FAK in cancer: mechanistic findings and clinical applications

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Items 601–700 of 1,000

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19. Focal adhesion kinase (FAK) phosphorylation is a key regulator of embryonal rhabdomyosarcoma (ERMS) cell viability and migration
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20. Focal Adhesion Kinase Promotes Hepatic Stellate Cell Activation by Regulating Plasma Membrane Localization of TGFβ Receptor 2
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21. Dynamic extracellular matrix stiffening induces a phenotypic transformation and a migratory shift in epithelial cells
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22. ITGA2 Overexpression Promotes Esophageal Squamous Cell Carcinoma Aggression via FAK/AKT Signaling Pathway
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23. A Phase 0 Trial of Ceritinib in Patients with Brain Metastases and Recurrent Glioblastoma
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24. Desmoglein‐3 induces YAP phosphorylation and inactivation during collective migration of oral carcinoma cells
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25. Yes-mediated phosphorylation of focal adhesion kinase at tyrosine 861 increases metastatic potential of prostate cancer cells
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26. A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers
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27. Antitumor Activity and Acquired Resistance Mechanism of Dovitinib (TKI258) in RET -Rearranged Lung Adenocarcinoma
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28. BAIAP2L2 facilitates the malignancy of prostate cancer (PCa) via VEGF and apoptosis signaling pathways
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29. Cordycepin attenuates migration and invasion of HSC-4 oral squamous carcinoma cells through autophagy-dependent FAK/Akt and MMP2/MMP9 suppression
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30. Current Status and Trends in Nucleic Acids for Cancer Therapy: A Focus on Polysaccharide‐Based Nanomedicines
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31. MicroRNA-142-3P suppresses the progression of papillary thyroid carcinoma by targeting FN1 and inactivating FAK/ERK/PI3K signaling
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32. The emerging roles of SUMOylation in pulmonary diseases
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33. An arabinose-rich heteropolysaccharide isolated from Belamcanda chinensis (L.) DC treats liver cancer by targeting FAK and activating CD40
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34. Acinar to β-like cell conversion through inhibition of focal adhesion kinase
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35. Prolactin signaling through focal adhesion complexes is amplified by stiff extracellular matrices in breast cancer cells
    Craig E. Barcus, Patricia J. Keely, Kevin W. Eliceiri, Linda A. Schuler · 2016 · Oncotarget
36. The function of FAK/CCDC80/E‑cadherin pathway in the regulation of B16F10 cell migration
    Guoshun Pei, Yan Lan, Weijie Lu, Lina Ji, Zichun Hua · 2018 · Oncology Letters
37. High resolution crystal structure of the FAK FERM domain reveals new insights on the Druggability of tyrosine 397 and the Src SH3 binding site
    Timothy A. Marlowe, Alexey Dementiev, Sheila A. Figel, Andrew Rivera, Michael T. Flavin, William G. Cance · 2019 · BMC Molecular and Cell Biology
38. Rab18 regulates focal adhesion dynamics by interacting with kinectin-1 at the endoplasmic reticulum
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39. Signaling pathways and microRNAs, the orchestrators of NANOG activity during cancer induction
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40. Optimal Clinical Management and the Molecular Biology of Angiosarcomas
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41. The Adhesome Network: Key Components Shaping the Tumour Stroma
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42. COL8A1 facilitates the growth of triple-negative breast cancer via FAK/Src activation
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43. PTK2-mediated degradation of ATG3 impedes cancer cells susceptible to DNA damage treatment
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44. Effects of Electrical Stimulation on the Signal Transduction-Related Proteins, c-Src and Focal Adhesion Kinase, in Fibroblasts
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45. Ligand-independent integrin β1 signaling supports lung adenocarcinoma development
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46. Oxidative stress‐induced FAK activation contributes to uterine serous carcinoma aggressiveness
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50. Design, synthesis and biological evaluation of novel 2,4-diaminopyrimidine cinnamyl derivatives as inhibitors of FAK with potent anti-gastric cancer activities
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52. Focal adhesion kinase (FAK): emerging target for drug-resistant malignant tumors
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53. Targeting non-receptor tyrosine kinases using small molecule inhibitors: an overview of recent advances
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58. The Netrin-1-Neogenin-1 signaling axis controls neuroblastoma cell migration via integrin-β1 and focal adhesion kinase activation
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73. Adaptive Resistance to Chemotherapy, A Multi–FAK-torial Linkage
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76. Platelet endothelial aggregation receptor-1 regulates bovine muscle satellite cell migration and differentiation via integrin beta-1 and focal adhesion kinase
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77. Design, synthesis and biological evaluation of ring-fused pyrazoloamino pyridine/pyrimidine derivatives as potential FAK inhibitors
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78. Design, Synthesis, Biological Evaluation, and Molecular Docking of 2,4-Diaminopyrimidine Derivatives Targeting Focal Adhesion Kinase as Tumor Radiotracers
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79. Phosphorylation of pericyte FAK-Y861 affects tumour cell apoptosis and tumour blood vessel regression
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82. Identification of key pathways and genes changes in pancreatic cancer cells (BXPC-3) after cross-talk with primary pancreatic stellate cells using bioinformatics analysis
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83. Elucidating the role of the kinase activity of endothelial cell focal adhesion kinase in angiocrine signalling and tumour growth
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84. FAK downregulation suppresses stem-like properties and migration of human colorectal cancer cells
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85. Development and Characterization of Selective FAK Inhibitors and PROTACs with In Vivo Activity
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86. Collagen I-induced VCAN/ERK signaling and PARP1/ZEB1-mediated metastasis facilitate OSBPL2 defect to promote colorectal cancer progression
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88. Diverse and cancer type‑specific roles of the p53 R248Q gain‑of‑function mutation in cancer migration and invasiveness
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89. Long Noncoding RNA DUXAP8 Promotes Pancreatic Carcinoma Cell Migration and Invasion Via Pathway by miR-448/WTAP/Fak Signaling Axis
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90. SWAN pathway-network identification of common aneuploidy-based oncogenic drivers
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91. Tumor–stroma ratio can predict lymph-node metastasis in cT1/2N0 oral tongue squamous cell carcinoma independent of tumor budding grade
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92. PTEN Expression as a Predictor of Response to Focal Adhesion Kinase Inhibition in Uterine Cancer
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93. Discovery and Optimization of N-Substituted 2-(4-pyridinyl)thiazole carboxamides against Tumor Growth through Regulating Angiogenesis Signaling Pathways
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94. Semisynthetic oleanane triterpenoids inhibit migration and invasion of human breast cancer cells through downregulated expression of the ITGB1/PTK2/PXN pathway
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95. Microelements induce changes in characterization of sulfated polysaccharides from Antrodia cinnamomea
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97. Design, synthesis and biological evaluation of novel FAK inhibitors with better selectivity over IR than TAE226
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98. Development and validation of a necroptosis-related gene prognostic score to predict prognosis and efficiency of immunotherapy in gastric cancer
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99. Long non-coding RNA NRSN2-AS1 promotes ovarian cancer progression through targeting PTK2/β-catenin pathway
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100. Arene–Arene Coupled Disulfamethazines (or Sulfadiazine)-Phenanthroline-Metal(II) Complexes were Synthesized by In Situ Reactions and Inhibited the Growth and Development of Triple-Negative Breast Cancer through the Synergistic Effect of Antiangiogenesis, Anti-Inflammation, Pro-Apoptosis, and Cuproptosis
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