Cited by 1,689Gut microbiota and healthOral microbiology and periodontitis researchBacterial Cancer Therapy

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The microbiome and cancer

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Schwabe, Robert F., Jobin, Christian·2013·Nature Reviews Cancer

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Abstract

Microbiota and host form a complex 'super-organism' in which symbiotic relationships confer benefits to the host in many key aspects of life. However, defects in the regulatory circuits of the host that control bacterial sensing and homeostasis, or alterations of the microbiome, through environmental changes (infection, diet or lifestyle), may disturb this symbiotic relationship and promote disease. Increasing evidence indicates a key role for the bacterial microbiota in carcinogenesis. In this Opinion article, we discuss links between the bacterial microbiota and cancer, with a particular focus on immune responses, dysbiosis, genotoxicity, metabolism and strategies to target the microbiome for cancer prevention.

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Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
Immunity, Inflammation, and Cancer
Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
Inflammation and cancer: back to Virchow?
Balkwill, F., & Mantovani, A. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04046-0 · Cited by 7,746
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277
Metagenomic Analysis of the Human Distal Gut Microbiome
Gill, S. R., Pop, M., DeBoy, R. T., Eckburg, P. B., Turnbaugh, P. J., Samuel, B. S., Gordon, J. I., Relman, D. A., Fraser-Liggett, C. M., & Nelson, K. E. (2006) · Science · doi:10.1126/science.1124234 · Cited by 4,699

Show all 205 references

Research works printed but not linked: 2

Koch, R. in Tenth International Congress of Medicine 1 (August Hirschwald, Berlin, 1891).
Laqueur, G. L., Matsumoto, H. & Yamamoto, R. S. Comparison of the carcinogenicity of methylazoxymethanol-β-D-glucosiduronic acid in conventional and germfree Sprague-Dawley rats. J. Natl Cancer Inst. 67, 1053–1055 (1981).

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Authors: Schwabe, R. F., & Jobin, C.
Affiliations: Columbia University (US)
University of Florida Health (US)
Corresponding author: Schwabe, Robert F.
Jobin, Christian
ORCID: Schwabe, Robert F.
Jobin, Christian
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2013-10-17
Volume: 13
Issue: 11
Pages: 800-812
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc3610
PMC: PMC3986062
OpenAlex: W2016853666
Cited by: 1,689
References: 205
Citations by year: 2026: 87 · 2025: 123 · 2024: 135 · 2023: 141 · 2022: 207 · 2021: 214 · 2020: 150 · 2019: 138 · 2018: 146 · 2017: 103 · 2016: 110 · 2015: 77 · 2014: 54
FWCI: 7.55
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Alcohol Abuse and Alcoholism (R01AA020211)
National Cancer Institute (U54CA163111)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK047700, R01DK073338, R01DK076920)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
Keywords: gut microbiota, carcinogenesis, dysbiosis, host-microbe symbiosis, bacterial sensing, immune response, genotoxicity, host metabolism, cancer prevention, microbiome-targeted therapy
MeSH terms: Animals, Bacteria, Diet, Humans, Immune System, Mutagens, Neoplasms, Symbiosis, Gene Expression Regulation, Bacterial, Gene Expression Regulation, Neoplastic, Virulence Factors, Mice, Carcinogenesis, Microbiota

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