicity, metabolism and strategies to target the microbiome for cancer prevention.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nrc3610

Cites

206 of 206 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
Immunity, Inflammation, and Cancer
Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
Inflammation and cancer: back to Virchow?
Balkwill, F., & Mantovani, A. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04046-0 · Cited by 7,746
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277
Metagenomic Analysis of the Human Distal Gut Microbiome
Gill, S. R., Pop, M., DeBoy, R. T., Eckburg, P. B., Turnbaugh, P. J., Samuel, B. S., Gordon, J. I., Relman, D. A., Fraser-Liggett, C. M., & Nelson, K. E. (2006) · Science · doi:10.1126/science.1124234 · Cited by 4,699
Richness of human gut microbiome correlates with metabolic markers
Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662
Interactions Between the Microbiota and the Immune System
Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173
Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile
van Nood, E., Vrieze, A., Nieuwdorp, M., Fuentes, S., Zoetendal, E. G., de Vos, W. M., Visser, C. E., Kuijper, E. J., Bartelsman, J. F. W. M., Tijssen, J. G. P., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1205037 · Cited by 3,708
Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
Calle, E. E., & Kaaks, R. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1408 · Cited by 3,613
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241
Bacterial Community Variation in Human Body Habitats Across Space and Time
Costello, E. K., Lauber, C. L., Hamady, M., Fierer, N., Gordon, J. I., & Knight, R. (2009) · Science · doi:10.1126/science.1177486 · Cited by 3,231
The skin microbiome
Grice, E. A., & Segre, J. A. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2537 · Cited by 3,143
The gut flora as a forgotten organ
O'Hara, A. M., & Shanahan, F. (2006) · The EMBO Reports · doi:10.1038/sj.embor.7400731 · Cited by 2,791
Genetics and pathogenesis of inflammatory bowel disease
Khor, B., Gardet, A., & Xavier, R. J. (2011) · Nature · doi:10.1038/nature10209 · Cited by 2,733
Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment
Kostic, A. D., Chun, E., Robertson, L., Glickman, J. N., Gallini, C. A., Michaud, M., Clancy, T. E., Chung, D. C., Lochhead, P., Hold, G. L., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.007 · Cited by 2,718
Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment
Morgan, X. C., Tickle, T. L., Sokol, H., Gevers, D., Devaney, K. L., Ward, D. V., Reyes, J. A., Shah, S. A., LeLeiko, N., Snapper, S. B., et al. (2012) · Genome Biology · doi:10.1186/gb-2012-13-9-r79 · Cited by 2,713
Human nutrition, the gut microbiome and the immune system
Kau, A. L., Ahern, P. P., Griffin, N. W., Goodman, A. L., & Gordon, J. I. (2011) · Nature · doi:10.1038/nature10213 · Cited by 2,588
Fusobacterium nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/β-Catenin Signaling via its FadA Adhesin
Rubinstein, M. R., Wang, X., Liu, W., Hao, Y., Cai, G., & Han, Y. W. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.012 · Cited by 2,476
MICROBIAL ECOLOGY OF THE GASTROINTESTINAL TRACT
Savage, D. C. (1977) · Annual Review of Microbiology · doi:10.1146/annurev.mi.31.100177.000543 · Cited by 2,436
Intestinal inflammation targets cancer-inducing activity of the microbiota
Arthur, J. C., Perez-Chanona, E., Mühlbauer, M., Tomkovich, S., Uronis, J. M., Fan, T.-J., Campbell, B. J., Abujamel, T., Dogan, B., Rogers, A. B., et al. (2012) · Science · doi:10.1126/science.1224820 · Cited by 2,263
Self-citation
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
Yoshimoto, S., Loo, T. M., Atarashi, K., Kanda, H., Sato, S., Oyadomari, S., Iwakura, Y., Oshima, K., Morita, H., Hattori, M., et al. (2013) · Nature · doi:10.1038/nature12347 · Cited by 2,219
Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori
Wotherspoon, A. C., Diss, T. C., Pan, L., Isaacson, P. G., Doglioni, C., Moschini, A., & Boni, M. D. (1993) · The Lancet · doi:10.1016/0140-6736(93)91409-f · Cited by 2,113
Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5
Vijay-Kumar, M., Aitken, J. D., Carvalho, F. A., Cullender, T. C., Mwangi, S., Srinivasan, S., Sitaraman, S. V., Knight, R., Ley, R. E., & Gewirtz, A. T. (2010) · Science · doi:10.1126/science.1179721 · Cited by 2,068
Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma
Castellarin, M., Warren, R. L., Freeman, J. D., Dreolini, L., Krzywinski, M., Strauss, J., Barnes, R., Watson, P., Allen-Vercoe, E., Moore, R. A., et al. (2012) · Genome Research · doi:10.1101/gr.126516.111 · Cited by 2,043
Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity
Markle, J. G. M., Frank, D. N., Mortin-Toth, S., Robertson, C. E., Feazel, L. M., Rolle-Kampczyk, U., von Bergen, M., McCoy, K. D., Macpherson, A. J., & Danska, J. S. (2013) · Science · doi:10.1126/science.1233521 · Cited by 2,025
The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon
Donohoe, D. R., Garge, N., Zhang, X., Sun, W., O'Connell, T. M., Bunger, M. K., & Bultman, S. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.018 · Cited by 2,003
Genomic analysis identifies association of Fusobacterium with colorectal carcinoma
Kostic, A. D., Gevers, D., Pedamallu, C. S., Michaud, M., Duke, F., Earl, A. M., Ojesina, A. I., Jung, J., Bass, A. J., Tabernero, J., et al. (2012) · Genome Research · doi:10.1101/gr.126573.111 · Cited by 1,960
Gender Disparity in Liver Cancer Due to Sex Differences in MyD88-Dependent IL-6 Production
Naugler, W. E., Sakurai, T., Kim, S., Maeda, S., Kim, K., Elsharkawy, A. M., & Karin, M. (2007) · Science · doi:10.1126/science.1140485 · Cited by 1,955
TLR4 enhances TGF-β signaling and hepatic fibrosis
Seki, E., De Minicis, S., Österreicher, C. H., Kluwe, J., Osawa, Y., Brenner, D. A., & Schwabe, R. F. (2007) · Nature Medicine · doi:10.1038/nm1663 · Cited by 1,942
Self-citation
Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice
Devkota, S., Wang, Y., Musch, M. W., Leone, V., Fehlner-Peach, H., Nadimpalli, A., Antonopoulos, D. A., Jabri, B., & Chang, E. B. (2012) · Nature · doi:10.1038/nature11225 · Cited by 1,904
Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract
Kobayashi, K. S., Chamaillard, M., Ogura, Y., Henegariu, O., Inohara, N., Núñez, G., & Flavell, R. A. (2005) · Science · doi:10.1126/science.1104911 · Cited by 1,834
Dietary intervention impact on gut microbial gene richness
Cotillard, A., Kennedy, S. P., Kong, L. C., Prifti, E., Pons, N., Le Chatelier, E., Almeida, M., Quinquis, B., Levenez, F., Galleron, N., et al. (2013) · Nature · doi:10.1038/nature12480 · Cited by 1,832
A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses
Wu, S., Rhee, K.-J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H.-R., Huso, D. L., Brancati, F. L., Wick, E., McAllister, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2015 · Cited by 1,812
Helicobacter pylori and gastrointestinal tract adenocarcinomas
Peek, R. M., & Blaser, M. J. (2002) · Nature reviews. Cancer · doi:10.1038/nrc703 · Cited by 1,807
The keystone-pathogen hypothesis
Hajishengallis, G., Darveau, R. P., & Curtis, M. A. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2873 · Cited by 1,790
An ecological and evolutionary perspective on human–microbe mutualism and disease
Dethlefsen, L., McFall-Ngai, M., & Relman, D. A. (2007) · Nature · doi:10.1038/nature06245 · Cited by 1,660
Oncogenically active MYD88 mutations in human lymphoma
Ngo, V. N., Young, R. M., Schmitz, R., Jhavar, S. G., Xiao, W., Lim, K., Kohlhammer, H., Xu, W., Yang, Y., Zhao, H., et al. (2010) · Nature · doi:10.1038/nature09671 · Cited by 1,560
Skin immune sentinels in health and disease
Nestle, F. O., Meglio, P. D., Qin, J., & Nickoloff, B. J. (2009) · Nature reviews. Immunology · doi:10.1038/nri2622 · Cited by 1,520
Helicobacter pylori Eradication to Prevent Gastric Cancer in a High-Risk Region of China
Wong, B. C., Lam, S. K., Wong, W. M., Chen, J. S., Zheng, T., Feng, R. E., Lai, K. C., Hu, W. H. C., Yuen, S. T., Leung, S. Y., et al. (2004) · JAMA · doi:10.1001/jama.291.2.187 · Cited by 1,436
Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4
Dapito, D. H., Mencin, A., Gwak, G.-Y., Pradere, J.-P., Jang, M.-K., Mederacke, I., Caviglia, J. M., Khiabanian, H., Adeyemi, A., Bataller, R., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.007 · Cited by 1,346
Self-citation
Adenoma–linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth
Grivennikov, S. I., Wang, K., Mucida, D., Stewart, C. A., Schnabl, B., Jauch, D., Taniguchi, K., Yu, G.-Y., Österreicher, C. H., Hung, K. E., et al. (2012) · Nature · doi:10.1038/nature11465 · Cited by 1,327
Host-Mediated Inflammation Disrupts the Intestinal Microbiota and Promotes the Overgrowth of Enterobacteriaceae
Lupp, C., Robertson, M. L., Wickham, M. E., Sekirov, I., Champion, O. L., Gaynor, E. C., & Finlay, B. B. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.06.010 · Cited by 1,310
Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers
Wang, T., Cai, G., Qiu, Y., Fei, N., Zhang, M., Pang, X., Jia, W., Cai, S., & Zhao, L. (2012) · The ISME Journal · doi:10.1038/ismej.2011.109 · Cited by 1,287
Gut immune maturation depends on colonization with a host-specific microbiota
Chung, H., Pamp, S. J., Hill, J. A., Surana, N. K., Edelman, S. M., Troy, E. B., Reading, N. C., Villablanca, E. J., Wang, S., Mora, J. R., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.037 · Cited by 1,241
Infection in the Pathogenesis and Course of Chronic Obstructive Pulmonary Disease
Sethi, S., & Murphy, T. F. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0800353 · Cited by 1,238
Filaggrin Mutations Associated with Skin and Allergic Diseases
Irvine, A. D., McLean, W. H. I., & Leung, D. Y. M. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1011040 · Cited by 1,217
Escherichia coli Induces DNA Double-Strand Breaks in Eukaryotic Cells
Nougayrède, J.-P., Homburg, S., Taieb, F., Boury, M., Brzuszkiewicz, E., Gottschalk, G., Buchrieser, C., Hacker, J., Dobrindt, U., & Oswald, E. (2006) · Science · doi:10.1126/science.1127059 · Cited by 1,188
Antioxidant activity of fresh apples
Eberhardt, M. V., Lee, C. Y., & Liu, R. H. (2000) · Nature · doi:10.1038/35016151 · Cited by 1,182
Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor
Smith, M. I., Yatsunenko, T., Manary, M. J., Trehan, I., Mkakosya, R., Cheng, J., Kau, A. L., Rich, S. S., Concannon, P., Mychaleckyj, J. C., et al. (2013) · Science · doi:10.1126/science.1229000 · Cited by 1,173
Molecular mechanisms of alcohol-mediated carcinogenesis
Seitz, H. K., & Stickel, F. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2191 · Cited by 1,166
Cancer prevention by tea: animal studies, molecular mechanisms and human relevance
Yang, C. S., Wang, X., Lü, G., & Picinich, S. C. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2641 · Cited by 1,153
Moving pictures of the human microbiome
Caporaso, J. G., Lauber, C. L., Costello, E. K., Berg-Lyons, D., Gonzalez, A., Stombaugh, J., Knights, D., Gajer, P., Ravel, J., Fierer, N., et al. (2011) · Genome Biology · doi:10.1186/gb-2011-12-5-r50 · Cited by 1,138
Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme
Wallace, B. D., Wang, H., Lane, K. T., Scott, J. E., Orans, J., Koo, J. S., Venkatesh, M., Jobin, C., Yeh, L.-A., Mani, S., et al. (2010) · Science · doi:10.1126/science.1191175 · Cited by 1,080
Self-citation
Human Intestinal Lumen and Mucosa-Associated Microbiota in Patients with Colorectal Cancer
Chen, W., Liu, F., Ling, Z., Tong, X., & Xiang, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039743 · Cited by 1,054
Th17 and regulatory T cells in mediating and restraining inflammation
Littman, D. R., & Rudensky, A. Y. (2010) · Cell · doi:10.1016/j.cell.2010.02.021 · Cited by 1,039
Host-Derived Nitrate Boosts Growth of E. coli in the Inflamed Gut
Winter, S. E., Winter, M. G., Xavier, M. N., Thiennimitr, P., Poon, V., Keestra, A. M., Laughlin, R. C., Gomez, G., Wu, J., Lawhon, S. D., et al. (2013) · Science · doi:10.1126/science.1232467 · Cited by 1,019
The genetics and immunopathogenesis of inflammatory bowel disease
Cho, J. H. (2008) · Nature Reviews Immunology · doi:10.1038/nri2340 · Cited by 940
Colorectal Cancer in Mice Genetically Deficient in the Mucin Muc2
Velcich, A., Yang, W., Heyer, J., Fragale, A., Nicholas, C., Viani, S., Kucherlapati, R., Lipkin, M., Yang, K., & Augenlicht, L. (2002) · Science · doi:10.1126/science.1069094 · Cited by 936
Microbial Dysbiosis in Colorectal Cancer (CRC) Patients
Sobhani, I., Tap, J., Roudot‐Thoraval, F., Roperch, J. P., Letulle, S., Langella, P., Corthier, G., Nhieu, J. T. V., & Furet, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016393 · Cited by 859
Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells
Cuevas-Ramos, G., Petit, C. R., Marcq, I., Boury, M., Oswald, E., & Nougayrède, J.-P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001261107 · Cited by 855
The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer
Allen, I. C., TeKippe, E. M., Woodford, R.-M. T., Uronis, J. M., Holl, E. K., Rogers, A. B., Herfarth, H. H., Jobin, C., & Ting, J. P.-Y. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100050 · Cited by 826
Self-citation
Enterobacteriaceae Act in Concert with the Gut Microbiota to Induce Spontaneous and Maternally Transmitted Colitis
Garrett, W. S., Gallini, C. A., Yatsunenko, T., Michaud, M., DuBois, A., Delaney, M. L., Punit, S., Karlsson, M., Bry, L., Glickman, J. N., et al. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2010.08.004 · Cited by 788
Why do viruses cause cancer? Highlights of the first century of human tumour virology
Moore, P. S., & Chang, Y. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2961 · Cited by 781
High-protein, reduced-carbohydrate weight-loss diets promote metabolite profiles likely to be detrimental to colonic health
Russell, W. R., Gratz, S. W., Duncan, S. H., Holtrop, G., Ince, J., Scobbie, L., Duncan, G., Johnstone, A. M., Lobley, G. E., Wallace, R. J., et al. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.002188 · Cited by 775
Inflammation, atrophy, and gastric cancer
Fox, J. G., & Wang, T. C. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30111 · Cited by 772
Microbiome and malignancy
Plottel, C. S., & Blaser, M. J. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.10.003 · Cited by 743
Relevance of protein fermentation to gut health
Windey, K., De Preter, V., & Verbeke, K. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100542 · Cited by 692
Cancer epidemiology in the last century and the next decade
Peto, J. (2001) · Nature · doi:10.1038/35077256 · Cited by 688
Regulated virulence controls the ability of a pathogen to compete with the gut microbiota
Kamada, N., Kim, Y.-G., Sham, H. P., Vallance, B. A., Puente, J. L., Martens, E. C., & Núñez, G. (2012) · Science · doi:10.1126/science.1222195 · Cited by 682
Bacterial translocation (BT) in cirrhosis†
Wiest, R., & Garcia‐Tsao, G. (2005) · Hepatology · doi:10.1002/hep.20632 · Cited by 677
Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer
Farrell, J. J., Zhang, L., Zhou, H., Chia, D., Elashoff, D., Akin, D., Paster, B. J., Joshipura, K., & Wong, D. T. W. (2012) · Gut · doi:10.1136/gutjnl-2011-300784 · Cited by 662
Phyto-oestrogens and cancer
Adlercreutz, H. (2002) · The Lancet Oncology · doi:10.1016/s1470-2045(02)00777-5 · Cited by 662
New concepts in the generation and functions of IgA
Pabst, O. (2012) · Nature reviews. Immunology · doi:10.1038/nri3322 · Cited by 656
Toll-Like Receptor-4 Promotes the Development of Colitis-Associated Colorectal Tumors
Fukata, M., Chen, A., Vamadevan, A. S., Cohen, J., Breglio, K. J., Krishnareddy, S., Hsu, D. S., Xu, R., Harpaz, N., Dannenberg, A. J., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.09.008 · Cited by 623
Regulation of Spontaneous Intestinal Tumorigenesis Through the Adaptor Protein MyD88
Rakoff-Nahoum, S., & Medzhitov, R. M. (2007) · Science · doi:10.1126/science.1140488 · Cited by 594
Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse
Ohnishi, N., Yuasa, H., Tanaka, S., Sawa, H., Miura, M., Matsui, A., Higashi, H., Musashi, M., Iwabuchi, K., Suzuki, M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711183105 · Cited by 593
Inflammation and colorectal cancer: colitis-associated neoplasia
Grivennikov, S. I. (2012) · Seminars in Immunopathology · doi:10.1007/s00281-012-0352-6 · Cited by 574
NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer
Couturier-Maillard, A., Sécher, T., Rehman, A., Normand, S., Arcangelis, A. D., Häsler, R., Huot, L., Grandjean, T., Bressenot, A., Delanoye, A., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci62236 · Cited by 571
Nod2 is required for the regulation of commensal microbiota in the intestine
Petnicki-Ocwieja, T., Hrncir, T., Liu, Y.-J., Biswas, A., Hudcovic, T., Tlaskalova-Hogenova, H., & Kobayashi, K. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907722106 · Cited by 564
NLRP12 Suppresses Colon Inflammation and Tumorigenesis through the Negative Regulation of Noncanonical NF-κB Signaling
Allen, I. C., Wilson, J. E., Schneider, M., Lich, J. D., Roberts, R. A., Arthur, J. C., Woodford, R.-M. T., Davis, B. K., Uronis, J. M., Herfarth, H. H., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.012 · Cited by 549
Self-citation
Microbial pathways in colonic sulfur metabolism and links with health and disease
Carbonero, F., Benefiel, A. C., Alizadeh-Ghamsari, A. H., & Gaskins, H. R. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00448 · Cited by 544
Metabolic fate of polyphenols in the human superorganism
van Duynhoven, J., Vaughan, E. E., Jacobs, D. M., A. Kemperman, R., van Velzen, E. J. J., Gross, G., Roger, L. C., Possemiers, S., Smilde, A. K., Doré, J., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000098107 · Cited by 540
High Prevalence of Mucosa-Associated E. coli Producing Cyclomodulin and Genotoxin in Colon Cancer
Buc, E., Dubois, D., Sauvanet, P., Raisch, J., Delmas, J., Darfeuille-Michaud, A., Pezet, D., & Bonnet, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056964 · Cited by 535
Fusobacterium Is Associated with Colorectal Adenomas
McCoy, A. N., Araújo-Pérez, F., Azcárate-Peril, M. A., Yeh, J. J., Sandler, R. S., & Keku, T. O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053653 · Cited by 533
Cancer and Inflammation: An Old Intuition with Rapidly Evolving New Concepts
Trinchieri, G. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075008 · Cited by 522
Host-Mediated Inflammation Disrupts the Intestinal Microbiota and Promotes the Overgrowth of Enterobacteriaceae
Lupp, C., Robertson, M. L., Wickham, M. E., Sekirov, I., Champion, O. L., Gaynor, E. C., & Finlay, B. B. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.08.002 · Cited by 501
Toll-like receptors
Moresco, E. M. Y., LaVine, D., & Beutler, B. (2011) · Current Biology · doi:10.1016/j.cub.2011.05.039 · Cited by 500
Gut inflammation can boost horizontal gene transfer between pathogenic and commensal Enterobacteriaceae
Stecher, B., Denzler, R., Maier, L., Bernet, F., Sanders, M. J., Pickard, D. J., Barthel, M., Westendorf, A. M., Krogfelt, K. A., Walker, A. W., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113246109 · Cited by 492
Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk
Holmes, E., Li, J. V., Marchesi, J. R., & Nicholson, J. K. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.10.007 · Cited by 490
Bile Acid and Inflammation Activate Gastric Cardia Stem Cells in a Mouse Model of Barrett-Like Metaplasia
Quante, M., Bhagat, G., Abrams, J. A., Marache, F., Good, P., Lee, M. D., Lee, Y., Friedman, R. A., Asfaha, S., Dubeykovskaya, Z. A., et al. (2012) · Cancer Cell · doi:10.1016/j.ccell.2026.07.005 · Cited by 485
Die krankhaften Geschwülste
Virchow, R. (1978) · Springer eBooks · doi:10.1007/978-3-642-66491-5 · Cited by 481
Competition sensing: the social side of bacterial stress responses
Cornforth, D. M., & Foster, K. R. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro2977 · Cited by 472
Immunoproliferative Small Intestinal Disease Associated with Campylobacter jejuni
Lecuit, M., Abachin, É., Martin, A., Poyart, C., Pochart, P., Suárez, F., Bengoufa, D., Feuillard, J., Lavergne‐Slove, A., Gordon, J. I., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031887 · Cited by 461
Fifteen-Year Effects of Helicobacter pylori, Garlic, and Vitamin Treatments on Gastric Cancer Incidence and Mortality
Ma, J.-L., Zhang, L., Brown, L. M., Li, W., Shen, L., Pan, K., Liu, W., Hu, Y., Han, Z.-X., Crystal-Mansour, S., et al. (2012) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djs003 · Cited by 460
Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4
Hu, B., Elinav, E., Huber, S., Booth, C. J., Strowig, T., Jin, C., Eisenbarth, S. C., & Flavell, R. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016814108 · Cited by 452
European Organization for Research and Treatment of Cancer and International Society for Cutaneous Lymphoma consensus recommendations for the management of cutaneous B-cell lymphomas
Senff, N. J., Noordijk, E. M., Kim, Y. H., Bagot, M., Berti, E., Cerroni, L., Dummer, R., Duvic, M. A., Hoppe, R. T., Pimpinelli, N., et al. (2008) · Blood · doi:10.1182/blood-2008-04-152850 · Cited by 451
The lung microbiome in moderate and severe chronic obstructive pulmonary disease
Pragman, A. A., Kim, H. B., Reilly, C. S., Wendt, C., & Isaacson, R. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047305 · Cited by 437
Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria
Kim, S. C., Tonkonogy, S. L., Albright, C. A., Tsang, J., Balish, E., Braun, J., Huycke, M. M., & Sartor, R. B. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.02.009 · Cited by 433
MyD88-mediated signaling prevents development of adenocarcinomas of the colon: Role of interleukin 18
Salcedo, R., Worschech, A., Cardone, M., Jones, Y., Gyulai, Z., Dai, R.-M., Wang, E., Ma, W., Haines, D., O'hUigin, C., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100199 · Cited by 429
Mechanistic links between COPD and lung cancer
Houghton, A. M. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3477 · Cited by 428
Modulation of the Intestinal Microbiota Alters Colitis-Associated Colorectal Cancer Susceptibility
Uronis, J. M., Mühlbauer, M., Herfarth, H. H., Rubinas, T. C., Jones, G. S., & Jobin, C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006026 · Cited by 425
Self-citation
Paneth cells, defensins, and the commensal microbiota: A hypothesis on intimate interplay at the intestinal mucosa
Salzman, N. H., Underwood, M. A., & Bevins, C. L. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.04.002 · Cited by 414
Production of isoprenoid pharmaceuticals by engineered microbes
Chang, M. C. Y., & Keasling, J. D. (2006) · Nature Chemical Biology · doi:10.1038/nchembio836 · Cited by 398
Chronic Active Hepatitis and Associated Liver Tumors in Mice Caused by a Presistent Bacterial Infection With a Novel Helicobacter Species
Ward, J. M., Fox, J. G., Anver, M. R., Haines, D. C., George, C. V., Collins, M. J., Gorelick, P. L., Nagashima, K., Gonda, M. A., Gilden, R. V., et al. (1994) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/86.16.1222 · Cited by 386
Techniques used to characterize the gut microbiota: a guide for the clinician
Fraher, M. H., O'Toole, P. W., & Quigley, E. M. M. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.44 · Cited by 385
Immunoproliferative small intestinal disease associated with Campylobacter jejuni
Mesnard, B., Vroey, B. D., Maunoury, V., & Lecuit, M. (2012) · Digestive and Liver Disease · doi:10.1016/j.dld.2012.03.020 · Cited by 382
Lack of Commensal Flora in Helicobacter pylori–Infected INS-GAS Mice Reduces Gastritis and Delays Intraepithelial Neoplasia
Lofgren, J. L. S., Whary, M. T., Ge, Z., Muthupalani, S., Taylor, N. S., Mobley, M. W., Potter, A. F., Varró, A., Eibach, D., Suerbaum, S., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.09.048 · Cited by 380
Evidence That Hydrogen Sulfide Is a Genotoxic Agent
Attene‐Ramos, M. S., Wagner, E. D., Plewa, M. J., & Gaskins, H. R. (2006) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0126 · Cited by 367
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33
The COGENT Consortium, Houlston, R. S., The CORGI Consortium, The COIN Collaborative Group, The COINB Collaborative Group, Cheadle, J., Dobbins, S. E., Tenesa, A., Jones, A. M., Howarth, K., et al. (2010) · Nature Genetics · doi:10.1038/ng.670 · Cited by 360
Regulation of the Antimicrobial Response by NLR Proteins
Elinav, E., Strowig, T., Henao‐Mejia, J., & Flavell, R. A. (2011) · Immunity · doi:10.1016/j.immuni.2011.05.007 · Cited by 355
Enterococcus faecalis Induces Inflammatory Bowel Disease in Interleukin-10 Knockout Mice
Balish, E., & WARNER, T. F. C. S. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61172-8 · Cited by 352
Carcinogenicity of deoxycholate, a secondary bile acid
Bernstein, C., Holubec, H., Bhattacharyya, A. K., Nguyen, H., Payne, C. M., Zaitlin, B., & Bernstein, H. (2011) · Archives of Toxicology · doi:10.1007/s00204-011-0648-7 · Cited by 351
Endotoxin Accumulation Prevents Carcinogen-Induced Apoptosis and Promotes Liver Tumorigenesis in Rodents
Yu, L.-X., Yan, H.-X., Liu, Q., Yang, W., Wu, H.-P., Dong, W., Tang, L., Lin, Y., He, Y.-Q., Zou, S.-S., et al. (2010) · Hepatology · doi:10.1002/hep.23845 · Cited by 349
The Yin and Yang of Toll-like receptors in cancer
Pradère, J., Dapito, D. H., & Schwabe, R. F. (2013) · Oncogene · doi:10.1038/onc.2013.302 · Cited by 345
Self-citation
Bacteria and host interactions in the gut epithelial barrier
Ashida, H., Ogawa, M., Kim, M., Mimuro, H., & Sasakawa, C. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.741 · Cited by 345
Assembly and function of a bacterial genotoxin
Nes̆ić, D., Hsu, Y., & Stebbins, C. E. (2004) · Nature · doi:10.1038/nature02532 · Cited by 344
Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer
Hu, B., Elinav, E., Huber, S., Strowig, T., Hao, L., Hafemann, A., Jin, C., Wunderlich, C. M., Wunderlich, T., Eisenbarth, S. C., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307575110 · Cited by 334
Nod2 is essential for temporal development of intestinal microbial communities
Rehman, A., Sina, C., Gavrilova, O., Häsler, R., Ott, S. J., Baines, J. F., Schreiber, S., & Rosenstiel, P. C. (2011) · Gut · doi:10.1136/gut.2010.216259 · Cited by 331
A Prospective Study of Periodontal Disease and Pancreatic Cancer in US Male Health Professionals
Michaud, D. S., JOSHIPURA, K. J., Giovannucci, E. L., & Fuchs, C. S. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djk021 · Cited by 327
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis
Peters, U., Jiao, S., Schumacher, F. R., Hutter, C. M., Aragaki, A. K., Baron, J. A., Berndt, S. I., Bezieau, S., Brenner, H., Butterbach, K., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.12.020 · Cited by 324
Helicobacter pylori and Esophageal Cancer Risk: A Meta-analysis
Islami, F., & Kamangar, F. (2008) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-08-0109 · Cited by 321
Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis
Swann, J. B., Vesely, M. D., Silva, A., Sharkey, J., Akira, S., Schreiber, R. D., & Smyth, M. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708594105 · Cited by 320
Genetic Structure and Distribution of the Colibactin Genomic Island among Members of the Family Enterobacteriaceae
Putze, J., Hennequin, C., Nougayrède, J., Zhang, W., Homburg, S., Karch, H., Bringer, M.-A., Fayolle, C., Carniel, É., Rabsch, W., et al. (2009) · Infection and Immunity · doi:10.1128/iai.00522-09 · Cited by 319
Association between a complex insertion/deletion polymorphism in NOD1 (CARD4) and susceptibility to inflammatory bowel disease
McGovern, D. P. B., Hysi, P. G., Ahmad, T., van Heel, D. A., Moffatt, M. F., Carey, A. H., Cookson, W., & Jewell, D. P. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi135 · Cited by 318
Gut microbiota-derived propionate reduces cancer cell proliferation in the liver
Bindels, L. B., Porporato, P. E., Dewulf, E. M., Verrax, J., Neyrinck, A. M., Martin, J. C., Scott, K. P., Calderón, P. B., Féron, O., Muccioli, G. G., et al. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.409 · Cited by 317
Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice
Ubeda, C., Lipuma, L., Gobourne, A., Viale, A., Leiner, I., Equinda, M., Khanin, R., & Pamer, E. G. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120504 · Cited by 310
MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells
Ochi, A., Nguyen, A. H., Bedrosian, A. S., Mushlin, H. M., Zarbakhsh, S., Barilla, R., Zambirinis, C. P., Fallon, N. C., Rehman, A. U., Pylayeva‐Gupta, Y., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20111706 · Cited by 309
DNase I homologous residues in CdtB are critical for cytolethal distending toxin‐mediated cell cycle arrest
Elwell, C. A., & Dreyfus, L. A. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.02070.x · Cited by 301
Coley's toxins in perspective
Starnes, C. O. (1992) · Nature · doi:10.1038/357011a0 · Cited by 284
STAT3-Driven Upregulation of TLR2 Promotes Gastric Tumorigenesis Independent of Tumor Inflammation
Tye, H., Kennedy, C. L., Najdovska, M., McLeod, L., McCormack, W. J., Hughes, N. R., Dev, A. T., Sievert, W., Ooi, C.-H., Ishikawa, T., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.08.010 · Cited by 283
Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats
Zhang, H.-L., Yu, L.-X., Yang, W., Tang, L., Lin, Y., Wu, H., Zhai, B., Tan, Y.-X., Shan, L., Liu, Q., et al. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.06.011 · Cited by 281
Gut Microbial Activity, Implications for Health and Disease: The Potential Role of Metabolite Analysis
Nyangale, E. P., Mottram, D. S., & Gibson, G. R. (2012) · Journal of Proteome Research · doi:10.1021/pr300637d · Cited by 275
Immunoproliferative small intestinal disease associated with Campylobacter jejuni
Lecuit, M. (2009) · Hematology Meeting Reports · doi:10.4081/hmr.v1i5.265 · Cited by 264
The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis
Chen, G. Y., Shaw, M. H., Redondo, G., & Núñez, G. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2061 · Cited by 261
Identification and Characterization of a Novel Adhesin Unique to Oral Fusobacteria
Han, Y. W., Ikegami, A., Rajanna, C., Kawsar, H. I., Zhou, Y., Li, M., Sojar, H. T., Genco, R. J., Kuramitsu, H. K., & Deng, C. X. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.15.5330-5340.2005 · Cited by 260
Stochastic changes over time and not founder effects drive cage effects in microbial community assembly in a mouse model
McCafferty, J., Mühlbauer, M., Gharaibeh, R. Z., Arthur, J. C., Perez-Chanona, E., Sha, W., Jobin, C., & Fodor, A. A. (2013) · The ISME Journal · doi:10.1038/ismej.2013.106 · Cited by 259
Self-citation
Commensal Bacteria, Redox Stress, and Colorectal Cancer: Mechanisms and Models
Huycke, M. M., & Gaskins, H. R. (2004) · Experimental Biology and Medicine · doi:10.1177/153537020422900702 · Cited by 244
Extracellular Superoxide Production by Enterococcus faecalis Promotes Chromosomal Instability in Mammalian Cells
Wang, X., & Huycke, M. M. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.11.040 · Cited by 243
The Microbe-Derived Short Chain Fatty Acid Butyrate Targets miRNA-Dependent p21 Gene Expression in Human Colon Cancer
Hu, S., Dong, T. S., Dalal, S. R., Wu, F., Bissonnette, M., Kwon, J. H., & Chang, E. B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016221 · Cited by 233
Possible role of acetaldehyde in ethanol-related rectal cocarcinogenesis in the rat
Seitz, H. K., Simanowski, U. A., Garzon, F. T., Rideout, J. M., Peters, T. J., Koch, A., Berger, M. R., Einecke, H., & Maiwald, M. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90832-l · Cited by 232
The Human Microbiome: From Symbiosis to Pathogenesis
Eloe‐Fadrosh, E. A., & Rasko, D. A. (2013) · Annual Review of Medicine · doi:10.1146/annurev-med-010312-133513 · Cited by 227
Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans
Sanapareddy, N., Legge, R. M., Jovov, B., McCoy, A. N., Burcal, L., Araújo-Pérez, F., Randall, T. A., Galanko, J. A., Benson, A. K., Sandler, R. S., et al. (2012) · The ISME Journal · doi:10.1038/ismej.2012.43 · Cited by 219
Gut microbiota accelerate tumor growth via c-jun and STAT3 phosphorylation in APC Min/+ mice
Li, Y., Kundu, P., Seow, S. W., de Matos, C. T., Aronsson, L., Chin, K. C., Kärre, K., Pettersson, S., & Greicius, G. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs137 · Cited by 216
Epidemiology — identifying the causes and preventability of cancer?
Colditz, G. A., Sellers, T. A., & Trapido, E. J. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1784 · Cited by 215
The Contribution of Cytolethal Distending Toxin to Bacterial Pathogenesis
Smith, L., & Bayles, D. O. (2006) · Critical Reviews in Microbiology · doi:10.1080/10408410601023557 · Cited by 207
Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis
Fukata, M., Shang, L., Santaolalla, R., Sotolongo, J. P., Pastorini, C., España, C., Ungaro, R. C., Harpaz, N., Cooper, H. S., Elson, G., et al. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21527 · Cited by 199
TLR4‐mediated skin carcinogenesis is dependent on immune and radioresistant cells
Mittal, D., Saccheri, F., Vénéreau, E., Pusterla, T., Bianchi, M. E., & Rescigno, M. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.94 · Cited by 196
Colon carcinogenesis with azoxymethane and dimethylhydrazine in germ-free rats.
Reddy, B. S., Narisawa, T., Wright, P., Vukusich, D., Weisburger, J. H., & Wynder, E. L. (1975) · PubMed · Cited by 193
ERK activation drives intestinal tumorigenesis in Apcmin/+ mice
Lee, S. H., Hu, L., González-Navajas, J. M., Seo, G. S., Shen, C., Brick, J., Herdman, S., Varki, N. M., Corr, M., Lee, J., et al. (2010) · Nature Medicine · doi:10.1038/nm.2143 · Cited by 188
Gastroenteritis in NF-κB-Deficient Mice Is Produced with Wild-TypeCamplyobacter jejunibut Not withC. jejuniLacking Cytolethal Distending Toxin despite Persistent Colonization with Both Strains
Fox, J. G., Rogers, A. B., Whary, M. T., Ge, Z., Taylor, N. S., Xu, S., Horwitz, B. H., & Erdman, S. E. (2004) · Infection and Immunity · doi:10.1128/iai.72.2.1116-1125.2004 · Cited by 188
Cancer mortality in chronic typhoid and paratyphoid carriers
CAYGILL, C. P. J., Hill, M. J., Braddick, M. R., & Sharp, J. C. M. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90816-8 · Cited by 186
Nitric oxide and TNF-α trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus -infected, Rag2 -deficient mice
Erdman, S. E., Rao, V. P., Poutahidis, T., Rogers, A. B., Taylor, C. L., Jackson, E. A., Ge, Z., Lee, C. W., Schauer, D. B., Wogan, G. N., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812347106 · Cited by 183
Bacteria and the N-Nitrosation of Secondary Amines
HAWKSWORTH, G. M., & Hill, M. J. (1971) · British Journal of Cancer · doi:10.1038/bjc.1971.66 · Cited by 182
Chlamydophila Psittaci Eradication With Doxycycline As First-Line Targeted Therapy for Ocular Adnexae Lymphoma: Final Results of an International Phase II Trial
Ferreri, A. J. M., Govi, S., Pasini, E., Mappa, S., Bertoni, F., Zaja, F. F., Montalbán, C., Stelitano, C. C., Cabrera, M. E., Resti, A. G., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.41.4466 · Cited by 168
GUMMA OF THE THYROID
Ah, B. (1947) · The Lancet · doi:10.1016/s0140-6736(47)91543-2 · Cited by 160
Intestinal neoplasia in the ApcMin mouse: independence from the microbial and natural killer (beige locus) status.
Dove, W. F., Clipson, L. J., Gould, K. A., Luongo, C., Marshall, D. J., Moser, A. R., Newton, M. A., & Jacoby, R. F. (1997) · PubMed · Cited by 159
ASSOCIATION BETWEEN HEPATOBILIARY CANCER AND TYPHOID CARRIER STATE
Welton, J., Marr, J., & Friedman, S. (1979) · The Lancet · doi:10.1016/s0140-6736(79)91315-1 · Cited by 158
Gumm of the thyroid.
Ah, B. (1947) · PubMed · Cited by 157
Nod1 and Nod2 signaling does not alter the composition of intestinal bacterial communities at homeostasis
Robertson, S. J., Zhou, J. Y., Geddes, K., Rubino, S. J., Cho, J., Girardin, S. E., & Philpott, D. J. (2013) · Gut Microbes · doi:10.4161/gmic.24373 · Cited by 156
Colitis-Associated Colorectal Cancer Driven by T-bet Deficiency in Dendritic Cells
Garrett, W. S., Punit, S., Gallini, C. A., Michaud, M., Zhang, D., Sigrist, K. S., Lord, G. M., Glickman, J. N., & Glimcher, L. H. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.07.015 · Cited by 155
Abating colon cancer polyposis by Lactobacillus acidophilus deficient in lipoteichoic acid
Khazaie, K., Zadeh, M., Khan, M. W., Bere, P., Gounari, F., Dennis, K., Blatner, N. R., Owen, J. L., Klaenhammer, T. R., & Mohamadzadeh, M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1207230109 · Cited by 151
Fusobacterium nucleatum
Allen‐Vercoe, E., Strauss, J., & Chadee, K. (2011) · Gut Microbes · doi:10.4161/gmic.2.5.18603 · Cited by 149
Simultaneous Targeting of Toll- and Nod-Like Receptors Induces Effective Tumor-Specific Immune Responses
Garaude, J., Kent, A., van Rooijen, N., & Blander, J. M. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3002868 · Cited by 147
MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands
Brandl, K., Sun, L., Neppl, C., Siggs, O. M., Gall, S. M. L., Tomisato, W., Li, X., Du, X., Männel, D. N., Blobel, C., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014669107 · Cited by 145
Colon carcinogenesis in germ-free rats with 1,2-dimethylhydrazine and N-methyl-n'-nitro-N-nitrosoguanidine.
Reddy, B. S., Weisburger, J. H., Narisawa, T., & Wynder, E. L. (1974) · PubMed · Cited by 144
4-Hydroxy-2-Nonenal Mediates Genotoxicity and Bystander Effects Caused by Enterococcus faecalis–Infected Macrophages
Wang, X., Yang, Y., Moore, D. R., Nimmo, S. L., Lightfoot, S. A., & Huycke, M. M. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.11.020 · Cited by 141
Is It Time for a Metagenomic Basis of Therapeutics?
Haiser, H. J., & Turnbaugh, P. J. (2012) · Science · doi:10.1126/science.1224396 · Cited by 136
Colorectal carcinogenesis in germ-free and conventionally reared rats: Different intestinal environments affect the systemic immunity
Vannucci, L. E., Štëpánková, R., Kozáková, H., Fišerová, A., Rossmann, P., & Tlaskalová-Hogenová, H. (2008) · International Journal of Oncology · doi:10.3892/ijo.32.3.609 · Cited by 128
Bacterial degradation of bile salts
Philipp, B. (2010) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-010-2998-0 · Cited by 124
The renaissance of continuous culture in the post-genomics age
Bull, A. T. (2010) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-010-0816-4 · Cited by 123
Helicobacter pylori Eradication Prevents Progression of Gastric Cancer in Hypergastrinemic INS-GAS Mice
Lee, C., Rickman, B. H., Rogers, A. B., Ge, Z., Wang, T. C., & Fox, J. G. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6786 · Cited by 120
Tumor fibroblast–derived epiregulin promotes growth of colitis-associated neoplasms through ERK
Neufert, C. F., Becker, C., Türeci, Ö., Waldner, M. J., Backert, I., Floh, K., Atreya, I., Leppkes, M., Jefremow, A., Vieth, M., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci63748 · Cited by 117
IL-1R–MyD88 signaling in keratinocyte transformation and carcinogenesis
Cataisson, C., Salcedo, R., Hakim, S., Moffitt, A. B., Wright, L. N., Yi, M., Stephens, R. M., Dai, R., Lyakh, L. A., Schenten, D., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20101355 · Cited by 112
Aerobic biodegradation of N‐nitrosodimethylamine (NDMA) by axenic bacterial strains
Sharp, J. O., Wood, T. K., & Alvarez‐Cohen, L. (2005) · Biotechnology and Bioengineering · doi:10.1002/bit.20405 · Cited by 112
Mouse Paneth cell antimicrobial function is independent of Nod2
Shanahan, M. T., Carroll, I. M., Grossniklaus, E. J., White, A., von Furstenberg, R. J., Barner, R., Fodor, A. A., Henning, S., Sartor, R. B., & Gulati, A. (2013) · Gut · doi:10.1136/gutjnl-2012-304190 · Cited by 106
TREATMENT OF INOPERABLE MALIGNANT TUMORS WITH THE TOXINES OF ERYSIPELAS AND THE BACILLUS PRODIGIOSUS
COLEY, W. B. (1894) · The American Journal of the Medical Sciences · doi:10.1097/00000441-189407000-00006 · Cited by 104
The complex interplay between inflammation, the microbiota and colorectal cancer
Arthur, J. C., & Jobin, C. (2013) · Gut Microbes · doi:10.4161/gmic.24220 · Cited by 99
Self-citation
Altered Gut Microbiota Promotes Colitis-Associated Cancer in IL-1 Receptor–Associated Kinase M–Deficient Mice
Kostovcikova, K., Kverka, M., Zakostelska, Z. J., Hudcovic, T., Hrnčíř, T., Štëpánková, R., Rossmann, P., Rídl, J., Kostovčík, M., Mrázek, J., et al. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e318281330a · Cited by 95
Occurrence of Spontaneous Tumors in the Germfree F344 Rat 2
Sacksteder, M. R. (1976) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/57.6.1371 · Cited by 90
Lignan transformation by gut bacteria lowers tumor burden in a gnotobiotic rat model of breast cancer
Mabrok, H. B., Klopfleisch, R., Ghanem, K. Z., Clavel, T., Blaut, M., & Loh, G. (2012) · Carcinogenesis · doi:10.1093/carcin/bgr256 · Cited by 89
Chronic intestinal inflammation induces stress-response genes in commensal Escherichia coli
Patwa, L. G., Fan, T., Tchaptchet, S., Liu, Y., Lussier, Y. A., Sartor, R. B., & Hansen, J. J. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.064 · Cited by 85
Proinflammatory CD4+CD45RBhi Lymphocytes Promote Mammary and Intestinal Carcinogenesis in Apc Min/+ Mice
Rao, V. P., Poutahidis, T., Ge, Z., Nambiar, P. R., Horwitz, B. H., Fox, J. G., & Erdman, S. E. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3445 · Cited by 81
Metabolomics Provide New Insight on the Metabolism of Dietary Phytochemicals in Rats
Fardet, A., Llorach, R., Orsoni, A., Martin, J., Pujos‐Guillot, E., Lapierre, C., & Scalbert, A. (2008) · Journal of Nutrition · doi:10.1093/jn/138.7.1282 · Cited by 70
Intestinal microflora plays a crucial role in the genotoxicity of the cooked food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)
Kassie, F. (2001) · Carcinogenesis · doi:10.1093/carcin/22.10.1721 · Cited by 70
Lipopolysaccharide Enhances Mouse Lung Tumorigenesis
Melkamu, T., Qian, X., Upadhyaya, P., O’Sullivan, M. G., & Kassie, F. (2013) · Veterinary Pathology · doi:10.1177/0300985813476061 · Cited by 68
Induction of Lung Cancer in Germfree, Specific-Pathogen-Free, and Infected Rats by N-Nitrosoheptamethyleneimine: Enhancement by Respiratory Infection 2
Schreiber, H. W., Nettesheim, P., Lijinsky, W., Richter, C. B., & Walburg, H. E. (1972) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/49.4.1107 · Cited by 67
Axenic culture of fastidious and intracellular bacteria
Singh, S., Eldin, C., Kowalczewska, M., & Raoult, D. (2012) · Trends in Microbiology · doi:10.1016/j.tim.2012.10.007 · Cited by 64
Cytolethal Distending Toxin PromotesHelicobacter cinaedi-Associated Typhlocolitis in Interleukin-10-Deficient Mice
Shen, Z., Feng, Y., Rogers, A. B., Rickman, B. H., Whary, M. T., Xu, S., Clapp, K. M., Boutin, S. R., & Fox, J. G. (2009) · Infection and Immunity · doi:10.1128/iai.00166-09 · Cited by 61
Differential role of MyD88 and Mal/TIRAP in TLR2-mediated gastric tumourigenesis
Kennedy, C. L., Najdovska, M., Tye, H., McLeod, L., Yu, L., Jarnicki, A., Bhathal, P. S., Putoczki, T. L., Ernst, M., & Jenkins, B. J. (2013) · Oncogene · doi:10.1038/onc.2013.205 · Cited by 53
The Rho-activating CNF1 toxin from pathogenic E. coli: A risk factor for human cancer development?
Travaglione, S., Fabbri, A., & Fiorentini, C. (2008) · Infectious Agents and Cancer · doi:10.1186/1750-9378-3-4 · Cited by 52
Effects of human intestinal flora on mutagenicity of and DNA adduct formation from food and environmental mutagens
Hirayama, K. (2000) · Carcinogenesis · doi:10.1093/carcin/21.11.2105 · Cited by 51
Intestinal bacteria metabolize the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine following consumption of a single cooked chicken meal in humans
Vanhaecke, L., Knize, M. G., Noppe, H., Brabander, H. D., Verstraete, W., & de Wiele, T. V. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.07.008 · Cited by 50
Taking a metagenomic view of human nutrition
Dutton, R. J., & Turnbaugh, P. J. (2012) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3283561133 · Cited by 50
Identification of a genetic locus controlling bacteria-driven colitis and associated cancer through effects on innate inflammation
Boulard, O., Kirchberger, S., Royston, D. J., Maloy, K. J., & Powrie, F. M. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20120239 · Cited by 50
Effect of Intestinal Microflora on 3,2′-Dimethyl-4-aminobiphenyl-Induced Carcinogenesis in F344 Rats2
Reddy, B. S., & Watanabe, K. (1978) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/61.5.1269 · Cited by 40

Research works printed but not linked: 2

Koch, R. in Tenth International Congress of Medicine 1 (August Hirschwald, Berlin, 1891).
Laqueur, G. L., Matsumoto, H. & Yamamoto, R. S. Comparison of the carcinogenicity of methylazoxymethanol-β-D-glucosiduronic acid in conventional and germfree Sprague-Dawley rats. J. Natl Cancer Inst. 67, 1053–1055 (1981).

Sorted by citations

The gut microbiota, bacterial metabolites and colorectal cancer
Louis, P., Hold, G. L., & Flint, H. J. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3344 · Cited by 2,925
NF-κB, inflammation, immunity and cancer: coming of age
Taniguchi, K., & Karin, M. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.142 · Cited by 2,679
Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy
Yu, T., Guo, F., Yu, Y., Sun, T., Ma, D., Han, J., Qian, Y., Kryczek, I., Sun, D., Nagarsheth, N., et al. (2017) · Cell · doi:10.1016/j.cell.2017.07.008 · Cited by 2,198
Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis
Jia, W., Xie, G., & Jia, W. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.119 · Cited by 1,924
Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer
Mármol, I., Sánchez‐de‐Diego, C., Pradilla-Dieste, A., Cerrada, E., & Yoldi, M. R. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18010197 · Cited by 1,632

See all 1,689

Authors: Schwabe, R. F., & Jobin, C.
Affiliations: Columbia University (US)
University of Florida Health (US)
Corresponding author: Schwabe, Robert F.
Jobin, Christian
ORCID: Schwabe, Robert F.
Jobin, Christian
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2013-10-17
Volume: 13
Issue: 11
Pages: 800-812
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc3610
PMC: PMC3986062
OpenAlex: W2016853666
Cited by: 1,689
References: 205
Citations by year: 2026: 87 · 2025: 123 · 2024: 135 · 2023: 141 · 2022: 207 · 2021: 214 · 2020: 150 · 2019: 138 · 2018: 146 · 2017: 103 · 2016: 110 · 2015: 77 · 2014: 54
FWCI: 7.55
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Alcohol Abuse and Alcoholism (R01AA020211)
National Cancer Institute (U54CA163111)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK047700, R01DK073338, R01DK076920)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
Keywords: gut microbiota, carcinogenesis, dysbiosis, host-microbe symbiosis, bacterial sensing, immune response, genotoxicity, host metabolism, cancer prevention, microbiome-targeted therapy
MeSH terms: Animals, Bacteria, Diet, Humans, Immune System, Mutagens, Neoplasms, Symbiosis, Gene Expression Regulation, Bacterial, Gene Expression Regulation, Neoplastic, Virulence Factors, Mice, Carcinogenesis, Microbiota

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The microbiome and cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks