FAK in cancer: mechanistic findings and clinical applications

Comprehensive molecular portraits of human breast tumours

The Cancer Genome Atlas Network (2012) · Nature · doi:10.1038/nature11412 · Cited by 12,129

The protein kinase complement of the human genome

Manning, G., Whyte, D. B., Martinez, R., Hunter, T., & Sudarsanam, S. (2002) · Science · doi:10.1126/science.1075762 · Cited by 8,145

Integrated genomic analyses of ovarian carcinoma

Perou, C. M. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/hvp3-wg08 · Cited by 7,927

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

Levental, K. R., Yu, H., Kass, L., Lakins, J. N., Egeblad, M., Erler, J. T., Fong, S. F. T., Csiszar, K., Giaccia, A., Weninger, W., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.027 · Cited by 4,101

Focal adhesion kinase: in command and control of cell motility

Mitra, S. K., Hanson, D. A., & Schlaepfer, D. D. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1549 · Cited by 2,657

Focal adhesion kinase: the first ten years

Parsons, J. T. (2003) · Journal of Cell Science · doi:10.1242/jcs.00373 · Cited by 1,389

The role of focal-adhesion kinase in cancer — a new therapeutic opportunity

McLean, G. W., Carragher, N. O., Avizienyte, E., EVANS, J., Brunton, V. G., & Frame, M. C. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1647 · Cited by 1,049

E-cadherin–integrin crosstalk in cancer invasion and metastasis

Canel, M., Serrels, A., Frame, M. C., & Brunton, V. G. (2013) · Journal of Cell Science · doi:10.1242/jcs.100115 · Cited by 651

Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions

Schaller, M. D. (2010) · Journal of Cell Science · doi:10.1242/jcs.045112 · Cited by 613

Signal transduction by focal adhesion kinase in cancer

Zhao, J., & Guan, J. (2009) · Cancer and Metastasis Reviews · doi:10.1007/s10555-008-9165-4 · Cited by 608

Cancer-associated fibroblasts (CAFs) gene signatures predict outcomes in breast and prostate tumor patients

Talia, M., Cesario, E., Cirillo, F., Scordamaglia, D., Dio, M. D., Zicarelli, A., Mondino, A. A., Occhiuzzi, M. A., Francesco, E. M. D., Belfiore, A., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05413-2 · Cited by 28

Filamin A upregulation correlates with Snail-induced epithelial to mesenchymal transition (EMT) and cell adhesion but its inhibition increases the migration of colon adenocarcinoma HT29 cells

Wieczorek, K., Wiktorska, M., Sacewicz‐Hofman, I., Boncela, J., Lewiñski, A., Kowalska, M. A., & Niewiarowska, J. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.07.035 · Cited by 28

Identification of zinc finger protein of the cerebellum 5 as a survival factor of prostate and colorectal cancer cells

Satow, R., Inagaki, S., Kato, C., Shimozawa, M., & Fukami, K. (2017) · Cancer Science · doi:10.1111/cas.13419 · Cited by 28

Snake Venom Disintegrins: An Overview of their Interaction with Integrins

César, P. H. S., Braga, M. A., Trento, M. V. C., Menaldo, D. L., & Marcussi, S. (2018) · Current Drug Targets · doi:10.2174/1389450119666181022154737 · Cited by 28

TRAF2 Cooperates with Focal Adhesion Signaling to Regulate Cancer Cell Susceptibility to Anoikis

da Silva, S. D., Xu, B., Maschietto, M. C., Marchi, F. A., Alkailani, M. I., Bijian, K., Xiao, D., & Alaoui‐Jamali, M. A. (2018) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-17-1261 · Cited by 28

Inhibition of FAK Signaling Elicits Lamin A/C-Associated Nuclear Deformity and Cellular Senescence

Chuang, H.-H., Wang, P., Niu, S., Zhen, Y., Huang, M., Hsiao, M., & Yang, C. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00022 · Cited by 29

Fluid flow-induced activation of subcellular AMPK and its interaction with FAK and Src

Guo, Y., Steele, H. E., Li, B., & Na, S. (2019) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2019.108208 · Cited by 28

The Membrane Protein Sortilin Can Be Targeted to Inhibit Pancreatic Cancer Cell Invasion

Gao, F., Griffin, N., Faulkner, S., Li, X., King, S. J., Jobling, P., Denham, J. W., Jiang, C. C., & Hondermarck, H. (2020) · American Journal Of Pathology · doi:10.1016/j.ajpath.2020.05.018 · Cited by 29

Vitamin C: A stem cell promoter in cancer metastasis and immunotherapy

Fu, J., Wu, Z., Liu, J., & Wu, T. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110588 · Cited by 28

Potent molecular-targeted therapies for advanced esophageal squamous cell carcinoma

Ooki, A., Osumi, H., Chìn, K., Watanabe, M., & Yamaguchi, K. (2023) · Therapeutic Advances in Medical Oncology · doi:10.1177/17588359221138377 · Cited by 28

Dual roles of FAK in tumor angiogenesis: A review focused on pericyte FAK

Zhang, J., Li, W., Wang, W., Chen, Q., Xu, Z., Deng, M., Zhou, L., & He, G. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175694 · Cited by 28

The Adhesion G-Protein-Coupled Receptor, GPR56/ADGRG1, Inhibits Cell–Extracellular Matrix Signaling to Prevent Metastatic Melanoma Growth

Millar, M. W., Corson, N., & Xu, L. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00008 · Cited by 28

Breaking down Leukemia Walls: Heteronemin, a Sesterterpene Derivative, Induces Apoptosis in Leukemia Molt4 Cells through Oxidative Stress, Mitochondrial Dysfunction and Induction of Talin Expression

Chen, Y., Lu, M., El‐Shazly, M., Lai, K.-H., Wu, T., Hsu, Y., Lee, Y.-L., & Liu, Y. (2018) · Marine Drugs · doi:10.3390/md16060212 · Cited by 28

EpCAM associates with integrin and regulates cell adhesion in cancer cells

Yang, J. A., Isaji, T., Zhang, G., Qi, F., Duan, C., Fukuda, T., & Gu, J. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.11.152 · Cited by 28

Design, synthesis and biological evaluation of 7-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)-2,3-dihydro-1H-inden-1-one derivatives as potent FAK inhibitors for the treatment of ovarian cancer

Wei, W., Feng, Z., Liu, Z., Li, X., He, H., Ran, K., Shi, Y., Zhu, Y., Ye, T., Gao, C., et al. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113978 · Cited by 27

Suppression of Endothelial Cell FAK Expression Reduces Pancreatic Ductal Adenocarcinoma Metastasis after Gemcitabine Treatment

Roy-Luzarraga, M., Reynolds, L. E., de Luxán‐Delgado, B., Maiques, Ó., Wisniewski, L., Newport, E., Rajeeve, V., Drake, R. J. G., Gómez-Escudero, J., Richards, F. M., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-20-3807 · Cited by 28

P130cas-FAK interaction is essential for YAP-mediated radioresistance of non-small cell lung cancer

Li, J., Zhang, X., Hou, Z., Cai, S., Guo, Y., Sun, L., Li, A., Li, Q., Wang, E., & Miao, Y. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05224-7 · Cited by 28

Focal Adhesion Kinase (FAK) tyrosine 397E mutation restores the vascular leakage defect in endothelium‐specific FAK‐kinase dead mice

Alexopoulou, A. N., Lees, D. M., Bodrug, N., Lechertier, T., Fernandez, I., D’Amico, G., Dukinfield, M., Batista, S., Tavora, B., Serrels, B., et al. (2017) · The Journal of Pathology · doi:10.1002/path.4911 · Cited by 27

Reduction of Membrane Protein CRIM1 Decreases E-Cadherin and Increases Claudin-1 and MMPs, Enhancing the Migration and Invasion of Renal Carcinoma Cells

Ogasawara, N., Kudo, T., Sato, M., Kawasaki, Y., Yonezawa, S., Takahashi, S., Miyagi, Y., Natori, Y., & Sugiyama, A. (2018) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b17-00990 · Cited by 27

Androgen Receptor-CaMKK2 Axis in Prostate Cancer and Bone Microenvironment

Dadwal, U. C., Chang, E. S., & Sankar, U. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00335 · Cited by 27

Bufalin inhibits glycolysis-induced cell growth and proliferation through the suppression of Integrin β2/FAK signaling pathway in ovarian cancer.

Li, H., Hu, S., Pang, Y., Li, M., Chen, L., Liu, F., Liu, M., Wang, Z., & Cheng, X. (2018) · Europe PMC (PubMed Central) · Cited by 27

CircRPAP2 regulates the alternative splicing of PTK2 by binding to SRSF1 in breast cancer

Yu, Y., & Fang, L. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-00965-y · Cited by 27

Inhibiting focal adhesion kinase: A potential target for enhancing therapeutic efficacy in colorectal cancer therapy

Jeong, K. (2018) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v10.i10.290 · Cited by 27

KRAS mutations in advanced non-small cell lung cancer: From biology to novel therapeutic strategies

Liguori, L., Salomone, F., Viggiano, A., Sabbatino, F., Pepe, S., Formisano, L., Bianco, R., & Servetto, A. (2024) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2024.104554 · Cited by 27

Focal adhesions are foci for tyrosine-based signal transduction via GIV/Girdin and G proteins

López-Sánchez, I., Kalogriopoulos, N. A., Lo, I., Kabir, F., Midde, K., Wang, H., & Ghosh, P. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-07-0496 · Cited by 26

GIV/Girdin (Gα-interacting, Vesicle-associated Protein/Girdin) Creates a Positive Feedback Loop That Potentiates Outside-in Integrin Signaling in Cancer Cells

Leyme, A., Marivin, A., & Garcia‐Marcos, M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.691550 · Cited by 26

miRNA-7 and miRNA-324-5p regulate alpha9-Integrin expression and exert anti-oncogenic effects in rhabdomyosarcoma

Molist, C., Navarro, N., Giralt, I., Zarzosa, P., Gallo-Oller, G., Pons, G., Magdaleno, A., Moreno, L., Guillén, G., Hladun, R., et al. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.02.035 · Cited by 26

FAK inhibition radiosensitizes pancreatic ductal adenocarcinoma cells in vitro

Mohamed, A. A., Thomsen, A. R., Follo, M., Zamboglou, C., Bronsert, P., Mostafa, H., Amen, A., Mekawy, M., Grosu, A., & Brunner, T. B. (2020) · Strahlentherapie und Onkologie · doi:10.1007/s00066-020-01666-0 · Cited by 26

RAGE Up-Regulation Differently Affects Cell Proliferation and Migration in Pancreatic Cancer Cells

Swami, P., Thiyagarajan, S., Vidger, A. J., Indurthi, V. S. K., Vetter, S. W., & Leclerc, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207723 · Cited by 26

Tumour suppression through modulation of neprilysin signaling: A comprehensive review

Sankhe, R., Pai, K. S. R., & Kishore, A. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173727 · Cited by 26

Emerging technologies provide insights on cancer extracellular matrix biology and therapeutics

Cruz‐Acuña, R., Vunjak‐Novakovic, G., Burdick, J. A., & Rustgi, A. K. (2021) · iScience · doi:10.1016/j.isci.2021.102475 · Cited by 26

Metabolic radiolabeling and in vivo PET imaging of cytotoxic T lymphocytes to guide combination adoptive cell transfer cancer therapy

Lu, D., Wang, Y., Zhang, T., Wang, F., Li, K., Zhou, S., Zhu, H., Yang, Z., & Liu, Z. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00924-2 · Cited by 26

Iridium(III)-BBIP complexes induce apoptosis via PI3K/AKT/mTOR pathway and inhibit A549 lung tumor growth in vivo

Zhou, Y., Bai, L., Li, T. X., Yang, L., Zhang, H., Zhang, Y., Hao, J., Gu, Y., & Liu, Y. (2021) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2021.111550 · Cited by 26

Multi-layered proteogenomic analysis unravels cancer metastasis directed by MMP-2 and focal adhesion kinase signaling

Kwon, Y. M., Park, S.-J., Nguyen, B. T., Kim, M. J., Oh, S., Lee, H., Park, N., Kim, H. S., Kang, M., Min, B. S., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-96635-7 · Cited by 26

Chrysin serves as a novel inhibitor of DGKα/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma (ESCC)

Chen, J., Wang, Y., Zhao, D., Zhang, L., Zhang, W., Fan, J., Li, J., & Zhan, Q. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.07.011 · Cited by 26

Activation of Focal Adhesion Kinase Restores Simulated Microgravity-Induced Inhibition of Osteoblast Differentiation via Wnt/Β-Catenin Pathway

Fan, C., Wu, Z., Cooper, D. M. L., Magnus, A., Harrison, K. D., Eames, B. F., Chibbar, R., Groot, G., Huang, J., Genth, H., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105593 · Cited by 26

PYK2 senses calcium through a disordered dimerization and calmodulin-binding element

Momin, A. A., Mendes, T., Barthe, P., Faure, C., Hong, S., Yu, P., Kadaré, G., Jaremko, M., Girault, J., Jaremko, Ł., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03760-8 · Cited by 26

FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner

Pifer, P. M., Yang, L., Kumar, M., Xie, T., Frederick, M. J., Hefner, A. J., Beadle, B. M., Molkentine, D. P., Molkentine, J. M., Dhawan, A., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-0964 · Cited by 27

Gambogic Acid and Its Role in Chronic Diseases

Pandey, M. K., Karelia, D. N., & Amin, S. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-41334-1_15 · Cited by 26

Epigenetic regulation of RTK signaling

Spangle, J. M., & Roberts, T. M. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-017-1546-0 · Cited by 26

The Cytoskeletal Protein Cyclase-Associated Protein 1 (CAP1) in Breast Cancer: Context-Dependent Roles in Both the Invasiveness and Proliferation of Cancer Cells and Underlying Cell Signals

Hasan, R., & Zhou, G.-L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112653 · Cited by 26

Targeting the Extra-Cellular Matrix—Tumor Cell Crosstalk for Anti-Cancer Therapy: Emerging Alternatives to Integrin Inhibitors

Lorusso, G., Rüegg, C., & Kuonen, F. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01231 · Cited by 28

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway

Prosdocimi, E., Carpanese, V., Todesca, L. M., Varanita, T., Bachmann, M., Festa, M., Bonesso, D., Pérez-Verdaguer, M., Carrer, A., Velle, A., et al. (2024) · Science Advances · doi:10.1126/sciadv.adn9361 · Cited by 25

Mechanical regulation of metabolism, epigenetics, and their interplay

Nam, H., Yu, G., Ahn, S. I., & Nam, S. (2026) · npj Biomedical Innovations. · doi:10.1038/s44385-025-00059-1 · Cited by 25

Novel therapeutic mechanisms determine the effectiveness of lipid-core nanocapsules on melanoma models

Farsky, S. H. P., Drewes, C. C., Fiel, L. A., Bexiga, C. G., Asbahr, A. C. C., Uchiyama, M. K., Cogliati, B., Araki, K., Guterres, S. S., & Pohlmann, A. R. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s101543 · Cited by 25

Novel Small Molecule JP-153 Targets the Src-FAK-Paxillin Signaling Complex to Inhibit VEGF-Induced Retinal Angiogenesis

Toutounchian, J. J., Pagadala, J., Miller, D. D., Baudry, J. Y., Park, F., Chaum, E., & Yates, C. R. (2016) · Molecular Pharmacology · doi:10.1124/mol.116.105031 · Cited by 25

CPNE3 promotes migration and invasion in non-small cell lung cancer by interacting with RACK1 via FAK signaling activation

Lin, H., Zhang, X., Liao, L., Yu, T., Li, J., Pan, H., Liu, L., Kong, H., Sun, L., Yan, M., et al. (2018) · Journal of Cancer · doi:10.7150/jca.25872 · Cited by 25

Combined proteomics/miRNomics of dendritic cell immunotherapy-treated glioblastoma patients as a screening for survival-associated factors

Erhart, F., Hackl, M., Hahne, H., Buchroithner, J., Meng, C., Klingenbrunner, S., Reitermaier, R., Fischhuber, K., Skalicky, S., Berger, W., et al. (2020) · npj Vaccines · doi:10.1038/s41541-019-0149-x · Cited by 25

Extracellular vesicles carrying miR-193a derived from mesenchymal stem cells impede cell proliferation, migration and invasion of colon cancer by downregulating FAK

Ying, H., Feng, L., Ding, R., Wang, W., & Hong, W. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112144 · Cited by 25

Stromal Protein-Mediated Immune Regulation in Digestive Cancers

Gamradt, P., de la Fouchardière, C., & Hennino, A. (2021) · Cancers · doi:10.3390/cancers13010146 · Cited by 27

The driving role of the Cdk5/Tln1/FAKS732 axis in cancer cell extravasation dissected by human vascularized microfluidic models

Gilardi, M., Bersini, S., Valtorta, S., Proietto, M., Crippa, M., Boussommier-Calleja, A., Labelle, M., Moresco, R. M., Vanoni, M., Kamm, R. D., et al. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120975 · Cited by 26

miR-497 defect contributes to gastric cancer tumorigenesis and progression via regulating CDC42/ITGB1/FAK/PXN/AKT signaling

Zhang, L., Yao, L., Zhou, W., Tian, J., Ruan, B., Lu, Z., Deng, Y., Li, Q., Zeng, Z. R., Yang, D., et al. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.07.025 · Cited by 25

Ups and downs: The PPARγ/p-PPARγ seesaw of follistatin-like 1 and integrin receptor signaling in adipogenesis

Fang, D., Shi, X., Jia, X., Yang, C., Wang, L., Du, B., Lu, T., Shan, L., & Gao, Y. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101400 · Cited by 25

Caffeine Induces G0/G1 Cell Cycle Arrest and Inhibits Migration through Integrin αv, β3, and FAK/Akt/c-Myc Signaling Pathway

Meisaprow, P., Aksorn, N., Vinayanuwattikun, C., Pithi Chanvorachote, B., & Sukprasansap, M. (2021) · Molecules · doi:10.3390/molecules26247659 · Cited by 25

FAK/IL-8 axis promotes the proliferation and migration of gastric cancer cells

Ma, Y., Fu, Y., Fan, X., Ji, Q., Duan, X., Wang, Y., Zhang, Y., Wang, Z., & Hao, H. (2023) · Gastric Cancer · doi:10.1007/s10120-023-01384-3 · Cited by 25

Prognostic Value of Focal Adhesion Kinase (FAK) in Human Solid Carcinomas: A Meta-Analysis

Zeng, X., Li, N., Ma, L., Tseng, Y., Zhao, N., & Chen, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162666 · Cited by 25

PRL-3/PTP4A3 phosphatase regulates integrin β1 in adhesion structures during migration of human ocular melanoma cells

Foy, M., Anezo, O., Saule, S., & Planque, N. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.03.012 · Cited by 25

Dysregulation of Blimp1 transcriptional repressor unleashes p130Cas/ErbB2 breast cancer invasion

Sciortino, M., Leal, M. D. P. C., Orso, F., Grassi, E., Costamagna, A., Provero, P., Tam, W., Turco, E., Defilippi, P., Taverna, D., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-01332-z · Cited by 25

NEDD9 stimulated MMP9 secretion is required for invadopodia formation in oral squamous cell carcinoma

Grauzam, S. E., Brock, A. M., Holmes, C. O., Tiedeken, J. A., Boniface, S. G., Pierson, B. N., Patterson, D. G., Coaxum, S. D., Neskey, D. M., & Rosenzweig, S. A. (2018) · Oncotarget · doi:10.18632/oncotarget.25347 · Cited by 25

A sulfated glucan from Antrodia cinnamomea reduces Slug expression through regulation of TGFβ/AKT/GSK3β axis in lung cancer

Lin, T., Tseng, A.-J., Qiu, W.-L., Chao, C., & Lu, M. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.01.078 · Cited by 25

High Expression of TRIM15 Is Associated with Tumor Invasion and Predicts Poor Prognosis in Patients with Gastric Cancer

Zhou, W., Chen, H., Ruan, Y., Zeng, X., & Liu, F. (2020) · Journal of Investigative Surgery · doi:10.1080/08941939.2019.1705443 · Cited by 25

Downregulation of mitochondrial complex I induces ROS production in colorectal cancer subtypes that differently controls migration

Bastin, J., Sroussi, M., Nemazanyy, I., Laurent-Puig, P., Mouillet-Richard, S., & Djouadi, F. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04341-x · Cited by 24

Focal adhesion kinase confers pro‐migratory and antiapoptotic properties and is a potential therapeutic target in Ewing sarcoma

Steinestel, K., Trautmann, M., Jansen, E.-P., Dirksen, U., Rehkämper, J., Mikesch, J., Gerke, J. S., Orth, M. F., Sannino, G., Arteaga, M. F., et al. (2019) · Molecular Oncology · doi:10.1002/1878-0261.12610 · Cited by 24

New Insights on Fak and Fak Inhibitors

Brullo, C., & Tasso, B. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327666201103162239 · Cited by 24

Discovery of a Pyrimidothiazolodiazepinone as a Potent and Selective Focal Adhesion Kinase (FAK) Inhibitor

Groendyke, B. J., Nabet, B., Mohardt, M. L., Zhang, H., Peng, K., Koide, E., Coffey, C. R., Che, J., Scott, D. A., Bass, A. J., et al. (2020) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.0c00338 · Cited by 24

Cytotoxic and apoptosis-inducing effects of novel 8-amido isocoumarin derivatives against breast cancer cells

Das, V., Kaishap, P. P., Duarah, G., Chikkaputtaiah, C., Boruah, H. P. D., & Pal, M. (2021) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-021-02063-9 · Cited by 24

Phosphorylated paxillin and phosphorylated FAK constitute subregions within focal adhesions

Bachmann, M., Skripka, A., Weißenbruch, K., Wehrle‐Haller, B., & Bastmeyer, M. (2022) · Journal of Cell Science · doi:10.1242/jcs.258764 · Cited by 24

Roles of IGFBP-3 in cell migration and growth in an endophytic tongue squamous cell carcinoma cell line

Ng, E. F. Y., Kaida, A., Nojima, H., & Miura, M. (2022) · Scientific Reports · doi:10.1038/s41598-022-15737-y · Cited by 24

Increasing cancer permeability by photodynamic priming: from microenvironment to mechanotransduction signaling

Gutierrez, N. M. C., Pujol‐Solé, N., Arifi, Q., Coll, J., Clainche, T. L., & Broekgaarden, M. (2022) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10064-0 · Cited by 25

Tyrosine Kinase Signaling in Clear Cell and Papillary Renal Cell Carcinoma Revealed by Mass Spectrometry–Based Phosphotyrosine Proteomics

Haake, S. M., Li, J., Bai, Y., Kinose, F., Fang, B., Welsh, E. A., Zent, R., Dhillon, J., Pow‐Sang, J. M., Chen, Y. A., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-1673 · Cited by 24

Myocardin-related transcription factor A (MRTF-A) activity-dependent cell adhesion is correlated to focal adhesion kinase (FAK) activity

Kishi, T., Mayanagi, T., Iwabuchi, S., Akasaka, T., & Sobue, K. (2016) · Oncotarget · doi:10.18632/oncotarget.12350 · Cited by 24

Molecular and cellular impact of Psoriasin (S100A7) on the healing of human wounds

Rangaraj, A., Ye, L., Sanders, A. J., Price, P., Harding, K. G., & Jiang, W. G. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4275 · Cited by 24

Phosphoproteome Analysis of Cells Infected with Adapted and Nonadapted Influenza A Virus Reveals Novel Pro- and Antiviral Signaling Networks

Weber, A., Dam, S., Saul, V. V., Kuznetsova, I., Müller, C., Fritz‐Wolf, K., Becker, K., Linne, U., Gu, H., Stokes, M. P., et al. (2019) · Journal of Virology · doi:10.1128/jvi.00528-19 · Cited by 24

Verticillin A suppresses HGF-induced migration and invasion via repression of the c-Met/FAK/Src pathway in human gastric and cervical cancer cells

Lu, J., Li, X., Tu, K., Guan, Y., Fung, K., & Liu, F. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s208683 · Cited by 24

NEDD9 promotes invasion and migration of colorectal cancer cell line HCT116 via JNK/EMT

Meng, H., Wu, J., Huang, Q. Y., Yang, X., Yang, K., Qiu, Y., Ren, J., Shen, R., & Qi, H. (2019) · Oncology Letters · doi:10.3892/ol.2019.10756 · Cited by 24

Targeting focal adhesion kinase overcomes erlotinib resistance in smoke induced lung cancer by altering phosphorylation of epidermal growth factor receptor

Solanki, H. S., Raja, R., Zhavoronkov, A. A., Ozerov, I. V., Artemov, A. V., Advani, J., Radhakrishnan, A., Babu, N., Puttamallesh, V. N., Syed, N., et al. (2018) · Oncoscience · doi:10.18632/oncoscience.395 · Cited by 24

Critical role of lipid membranes in polarization and migration of cells: a biophysical view

Sackmann, E., & Tanaka, M. (2021) · Biophysical Reviews · doi:10.1007/s12551-021-00781-1 · Cited by 26

Electrophilic Natural Products as Drug Discovery Tools

Gehrtz, P., & London, N. (2021) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2021.03.008 · Cited by 25

The emerging promise of tumour mechanobiology in cancer treatment

Papavassiliou, K. A., Basdra, E. K., & Papavassiliou, A. G. (2023) · European Journal of Cancer · doi:10.1016/j.ejca.2023.112938 · Cited by 23

The stromal microenvironment endows pancreatic neuroendocrine tumors with spatially specific invasive and metastatic phenotypes

Zeng, Y., Li, Q., Hu, Y., Hu, H., Xu, J., Guo, M., Zhang, W., Lou, X., Wang, Y., Gao, H., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216769 · Cited by 26

DNA hypermethylation of extracellular matrix‐related genes in human periodontal fibroblasts induced by stimulation for a prolonged period with lipopolysaccharide derived from Porphyromonas gingivalis

Takai, R., Uehara, O., Harada, F., Utsunomiya, M., Chujo, T., Yoshida, K., Sato, J., Nishimura, M., Chiba, I., & Abiko, Y. (2015) · Journal of Periodontal Research · doi:10.1111/jre.12330 · Cited by 23

Development and validation of prognostic index based on autophagy-related genes in patient with head and neck squamous cell carcinoma

Feng, H., Zhong, L., Yang, X., Wan, Q., Pei, X., & Wang, J. (2020) · Cell Death Discovery · doi:10.1038/s41420-020-00294-y · Cited by 24

BRD4 modulates vulnerability of triple-negative breast cancer to targeting of integrin-dependent signaling pathways

Zhang, Y., Xu, B., Shi, J., Li, J., Lu, X., Xu, L., Yang, H. L., Hamad, N., Wang, C., Napier, D. L., et al. (2020) · Cellular Oncology · doi:10.1007/s13402-020-00537-1 · Cited by 23

ASC-J9® suppresses prostate cancer cell proliferation and invasion via altering the ATF3-PTK2 signaling

Tian, H., Chou, F.-J., Tian, J., Zhang, Y., You, B., Huang, C., Yeh, S., Niu, Y., & Chang, C. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01760-2 · Cited by 23

Integrin αvβ6 contributes to the development of intestinal fibrosis via the FAK/AKT signaling pathway

Xie, H., Jiao, Y., Zhou, X., Liao, X., Chen, J., Chen, H., Chen, L., Yu, S., Deng, Q., Sun, L., et al. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.113003 · Cited by 23

Focal adhesion kinase-related non-kinase ameliorates liver fibrosis by inhibiting aerobic glycolysis via the FAK/Ras/c-myc/ENO1 pathway

Huang, T., Li, Y.-Q.-X., Zhou, M., Hu, R.-H., Zou, G.-L., Li, J.-C., Feng, S. Y., Liu, Y., Xin, C.-Q., & Zhao, X. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i1.123 · Cited by 23

Pharmacological Inhibition of FAK-Pyk2 Pathway Protects Against Organ Damage and Prolongs the Survival of Septic Mice

Alves, G. F., Aimaretti, E., Einaudi, G., Mastrocola, R., Oliveira, J. G., Collotta, D., Porchietto, E., Aragno, M., Cifani, C., Sordi, R., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.837180 · Cited by 24

Truncated O-Glycan-Bearing MUC16 Enhances Pancreatic Cancer Cells Aggressiveness via α4β1 Integrin Complexes and FAK Signaling

Rajesh, C., Sagar, S., Ashokkumar, R., Chemparathy, D. T., Peng, X. L., Yeh, J. J., Hollingsworth, M. A., & Radhakrishnan, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105459 · Cited by 23

Identification of hub genes involved in cisplatin resistance in head and neck cancer

Chaudhary, R. K., Khanal, P., Mateti, U. V., Shastry, C. S., & Shetty, J. (2023) · Journal of Genetic Engineering and Biotechnology · doi:10.1186/s43141-023-00468-y · Cited by 23

Design, synthesis and biological evaluation of 4-arylamino-pyrimidine derivatives as focal adhesion kinase inhibitors

Long, Z., Zuo, Y., Li, R., Le, Y., Dong, Y., & Yan, L. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.106792 · Cited by 23

Cannabinoids and standardized cannabis extracts inhibit migration, invasion, and induce apoptosis in MCF-7 cells through FAK/MAPK/Akt/NF-κB signaling

Suttithumsatid, W., Sukketsiri, W., & Panichayupakaranant, P. (2023) · Toxicology in Vitro · doi:10.1016/j.tiv.2023.105667 · Cited by 23

Targeting FAK improves the tumor uptake of antibody-drug conjugates to strengthen the anti-cancer responses

Zhang, B., Zhang, Z., Gao, J., Lu, S., Pang, R., Li, D., Huang, X., Qin, N., Liu, L., & Wang, Z. (2024) · iScience · doi:10.1016/j.isci.2024.111536 · Cited by 24

Role of Acid Sphingomyelinase-Induced Signaling in Melanoma Cells for Hematogenous Tumor Metastasis

Carpinteiro, A., Beckmann, N., Seitz, A. P., Hessler, G., Wilker, B., Soddemann, M., Helfrich, I., Edelmann, B., Gulbins, E., & Becker, K. A. (2016) · Cellular Physiology and Biochemistry · doi:10.1159/000438604 · Cited by 23

A20 inhibits the motility of HCC cells induced by TNF-α

Wang, X., Ma, C., Zong, Z., Xiao, Y., Li, N., Guo, C. H., Zhang, L., & Shi, Y. (2016) · Oncotarget · doi:10.18632/oncotarget.7521 · Cited by 23

Kinase inhibitors as potential agents in the treatment of multiple myeloma

Abramson, H. N. (2016) · Oncotarget · doi:10.18632/oncotarget.10745 · Cited by 23

Activation of Focal Adhesion Kinase and Src Mediates Acquired Sorafenib Resistance in A549 Human Lung Adenocarcinoma Xenografts

Zhou, Q. S., Guo, X., & Choksi, R. (2017) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.240507 · Cited by 23

Phosphamide-containing diphenylpyrimidine analogues (PA-DPPYs) as potent focal adhesion kinase (FAK) inhibitors with enhanced activity against pancreatic cancer cell lines

Liu, H., Wu, B., Yang, G., Huang, J., Song, S., Wang, C., Yao, J., Liu, K., Li, Y., Li, Y., et al. (2017) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2017.09.041 · Cited by 23

Development of novel focal adhesion kinase (FAK) inhibitors for targeting cancer: Structural insights and therapeutic potential

Li, Y., Zhang, Y., Zhang, J., Zhan, Z., & Mao, W. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116913 · Cited by 22

FAK Promotes Early Osteoprogenitor Cell Proliferation by Enhancing mTORC1 Signaling

Qi, S., Sun, X., Choi, H. K., Yao, J., Wang, L., Wu, G., He, Y., Pan, J., Guan, J., & Liu, F. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4029 · Cited by 22

Combinatorial Inhibition of Focal Adhesion Kinase and BCL-2 Enhances Antileukemia Activity of Venetoclax in Acute Myeloid Leukemia

Wang, X., Mak, P. Y., Mu, H., Tao, W., Rao, A. U. K., Ravikumar, V., Ruvolo, V. R., Pachter, J. A., Weaver, D. T., Andreeff, M., et al. (2020) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-19-0841 · Cited by 22

Understanding the Roles of FAK in Cancer

Yoon, H., Dehart, J. P., Murphy, J. M., & Lim, S. (2014) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155414561498 · Cited by 228

Emerging Roles of Focal Adhesion Kinase in Cancer

Tai, Y.-L., Chen, L., & Shen, T. (2015) · BioMed Research International · doi:10.1155/2015/690690 · Cited by 233

Targeting focal adhesion kinase in cancer cells and the tumor microenvironment

Murphy, J. M., Rodriguez, Y. A. R., Jeong, K., Ahn, E.-Y. E., & Lim, S. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0447-4 · Cited by 226

Prospects of focal adhesion kinase inhibitors as a cancer therapy in preclinical and early phase study

Gao, J., Cheng, J., Xie, W., Zhang, P., Liu, X., Wang, Z., & Zhang, B. (2024) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2024.2348068 · Cited by 14

Focal adhesion kinase—An emerging viable target in cancer and development of focal adhesion kinase inhibitors

Chauhan, A., & Khan, T. A. (2020) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13808 · Cited by 52