FAK in cancer: mechanistic findings and clinical applications

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Items 101–200 of 1,000

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2. Endosomes: Emerging Platforms for Integrin-Mediated FAK Signalling
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3. Genistein inhibits the growth and regulates the migration and invasion abilities of melanoma cells via the FAK/paxillin and MAPK pathways
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4. FAK-Dependent Cell Motility and Cell Elongation
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5. Disrupting biological sensors of force promotes tissue regeneration in large organisms
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7. PTK2 promotes cancer stem cell traits in hepatocellular carcinoma by activating Wnt/β-catenin signaling
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8. GNAQ and GNA11 Genes: A Comprehensive Review on Oncogenesis, Prognosis and Therapeutic Opportunities in Uveal Melanoma
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11. Sensing the mechano-chemical properties of the extracellular matrix
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12. Progress in the Development of Small Molecular Inhibitors of Focal Adhesion Kinase (FAK)
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16. FAK-targeted and combination therapies for the treatment of cancer: an overview of phase I and II clinical trials
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17. Molecular Pathways: Endothelial Cell FAK—A Target for Cancer Treatment
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18. FAK activity in cancer‐associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer
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19. MicroRNA-379-5p inhibits tumor invasion and metastasis by targeting FAK/AKT signaling in hepatocellular carcinoma
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20. Kaempferol Inhibits the Invasion and Migration of Renal Cancer Cells through the Downregulation of AKT and FAK Pathways
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21. Focal adhesion kinase a potential therapeutic target for pancreatic cancer and malignant pleural mesothelioma
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22. Disrupting mechanotransduction decreases fibrosis and contracture in split-thickness skin grafting
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23. Extracellular vesicles isolated from human renal cell carcinoma tissues disrupt vascular endothelial cell morphology via azurocidin
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24. Curcumin as tyrosine kinase inhibitor in cancer treatment
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25. IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks
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26. KRAS G12C inhibitor combination therapies: current evidence and challenge
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27. Focal adhesion kinase (FAK) activation by estrogens involves GPER in triple-negative breast cancer cells
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29. Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma: An Update on Heterogeneity and Therapeutic Targeting
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30. Lycorine inhibits breast cancer growth and metastasis via inducing apoptosis and blocking Src/FAK-involved pathway
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31. Triptolide Inhibits Lung Cancer Cell Migration, Invasion, and Metastasis
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32. Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition
    Edward R. Horton, Jonathan D. Humphries, Ben Stutchbury, Guillaume Jacquemet, Christoph Ballestrem, Simon T. Barry, Martin James Humphries · 2016 · The Journal of Cell Biology
33. MERTK tyrosine kinase receptor together with TIM4 phosphatidylserine receptor mediates distinct signal transduction pathways for efferocytosis and cell proliferation
    Chihiro Nishi, Yuichi Yanagihashi, Katsumori Segawa, Shigekazu Nagata · 2019 · Journal of Biological Chemistry
34. Parthenolide Covalently Targets and Inhibits Focal Adhesion Kinase in Breast Cancer Cells
    Charles A. Berdan, Raymond Y. Ho, Haley S. Lehtola, Milton To, Xirui Hu, Tucker R. Huffman, Yana D. Petri, Chad R. Altobelli, Sasha K. Demeulenaere, James A. Olzmann et al. · 2019 · Cell chemical biology
35. Focal Adhesion Kinase Regulates the DNA Damage Response and Its Inhibition Radiosensitizes Mutant <i>KRAS</i> Lung Cancer
    Tang, Ke-Jing, Constanzo, Jerfiz D., Venkateswaran, Niranjan, Melegari, Margherita, Ilcheva, Mariya, Morales, Julio C., Skoulidis, Ferdinandos, Heymach, John V., Boothman, David A., Scaglioni, Pier Paolo · 2016 · Clinical Cancer Research
36. Roles and inhibitors of FAK in cancer: current advances and future directions
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37. Large-scale, spatially resolved panoramic CRISPR screening in native tissue environments using Perturb-DBiT
    Alev Baysoy, Xiaolong Tian, Paul A. Renauer, Feifei Zhang, Zhiliang Bai, Hao Shi, Mingyu Yang, Dingyao Zhang, Miao Liu, Haikuo Li et al. · 2026 · Nature Biotechnology
38. The extracellular matrix and focal adhesion kinase signaling regulate cancer stem cell function in pancreatic ductal adenocarcinoma
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39. Mesenchymal Stem Cells Induce Directional Migration of Invasive Breast Cancer Cells through TGF-β
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40. Design and synthesis of emodin derivatives as novel inhibitors of ATP-citrate lyase
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41. IGF-1/IGF-1R/FAK/YAP Transduction Signaling Prompts Growth Effects in Triple-Negative Breast Cancer (TNBC) Cells
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42. Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer Development
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43. Endothelin-1 promotes vascular smooth muscle cell migration across the artery wall: a mechanism contributing to vascular remodelling and intimal hyperplasia in giant-cell arteritis
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44. An overview of resistance to chemotherapy in osteosarcoma and future perspectives
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45. Plasticity of Cancer Cell Invasion—Mechanisms and Implications for Therapy
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46. Circular RNA circPICALM sponges miR-1265 to inhibit bladder cancer metastasis and influence FAK phosphorylation
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47. Molecular characteristics of meningiomas
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48. MOB2 suppresses GBM cell migration and invasion via regulation of FAK/Akt and cAMP/PKA signaling
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49. Drug Discovery Targeting Focal Adhesion Kinase (FAK) as a Promising Cancer Therapy
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50. Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe
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51. Resveratrol Regulates Colorectal Cancer Cell Invasion by Modulation of Focal Adhesion Molecules
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52. Focal Adhesion Kinase (FAK) Inhibition Synergizes with KRAS G12C Inhibitors in Treating Cancer through the Regulation of the FAK–YAP Signaling
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53. New emerging roles of CD133 in cancer stem cell: Signaling pathway and miRNA regulation
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54. ROCK1 promotes migration and invasion of non‑small‑cell lung cancer cells through the PTEN/PI3K/FAK pathway
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55. New Opportunities and Challenges to Defeat Cancer Stem Cells
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56. FSTL1 interacts with VIM and promotes colorectal cancer metastasis via activating the focal adhesion signalling pathway
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57. Matrix stiffness regulates vascular integrity through focal adhesion kinase activity
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58. Understanding Lineage Plasticity as a Path to Targeted Therapy Failure in EGFR-Mutant Non-small Cell Lung Cancer
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59. The conformational state of hERG1 channels determines integrin association, downstream signaling, and cancer progression
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60. Simulated microgravity inhibits cell focal adhesions leading to reduced melanoma cell proliferation and metastasis via FAK/RhoA-regulated mTORC1 and AMPK pathways
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61. MicroRNA-7 inhibits cell proliferation, migration and invasion in human non-small cell lung cancer cells by targeting FAK through ERK/MAPK signaling pathway
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62. Depression promotes prostate cancer invasion and metastasis via a sympathetic-cAMP-FAK signaling pathway
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63. Approved and Experimental Small‐Molecule Oncology Kinase Inhibitor Drugs: A Mid‐2016 Overview
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64. New insights into FAK structure and function in focal adhesions
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65. An Update on Src Family of Nonreceptor Tyrosine Kinases Biology
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66. Structural basis of Focal Adhesion Kinase activation on lipid membranes
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67. Tumor FAK orchestrates immunosuppression in ovarian cancer via the CD155/TIGIT axis
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68. Recent Advances in PROTACs for Drug Targeted Protein Research
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69. Crabp2 Promotes Metastasis of Lung Cancer Cells via HuR and Integrin β1/FAK/ERK Signaling
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70. FAK Promotes Osteoblast Progenitor Cell Proliferation and Differentiation by Enhancing Wnt Signaling
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71. P38 delta MAPK promotes breast cancer progression and lung metastasis by enhancing cell proliferation and cell detachment
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72. Inhibition of the integrin/FAK signaling axis and c-Myc synergistically disrupts ovarian cancer malignancy
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73. Therapeutic Implication of SOCS1 Modulation in the Treatment of Autoimmunity and Cancer
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74. Recent progress on FAK inhibitors with dual targeting capabilities for cancer treatment
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75. Ling Zhi-8 reduces lung cancer mobility and metastasis through disruption of focal adhesion and induction of MDM2-mediated Slug degradation
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76. Dynamic Mechanics‐Modulated Hydrogels to Regulate the Differentiation of Stem‐Cell Spheroids in Soft Microniches and Modeling of the Nonlinear Behavior
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77. Targeting cancer stem cells in the clinic: Current status and perspectives
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78. WT1 associated protein promotes metastasis and chemo-resistance to gemcitabine by stabilizing Fak mRNA in pancreatic cancer
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79. The Crosstalk between FAK and Wnt Signaling Pathways in Cancer and Its Therapeutic Implication
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80. CD151 drives cancer progression depending on integrin α3β1 through EGFR signaling in non-small cell lung cancer
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81. TNF-Related Apoptosis-Inducing Ligand: Non-Apoptotic Signalling
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82. Signal Transduction Mechanisms of Focal Adhesions: Src and FAK-Mediated Cell Response
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83. Inhibition of FAK kinase activity preferentially targets cancer stem cells
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84. Role and Therapeutic Targeting of the HGF/MET Pathway in Glioblastoma
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85. MicroRNA-106b promotes colorectal cancer cell migration and invasion by directly targeting DLC1
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86. The Interplay of the Extracellular Matrix and Stromal Cells as a Drug Target in Stroma-Rich Cancers
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87. Molecular Mechanisms of Chemotherapy Resistance in Head and Neck Cancers
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88. Prediction of biomarkers and therapeutic combinations for anti-PD-1 immunotherapy using the global gene network association
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89. Targeting extracellular matrix stiffness for cancer therapy
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90. Proteomic Profiling Identifies PTK2/FAK as a Driver of Radioresistance in HPV-negative Head and Neck Cancer
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91. FAK signalling controls insulin sensitivity through regulation of adipocyte survival
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92. Focal adhesion kinase activity is required for actomyosin contractility-based invasion of cells into dense 3D matrices
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93. The RNA-editing enzyme ADAR promotes lung adenocarcinoma migration and invasion by stabilizing FAK
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94. Quercetin inhibits LPS-induced macrophage migration by suppressing the iNOS/FAK/paxillin pathway and modulating the cytoskeleton
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95. FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth
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96. The pancreatic cancer microenvironment: A true double agent
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97. Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4–NDRG1 Axis
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98. α5β1-Integrin promotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site
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99. Integrating chemical and mechanical signals through dynamic coupling between cellular protrusions and pulsed ERK activation
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100. Effects of WSG, a polysaccharide from Ganoderma lucidum, on suppressing cell growth and mobility of lung cancer
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