FAK in cancer: mechanistic findings and clinical applications

Sulzmaier, Florian J., Jean, Christine, Schlaepfer, David D.·2014·Nature Reviews Cancer

DOI 10.1038/nrc3792

Cited by (1,000)

Items 801–900 of 1,000

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C1632 inhibits ovarian cancer cell growth and migration by inhibiting LIN28 B/let-7/FAK signaling pathway and FAK phosphorylation
Qian Zhang, Mengyun Shi, Ruiling Zheng, Haoyi Han, Xin Zhang, Feng Lin · 2023 · European Journal of Pharmacology
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Ethanol Enhances Estrogen Mediated Angiogenesis in Breast Cancer
Rachana R. Maniyar, Sanjukta Chakraborty, Robert Suriano · 2018 · Journal of Cancer
FAK-Copy-Gain Is a Predictive Marker for Sensitivity to FAK Inhibition in Breast Cancer
Young-Ho Kim, Hyun‐Kyoung Kim, Hee Yeon Kim, HyeRan Gwak, Seung-Hyun Bae, Hye Won Sim, Eun‐Kyung Kang, Ju‐Young Seoh, Hyonchol Jang, Kyeong‐Man Hong · 2019 · Cancers
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Phosphoproteomic Analysis Identified Mutual Phosphorylation of FAK and Src as a Mechanism of Osimertinib Resistance in EGFR-Mutant Lung Cancer
Takehiro Tozuka, Rintaro Noro, Keisuke Yoshida, Satoshi Takahashi, Mariko Hirao, Kuniko Matsuda, Yasuhiro X. Kato, Shinji Nakamichi, Susumu Takeuchi, Masaru Matsumoto et al. · 2024 · JTO Clinical and Research Reports
Diosmin reduces the stability of Snail and Cyclin D1 by targeting FAK to inhibit NSCLC progression
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Targeting a key FAK-tor: the therapeutic potential of combining focal adhesion kinase (FAK) inhibitors and chemotherapy for chemoresistant non-small cell lung cancer
Emma Geijerman, Francesca Terrana, Godefridus J. Peters, Dongmei Deng, Patrizia Diana, Elisa Giovannetti, Geng Xu · 2024 · Expert Opinion on Investigational Drugs
Discovery of 2,4-diaminopyrimidine derivatives as potent inhibitors of FAK capable of activating the Hippo pathway for the treatment of esophageal squamous cell carcinoma
Xiao Wang, Yin-Ru Li, Ji Wu, Jin-Bo Niu, Jian H. Song, Sai‐Yang Zhang · 2025 · European Journal of Medicinal Chemistry
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Drug Combinations Targeting FAK and MEK Overcomes Tumor Heterogeneity in Glioblastoma
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GMI, a Ganoderma microsporum protein, abolishes focal adhesion network to reduce cell migration and metastasis of lung cancer
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Knockdown of ribosome RNA processing protein 15 suppresses migration of hepatocellular carcinoma through inhibiting PATZ1-associated LAMC2/FAK pathway
Tongtong Pan, Jinhai Li, Ouyang Zhang, Yuqin Zhu, Hongfei Zhou, Mengchen Ma, Yanwen Yu, Jiaojian Lyu, Yongping Chen, Liang Xu · 2024 · BMC Cancer
Focal adhesion kinase-mediated interaction between tumor and immune cells in the tumor microenvironment: implications for cancer-associated therapies and tumor progression
Louis Boafo Kwantwi, Theophilus Tandoh · 2024 · Clinical & Translational Oncology
Association of the upregulated expression of focal adhesion kinase with poor prognosis and tumor dissemination in hypopharyngeal cancer
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Capn4 contributes to tumor invasion and metastasis in clear cell renal cell carcinoma cells via modulating talin–focal adhesion kinase signaling pathway
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RHBDD2 overexpression promotes a chemoresistant and invasive phenotype to rectal cancer tumors via modulating UPR and focal adhesion genes
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Lipopolyplex-Mediated Co-Delivery of Doxorubicin and FAK siRNA to Enhance Therapeutic Efficiency of Treating Colorectal Cancer
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Phosphoinositide-3-Kinase Enhancers, PIKEs: Their Biological Functions and Roles in Cancer.
Weijuan Jia, Y I Feng, Andrew James Sanders, Eleri Lloyd Davies, Wen G. Jiang · 2016 · PubMed
Trafficking of Adhesion and Growth Factor Receptors and Their Effector Kinases
Christina Schoenherr, Margaret C. Frame, Adam Byron · 2018 · Annual Review of Cell and Developmental Biology
Structure-Based Virtual Screening, Synthesis and Biological Evaluation of Potential FAK-FAT Domain Inhibitors for Treatment of Metastatic Cancer
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Inhibiting focal adhesion kinase (FAK) blocks IL-4 induced VCAM-1 expression and eosinophil recruitment in vitro and in vivo
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Focal Adhesion Kinase Alleviates Simulated Microgravity-Induced Inhibition of Osteoblast Differentiation by Activating Transcriptional Wnt/β-Catenin-BMP2-COL1 and Metabolic SIRT1-PGC-1α-CPT1A Pathways
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