FAK in cancer: mechanistic findings and clinical applications

Comprehensive molecular portraits of human breast tumours

The Cancer Genome Atlas Network (2012) · Nature · doi:10.1038/nature11412 · Cited by 12,129

The protein kinase complement of the human genome

Manning, G., Whyte, D. B., Martinez, R., Hunter, T., & Sudarsanam, S. (2002) · Science · doi:10.1126/science.1075762 · Cited by 8,145

Integrated genomic analyses of ovarian carcinoma

Perou, C. M. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/hvp3-wg08 · Cited by 7,927

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

Levental, K. R., Yu, H., Kass, L., Lakins, J. N., Egeblad, M., Erler, J. T., Fong, S. F. T., Csiszar, K., Giaccia, A., Weninger, W., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.027 · Cited by 4,101

Focal adhesion kinase: in command and control of cell motility

Mitra, S. K., Hanson, D. A., & Schlaepfer, D. D. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1549 · Cited by 2,657

Focal adhesion kinase: the first ten years

Parsons, J. T. (2003) · Journal of Cell Science · doi:10.1242/jcs.00373 · Cited by 1,389

The role of focal-adhesion kinase in cancer — a new therapeutic opportunity

McLean, G. W., Carragher, N. O., Avizienyte, E., EVANS, J., Brunton, V. G., & Frame, M. C. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1647 · Cited by 1,049

E-cadherin–integrin crosstalk in cancer invasion and metastasis

Canel, M., Serrels, A., Frame, M. C., & Brunton, V. G. (2013) · Journal of Cell Science · doi:10.1242/jcs.100115 · Cited by 651

Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions

Schaller, M. D. (2010) · Journal of Cell Science · doi:10.1242/jcs.045112 · Cited by 613

Signal transduction by focal adhesion kinase in cancer

Zhao, J., & Guan, J. (2009) · Cancer and Metastasis Reviews · doi:10.1007/s10555-008-9165-4 · Cited by 608

Cell-surface major vault protein promotes cancer progression through harboring mesenchymal and intermediate circulating tumor cells in hepatocellular carcinomas

Lee, H. M., Joh, J., Seo, S.-R., Kim, W., Kim, M. K., Choi, H. S., Kim, S. Y., Jang, Y., Sinn, D. H., Choi, G., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-13501-1 · Cited by 37

Therapeutic resistance and susceptibility is shaped by cooperative multi-compartment tumor adaptation

Long, J. E., Wongchenko, M. J., Nickles, D., Chung, W., Wang, B.-E., Riegler, J., Li, J., Li, Q., Sandoval, W. N., Eastham-Anderson, J., et al. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0310-0 · Cited by 37

Cyclic isoDGR and RGD Peptidomimetics Containing Bifunctional Diketopiperazine Scaffolds are Integrin Antagonists

Panzeri, S., Zanella, S., Arosio, D., Vahdati, L., Corso, A. D., Pignataro, L., Paolillo, M., Schinelli, S., Belvisi, L., Gennari, C., et al. (2015) · Chemistry - A European Journal · doi:10.1002/chem.201406567 · Cited by 36

Phase I Study of the Focal Adhesion Kinase Inhibitor BI 853520 in Japanese and Taiwanese Patients with Advanced or Metastatic Solid Tumors

Doi, T., Yang, J. C., Shitara, K., Naito, Y., Cheng, A., Sarashina, A., Pronk, L. C., Takeuchi, Y., & Lin, C. (2019) · Targeted Oncology · doi:10.1007/s11523-019-00620-0 · Cited by 36

MicroRNA-1224 Inhibits Tumor Metastasis in Intestinal-Type Gastric Cancer by Directly Targeting FAK

Wang, J., Wen, T., Li, Z., Che, X., Gong, L., Yang, X., Zhang, J., Tang, H., He, L., Qu, X., et al. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00222 · Cited by 36

Inhibiting FAK–Paxillin Interaction Reduces Migration and Invadopodia-Mediated Matrix Degradation in Metastatic Melanoma Cells

Mousson, A., Legrand, M., Steffan, T., Vauchelles, R., Carl, P., Gies, J., Lehmann, M., Zuber, G., Mey, J. D., Dujardin, D., et al. (2021) · Cancers · doi:10.3390/cancers13081871 · Cited by 36

Cabozantinib for HCC Treatment, From Clinical Back to Experimental Models

Deng, S., Solinas, A., & Calvisi, D. F. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.756672 · Cited by 36

Focal adhesion kinase inhibitors, a heavy punch to cancer

Wu, Y., Li, N., Ye, C., Jiang, X., Luo, H., Zhang, B., Zhang, Y., & Zhang, Q. (2021) · Discover Oncology · doi:10.1007/s12672-021-00449-y · Cited by 38

Anoikis resistance in diffuse glioma: The potential therapeutic targets in the future

Zhu, Z., Fang, C., Xu, H., Yuan, L., Du, Y., Ni, Y., Xu, Y., Shao, A., Zhang, A., & Lou, M. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.976557 · Cited by 37

Structure elucidation, immunomodulatory activity, antitumor activity and its molecular mechanism of a novel polysaccharide from Boletus reticulatus Schaeff

Su, S., Ding, X. D., Hou, Y., Liu, B., ZhouHe, D., & Liu, J. (2022) · Food Science and Human Wellness · doi:10.1016/j.fshw.2022.07.067 · Cited by 36

Targeting Tumor Physical Microenvironment for Improved Radiotherapy

Wang, J., Han, Y., Li, Y., Zhang, F., Cai, M., Zhang, X., Chen, J., Ji, C., Ma, J., & Xu, F. (2022) · Small Methods · doi:10.1002/smtd.202200570 · Cited by 36

MUC4-promoted neural invasion is mediated by the axon guidance factor netrin-1 in PDAC

Wang, L., Zhi, X., Zhu, Y., Zhang, Q., Wang, W., Li, Z., Tang, J., Wang, J., Wei, S., Li, B., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5668 · Cited by 36

Differences in p53 status significantly influence the cellular response and cell survival to 1,25‐dihydroxyvitamin D3‐metformin cotreatment in colorectal cancer cells

el Maaty, M. A. A., Strassburger, W., Qaiser, T., Dabiri, Y., & Wölfl, S. (2017) · Molecular Carcinogenesis · doi:10.1002/mc.22696 · Cited by 36

PYK2, a hub of signaling networks in breast cancer progression

Gil-Henn, H., Girault, J., & Lev, S. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.07.006 · Cited by 35

Targeting focal adhesion kinase boosts immune response in KRAS/LKB1 co-mutated lung adenocarcinoma via remodeling the tumor microenvironment

Qiao, M., Zhou, F., Liu, X., Jiang, T., Wang, H., Li, X., Zhao, C., Cheng, L., Chen, X., Ren, S., et al. (2024) · Experimental Hematology and Oncology · doi:10.1186/s40164-023-00471-6 · Cited by 35

Focal adhesion in the tumour metastasis: from molecular mechanisms to therapeutic targets

Liu, Z., Zhang, X., Ben, T., Li, M., Jin, Y., Wang, T., & Song, Y. (2025) · Biomarker Research · doi:10.1186/s40364-025-00745-7 · Cited by 43

Sunitinib activates Axl signaling in renal cell cancer

van der Mijn, J. C., Broxterman, H. J., Knol, J. C., Piersma, S. R., de Haas, R. R., Dekker, H., Pham, T. V., van Beusechem, V. W., Halmos, B., Mier, J. W., et al. (2016) · International Journal of Cancer · doi:10.1002/ijc.30022 · Cited by 37

The cancer stem cell phenotype as a determinant factor of the heterotypic nature of breast tumors

Fonseca, N. A., Cruz, A. F., Moura, V., Simões, S., & Moreira, J. N. (2017) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2017.03.016 · Cited by 36

p14ARF interacts with the focal adhesion kinase and protects cells from anoikis

Vivo, M., Fontana, R., Ranieri, M., Capasso, G., Angrisano, T., Pollice, A., Calabrò, V., & Mantia, G. L. (2017) · Oncogene · doi:10.1038/onc.2017.104 · Cited by 35

G9a Promotes Invasion and Metastasis of Non–Small Cell Lung Cancer through Enhancing Focal Adhesion Kinase Activation via NF-κB Signaling Pathway

Sun, T., Zhang, K., Pangeni, R. P., Wu, J., Li, W., Du, Y., Guo, Y., Chaurasiya, S., Arvanitis, L. D., & Raz, D. J. (2020) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0557 · Cited by 35

Antimetastatic Effects of Ganoderma lucidum Polysaccharide Peptide on B16-F10-luc-G5 Melanoma Mice With Sleep Fragmentation

Xian, H., Li, J., Zhang, Y., Li, D., Zhu, Y., Li, S., Tan, Z., Lin, Z., Li, X., & Pan, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.650216 · Cited by 35

The role of Globo H and SSEA-4 in the Development and Progression of Cancer, and their Potential as Therapeutic Targets

Sigal, D. S., Hermel, D. J., Hsu, P., & Pearce, T. E. (2021) · Future Oncology · doi:10.2217/fon-2021-1110 · Cited by 35

Cell-cell and cell-matrix adhesion in survival and metastasis: Stat3 versus Akt

Niit, M., Hoskin, V., Carefoot, E., Geletu, M., Arulanandam, R., Elliott, B. E., & Raptis, L. H. (2015) · BioMolecular Concepts · doi:10.1515/bmc-2015-0022 · Cited by 35

Filamin B Enhances the Invasiveness of Cancer Cells into 3D Collagen Matrices

Iguchi, Y., Ishihara, S., Uchida, Y., Tajima, K., Mizutani, T., Kawabata, K., & Haga, H. (2015) · Cell Structure and Function · doi:10.1247/csf.15001 · Cited by 34

Synthetic Lethal Screens Identify Vulnerabilities in GPCR Signaling and Cytoskeletal Organization in E-Cadherin–Deficient Cells

Telford, B. J., Chen, A., Beetham, H. G., Frick, J., Brew, T. P., Gould, C. M., Single, A., Godwin, T. D., Simpson, K. J., & Guilford, P. (2015) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-14-1092 · Cited by 34

Regulation of Lymph Node Vascular–Stromal Compartment by Dendritic Cells

Dasoveanu, D., Shipman, W. D., Chia, D. J., Chyou, S., & Lu, T. T. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.08.013 · Cited by 35

ZNF 703 Overexpression may act as an oncogene in non‐small cell lung cancer

Baykara, O., Dalay, N., Kaynak, K., & Buyru, N. (2016) · Cancer Medicine · doi:10.1002/cam4.847 · Cited by 34

Drug development against the hippo pathway in mesothelioma

Woodard, G. A., Yang, Y., You, L., & Jablons, D. M. (2017) · Translational Lung Cancer Research · doi:10.21037/tlcr.2017.06.02 · Cited by 34

Molecular and functional imaging insights into the role of hypoxia in cancer aggression

Kakkad, S. M., Krishnamachary, B., Jacob, D., Pacheco‐Torres, J., Goggins, E. S., Bharti, S. K., Penet, M., & Bhujwalla, Z. M. (2019) · Cancer and Metastasis Reviews · doi:10.1007/s10555-019-09788-3 · Cited by 34

Impact of Fibroblast-Derived SPARC on Invasiveness of Colorectal Cancer Cells

Drev, D., Harpain, F., Beer, A., Stift, A., Gruber, E. S., Klimpfinger, M., Thalhammer, S., Réti, A., Kenner, L., Bergmann, M. M., et al. (2019) · Cancers · doi:10.3390/cancers11101421 · Cited by 34

ADAM17-regulated CX3CL1 expression produced by bone marrow endothelial cells promotes spinal metastasis from hepatocellular carcinoma

Sun, C. C., Hu, A., Wang, S., Tian, B., Jiang, L., Liang, Y., Wang, H., & Dong, J. (2020) · International Journal of Oncology · doi:10.3892/ijo.2020.5045 · Cited by 34

Manipulating the Tumor Microenvironment in Tumor Organoids Induces Phenotypic Changes and Chemoresistance

Dominijanni, A. J., Devarasetty, M., & Söker, S. (2020) · iScience · doi:10.1016/j.isci.2020.101851 · Cited by 34

The extracellular-regulated protein kinase 5 (ERK5) enhances metastatic burden in triple-negative breast cancer through focal adhesion protein kinase (FAK)-mediated regulation of cell adhesion

Xu, Q., Zhang, J., Telfer, B. A., Zhang, H., Ali, N., Chen, F., Risa-Ebrí, B., Pearson, A. J., Zhang, W., Finegan, K. G., et al. (2021) · Oncogene · doi:10.1038/s41388-021-01798-2 · Cited by 34

Ibrutinib reverses IL-6-induced osimertinib resistance through inhibition of Laminin α5/FAK signaling

Li, L., Li, Z., Lu, C., Li, J., Zhang, K., Lin, C., Tang, X., Liu, Z., Zhang, Y., Han, R., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03111-7 · Cited by 34

Nintedanib alleviates pulmonary fibrosis in vitro and in vivo by inhibiting the FAK/ERK/S100A4 signalling pathway

Yang, W., Pan, L., Cheng, Y., Wu, X., Tang, B. H., Zhu, H., Zhang, M., & Zhang, Y. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109409 · Cited by 35

p63 drives invasion in keratinocytes expressing HPV16 E6/E7 genes through regulation of Src-FAK signalling

Srivastava, K., Pickard, A., McDade, S. S., & McCance, D. J. (2015) · Oncotarget · doi:10.18632/oncotarget.3892 · Cited by 36

Perspective: Cooperation of Nanog, NF-κΒ, and CXCR4 in a regulatory network for directed migration of cancer stem cells

Es-Haghi, M., Soltanian, S., & Dehghani, H. (2015) · Tumor Biology · doi:10.1007/s13277-015-4690-6 · Cited by 34

Exploring the key genes and pathways of osteosarcoma with pulmonary metastasis using a gene expression microarray

Shi, Z., Zhou, H., Pan, B., Lu, L., Wei, Z., Shi, L., Yao, X. X., Kang, Y., & Feng, S. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7577 · Cited by 34

Structure-based modification of carbonyl-diphenylpyrimidines (Car-DPPYs) as a novel focal adhesion kinase (FAK) inhibitor against various stubborn cancer cells

Wang, L., Ai, M., Yu, J., Jin, L., Wang, C., Liu, Z., Shu, X. H., Tang, Z., Liu, K., Luo, H., et al. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.04.004 · Cited by 34

Revealing dynamic regulations and the related key proteins of myeloma-initiating cells by integrating experimental data into a systems biological model

Zhang, L., Liu, G., Kong, M., Li, J., Wu, D., Zhou, X., Yang, C., Xia, L., Yang, Z., & Chen, L. (2019) · Bioinformatics · doi:10.1093/bioinformatics/btz542 · Cited by 34

Proteomic characterization of epithelial ovarian cancer delineates molecular signatures and therapeutic targets in distinct histological subtypes

Gong, T., Guo, S., Liu, F.-H., Huo, Y.-L., Zhang, M., Shi, Y., Zhou, H., Xu, P., Wang, X., Xu, H.-L., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43282-3 · Cited by 33

Targeting focal adhesion kinase (FAK) in cancer therapy: A recent update on inhibitors and PROTAC degraders

Wang, X., Li, N., Liu, Y., Wu, J., Liu, Q.-G., Niu, J.-B., Xu, Y., Huang, C., Zhang, S., & Song, J. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116678 · Cited by 34

FAK Expression, Not Kinase Activity, Is a Key Mediator of Thyroid Tumorigenesis and Protumorigenic Processes

Kessler, B. E., Sharma, V., Zhou, Q., Jing, X., Pike, L. A., Kerege, A. A., Sams, S. B., & Schweppe, R. E. (2016) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-16-0007 · Cited by 33

Characterization of a sulfated galactoglucan from Antrodia cinnamomea and its anticancer mechanism via TGFβ/FAK/Slug axis suppression

Lu, M., Lin, T., Hu, C.-H., Chao, C., Chang, C., & Hsu, H.-Y. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.02.104 · Cited by 33

ADAM17 promotes cell migration and invasion through the integrin β1 pathway in hepatocellular carcinoma

Li, Y., Ren, Z., Wang, Y., Dang, Y.-Z., Meng, B.-X., Wang, G.-D., Zhang, J., Wu, J., & Wen, N. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.06.039 · Cited by 33

S100A9 promotes prostate cancer cell invasion by activating TLR4/NF-κB/integrin β1/FAK signaling

Lv, Z., Li, W., & Wei, X. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s192250 · Cited by 33

Systematic Elucidation of the Mechanism of Quercetin against Gastric Cancer via Network Pharmacology Approach

Yang, L., Hu, Z., Zhu, J., Liang, Q., Zhou, H., Li, J., Fan, X., Zhao, Z., Pan, H., & Fei, B. (2020) · BioMed Research International · doi:10.1155/2020/3860213 · Cited by 33

FAK inhibition alone or in combination with adjuvant therapies reduces cancer stem cell activity

Timbrell, S., Aglan, H., Cramer, A., Foden, P., Weaver, D. T., Pachter, J. A., Kilgallon, A., Clarke, R. B., Farnie, G., & Bundred, N. J. (2021) · npj Breast Cancer · doi:10.1038/s41523-021-00263-3 · Cited by 33

Identification of novel and potent PROTACs targeting FAK for non-small cell lung cancer: Design, synthesis, and biological study

Sun, Y., Wang, R., Sun, Y., Wang, L., Xue, Y., Wang, J., Wu, T., Yin, W., Qin, Q., Sun, Y., et al. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114373 · Cited by 33

Diabetic concentrations of metformin inhibit platelet-mediated ovarian cancer cell progression

Erices, R., Cubillos, S., Aravena, R., Santoro, F., Marquez, M., Orellana, R., Ramírez, C., González, P., Fuenzalida, P., Bravo, M. L., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15348 · Cited by 33

The Cell Biology of Metastatic Invasion in Pancreatic Cancer: Updates and Mechanistic Insights

Joshi, V. B., Gutierrez Ruiz, O. L., & Razidlo, G. L. (2023) · Cancers · doi:10.3390/cancers15072169 · Cited by 32

The extracellular matrix in inflammation and cancer

Zhang, W., Xiang, Y., Lu, C., Wang, F., Ren, H., Wu, H., & Yan, M. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00415-6 · Cited by 34

A randomized, double-blind phase II study evaluating cediranib versus cediranib and saracatinib in patients with relapsed metastatic clear-cell renal cancer (COSAK)

Powles, T. B., Brown, J. E., Larkin, J., Jones, R. J., Ralph, C., Hawkins, R. E., Chowdhury, S., Boleti, E., Bhal, A., Fife, K. M., et al. (2016) · Annals of Oncology · doi:10.1093/annonc/mdw014 · Cited by 32

Bitter gourd (Momordica charantia) as a rich source of bioactive components to combat cancer naturally: Are we on the right track to fully unlock its potential as inhibitor of deregulated signaling pathways

Farooqı, A. A., Khalid, S., Tahir, F. Z., Sabitaliyevich, U. Y., Yaylım, İ., Attar, R., & Xu, B. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.05.024 · Cited by 34

Adhesion in Physiological, Benign and Malignant Proliferative States of the Endometrium: Microenvironment and the Clinical Big Picture

Rutherford, E. J., Hill, A. D. K., & Hopkins, A. M. (2018) · Cells · doi:10.3390/cells7050043 · Cited by 32

Mirage or long-awaited oasis: reinvigorating T-cell responses in pancreatic cancer

Ware, M. B., El‐Rayes, B. F., & Lesinski, G. B. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001100 · Cited by 32

Single-cell analysis of copy-number alterations in serous ovarian cancer reveals substantial heterogeneity in both low- and high-grade tumors

Kumar, M., Bowers, R. R., & Delaney, J. R. (2020) · Cell Cycle · doi:10.1080/15384101.2020.1836439 · Cited by 32

HOXA13 promotes gastric cancer progression partially via the FN1-mediated FAK/Src axis

Qin, Z., & Zhou, C. (2022) · Experimental Hematology and Oncology · doi:10.1186/s40164-022-00260-7 · Cited by 32

DDR1 promotes migration and invasion of breast cancer by modulating the Src-FAK signaling

Han, Q., Xiao, F., Ma, L., Zhou, J., Wang, L., Cheng, H., Zhu, J., Yao, F., Lyu, J., & Du, L. (2022) · Neoplasma · doi:10.4149/neo_2022_220316n289 · Cited by 32

Discovery of a novel ALK/ROS1/FAK inhibitor, APG-2449, in preclinical non-small cell lung cancer and ovarian cancer models

Fang, D. D., Tao, R., Wang, G., Li, Y., Zhang, K., Xu, C., Zhai, G., Wang, Q., Wang, J., Tang, C., et al. (2022) · BMC Cancer · doi:10.1186/s12885-022-09799-4 · Cited by 32

The Genome Conformation As an Integrator of Multi-Omic Data: The Example of Damage Spreading in Cancer

Tordini, F., Aldinucci, M., Milanesi, L., Lió, P., & Merelli, I. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00194 · Cited by 32

The soy-derived peptide Lunasin inhibits invasive potential of melanoma initiating cells

Shidal, C., Inaba, J.-I., Yaddanapudi, K., & Davis, K. (2017) · Oncotarget · doi:10.18632/oncotarget.16066 · Cited by 32

An epigenetic signature of adhesion molecules predicts poor prognosis of ovarian cancer patients

Chang, P., Liao, Y., Wang, H.-C., Chen, Y., Huang, R., Wang, Y., Yuan, C., & Lai, H.-C. (2017) · Oncotarget · doi:10.18632/oncotarget.18515 · Cited by 32

Paradoxical activation of c-Src as a drug-resistant mechanism

Higuchi, M., Ishiyama, K., Maruoka, M., Kanamori, R., Takaori-Kondo, A., & Watanabe, N. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108876 · Cited by 31

Advances in immunotherapy for pancreatic ductal adenocarcinoma

Miyazawa, M., Katsuda, M., Kawai, M., Hirono, S., Okada, K., Kitahata, Y., & Yamaue, H. (2021) · Journal of Hepato-Biliary-Pancreatic Sciences · doi:10.1002/jhbp.944 · Cited by 32

Target protein degradation by protacs: A budding cancer treatment strategy

Choudhary, D., Kaur, A., Singh, P., Chaudhary, G., Kaur, R., Bayan, M. F., Chandrasekaran, B., Marji, S. M., & Ayman, R. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108525 · Cited by 32

Epidermal growth factor receptor dual-target inhibitors as a novel therapy for cancer: A review

Wang, C., Zhang, Y., Zhang, T., Xu, J., Yan, S., Liang, B., & Xing, D. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.127440 · Cited by 31

The integrin αv-TGFβ signaling axis is necessary for epidermal proliferation during cutaneous wound healing

Duperret, E. K., Natale, C. A., Monteleon, C. L., Dahal, A., & Ridky, T. W. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1199306 · Cited by 31

Angiopoietin-like protein 3 blocks nuclear import of FAK and contributes to sorafenib response

Bao, Y., Yang, F., Liu, B., Zhao, T., Xu, Z., Xiong, Y., Sun, S., Qu, L., & Wang, L. (2018) · British Journal of Cancer · doi:10.1038/s41416-018-0189-4 · Cited by 31

Vitronectin from brain pericytes promotes adult forebrain neurogenesis by stimulating CNTF

Jia, C., Keasey, M. P., Malone, H. M., Lovins, C., Sante, R. R., Razskazovskiy, V., & Hagg, T. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.11.002 · Cited by 32

FAK alternative splice mRNA variants expression pattern in colorectal cancer

Devaud, C., Tilkin‐Mariamé, A., Vignolle‐Vidoni, A., Souleres, P., Denadai‐Souza, A., Rolland, C., Duthoit, C. T., Blanpied, C., Chabot, S., Bouillé, P., et al. (2019) · International Journal of Cancer · doi:10.1002/ijc.32120 · Cited by 31

A multi-kinase inhibitor APG-2449 enhances the antitumor effect of ibrutinib in esophageal squamous cell carcinoma via EGFR/FAK pathway inhibition

Luo, Q.-Y., Zhou, S.-N., Pan, W., Sun, J., Yang, L., Zhang, L., Qiu, M., & Yang, D. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114318 · Cited by 32

Genetic Landscape and Emerging Therapies in Uveal Melanoma

Seedor, R. S., Orloff, M. M., & Sato, T. (2021) · Cancers · doi:10.3390/cancers13215503 · Cited by 31

New Treatment Opportunities in Phosphatase and Tensin Homolog (PTEN)-Deficient Tumors: Focus on PTEN/Focal Adhesion Kinase Pathway

Alfieri, R. R., Giovannetti, E., Bonelli, M. A., & Cavazzoni, A. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00170 · Cited by 31

Activation of Rho-kinase and focal adhesion kinase regulates the organization of stress fibers and focal adhesions in the central part of fibroblasts

Katoh, K. (2017) · PeerJ · doi:10.7717/peerj.4063 · Cited by 31

Engineered systems to study the synergistic signaling between integrin-mediated mechanotransduction and growth factors (Review)

Isabela Monteiro, A., Kollmetz, T., & Malmström, J. (2018) · Biointerphases · doi:10.1116/1.5045231 · Cited by 33

Identification of a 4‐miRNA signature as a potential prognostic biomarker for pancreatic adenocarcinoma

Wang, Z., Deng, T.-X., & Ma, Z. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28601 · Cited by 30

Non-Receptor Tyrosine Kinases: Their Structure and Mechanistic Role in Tumor Progression and Resistance

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Distinct tumor-TAM interactions in IDH-stratified glioma microenvironments unveiled by single-cell and spatial transcriptomics

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