Cited by 1,689Gut microbiota and healthOral microbiology and periodontitis researchBacterial Cancer Therapy

The DOI matches its Crossref record; 206 of the 206 references it cites were found in a registry or an index.

The microbiome and cancer

Open access

Schwabe, Robert F., Jobin, Christian·2013·Nature Reviews Cancer

Open this paper in CoChat — free account

Abstract

Microbiota and host form a complex 'super-organism' in which symbiotic relationships confer benefits to the host in many key aspects of life. However, defects in the regulatory circuits of the host that control bacterial sensing and homeostasis, or alterations of the microbiome, through environmental changes (infection, diet or lifestyle), may disturb this symbiotic relationship and promote disease. Increasing evidence indicates a key role for the bacterial microbiota in carcinogenesis. In this Opinion article, we discuss links between the bacterial microbiota and cancer, with a particular focus on immune responses, dysbiosis, genotoxicity, metabolism and strategies to target the microbiome for cancer prevention.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nrc3610

Cites

206 of 206 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
Immunity, Inflammation, and Cancer
Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
Inflammation and cancer: back to Virchow?
Balkwill, F., & Mantovani, A. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04046-0 · Cited by 7,746
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277
Metagenomic Analysis of the Human Distal Gut Microbiome
Gill, S. R., Pop, M., DeBoy, R. T., Eckburg, P. B., Turnbaugh, P. J., Samuel, B. S., Gordon, J. I., Relman, D. A., Fraser-Liggett, C. M., & Nelson, K. E. (2006) · Science · doi:10.1126/science.1124234 · Cited by 4,699

Flagged first, then by citations

Show all 205 references

Research works printed but not linked: 2

Koch, R. in Tenth International Congress of Medicine 1 (August Hirschwald, Berlin, 1891).
Laqueur, G. L., Matsumoto, H. & Yamamoto, R. S. Comparison of the carcinogenicity of methylazoxymethanol-β-D-glucosiduronic acid in conventional and germfree Sprague-Dawley rats. J. Natl Cancer Inst. 67, 1053–1055 (1981).

Sorted by citations

Items 201–300 of 1,001

Blood-Based Biomarkers for Alzheimer’s Disease Diagnosis and Progression: An Overview
Varesi, A., Carrara, A., Pires, V. G., Floris, V., Pierella, E., Savioli, G., Prasad, S., Esposito, C., Ricevuti, G., Chirumbolo, S., et al. (2022) · Cells · doi:10.3390/cells11081367 · Cited by 150
Protection of Anaerobic Microbes from Processing Stressors Using Metal–Phenolic Networks
Fan, G., Wasuwanich, P., Rodriguez-Otero, M. R., & Furst, A. L. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c09018 · Cited by 141
The Firmicutes/Bacteroidetes Ratio as a Risk Factor of Breast Cancer
An, J., Kwon, H., & Kim, Y. J. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12062216 · Cited by 141
Periodontal Health and Disease in the Context of Systemic Diseases
Isola, G., Santonocito, S., Lupi, S. M., Polizzi, A., Sclafani, R., Patini, R., & Marchetti, E. (2023) · Mediators of Inflammation · doi:10.1155/2023/9720947 · Cited by 140
The esophageal microbiota in health and disease
Di Pilato, V., Freschi, G., Ringressi, M. N., Pallecchi, L., Rossolini, G. M., & Bechi, P. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13127 · Cited by 139
Microbial markers in colorectal cancer detection and/or prognosis
Villéger, R., Lopès, A., Véziant, J., Gagnière, J., Barnich, N., Billard, E., Boucher, D., & Bonnet, M. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i22.2327 · Cited by 146
Exploring the Role of Gut Microbiome in Colon Cancer
Chattopadhyay, I., Dhar, R., Pethusamy, K., Seethy, A. A., Srivastava, T. P., Sah, R., Sharma, J. N., & Karmakar, S. (2021) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-021-03498-9 · Cited by 147
Collection media and delayed freezing effects on microbial composition of human stool
Flores, R., Shi, J., Yu, G., Ma, B., Ravel, J., Goedert, J. J., & Sinha, R. R. (2015) · Microbiome · doi:10.1186/s40168-015-0092-7 · Cited by 141
Dysbiosis signatures of the microbial profile in tissue from bladder cancer
Liu, F., Liu, A., Lu, X. L., Zhang, Z., Xue, Y., Xu, J., Zeng, S., Xiong, Q., Tan, H., He, X., et al. (2019) · Cancer Medicine · doi:10.1002/cam4.2419 · Cited by 138
Intestinal bacteria and colorectal cancer: etiology and treatment
Dougherty, M. W., & Jobin, C. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2185028 · Cited by 145
Self-citation
Materials Advances for Next-Generation Ingestible Electronic Medical Devices
Bettinger, C. J. (2015) · Trends in biotechnology · doi:10.1016/j.tibtech.2015.07.008 · Cited by 136
The microbiome and cancer for clinicians
Picardo, S. L., Coburn, B. A., & Hansen, A. R. (2019) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2019.06.004 · Cited by 141
The microbiome and its potential as a cancer preventive intervention
Bultman, S. J. (2016) · Seminars in Oncology · doi:10.1053/j.seminoncol.2015.09.001 · Cited by 134
Periodontal pathogens promote cancer aggressivity via TLR/MyD88 triggered activation of Integrin/FAK signaling that is therapeutically reversible by a probiotic bacteriocin
Kamarajan, P., Ateia, I., Shin, J. M., Fenno, J. C., Le, C., Zhan, L., Chang, A., Darveau, R., & Kapila, Y. L. (2020) · PLOS Pathogens · doi:10.1371/journal.ppat.1008881 · Cited by 134
Biological insights through nontargeted metabolomics
Sévin, D. C., Kuehne, A., Zamboni, N., & Sauer, U. (2014) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2014.10.001 · Cited by 141
The interplay of extracellular matrix and microbiome in urothelial bladder cancer
Alfano, M., Canducci, F., Nebuloni, M., Clementi, M., Montorsi, F., & Salonia, A. (2015) · Nature Reviews Urology · doi:10.1038/nrurol.2015.292 · Cited by 136
The role of gut microbiota in T cell immunity and immune mediated disorders
Shim, J. A., Ryu, J. H., Jo, Y., & Hong, C. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.79430 · Cited by 140
Increased colon cancer risk after severe Salmonella infection
Mughini-Gras, L., Schaapveld, M., Kramers, J., Mooij, S., Neefjes-Borst, E. A., Pelt, W. V., & Neefjes, J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0189721 · Cited by 133
Microbiota Effects on Carcinogenesis: Initiation, Promotion, and Progression
Lopez, L. R., Bleich, R. M., & Arthur, J. C. (2020) · Annual Review of Medicine · doi:10.1146/annurev-med-080719-091604 · Cited by 136
Fusobacterium and Enterobacteriaceae: Important players for CRC?
Allen‐Vercoe, E., & Jobin, C. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.05.014 · Cited by 137
Self-citation
Barcoded sequencing reveals diverse intrauterine microbiomes in patients suffering with endometrial polyps.
Fang, R., Chen, L.-X., Shu, W., Yao, S., Wang, S., & Chen, Y. (2016) · PubMed Central · Cited by 132
An essential role of Ffar2 (Gpr43) in dietary fibre-mediated promotion of healthy composition of gut microbiota and suppression of intestinal carcinogenesis
Sivaprakasam, S., Gurav, A., Paschall, A. V., Coe, G. L., Chaudhary, K., Cai, Y., Kolhe, R. B., Martin, P. M., Browning, D. D., Huang, L., et al. (2016) · Oncogenesis · doi:10.1038/oncsis.2016.38 · Cited by 135
Psoriasis and Microbiota: A Systematic Review
Benhadou, F., Mintoff, D., Schnebert, B., & Thio, H. B. (2018) · Diseases · doi:10.3390/diseases6020047 · Cited by 135
The Microbiome as a Component of the Tumor Microenvironment
Kovàcs, T., Mikó, E., Ujlaki, G., Sári, Z., & Bai, P. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-35727-6_10 · Cited by 134
Periodontitis and risk of cancer: Mechanistic evidence
Baima, G., Minoli, M., Michaud, D. S., Aimetti, M., Sanz, M., Loos, B. G., & Romandini, M. (2023) · Periodontology 2000 · doi:10.1111/prd.12540 · Cited by 131
Comparison of human gut microbiota in control subjects and patients with colorectal carcinoma in adenoma: Terminal restriction fragment length polymorphism and next-generation sequencing analyses
Kasai, C., Sugimoto, K., Moritani, I., Tanaka, J., Oya, Y., Inoue, H., Tameda, M., Shiraki, K., Ito, M., Takei, Y., et al. (2015) · Oncology Reports · doi:10.3892/or.2015.4398 · Cited by 130
Tissue Microbiome Profiling Identifies an Enrichment of Specific Enteric Bacteria in Opisthorchis viverrini Associated Cholangiocarcinoma
Chng, K. R., Chan, S. H., Ng, A. H. Q., Li, C., Jusakul, A., Bertrand, D., Wilm, A., Choo, S. P., Tan, D. M. Y., Lim, K. H., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.04.034 · Cited by 127
Measuring the diversity of the human microbiota with targeted next-generation sequencing
Finotello, F., Mastrorilli, E., & Camillo, B. D. (2016) · Briefings in Bioinformatics · doi:10.1093/bib/bbw119 · Cited by 145
Widespread sex dimorphism in aging and age-related diseases
Sampathkumar, N. K., Bravo, J. I., Chen, Y., Danthi, P. S., Donahue, E. K., Lai, R. W., Lu, R. J., Randall, L. T., Vinson, N. M., & Benayoun, B. A. (2019) · Human Genetics · doi:10.1007/s00439-019-02082-w · Cited by 130
Specific Gut Microbiome and Serum Metabolome Changes in Lung Cancer Patients
Zhao, F., An, R., Wang, L., Shan, J., & Wang, X. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.725284 · Cited by 129
Diet rich in animal protein promotes pro-inflammatory macrophage response and exacerbates colitis in mice
Kostovcikova, K., Coufal, S., Galanova, N., Fajstova, A., Hudcovic, T., Kostovcik, M., Prochazkova, P., Jiraskova Zakostelska, Z., Cermakova, M., Sediva, B., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00919 · Cited by 126
NMR-based fecal metabolomics fingerprinting as predictors of earlier diagnosis in patients with colorectal cancer
Lin, Y., Ma, C., Liu, C., Wang, Z., Yang, J., Liu, X., Shen, Z., & Wu, R. (2016) · Oncotarget · doi:10.18632/oncotarget.8762 · Cited by 126
Alteration of the esophageal microbiota in Barrett's esophagus and esophageal adenocarcinoma
Lv, J., Guo, L., Liu, J., Zhao, H., Zhang, J., & Wang, J.-H. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i18.2149 · Cited by 128
LRLSHMDA: Laplacian Regularized Least Squares for Human Microbe–Disease Association prediction
Wang, F., Huang, Z.-A., Chen, X., Zhu, Z., Wen, Z., Zhao, J., & Yan, G. (2017) · Scientific Reports · doi:10.1038/s41598-017-08127-2 · Cited by 126
Association of oral dysbiosis with oral cancer development (Review)
Rosa, G. R. M. L., Gattuso, G., Pedull�, E., Rapisarda, E., Nicolosi, D., & Salmeri, M. (2020) · Oncology Letters · doi:10.3892/ol.2020.11441 · Cited by 129
Review of the gut microbiome and esophageal cancer: Pathogenesis and potential clinical implications
Baba, Y., Iwatsuki, M., Yoshida, N., Watanabe, M., & Baba, H. (2017) · Annals of Gastroenterological Surgery · doi:10.1002/ags3.12014 · Cited by 123
Compositional and functional variations of oral microbiota associated with the mutational changes in oral cancer
Yang, S., Huang, H., Fan, W., Jong, Y., Chen, M., Huang, C., Chuang, C., Kuo, Y., Chung, W., & Su, S. (2017) · Oral Oncology · doi:10.1016/j.oraloncology.2017.12.005 · Cited by 127
Cancer metastasis: Molecular mechanisms and clinical perspectives
Khan, S. U., Fatima, K., Malik, F. A., Kalkavan, H., & Wani, A. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108522 · Cited by 127
Gut Microbe-Mediated Suppression of Inflammation-Associated Colon Carcinogenesis by Luminal Histamine Production.
Gao, C., Ganesh, B. P., Shi, Z., Shah, R. R., Fultz, R., Major, A., Venable, S., Lugo, M., Hoch, K., Chen, X., et al. (2017) · The American Journal of Pathology · doi:10.1016/j.ajpath.2017.06.011 · Cited by 122
PARP1 Is Up-Regulated in Non-small Cell Lung Cancer Tissues in the Presence of the Cyanobacterial Toxin Microcystin
Apopa, P. L., Alley, L., Penney, R. B., Arnaoutakis, K., Steliga, M. A., Jeffus, S., Bircan, E., Gopalan, B., Jin, J., Patumcharoenpol, P., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01757 · Cited by 123
Studying cancer immunotherapy using patient-derived xenografts (PDXs) in humanized mice
Choi, Y., Lee, S., Kim, K., Kim, S. H., Chung, Y., & Lee, C. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0115-0 · Cited by 130
Gut Microbiota Conversion of Dietary Ellagic Acid into Bioactive Phytoceutical Urolithin A Inhibits Heme Peroxidases
Saha, P., Yeoh, B. S., Singh, R., Chandrasekar, B., Vemula, P. K., Haribabu, B., Vijay‐Kumar, M., & Jala, V. R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0156811 · Cited by 121
Candida albicansand cancer: Can this yeast induce cancer development or progression?
Ramirez‐Garcia, A., Rementería, A., Urízar, J. M. A., Moragues, M. D., Antoran, A., Pellón, A., Abad, A., & Hernando, F. L. (2014) · Critical Reviews in Microbiology · doi:10.3109/1040841x.2014.913004 · Cited by 128
Microbiota in cancer development and treatment
Raza, M. H., Gul, K., Arshad, A., Riaz, N., Waheed, U., Rauf, A., Aldakheel, F. M., Alduraywish, S. A., Rehman, M. U., Abdullah, M., et al. (2018) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-018-2816-0 · Cited by 122
The power of small changes: Comprehensive analyses of microbial dysbiosis in breast cancer
Parida, S., & Sharma, D. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.04.001 · Cited by 126
Lithocholic Acid, a Metabolite of the Microbiome, Increases Oxidative Stress in Breast Cancer
Kovács, P., Csonka, T., Kovàcs, T., Sári, Z., Ujlaki, G., Sipos, A. A., Karányi, Z., Szeőcs, D., Hegedűs, C., Uray, K., et al. (2019) · Cancers · doi:10.3390/cancers11091255 · Cited by 120
Intestinal Microbiota: A Novel Target to Improve Anti-Tumor Treatment?
Villéger, R., Lopès, A., Carrier, G., Véziant, J., Billard, E., Barnich, N., Gagnière, J., Vazeille, E., & Bonnet, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184584 · Cited by 125
Alterations of fecal bacterial communities in patients with lung cancer.
Zhang, W., Zhao, S., Luo, J., Dong, X., Hao, Y., Li, H., Shan, L., Zhou, Y., Shi, H., Zhang, Z.-Y., et al. (2018) · Europe PMC (PubMed Central) · Cited by 128
Fine-Tuning Cancer Immunotherapy: Optimizing the Gut Microbiome
Pitt, J. M., Vétizou, M., Waldschmitt, N., Kroemer, G., Chamaillard, M., Boneca, I. G., & Zitvogel, L. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-0448 · Cited by 122
Caesarean delivery and risk of childhood leukaemia: a pooled analysis from the Childhood Leukemia International Consortium (CLIC)
Marcotte, E. L., Thomopoulos, T., Infante-Rivard, C., Clavel, J., Petridou, E., Schüz, J., Ezzat, S., Dockerty, J., Metayer, C., Magnani, C., et al. (2016) · The Lancet Haematology · doi:10.1016/s2352-3026(16)00002-8 · Cited by 110
The Complex Interplay between Chronic Inflammation, the Microbiome, and Cancer: Understanding Disease Progression and What We Can Do to Prevent It
Armstrong, H., Bording‐Jorgensen, M., Dijk, S., & Wine, E. (2018) · Cancers · doi:10.3390/cancers10030083 · Cited by 122
Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice
Mendes, M. C. S., Paulino, D. S., Brambilla, S. R., Camargo, J. A., Persinoti, G. F., & Carvalheira, J. B. C. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i18.1995 · Cited by 116
Understanding the microbiome: Emerging biomarkers for exploiting the microbiota for personalized medicine against cancer
Rajpoot, M., Sharma, A. K., Sharma, A. K., & Gupta, G. K. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.02.003 · Cited by 119
Oral Microbiota: A Major Player in the Diagnosis of Systemic Diseases
Thomas, C., Minty, M., Vinel, A., Canceill, T., Loubières, P., Burcelin, R., Kaddech, M., Blasco‐Baqué, V., & Laurencin‐Dalicieux, S. (2021) · Diagnostics · doi:10.3390/diagnostics11081376 · Cited by 122
Tumorigenic bacteria in colorectal cancer: mechanisms and treatments
Li, S., Liu, J., Zheng, X., Ren, L., Yang, Y., Li, W., Fu, W., Wang, J., & Du, G. (2021) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2020.0651 · Cited by 116
Klebsiella oxytoca expands in cancer cachexia and acts as a gut pathobiont contributing to intestinal dysfunction
Pötgens, S. A., Brossel, H., Sboarina, M., Catry, E., Cani, P. D., Neyrinck, A. M., Delzenne, N. M., & Bindels, L. B. (2018) · Scientific Reports · doi:10.1038/s41598-018-30569-5 · Cited by 114
Pathogenesis of Human Diffusely Adhering Escherichia coli Expressing Afa/Dr Adhesins (Afa/Dr DAEC): Current Insights and Future Challenges
Servin, A. L. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00036-14 · Cited by 116
Microbial imbalance and intestinal pathologies: connections and contributions
Yang, Y., & Jobin, C. (2014) · Disease Models & Mechanisms · doi:10.1242/dmm.016428 · Cited by 118
Self-citation
Potential effects of gut microbiota on host cancers: focus on immunity, DNA damage, cellular pathways, and anticancer therapy
Sun, J., Chen, F., & Wu, G. (2023) · The ISME Journal · doi:10.1038/s41396-023-01483-0 · Cited by 118
Advancing Gut Microbiome Research: The Shift from Metagenomics to Multi-Omics and Future Perspectives
Yang, S.-Y., Han, S. M., Lee, J., Kim, K. S., Lee, J. E., & Lee, D. (2025) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2412.12001 · Cited by 124
Microbiota dysbiosis: a new piece in the understanding of the carcinogenesis puzzle
García-Castillo, V., Sanhueza, E., McNerney, E. M., Oñate, S. A., & García, A. (2016) · Journal of Medical Microbiology · doi:10.1099/jmm.0.000371 · Cited by 113
The Dynamic Changes of Gut Microbiota in Muc2 Deficient Mice
Wu, M., Wu, Y., Li, J., Bao, Y., Guo, Y., & Yang, W. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092809 · Cited by 112
Stool Microbiota Composition Differs in Patients with Stomach, Colon, and Rectal Neoplasms
Youssef, O., Lahti, L., Kokkola, A., Karla, T., Tikkanen, M., Ehsan, H., Carpelan-Holmström, M. A., Koskensalo, S., Böhling, T., Rautelin, H., et al. (2018) · Digestive Diseases and Sciences · doi:10.1007/s10620-018-5190-5 · Cited by 111
Porphyromonas gingivalis promotes tumor progression in esophageal squamous cell carcinoma
Chen, M., Lu, M., Hsieh, C., & Chen, W. (2020) · Cellular Oncology · doi:10.1007/s13402-020-00573-x · Cited by 113
Microbiome and Cervical Cancer
Castanheira, C. P., Sallas, M. L., Nunes, R. A. L., Lorenzi, N. P. C., & Termini, L. (2020) · Pathobiology · doi:10.1159/000511477 · Cited by 114
The Oral Host–Microbial Interactome: An Ecological Chronometer of Health?
Freire, M., Nelson, K. E., & Edlund, A. (2020) · Trends in Microbiology · doi:10.1016/j.tim.2020.11.004 · Cited by 111
Klebsiella oxytoca and Emerging Nosocomial Infections
Neog, N., Phukan, U., Puzari, M., Sharma, M., & Chetia, P. (2021) · Current Microbiology · doi:10.1007/s00284-021-02402-2 · Cited by 109
Customized materials-assisted microorganisms in tumor therapeutics
Chen, Q., Qiao, J., Liu, X., Zhang, C., & Zhang, X. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01571g · Cited by 109
The significance of microbiome in personalized medicine
Behrouzi, A., Nafari, A. H., & Siadat, S. D. (2019) · Clinical and Translational Medicine · doi:10.1186/s40169-019-0232-y · Cited by 113
Urinary microbiota – a potential biomarker and therapeutic target for bladder cancer
Bi, H., Tian, Y., Song, C., Li, J., Liu, T., Chen, Z., Chen, C., Huang, Y., & Zhang, Y. (2019) · Journal of Medical Microbiology · doi:10.1099/jmm.0.001058 · Cited by 108
The Microbiome and Cancer: Is the ‘Oncobiome’ Mirage Real?
Thomas, R. M., & Jobin, C. (2015) · Trends in cancer · doi:10.1016/j.trecan.2015.07.005 · Cited by 112
Self-citation
Molecular mechanisms involved in dendritic cell dysfunction in cancer
Tang, M., Diao, J., & Cattral, M. S. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2317-8 · Cited by 106
Mini-review: perspective of the microbiome in the pathogenesis of urothelial carcinoma.
Xu, W., Yang, L., Lee, P., Huang, W. C. W., Nossa, C. W., Ma, Y., Deng, F., Zhou, M., Melamed, J., & Pei, Z. (2014) · PubMed Central · Cited by 106
Metagenomics and Bioinformatics in Microbial Ecology: Current Status and Beyond
Hiraoka, S., Yang, C.-C., & Iwasaki, W. (2016) · Microbes and Environments · doi:10.1264/jsme2.me16024 · Cited by 109
Microbial Communities Associated with Primary and Metastatic Head and Neck Squamous Cell Carcinoma – A High Fusobacterial and Low Streptococcal Signature
Shin, J. M., Luo, T. L., Kamarajan, P., Fenno, J. C., Rickard, A. H., & Kapila, Y. L. (2017) · Scientific Reports · doi:10.1038/s41598-017-09786-x · Cited by 107
Combination Therapy of TGF-β Blockade and Commensal-derived Probiotics Provides Enhanced Antitumor Immune Response and Tumor Suppression
Shi, L., Sheng, J., Wang, M., Luo, H., Zhu, J., Zhang, B., Liu, Z., & Yang, X. (2019) · Theranostics · doi:10.7150/thno.35131 · Cited by 104
Alginate-based double-network hydrogel improves the viability of encapsulated probiotics during simulated sequential gastrointestinal digestion: Effect of biopolymer type and concentrations
Qi, X., Şimşek, Ş., Chen, B., & Rao, J. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.10.028 · Cited by 102
Beyond Head and Neck Cancer: The Relationship Between Oral Microbiota and Tumour Development in Distant Organs
Mascitti, M., Togni, L., Troiano, G., Caponio, V. C. A., Gissi, D. B., Montebugnoli, L., Procaccini, M., Muzio, L. L., & Santarelli, A. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00232 · Cited by 100
Microbes and Cancer: Friends or Faux?
Azevedo, M. M., Pina‐Vaz, C., & Baltazar, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093115 · Cited by 101
Influence of Intratumor Microbiome on Clinical Outcome and Immune Processes in Prostate Cancer
Ma, J., Gnanasekar, A., Lee, A., Li, W. T., Haas, M., Wang‐Rodriguez, J., Chang, E. Y., Rajasekaran, M. R., & Ongkeko, W. M. (2020) · Cancers · doi:10.3390/cancers12092524 · Cited by 101
Unlocking the Potential of the Human Microbiome for Identifying Disease Diagnostic Biomarkers
Hajjo, R., Sabbah, D. A., & Bawab, A. Q. A. (2022) · Diagnostics · doi:10.3390/diagnostics12071742 · Cited by 105
PBHMDA: Path-Based Human Microbe-Disease Association Prediction
Huang, Z.-A., Chen, X., Zhu, Z., Liu, H., Yan, G., You, Z., & Wen, Z. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00233 · Cited by 99
Enhanced viability of layer-by-layer encapsulated Lactobacillus pentosus using chitosan and sodium phytate
Wang, M., Yang, J., Li, M., Wang, Y., Wu, H., Xiong, L., & Sun, Q. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2019.01.162 · Cited by 105
Do Antibiotics Cause Obesity Through Long-term Alterations in the Gut Microbiome? A Review of Current Evidence
Vallianou, N. G., Dalamaga, Μ., Stratigou, T., Karampela, Ι., & Tsigalou, C. (2021) · Current Obesity Reports · doi:10.1007/s13679-021-00438-w · Cited by 103
The Impact of Intratumoral and Gastrointestinal Microbiota on Systemic Cancer Therapy
Cogdill, A. P., Gaudreau, P. O., Arora, R., Gopalakrishnan, V., & Wargo, J. A. (2018) · Trends in Immunology · doi:10.1016/j.it.2018.09.007 · Cited by 98
Microbial-Derived Butyrate: An Oncometabolite or Tumor-Suppressive Metabolite?
Bultman, S. J., & Jobin, C. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.07.011 · Cited by 98
Self-citation
The Urinary Microbiome: Implications in Bladder Cancer Pathogenesis and Therapeutics
Bajic, P., Wolfe, A. J., & Gupta, G. N. (2019) · Urology · doi:10.1016/j.urology.2018.12.034 · Cited by 98
The gut microbiota in breast cancer development and treatment: The good, the bad, and the useful!
Nandi, D., Parida, S., & Sharma, D. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2221452 · Cited by 103
Microbiota—myeloid cell crosstalk beyond the gut
Gorjifard, S., & Goldszmid, R. S. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ri0516-222r · Cited by 100
Influence of gemcitabine chemotherapy on the microbiota of pancreatic cancer xenografted mice
Panebianco, C., Adamberg, K., Jaagura, M., Copetti, M., Fontana, A., Adamberg, S., Kolk, K., Vilu, R., Andriulli, A., & Pazienza, V. (2018) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-018-3549-0 · Cited by 97
Relating Urban Biodiversity to Human Health With the ‘Holobiont’ Concept
Mills, J. G., Brookes, J. D., Gellie, N. J. C., Liddicoat, C., Lowe, A. J., Sydnor, H. R., Thomas, T., Weinstein, P., Weyrich, L. S., & Breed, M. F. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00550 · Cited by 103
Recent Advances in Our Understanding of the Link between the Intestinal Microbiota and Systemic Lupus Erythematosus
Kim, J., Kwok, S., Choe, J., & Park, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194871 · Cited by 100
Synergy between Cell Surface Glycosidases and Glycan-Binding Proteins Dictates the Utilization of Specific Beta(1,3)-Glucans by Human Gut Bacteroides
Déjean, G., Tamura, K., Cabrera, A., Jain, N., Pudlo, N. A., Pereira, G. V., Viborg, A. H., Petegem, F. V., Martens, E. C., & Brumer, H. (2020) · mBio · doi:10.1128/mbio.00095-20 · Cited by 103
Predicting human microbe–disease associations via graph attention networks with inductive matrix completion
Long, Y., Luo, J., Zhang, Y., & Xia, Y. C. (2020) · Briefings in Bioinformatics · doi:10.1093/bib/bbaa146 · Cited by 96
The microbiome and lung cancer
Maddi, A., Sabharwal, A., Violante, T., Manuballa, S., Genco, R. J., Patnaik, S. K., & Yendamuri, S. (2019) · Journal of Thoracic Disease · doi:10.21037/jtd.2018.12.88 · Cited by 95
Oral delivery of bacteria: Basic principles and biomedical applications
Li, S., Jiang, W., Zheng, C., Shao, D., Liu, Y., Huang, S., Han, J., Ding, J., Tao, Y., & Li, M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.011 · Cited by 95
Histamine: A Mediator of Intestinal Disorders—A Review
Smolińska, S., Winiarska, E., Głobińska, A., & Jutel, M. (2022) · Metabolites · doi:10.3390/metabo12100895 · Cited by 100
Periodontal Disease and Breast Cancer: Prospective Cohort Study of Postmenopausal Women
Freudenheim, J. L., Genco, R. J., LaMonte, M. J., Millen, A. E., Hovey, K. M., Mai, X., Nwizu, N. N., Andrews, C., & Wactawski‐Wende, J. (2015) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-15-0750 · Cited by 95
Dysbiosis of skin microbiome and gut microbiome in melanoma progression
Mekadim, C., Skalníková, H. K., Čížková, J., Cizkova, V., Palanová, A., Horák, V., & Mrázek, J. (2022) · BMC Microbiology · doi:10.1186/s12866-022-02458-5 · Cited by 99
Investigating the association between the urinary microbiome and bladder cancer: An exploratory study
Hussein, A. A., Elsayed, A. S., Durrani, M., Jing, Z., Iqbal, U. H., Gomez, E. C., Singh, P. K., Liu, S., Smith, G. J., Tang, L., et al. (2021) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2020.12.011 · Cited by 93

Authors: Schwabe, R. F., & Jobin, C.
Affiliations: Columbia University (US)
University of Florida Health (US)
Corresponding author: Schwabe, Robert F.
Jobin, Christian
ORCID: Schwabe, Robert F.
Jobin, Christian
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2013-10-17
Volume: 13
Issue: 11
Pages: 800-812
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc3610
PMC: PMC3986062
OpenAlex: W2016853666
Cited by: 1,689
References: 205
Citations by year: 2026: 87 · 2025: 123 · 2024: 135 · 2023: 141 · 2022: 207 · 2021: 214 · 2020: 150 · 2019: 138 · 2018: 146 · 2017: 103 · 2016: 110 · 2015: 77 · 2014: 54
FWCI: 7.55
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Alcohol Abuse and Alcoholism (R01AA020211)
National Cancer Institute (U54CA163111)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK047700, R01DK073338, R01DK076920)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
Keywords: gut microbiota, carcinogenesis, dysbiosis, host-microbe symbiosis, bacterial sensing, immune response, genotoxicity, host metabolism, cancer prevention, microbiome-targeted therapy
MeSH terms: Animals, Bacteria, Diet, Humans, Immune System, Mutagens, Neoplasms, Symbiosis, Gene Expression Regulation, Bacterial, Gene Expression Regulation, Neoplastic, Virulence Factors, Mice, Carcinogenesis, Microbiota

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The microbiome and cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks