FAK in cancer: mechanistic findings and clinical applications

Comprehensive molecular portraits of human breast tumours

The Cancer Genome Atlas Network (2012) · Nature · doi:10.1038/nature11412 · Cited by 12,129

The protein kinase complement of the human genome

Manning, G., Whyte, D. B., Martinez, R., Hunter, T., & Sudarsanam, S. (2002) · Science · doi:10.1126/science.1075762 · Cited by 8,145

Integrated genomic analyses of ovarian carcinoma

Perou, C. M. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/hvp3-wg08 · Cited by 7,927

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

Levental, K. R., Yu, H., Kass, L., Lakins, J. N., Egeblad, M., Erler, J. T., Fong, S. F. T., Csiszar, K., Giaccia, A., Weninger, W., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.027 · Cited by 4,101

Focal adhesion kinase: in command and control of cell motility

Mitra, S. K., Hanson, D. A., & Schlaepfer, D. D. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1549 · Cited by 2,657

Focal adhesion kinase: the first ten years

Parsons, J. T. (2003) · Journal of Cell Science · doi:10.1242/jcs.00373 · Cited by 1,389

The role of focal-adhesion kinase in cancer — a new therapeutic opportunity

McLean, G. W., Carragher, N. O., Avizienyte, E., EVANS, J., Brunton, V. G., & Frame, M. C. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1647 · Cited by 1,049

E-cadherin–integrin crosstalk in cancer invasion and metastasis

Canel, M., Serrels, A., Frame, M. C., & Brunton, V. G. (2013) · Journal of Cell Science · doi:10.1242/jcs.100115 · Cited by 651

Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions

Schaller, M. D. (2010) · Journal of Cell Science · doi:10.1242/jcs.045112 · Cited by 613

Signal transduction by focal adhesion kinase in cancer

Zhao, J., & Guan, J. (2009) · Cancer and Metastasis Reviews · doi:10.1007/s10555-008-9165-4 · Cited by 608

Quantitative Evaluation of Cancer Cell Adhesion to Self-Assembled Monolayer-Patterned Substrates by Reflection Interference Contrast Microscopy

Matsuzaki, T., Ito, K., Masuda, K., Kakinuma, E., Sakamoto, R., Iketaki, K., Yamamoto, H., Suganuma, M., Kobayashi, N., Nakabayashi, S., et al. (2016) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.5b11870 · Cited by 17

Phosphoprotein patterns predict trametinib responsiveness and optimal trametinib sensitisation strategies in melanoma

Rožanc, J., Sakellaropoulos, T., Antoranz, A., Guttà, C., Podder, B., Vetma, V., Rufo, N., Agostinis, P., Pliaka, V., Sauter, T., et al. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0210-8 · Cited by 17

SRC and ERK cooperatively phosphorylate DLC1 and attenuate its Rho-GAP and tumor suppressor functions

Tripathi, B. K., Anderman, M. F., Qian, X., Zhou, M., Wang, D., Papageorge, A. G., & Lowy, D. R. (2019) · The Journal of Cell Biology · doi:10.1083/jcb.201810098 · Cited by 17

PYK2 Is Involved in Premalignant Acinar Cell Reprogramming and Pancreatic Ductal Adenocarcinoma Maintenance by Phosphorylating β-CateninY654

Gao, C., Chen, G., Zhang, D. H., Zhang, J., Kuan, S., Hu, W., Esni, F., Gao, X., Guan, J., Chu, E., et al. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.07.004 · Cited by 17

The Role of Tyrosine Kinases as a Critical Prognostic Parameter and Its Targeted Therapies in Ewing Sarcoma

Jin, W. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00613 · Cited by 17

Cleistanthin A induces apoptosis and suppresses motility of colorectal cancer cells

Jearawuttanakul, K., Khumkhrong, P., Suksen, K., Reabroi, S., Munyoo, B., Tuchinda, P., Borwornpinyo, S., Boonmuen, N., & Chairoungdua, A. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173604 · Cited by 17

In silico design of novel FAK inhibitors using integrated molecular docking, 3D-QSAR and molecular dynamics simulation studies

Shirvani, P., & Fassihi, A. (2021) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2021.1875880 · Cited by 17

Upregulation of CPNE3 suppresses invasion, migration and proliferation of glioblastoma cells through FAK pathway inactivation

Shi, D., Lin, B., Lai, J., Li, K., & Feng, Y. (2021) · Journal of Molecular Histology · doi:10.1007/s10735-021-09966-0 · Cited by 17

FAK Inhibitors As Promising Anticancer Targets: Present and Future Directions

Mustafa, M., El‐Hafeez, A. A. A., Abdelhafeez, D. A., Abdelhamid, D. S., Mostafa, Y. A., Ghosh, P., Hayallah, A. M., & Abuo‐Rahma, G. E. A. (2021) · Future Medicinal Chemistry · doi:10.4155/fmc-2021-0015 · Cited by 17

The emerging roles of circular RNAs in vessel co-option and vasculogenic mimicry: clinical insights for anti-angiogenic therapy in cancers

Shao, Y., & Lü, B. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-10000-8 · Cited by 17

A multiscale cell‐based model of tumor growth for chemotherapy assessment and tumor‐targeted therapy through a 3D computational approach

Nivlouei, S. J., Soltani, M., Shirani, E., Salimpour, M. R., Travasso, R. D. M., & Carvalho, J. (2022) · Cell Proliferation · doi:10.1111/cpr.13187 · Cited by 17

Metformin inhibition of colorectal cancer cell migration is associated with rebuilt adherens junctions and FAK downregulation

Amable, G., Martínez-León, E., Picco, M. E., Nemirovsky, S. I., Rozengurt, E., & Rey, O. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29677 · Cited by 17

Epstein–Barr virus induces aberrant B cell migration and diapedesis via FAK-dependent chemotaxis pathways

Delécluse, S., Baccianti, F., Zala, M., Steffens, A., Drenda, C., judt, D., Holland-Letz, T., Poirey, R., Sujobert, P., & Delecluse, H. (2025) · Nature Communications · doi:10.1038/s41467-025-59813-z · Cited by 16

Cell-Membrane-Anchored Synthetic Dynamic DNA Circuits for Signaling Transient Cell Migration

Lin, N., Ouyang, Y., Qin, Y., Liu, S., Willner, I., Zhang, Y., & Zhou, Z. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c03070 · Cited by 16

LED Light-Induced ROS Differentially Regulates Focal Adhesion Kinase Activity in HaCaT Cell Viability

Kim, J.-S., & Lim, S. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb44030082 · Cited by 16

AKT2S128/CCTαS315/319/323-positive cancer-associated fibroblasts (CAFs) mediate focal adhesion kinase (FAK) inhibitors resistance via secreting phosphatidylcholines (PCs)

Chen, J., Zhang, L., Zhu, Y., Zhao, D., Zhang, J., Zhu, Y., Pang, J., Xiao, Y., Wu, Q., Wang, Y., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01728-6 · Cited by 16

Current landscape of exosomal non-coding RNAs in prostate cancer: Modulators and biomarkers

Li, Y., Tang, X., Wang, B., Chen, M., Zheng, J., & Chang, K. (2024) · Non-coding RNA Research · doi:10.1016/j.ncrna.2024.07.003 · Cited by 16

Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells

Webber, P. J., Park, C., Qui, M., Ramalingam, S. S., Khuri, F. R., Fu, H., & Du, Y. (2015) · Oncoscience · doi:10.18632/oncoscience.245 · Cited by 16

Design and pharmaceutical applications of proteolysis-targeting chimeric molecules

Liang, Y., Nandakumar, K. S., & Cheng, K. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114211 · Cited by 16

A predictive biomarker panel for bone metastases: Liquid biopsy approach

Bhadresha, K. P., Patel, M., Jain, N. K., & Rawal, R. (2021) · Journal of bone oncology · doi:10.1016/j.jbo.2021.100374 · Cited by 16

Inhibiting Focal Adhesion Kinase Ameliorates Cyst Development in Polycystin-1–Deficient Polycystic Kidney Disease in Animal Model

He, J., Zhang, S., Qiu, Z., Li, X., Huang, H., Jin, W. W., Xu, Y. C., Shao, G., Wang, L., Meng, J., et al. (2021) · Journal of the American Society of Nephrology · doi:10.1681/asn.2020111560 · Cited by 16

Dan-Shen-Yin Granules Prevent Hypoxia-Induced Pulmonary Hypertension via STAT3/HIF-1α/VEGF and FAK/AKT Signaling Pathways

Wang, R., Yuan, T., Chen, D., Chen, Y.-C., Sun, S., Wang, S., Kong, L., Fang, L., & Du, G. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.844400 · Cited by 17

Overexpression of GATA5 Inhibits Prostate Cancer Progression by Regulating PLAGL2 via the FAK/PI3K/AKT Pathway

Wang, Q., Liu, Z., Zhai, G., Yu, X. Y., Ke, S., Shao, H., & Guo, J. (2022) · Cancers · doi:10.3390/cancers14092074 · Cited by 16

Cellular Adhesion Is a Controlling Factor in Neutrophil Extracellular Trap Formation Induced by Anti-Neutrophil Cytoplasmic Antibodies

Lelliott, P. M., Nishide, M., Pavillon, N., Okita, Y., Shibahara, T., Mizuno, Y., Yoshimura, H., Obata, S., Kumanogoh, A., & Smith, N. I. (2022) · ImmunoHorizons · doi:10.4049/immunohorizons.2200012 · Cited by 16

Nicotinamide riboside kinases regulate skeletal muscle fiber-type specification and are rate-limiting for metabolic adaptations during regeneration

Sonntag, T., Ancel, S., Karaz, S., Cichosz, P., Jacot, G. E., Giner, M. P., Sanchez-Garcia, J. L., Pannérec, A., Moco, S., Sorrentino, V., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1049653 · Cited by 16

EccDNA-oriented ITGB7 expression in breast cancer

Yang, L., Wang, M., Hu, X., Yuan, L., Chen, S., Peng, S., Yang, P., Yang, Z., Bao, G., & He, X. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-5716 · Cited by 16

Identification and characterization of the gene expression profiles for protein coding and non-coding RNAs of pancreatic ductal adenocarcinomas

Gutiérrez, M. L., Corchete, L. A., Teodósio, C., Sarasquete, M. E., Abad, M., Iglesias, M. J. I., Esteban, C., Sayagués, J. M., Órfão, A., & Muñoz‐Bellvís, L. (2015) · Oncotarget · doi:10.18632/oncotarget.4233 · Cited by 16

Rational combinations of immunotherapy for pancreatic ductal adenocarcinoma

Blair, A. B., & Zheng, L. (2017) · Chinese Clinical Oncology · doi:10.21037/cco.2017.06.04 · Cited by 16

Impaired Expression of Focal Adhesion Kinase in Mesenchymal Stromal Cells from Low-Risk Myelodysplastic Syndrome Patients

Wu, Y., Aanei, C. M., Kesr, S., Picot, T., Guyotat, D., & Campos, L. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00164 · Cited by 17

FHL2 mediates podocyte Rac1 activation and foot process effacement in hypertensive nephropathy

Li, S., Chu, P., Huang, P., Hsieh, T., Suszták, K., & Tarng, D. (2019) · Scientific Reports · doi:10.1038/s41598-019-42328-1 · Cited by 16

Recent advances in immunotherapy for pancreatic cancer

Chi, J., Patel, R., Rehman, H., Goyal, S. P., & Saif, M. W. (2020) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2020.90 · Cited by 15

Identification of TENM4 as a Novel Cancer Stem Cell-Associated Molecule and Potential Target in Triple Negative Breast Cancer

Ruiu, R., Barutello, G., Arigoni, M., Riccardo, F., Conti, L., Peppino, G., Annaratone, L., Marchiò, C., Mengozzi, G., Calogero, R., et al. (2021) · Cancers · doi:10.3390/cancers13040894 · Cited by 15

The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation

Ladewig, E., Michelini, F., Jhaveri, K., Castel, P., Carmona, J., Fairchild, L., Zuniga, A. G., Arruabarrena-Aristorena, A., Cocco, E., Blawski, R., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-0446 · Cited by 15

Mechanism and application of feedback loops formed by mechanotransduction and histone modifications

Sun, H., Gao, Y., Ma, X., Deng, Y., Bi, L., & Li, L. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.06.030 · Cited by 15

LncRNA FAISL Inhibits Calpain 2‐Mediated Proteolysis of FAK to Promote Progression and Metastasis of Triple Negative Breast Cancer

Zhang, Y., Wei, S., Chen, Z., Xu, R., Li, S., You, L., Wu, R., Zhang, Y., Liao, J., Xu, X., et al. (2024) · Advanced Science · doi:10.1002/advs.202407493 · Cited by 15

Targeting the MAPK pathway for NRAS mutant melanoma: from mechanism to clinic

Wang, Y., Xu, G., & Xia, H. (2025) · British Journal of Dermatology · doi:10.1093/bjd/ljaf178 · Cited by 15

Targeting glutamine metabolism and the focal adhesion kinase additively inhibits the mammalian target of the rapamycin pathway in spheroid cancer stem-like properties of ovarian clear cell carcinoma in vitro

Sato, M., Kawana, K., Adachi, K., Fujimoto, A., Yoshida, M., Nakamura, H., Nishida, H., Inoue, T., Taguchi, A., Ogishima, J., et al. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.3891 · Cited by 15

Proteolysis-targeting Chimeras for Targeting Protein for Degradation

Qi, J., & Zhang, G. (2019) · Future Medicinal Chemistry · doi:10.4155/fmc-2018-0557 · Cited by 15

Alternative splicing of Ikaros regulates the FUT4/LeX-α5β1 integrin-FAK axis in acute lymphoblastic leukemia

Yi, L., Hu, Q., Zhou, J., Liu, Z., & Li, H. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.01.064 · Cited by 15

Identification of new binding proteins of focal adhesion kinase using immunoprecipitation and mass spectrometry

Nguyen, B. T., Pyun, J., Lee, S., & Kang, M. (2019) · Scientific Reports · doi:10.1038/s41598-019-49145-6 · Cited by 15

Targeting the Hippo Pathway in Prostate Cancer: What’s New?

Coffey, K. (2021) · Cancers · doi:10.3390/cancers13040611 · Cited by 15

Neurofibromin Deficiency and Extracellular Matrix Cooperate to Increase Transforming Potential through FAK-Dependent Signaling

Errico, A., Stocco, A., Riccardi, V. M., Gambalunga, A., Bassetto, F., Grigatti, M., Ferlosio, A., Tadini, G., Garozzo, D., Ferraresi, S., et al. (2021) · Cancers · doi:10.3390/cancers13102329 · Cited by 17

The role of YAP in the control of the metastatic potential of oral cancer

Ahmad, U. S., SARAVANAN, K., & Wan, H. (2021) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.32604/or.2022.026085 · Cited by 15

Design, Synthesis and Antitumor Activity of FAK/PLK1 Dual Inhibitors with Quinazolinone as the Skeleton

Sun, J., Fang, Z.-Y., Tao, Y., Zhang, Y., Zhang, Y., Sun, H., Zhou, Y., & Wu, Y. (2023) · Chemistry & Biodiversity · doi:10.1002/cbdv.202300146 · Cited by 15

Resistin Induces Migration and Invasion in PC3 Prostate Cancer Cells: Role of Extracellular Vesicles

Oregel-Cortez, M. I., Frayde-Gómez, H., Quintana-González, G., García‐González, V., Vázquez-Jiménez, J. G., & Galindo‐Hernández, O. (2023) · Life · doi:10.3390/life13122321 · Cited by 15

Effects of digitoxin on cell migration in ovarian cancer inflammatory microenvironment

Trenti, A., Boscaro, C., Tedesco, S., Cignarella, A., Trevisi, L., & Bolego, C. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.06.008 · Cited by 15

Protein Tyrosine Kinase 6 Regulates UVB-Induced Signaling and Tumorigenesis in Mouse Skin

Chastkofsky, M. I., Bie, W., Ball-Kell, S. M., He, Y.-Y., & Tyner, A. L. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.166 · Cited by 15

16-Hydroxycleroda-3,13-dien-15,16-olide induces anoikis in human renal cell carcinoma cells: involvement of focal adhesion disassembly and signaling

Chen, Y., Huang, B., Lee, W.-C., & Chen, Y. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s173378 · Cited by 15

Focal adhesion kinase promotes aerobic glycolysis in hepatic stellate cells via the cyclin D1/c-Myc/MCT-1 pathway to induce liver fibrosis

Huang, T., Zhou, M.-Y., Zou, G.-L., Hu, R.-H., Han, L., Zhang, Q.-X., & Zhao, X.-K. (2025) · Scientific Reports · doi:10.1038/s41598-025-88538-8 · Cited by 14

CYP4F12 is a potential biomarker and inhibits cell migration of head and neck squamous cell carcinoma via EMT pathway

Jia, W., Chen, S., Wei, R., Yang, X., Zhang, M., Qian, Y., Liu, H., & Lei, D. (2023) · Scientific Reports · doi:10.1038/s41598-023-37950-z · Cited by 14

A Ubiquitin‐Dependent Switch on MEF2D Senses Pro‐Metastatic Niche Signals to Facilitate Intrahepatic Metastasis of Liver Cancer

Xiang, J., Zhang, N., Du, A., Li, J., Luo, M., Wang, Y., Liu, M., Yang, L., Li, X., Wang, L., et al. (2023) · Advanced Science · doi:10.1002/advs.202305550 · Cited by 15

ID4-dependent secretion of VEGFA enhances the invasion capability of breast cancer cells and activates YAP/TAZ via integrin β3-VEGFR2 interaction

Benedetti, A., Turco, C., Gallo, E., Daralioti, T., Sacconi, A., Pulito, C., Donzelli, S., Tito, C., Dragonetti, M., Perracchio, L., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06491-2 · Cited by 14

Inhibiting interferon-γ induced cancer intrinsic TNFRSF14 elevation restrains the malignant progression of glioblastoma

Han, Y., Zou, C., Liu, T., Cheng, W. M., Cheng, P., & Wu, A. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03131-7 · Cited by 14

Evaluation of Efficiency of Liposome-Entrapped Iridium(III) Complexes Inhibiting Tumor Growth In Vitro and In Vivo

Hu, H., Chen, J., Zhang, F., Sheng, Z., Yang, Y., Xie, Y., Zhou, L., & Liu, Y. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c01026 · Cited by 14

ERK5 suppression overcomes FAK inhibitor resistance in mutant KRAS-driven non-small cell lung cancer

Pozzato, C., Outeiro-Pinho, G., Galiè, M., Ramadori, G., & Konstantinidou, G. (2024) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00138-7 · Cited by 14

Anticancer Drug Discovery from Natural Compounds Targeting PI3K/AKT/mTOR Signaling Pathway

da Silva, M. F., Lins, A. A., Gomes, M. C., Marinho, W. P. D. J., de Araújo, R. S. A., de Moura, R. O., Zhan, P., Nascimento, I. J. D. S., & Júnior, E. F. D. S. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673325229240928040758 · Cited by 14

Targeting USP10–FAK pathway sensitizes BCR-ABL+ leukemia cells to tyrosine kinase inhibitors

Qiu, K., Wang, X., Liu, Z., Peng, X., Zhong, S., Dai, Z., Zha, X., Wang, P., & Zeng, C. (2025) · Cell investigation. · doi:10.1016/j.clnves.2025.100017 · Cited by 15

Integrin Activation Contributes to Lower Cisplatin Sensitivity in MV3 Melanoma Cells by Inducing the Wnt Signalling Pathway

Piva, M., Jakubzig, B., & Bendas, G. (2017) · Cancers · doi:10.3390/cancers9090125 · Cited by 14

Upregulation of TCTP is associated with cholangiocarcinoma progression and metastasis

Phanthaphol, N., Techasen, A., Loilome, W., Thongchot, S., Thanan, R., Sangkhamanon, S., Khuntikeo, N., Yongvanit, P., & Namwat, N. (2017) · Oncology Letters · doi:10.3892/ol.2017.6985 · Cited by 14

Cytosolic phospholipase A2α modulates cell-matrix adhesion via the FAK/paxillin pathway in hepatocellular carcinoma

Guo, P., He, Y., Chen, L., Qi, L., Dongming, L., Chen, Z., Xiao, M., Chen, L., Luo, Y., Zhang, N., et al. (2019) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2018.0386 · Cited by 14

The SHCA adapter protein cooperates with lipoma-preferred partner in the regulation of adhesion dynamics and invadopodia formation

Kiepas, A., Voorand, E., Senécal, J., Ahn, R., Annis, M. G., Jacquet, K., Tali, G., Bisson, N., Ursini‐Siegel, J., Siegel, P. M., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011903 · Cited by 14

The complex relationship between integrins and oncolytic herpes Simplex Virus 1 in high-grade glioma therapeutics

Rivera-Caraballo, K., Nair, M., Lee, T. J., Kaur, B., & Yoo, J. Y. (2022) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2022.05.013 · Cited by 14

The Role of Paxillin Aberrant Expression in Cancer and Its Potential as a Target for Cancer Therapy

Liu, W., Huang, X., Luo, W., Liu, X., & Chen, W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098245 · Cited by 14

Co‐targeting FAK and Gli1 inhibits the tumor‐associated macrophages‐released CCL22‐mediated esophageal squamous cell carcinoma malignancy

Chen, J., Zhu, Y., Zhao, D., Zhang, L., Zhang, J., Xiao, Y., Wu, Q., Wang, Y., & Zhan, Q. (2023) · MedComm · doi:10.1002/mco2.381 · Cited by 14

FAK and Pyk2 in disease

Murphy, J. M., Park, H.-S., & Lim, S. (2016) · Frontiers in Biology · doi:10.1007/s11515-016-1384-4 · Cited by 15

Ovatodiolide of Anisomeles indica Exerts the Anticancer Potential on Pancreatic Cancer Cell Lines through STAT3 and NF‐κB Regulation

Hsieh, Y., Tseng, S., Kuo, Y., Cheng, T.-L., Chiang, C.-Y., Tzeng, Y., & Tsai, W.-C. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/8680372 · Cited by 14

Attenuation of murine acute lung injury by PF-573,228, an inhibitor of focal adhesion kinase

Lederer, P. A., Zhou, T., Chen, W., Epshtein, Y., Wang, H., Mathew, B., & Jacobson, J. R. (2018) · Vascular Pharmacology · doi:10.1016/j.vph.2018.06.017 · Cited by 14

The knocking down of the oncoprotein Golgi phosphoprotein 3 in T98G cells of glioblastoma multiforme disrupts cell migration by affecting focal adhesion dynamics in a focal adhesion kinase-dependent manner

Arriagada, C., Luchsinger, C., González, A., Schwenke, T., Arriagada, G., Folch, H., Ehrenfeld, P., Burgos, P. V., & Mardones, G. A. (2019) · PLoS ONE · doi:10.1371/journal.pone.0212321 · Cited by 14

Survival of detached cancer cells is regulated by movement of intracellular Na+,K+-ATPase

Fujii, T., Shimizu, T., Katoh, M., Nagamori, S., Koizumi, K., Fukuoka, J., Tabuchi, Y., Sawaguchi, A., Okumura, T., Shibuya, K., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102412 · Cited by 14

Synergistically Anti-metastatic Effect of 5-Flourouracil on Colorectal Cancer Cells via Calcium-mediated Focal Adhesion Kinase Proteolysis

Park, M., Sundaramoorthy, P., Sim, J. J., Jeong, K., & Kim, H. M. (2017) · Anticancer Research · doi:10.21873/anticanres.11295 · Cited by 14

Sperm-oocyte contact induces outside-in signaling via PYK2 activation

Wang, H., Luo, J., Carlton, C. G., McGinnis, L. K., & Kinsey, W. H. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.05.016 · Cited by 14

Electronic cigarette liquids impair metabolic cooperation and alter proteomic profiles in V79 cells

Trifunovic, S., Smiljanić, K., Sickmann, A., Solari, F. A., Kolarević, S., Rankov, A. D., & Ljujić, M. (2022) · Respiratory Research · doi:10.1186/s12931-022-02102-w · Cited by 13

Prospects of focal adhesion kinase inhibitors as a cancer therapy in preclinical and early phase study

Gao, J., Cheng, J., Xie, W., Zhang, P., Liu, X., Wang, Z., & Zhang, B. (2024) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2024.2348068 · Cited by 14

SULF1 regulates malignant progression of colorectal cancer by modulating ARSH via FAK/PI3K/AKT/mTOR signaling

Zhu, W., Wu, C., Liu, Z., Zhao, S., Cheng, X., & Huang, J. C. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03383-5 · Cited by 13

White light increases anticancer effectiveness of iridium(III) complexes toward lung cancer A549 cells

Li, G., Chen, J., Xie, Y., Yang, Y., Niu, Y., Chen, X., Zeng, X., Zhou, L., & Liu, Y. (2024) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2024.112652 · Cited by 13

ADAR1 Promotes Invasion and Migration and Inhibits Ferroptosis via the FAK/AKT Pathway in Colorectal Cancer

He, D., Niu, C., Bai, R., Chen, N., & Cui, J. (2024) · Molecular Carcinogenesis · doi:10.1002/mc.23818 · Cited by 13

HINT1 aggravates aortic aneurysm by targeting ITGA6/FAK axis in vascular smooth muscle cells

Zhang, Y., Wu, W., Yang, X., Luo, S., Wang, X., Da, Q., Yan, K., Hu, L., Sun, S., Du, X., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci186628 · Cited by 13

Promising investigational drug candidates in phase I and phase II clinical trials for mesothelioma

Guazzelli, A., Bakker, E. Y., Tian, K., Demonacos, C., Krstic–Demonacos, M., & Mutti, L. (2017) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2017.1351545 · Cited by 13

Optogenetic control of focal adhesion kinase signaling

Hörner, M., Chatelle, C. V., Mühlhäuser, W. W. D., Stocker, D. R., Coats, M. T., Weber, W., & Radziwill, G. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.10.012 · Cited by 13

Genistein Inhibited Estradiol-Induced Vascular Endothelial Cell Injury by Downregulating the FAK/Focal Adhesion Pathway

Liu, B., Xu, L., Yu, X., Jiao, X., Yan, J., Li, W., & Guo, M. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000493830 · Cited by 13

Identification of a Candidate Gene Set Signature for the Risk of Progression in IgM MGUS to Smoldering/Symptomatic Waldenström Macroglobulinemia (WM) by a Comparative Transcriptome Analysis of B Cells and Plasma Cells

Trojani, A., Camillo, B. D., Bossi, L. E., Leuzzi, L., Greco, A., Tedeschi, A., Frustaci, A. M., Deodato, M., Zamprogna, G., Beghini, A., et al. (2021) · Cancers · doi:10.3390/cancers13081837 · Cited by 13

Design, synthesis and activity evaluation of isopropylsulfonyl-substituted 2,4- diarylaminopyrimidine derivatives as FAK inhibitors for the potential treatment of pancreatic cancer

Zheng, X., Li, X., Tian, L., Wu, B., Yu, J., Wang, C., Sun, X., Ma, X., Chen, L., & Li, Y. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114607 · Cited by 13

Recent Advances in the Design and Development of Anticancer Molecules based on PROTAC Technology

Mukhamejanova, Z., Tong, Y., Xiang, Q., Xu, F., & Pang, J. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327666200312112412 · Cited by 13

TP3, an antimicrobial peptide, inhibits infiltration and motility of glioblastoma cells via modulating the tumor microenvironment

Chen, Y., Shih, P., Kuo, H., Yang, S., Lin, Y., Chen, W.-F., Tzou, S., Liu, H., & Chen, N. (2020) · Cancer Medicine · doi:10.1002/cam4.3005 · Cited by 13

Antiviral Activity of PLK1-Targeting siRNA Delivered by Lipid Nanoparticles in HBV-Infected Hepatocytes

Foca, A., Dhillon, A. P., Lahlali, T., Lucifora, J., Salvetti, A., Rivoire, M. L., Lee, A. S., & Durantel, D. (2019) · Antiviral Therapy · doi:10.3851/imp3361 · Cited by 13

Anti-metastatic Effects of Cationic KT2 Peptide (a Lysine/Tryptophan-rich Peptide) on Human Melanoma A375.S2 Cells

Maraming, P., Klaynongsruang, S., Boonsiri, P., Peng, S., Daduang, S., Rungsa, P., Tavichakorntrakool, R., Chung, J., & Daduang, J. (2021) · In Vivo · doi:10.21873/invivo.12250 · Cited by 13

DHPAC, a novel microtubule depolymerizing agent, suppresses angiogenesis and vasculogenic mimicry formation of human non‐small cell lung cancer

Gong, F., Wang, L., Yu, L., Dang, Y., Jiang, X., Zhao, L., & Guo, X. (2020) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29690 · Cited by 13

Stress-adapted cancer-associated fibroblasts as mediators of immunosuppression and therapy resistance

Hu, Y., Ge, J., Xin, M., Guo, R., Wu, C., & Ma, W. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218706 · Cited by 13

Text-Mining Approach to Identify Hub Genes of Cancer Metastasis and Potential Drug Repurposing to Target Them

Saha, T., Gil-Henn, H., & Samson, A. O. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11082130 · Cited by 12

FAK inhibitor PF-562271 inhibits the migration and proliferation of high-grade serous ovarian cancer cells through FAK and FAK mediated cell cycle arrest

Pan, Q., Wang, Q., Zhao, T., Zhao, X., Liang, Y., Shi, M., Chen, C., & Lin, F. (2023) · Medical Oncology · doi:10.1007/s12032-023-02092-9 · Cited by 12

Selective Suppression of Integrin‐Ligand Binding by Single Molecular Tension Probes Mediates Directional Cell Migration

Han, S., Lee, G., Kim, D., Kim, J., Kim, I., Kim, H., & Kim, D. (2024) · Advanced Science · doi:10.1002/advs.202306497 · Cited by 12

Revisiting glioblastoma classification through an immunological lens: A narrative review

Abikenari, M. A., Schonfeld, E., Choi, J. H., Kim, L. H., & Lim, M. K. (2024) · Glioma · doi:10.4103/glioma.glioma_4_24 · Cited by 12

Paxillin and Kindlin: Research Progress and Biological Functions

Li, Z., Shao, R., Xin, H., Zhu, Y., Jiang, S., Wu, J., Yan, H., Jia, T., Ge, M., & Shi, X. (2025) · Biomolecules · doi:10.3390/biom15020173 · Cited by 12

Sensitization of HT29 colorectal cancer cells to vemurafenib in three‐dimensional collagen cultures

Kikuchi, K., & Hoshino, D. (2019) · Cell Biology International · doi:10.1002/cbin.11262 · Cited by 12

Runt-related transcription factor 2 influences cell adhesion-mediated drug resistance and cell proliferation in B-cell non-Hodgkin’s lymphoma and multiple myeloma

Zhang, P., Wang, Y., Cheng, C., Zhang, F., Ding, D., & Chen, D. (2020) · Leukemia Research · doi:10.1016/j.leukres.2020.106340 · Cited by 12

iPSC-derived progenitor stromal cells provide new insights into aberrant musculoskeletal development and resistance to cancer in down syndrome

Galat, Y., Perepitchka, M., Elcheva, I. A., Iannaccone, S., Iannaccone, P. M., & Galat, V. (2020) · Scientific Reports · doi:10.1038/s41598-020-69418-9 · Cited by 11

Association of Low Tumor Endothelial Cell pY397–Focal Adhesion Kinase Expression With Survival in Patients With Neoadjuvant-Treated Locally Advanced Breast Cancer

Roy-Luzarraga, M., Abdel-Fatah, T. M. A., Reynolds, L. E., Clear, A. J., Taylor, J. G., Gribben, J. G., Chan, S. Y. T., Jones, J. L., & Hodivala‐Dilke, K. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.19304 · Cited by 12

Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors for cancer treatment

Dawson, J. C., Munro, A. F., Macleod, K., Muir, M., Timpson, P., Williams, R. J., Frame, M. C., Brunton, V. G., & Carragher, N. O. (2021) · Molecular Oncology · doi:10.1002/1878-0261.13151 · Cited by 12

An Efficient Signature Based on Necroptosis-Related Genes for Prognosis of Patients With Pancreatic Cancer

Shi, H., Peng, Q., Zhou, X., He, Y., & Sun, S. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.848747 · Cited by 12

Dysadherin awakens mechanical forces and promotes colorectal cancer progression

Park, S., Lee, C.-J., Choi, J.-H., Kim, J., Lee, W.-J., Jang, T., Jeon, S.-E., Kim, J., Cho, S., Lee, J. S., et al. (2022) · Theranostics · doi:10.7150/thno.72354 · Cited by 12

Understanding the Roles of FAK in Cancer

Yoon, H., Dehart, J. P., Murphy, J. M., & Lim, S. (2014) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155414561498 · Cited by 228

Emerging Roles of Focal Adhesion Kinase in Cancer

Tai, Y.-L., Chen, L., & Shen, T. (2015) · BioMed Research International · doi:10.1155/2015/690690 · Cited by 233

Targeting focal adhesion kinase in cancer cells and the tumor microenvironment

Murphy, J. M., Rodriguez, Y. A. R., Jeong, K., Ahn, E.-Y. E., & Lim, S. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0447-4 · Cited by 226

Prospects of focal adhesion kinase inhibitors as a cancer therapy in preclinical and early phase study

Gao, J., Cheng, J., Xie, W., Zhang, P., Liu, X., Wang, Z., & Zhang, B. (2024) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2024.2348068 · Cited by 14

Focal adhesion kinase—An emerging viable target in cancer and development of focal adhesion kinase inhibitors

Chauhan, A., & Khan, T. A. (2020) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13808 · Cited by 52