Cited by 1,381Cell Adhesion Molecules ResearchCellular Mechanics and InteractionsCancer Cells and Metastasis

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FAK in cancer: mechanistic findings and clinical applications

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Sulzmaier, Florian J., Jean, Christine, Schlaepfer, David D.·2014·Nature Reviews Cancer

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Abstract

Focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase that is overexpressed and activated in several advanced-stage solid cancers. FAK promotes tumour progression and metastasis through effects on cancer cells, as well as stromal cells of the tumour microenvironment. The kinase-dependent and kinase-independent functions of FAK control cell movement, invasion, survival, gene expression and cancer stem cell self-renewal. Small molecule FAK inhibitors decrease tumour growth and metastasis in several preclinical models and have initial clinical activity in patients with limited adverse events. In this Review, we discuss FAK signalling effects on both tumour and stromal cell biology that provide rationale and support for future therapeutic opportunities.

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Authors: Sulzmaier, F. J., Jean, C., & Schlaepfer, D. D.
Affiliations: University of California San Diego (US)
Corresponding author: Schlaepfer, David D.
ORCID: Sulzmaier, Florian J.
Jean, Christine
Schlaepfer, David D.
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2014-08-07
Volume: 14
Issue: 9
Pages: 598-610
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc3792
PMC: PMC4365862
OpenAlex: W2044423100
Cited by: 1,381
References: 142
Citations by year: 2026: 92 · 2025: 85 · 2024: 131 · 2023: 111 · 2022: 147 · 2021: 154 · 2020: 144 · 2019: 122 · 2018: 105 · 2017: 128 · 2016: 91 · 2015: 63 · 2014: 6
FWCI: 12.73
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
HAL (submittedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: American Heart Association
Verastem Oncology
National Institutes of Health
National Cancer Institute (R01CA102310, CA102310, R01CA180769, CA180769, T32CA121938)
Topics: Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords: focal adhesion kinase, FAK inhibitors, tumor microenvironment, tumor stromal cells, metastasis, tumor progression, cancer stem cells, cell invasion, cell migration, small molecule inhibitors, clinical development
MeSH terms: Animals, Humans, Neoplasm Invasiveness, Neoplasms, Signal Transduction, Stromal Cells, Protein Kinase Inhibitors, Focal Adhesion Kinase 1, Small Molecule Libraries, Molecular Targeted Therapy, Tumor Microenvironment

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