FAK in cancer: mechanistic findings and clinical applications

Cited by (1,000)

Items 301–400 of 1,000

1. Macrophages as a Therapeutic Target in Metastatic Prostate Cancer: A Way to Overcome Immunotherapy Resistance?
   Clara Martori, Lidia Sánchez-Moral, Tony Paul, Juan Carlos Pardo, Albert Font Pous, Vicenç Ruiz de Porras, Maria‐Rosa Sarrias · 2022 · Cancers
2. BKM-120 (Buparlisib): A Phosphatidyl-Inositol-3 Kinase Inhibitor with Anti-Invasive Properties in Glioblastoma
   Maria Carmela Speranza, Michal Oskar Nowicki, Prajna Behera, Choi‐Fong Cho, Ennio Antonio Chiocca, Sean Edward Lawler · 2016 · Scientific Reports
3. Lung epithelial cell focal adhesion kinase signaling inhibits lung injury and fibrosis
   Amanda K. Wheaton, Manisha Agarwal, Shijing Jia, Kevin K. Kim · 2017 · American Journal of Physiology-Lung Cellular and Molecular Physiology
4. RETRACTED: Fibronectin promotes cervical cancer tumorigenesis through activating FAK signaling pathway
   Yuzhen Zhou, Changzhen Shu, Yan Huang · 2019 · Journal of Cellular Biochemistry · Retracted
5. Tumor Microenvironment‐Activatable Nanoenzymes for Mechanical Remodeling of Extracellular Matrix and Enhanced Tumor Chemotherapy
   Yinan Zhong, Jianguang Zhang, Junmei Zhang, Yong Xia Hou, Enping Chen, Dechun Huang, Wei Chen, Rainer Haag · 2020 · Advanced Functional Materials
6. Lunasin is a novel therapeutic agent for targeting melanoma cancer stem cells
   Chris Shidal, Numan Al-Rayyan, Kavitha Yaddanapudi, Keith Davis · 2016 · Oncotarget
7. High-throughput Chemical Screening Identifies Focal Adhesion Kinase and Aurora Kinase B Inhibition as a Synergistic Treatment Combination in Ewing Sarcoma
   Sarah Wang, Elizabeth E. Hwang, Rajarshi Guha, Allison Frances O'Neill, Nicole Melong, Chansey J. Veinotte, Amy Conway Saur, Kellsey Wuerthele, Min Shen, Crystal G. McKnight et al. · 2019 · Clinical Cancer Research
8. Discovery of 2,4-diarylaminopyrimidine derivatives bearing dithiocarbamate moiety as novel FAK inhibitors with antitumor and anti-angiogenesis activities
   Yue Su, Ridong Li, Xianling Ning, Zhiqiang Lin, Xuyang Zhao, Juntuo Zhou, Jia Liu, Yan Jin, Yuxin Yin · 2019 · European Journal of Medicinal Chemistry
9. Paracrine recruitment and activation of fibroblasts by c‐Myc expressing breast epithelial cells through the IGFs/IGF‐1R axis
   Anna De Vincenzo, Stefania Belli, Paola Franco, Marialucia Telesca, Ingram Iaccarino, Gerardo Botti, Maria Vincenza Carriero, Marie Ranson, Maria Patrizia Stoppelli · 2019 · International Journal of Cancer
10. A first-in-class anticancer dual HDAC2/FAK inhibitors bearing hydroxamates/benzamides capped by pyridinyl-1,2,4-triazoles
    Muhamad Mustafa, Amer Ali Abd El‐Hafeez, Dalia S. Abdelhamid, Gajanan Dattatray Katkar, Yaser A. Mostafa, Pradipta Ghosh, Alaa M. Hayallah, Gamal El‐Din A. Abuo‐Rahma · 2021 · European Journal of Medicinal Chemistry
11. Simulating the human colorectal cancer microenvironment in 3D tumor-stroma co-cultures in vitro and in vivo
    Mahesh Devarasetty, Anthony J. Dominijanni, Samuel Herberg, Ethan Shelkey, Aleksander Skardal, Shay Söker · 2020 · Scientific Reports
12. Stromal reprogramming overcomes resistance to RAS-MAPK inhibition to improve pancreas cancer responses to cytotoxic and immune therapy
    Xiuting Liu, John M. Baer, Meredith L. Stone, Brett L. Knolhoff, Graham D. Hogg, Madeleine C. Turner, Yu‐Lan Kao, Alyssa G. Weinstein, Faiz F. Ahmad, Jie Chen et al. · 2024 · Science Translational Medicine
13. Modulation of focal adhesion constituents and their down-stream events by EGF: On the cross-talk of integrins and growth factor receptors
    Philipp Eberwein, Dougal F. Laird, Simon Schulz, Thomas Reinhard, Thorsten Steinberg, Pascal Tomakidi · 2015 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
14. Preventive effect of celecoxib use against cancer progression and occurrence of oral squamous cell carcinoma
    Shang‐Lun Chiang, Bharath Kumar Velmurugan, Chia‐Min Chung, Shu‐Hui Lin, Zhi-Hong Wang, Chun‐Hung Hua, Ming‐Hsui Tsai, Tzer‐Min Kuo, Kun‐Tu Yeh, Pei‐Ying Chang et al. · 2017 · Scientific Reports
15. Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors
    Pauline J. Beckmann, Jon D. Larson, Alex T. Larsson, Jason Ostergaard, Sandra Wagner, Eric P. Rahrmann, Ghaidan A. Shamsan, George Maxwell Otto, Rory L. Williams, Jun Wang et al. · 2019 · Cancer Research
16. Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK–YAP signaling axis
    Yusuke Goto, Toshinori Ando, Hiroki Izumi, Xiaodong Feng, Nadia Arang, Mara Gilardi, Zhiyong Wang, Kazuyo Ando, Jorge Silvio Gutkind · 2020 · Oncogene
17. PHIP drives glioblastoma motility and invasion by regulating the focal adhesion complex
    David de Semir, Vladimir Bezrookove, Mehdi Nosrati, Kara R. Scanlon, Eric A. Singer, Jonathon Judkins, Christopher Rieken, Clayton Wu, Julia Shen, Christina Schmudermayer et al. · 2020 · Proceedings of the National Academy of Sciences
18. Protein kinase inhibitors for amyotrophic lateral sclerosis therapy
    Valle Palomo, Vanesa Nozal, Elisa Rojas‐Prats, Carmen Gil, Ana Martı́nez · 2020 · British Journal of Pharmacology
19. Paxillin family of focal adhesion adaptor proteins and regulation of cancer cell invasion
    Kyle M. Alpha, Weiyi Xu, Christopher E. Turner · 2020 · International review of cytology
20. The therapeutic potential of PROTACs
    Andrew B. Benowitz, Katherine L. Jones, John D. Harling · 2020 · Expert Opinion on Therapeutic Patents
21. Constitutive activation of integrin αvβ3 contributes to anoikis resistance of ovarian cancer cells
    Romana Dolinschek, Julia Hingerl, Anke Benge, Christian Zafiu, Elisabeth Schüren, Eva-Kathrin Ehmoser, Daniela Loessner, Ute Reuning · 2020 · Molecular Oncology
22. Dysregulation of Wnt/β‐catenin signaling by protein kinases in hepatocellular carcinoma and its therapeutic application
    Qian Li, Mengqing Sun, Menglan Wang, Mengqing Feng, Fan Yang, Lina Li, Jianbo Zhao, Cunjie Chang, Heng Dong, Tian Xie et al. · 2021 · Cancer Science
23. Inhibition of focal adhesion kinase induces apoptosis in bladder cancer cells via Src and the phosphatidylinositol 3-kinase/Akt pathway
    Debo Kong, Feng Chen, Ni Sima · 2015 · Experimental and Therapeutic Medicine
24. Focal Adhesion Kinase as a Potential Target in AML and MDS
    Bing Z. Carter, Po Yee Mak, Xiangmeng Wang, Hui Yang, Guillermo Garcia‐Manero, Duncan H. F. Mak, Hong Mu, Vivian R. Ruvolo, Yihua Qiu, Kevin R. Coombes et al. · 2017 · Molecular Cancer Therapeutics
25. Therapeutic concentrations of digitoxin inhibit endothelial focal adhesion kinase and angiogenesis induced by different growth factors
    Annalisa Trenti, Elisabetta Zulato, Lorenza Pasqualini, Stefano Indraccolo, Chiara Bolego, Lucia Trevisi · 2017 · British Journal of Pharmacology
26. miR-300 regulates the epithelial-mesenchymal transition and invasion of hepatocellular carcinoma by targeting the FAK/PI3K/AKT signaling pathway
    Rongchang Wang, Zheng Yu, Fan Chen, Hongxu Xu, Shunli Shen, Wei Chen, Lianzhou Chen, Qiao Su, Longjuan Zhang, Jiong Bi et al. · 2018 · Biomedicine & Pharmacotherapy
27. Systemic analysis of tyrosine kinase signaling reveals a common adaptive response program in a HER2-positive breast cancer
    Martin Schwill, Rastislav Tamaskovic, Aaron S. Gajadhar, Florian Kast, Forest M. White, Andreas Plückthun · 2019 · Science Signaling
28. LHX2 is a direct NF-κB target gene that promotes primary hair follicle placode down-growth
    Philip Tomann, Ralf Paus, Sarah E. Millar, Claus Scheidereit, Ruth Schmidt‐Ullrich · 2016 · Development
29. The iron chelator deferasirox induces apoptosis by targeting oncogenic Pyk2/β-catenin signaling in human multiple myeloma
    Kamihara, Yusuke, Takada, Kohichi, Sato, Tsutomu, Kawano, Yutaka, Murase, Kazuyuki, Arihara, Yohei, Kikuchi, Shohei, Hayasaka, Naotaka, Usami, Makoto, Iyama, Satoshi et al. · 2016 · Oncotarget
30. Induction of keratinocyte migration by ECa 233 is mediated through FAK/Akt, ERK, and p38 MAPK signaling
    Singkhorn, Sawana, Tantisira, Mayuree H., Tanasawet, Supita, Hutamekalin, Pilaiwanwadee, Wongtawatchai, Tulaporn, Sukketsiri, Wanida · 2018 · Phytotherapy Research
31. Identification of Thieno[3,2-d]pyrimidine Derivatives as Dual Inhibitors of Focal Adhesion Kinase and FMS-like Tyrosine Kinase 3
    Hanna Cho, Injae Shin, Hojong Yoon, Eunhye Jeon, Jiwon Lee, Younghoon Kim, SeongShick Ryu, Chiman Song, Nam Hoon Kwon, Youngji Moon et al. · 2021 · Journal of Medicinal Chemistry
32. HMGB1-mediated elevation of KLF7 facilitates hepatocellular carcinoma progression and metastasis through upregulating TLR4 and PTK2
    Weibo Feng, Jie Chen, Wenjie Huang, Guodong Wang, Xilang Chen, Lili Duan, Yue Yin, Xiaoping Chen, Bixiang Zhang, Mengyu Sun et al. · 2023 · Theranostics
33. CT-707, a Novel FAK Inhibitor, Synergizes with Cabozantinib to Suppress Hepatocellular Carcinoma by Blocking Cabozantinib-Induced FAK Activation
    Dandan Wang, Ying Chen, Zibo Chen, Fangjie Yan, Xiao-Yang Dai, Meidan Ying, Ji Cao, Jian Ma, Peihua Luo, Yongxin Han et al. · 2016 · Molecular Cancer Therapeutics
34. Chelerythrine Inhibits Human Hepatocellular Carcinoma Metastasis in Vitro
    Yuanzhang Zhu, Yingyi Pan, Gui-biao Zhang, Yingchun Wu, Weicai Zhong, Chunxiao Chu, Yun Qian, Guofu Zhu · 2017 · Biological and Pharmaceutical Bulletin
35. Adaptive and Reversible Resistance to Kras Inhibition in Pancreatic Cancer Cells
    Panyu Chen, Mandar Deepak Muzumdar, Kimberly Judith Dorans, Rebecca Robbins, Arjun J. Bhutkar, Amanda M. Del Rosario, Philipp Mertins, Jana Qiao, Claudia Schäfer, Frank B. Gertler et al. · 2017 · Cancer Research
36. KLF5-induced BBOX1-AS1 contributes to cell malignant phenotypes in non-small cell lung cancer via sponging miR-27a-5p to up-regulate MELK and activate FAK signaling pathway
    Jiang Shi, Chao Yang, Jinlu An, Dexun Hao, Cong Liu, Jumin Liu, Jing Fang Sun, Junguang Jiang · 2021 · Journal of Experimental & Clinical Cancer Research
37. Integrative Ligand-Based Pharmacophore Modeling, Virtual Screening, and Molecular Docking Simulation Approaches Identified Potential Lead Compounds against Pancreatic Cancer by Targeting FAK1
    Mohammad Habibur Rahman Molla, Mohammed Othman Aljahdali, Md Afsar Ahmed Sumon, Amer H. Asseri, Hisham N. Altayb, Md. Shafiqul Islam, Ahad Amer Alsaiari, Firoz A. Dain Md Opo, Nushrat Jahan, Foysal Ahammad et al. · 2023 · Pharmaceuticals
38. Crizotinib inhibits NF2-associated schwannoma through inhibition of focal adhesion kinase 1
    Scott A. Troutman, Susana Moleirinho, Smitha Kota, K.W. Nettles, Mohammad Fallahi, Gary L. Johnson, Joseph L. Kissil · 2016 · Oncotarget
39. Focal adhesion kinase inhibition synergizes with nab-paclitaxel to target pancreatic ductal adenocarcinoma
    Tessa Y. S. Le Large, Maarten F. Bijlsma, Btissame El Hassouni, Giulia Mantini, Tonny Lagerweij, Alex A. Henneman, Niccola Funel, B. Kok, Thang V. Pham, Richard de Goeij-de Haas et al. · 2021 · Journal of Experimental & Clinical Cancer Research
40. The application of PROTAC in HDAC
    Shaoting Chen, Yuxiang Zheng, Benji Liang, Yudong Yin, Jian Yao, Quande Wang, Yanghan Liu, Nouri Neamati · 2023 · European Journal of Medicinal Chemistry
41. ZDHHC5-mediated S-palmitoylation of FAK promotes its membrane localization and epithelial-mesenchymal transition in glioma
    Yang Wang, Na Shen, Yang� Yang, Yuan Xia, Wenhao Zhang, Lu Yu, Zhicheng Wang, Ze Yang, Zhangjie Wang · 2024 · Cell Communication and Signaling
42. “Scar-cinoma”: viewing the fibrotic lung mesenchymal cell in the context of cancer biology
    Jeffrey Craig Horowitz, John J. Osterholzer, Antonia Marazioti, Georgios T. Stathopoulos · 2016 · European Respiratory Journal
43. Focal adhesion kinases crucially regulate TGFβ-induced migration and invasion of bladder cancer cells via Src kinase and E-cadherin
    Debo Kong, Feng Chen, Ni Sima · 2017 · OncoTargets and Therapy
44. Dietary Fucoxanthin Induces Anoikis in Colorectal Adenocarcinoma by Suppressing Integrin Signaling in a Murine Colorectal Cancer Model
    Masaru Terasaki, Mimori Ikuta, Hiroyuki Kojima, Takuji Tanaka, H. Maeda, Kazuo Miyashita, Michihiro Mutoh · 2019 · Journal of Clinical Medicine
45. Extracellular Matrix-Based Hydrogels to Tailoring Tumor Organoids
    Hyun Jin Lee, Siwon Mun, Duc Minh Pham, Pilnam Kim · 2021 · ACS Biomaterials Science & Engineering
46. Design, synthesis, and biological evaluation of 2,4-diamino pyrimidine derivatives as potent FAK inhibitors with anti-cancer and anti-angiogenesis activities
    Shan Wang, Rong‐Hong Zhang, Hong Zhang, Yuchan Wang, Dan Yang, Yong‐Long Zhao, Guoyi Yan, Guo‐Bo Xu, Huan-Yu Guan, Yan-Hua Zhou et al. · 2021 · European Journal of Medicinal Chemistry
47. Correction: IQGAP1 promotes anoikis resistance and metastasis through Rac1-dependent ROS accumulation and activation of Src/FAK signalling in hepatocellular carcinoma
    Chunfen Mo, Jun Li, Shu-xia Yang, Huijie Guo, Yang Liu, Xingyan Luo, Yantang Wang, Jingyi Li, Jingyi Li, Qiang Zou · 2021 · British Journal of Cancer
48. PROTACS: A technology with a gold rush-like atmosphere
    Yuwei Wang, Li Lan, Min Wang, Jinyang Zhang, Yuhui Gao, Lei Shi, Li‐Ping Sun · 2022 · European Journal of Medicinal Chemistry
49. The treatment landscape of triple-negative breast cancer
    Yi Hu, Chen Wang, Huishi Liang, Jie Li, Qiong Yang · 2024 · Medical Oncology
50. Structural and functional analysis of cell adhesion and nuclear envelope nano-topography in cell death
    Hyuk‐Kwon Kwon, Jae‐Hyeok Lee, Hyeon‐Jun Shin, Jae Ho Kim, Sangdun Choi · 2015 · Scientific Reports
51. Somatic Mutations and Splicing Variants of Focal Adhesion Kinase in Non–Small Cell Lung Cancer
    Bo Zhou, Guizhen Wang, Zhesheng Wen, Yongchun Zhou, Yunchao Huang, Ying Chen, Guang‐Biao Zhou · 2017 · JNCI Journal of the National Cancer Institute
52. FAK is Required for Tumor Metastasis-Related Fluid Microenvironment in Triple-Negative Breast Cancer
    Mei‐Ren Pan, Ming‐Feng Hou, Fu Ou‐Yang, Chun‐Chieh Wu, Shu‐Jyuan Chang, Wen‐Chun Hung, Hon‐Kan Yip, Chi‐Wen Luo · 2019 · Journal of Clinical Medicine
53. LncRNA MIR22HG Abrogation Inhibits Proliferation and Induces Apoptosis in Esophageal Adenocarcinoma Cells Via Activation of the STAT3/c-Myc/FAK Signaling
    Wenmei Su, Chunfang Guo, Lihui Wang, Zhuwen Wang, Xia Yang, Feiyu Niu, Daniel Tzou, Xiao Yi Yang, Xiaobi Huang, Jiancong Wu et al. · 2018 · Aging
54. Multiscale modeling of tumor growth and angiogenesis: Evaluation of tumor-targeted therapy
    Sahar Jafari Nivlouei, Madjid Soltani, João Carvalho, Rui D. M. Travasso, Mohammad Reza Salimpour, Ebrahim Shirani · 2021 · PLoS Computational Biology
55. Physiological consequences of space flight, including abnormal bone metabolism, space radiation injury, and circadian clock dysregulation: Implications of melatonin use and regulation as a countermeasure
    Jun Hirayama, Atsuhiko Hattori, Akihisa Takahashi, Yukihiro Furusawa, Yoshiaki Tabuchi, Masahiro Shibata, Aiko Nagamatsu, Sachiko Yano, Yusuke Maruyama, Hajime Matsubara et al. · 2022 · Journal of Pineal Research
56. Automated tracking of tumor-stroma morphology in microtissues identifies functional targets within the tumor microenvironment for therapeutic intervention
    Malin Åkerfelt, Neslihan Bayramoğlu, Sean Robinson, Mervi Toriseva, Hannu-Pekka Schukov, Ville Härmä, Johannes Virtanen, Raija T. Sormunen, Mika Kaakinen, Juho Kannala et al. · 2015 · Oncotarget
57. Overexpression of SCARA5 inhibits tumor proliferation and invasion in osteosarcoma via suppression of the FAK signaling pathway
    Xinzhu Wen, Nan Wang, Fanfan Zhang, Chunjiao Dong · 2016 · Molecular Medicine Reports
58. Paris polyphyllaSuppresses Proliferation and Vasculogenic Mimicry of Human Osteosarcoma Cells and Inhibits Tumor GrowthIn Vivo
    Nan Yao, Ke Ren, Yimin Wang, Qiaomei Jin, Xiao Lu, Yan Lu, Cuihua Jiang, Dongjian Zhang, Jun Lü, Chen Wang et al. · 2017 · The American Journal of Chinese Medicine
59. RXRα provokes tumor suppression through p53/p21/p16 and PI3K-AKT signaling pathways during stem cell differentiation and in cancer cells
    Rui Zhang, Hui Li, Shuangshuang Zhang, Yujie Zhang, Nan Wang, Hao Zhou, Hongpeng He, Guang Hu, Tongcun Zhang, Wenjian Ma · 2018 · Cell Death and Disease
60. Agrin has a pathological role in the progression of oral cancer
    César Rivera, Flávia da Silva Zandonadi, Celeste Sánchez‐Romero, Ciro Dantas Soares, Daniela C. Granato, Wilfredo Alejandro González‐Arriagada, Adriana Franco Paes Leme · 2018 · British Journal of Cancer
61. Focal Adhesion Kinase in Ovarian Cancer: A Potential Therapeutic Target for Platinum and Taxane-Resistant Tumors
    Arkene Levy, Khalid Alhazzani, Priya Dondapati, Ali Mohammed Alaseem, Khadijah Cheema, Keerthi Thallapureddy, Paramjot Kaur, Saad Ebrahim Alobid, Appu Rathinavelu · 2018 · Current Cancer Drug Targets
62. miR-125a-5p regulation increases phosphorylation of FAK that contributes to imatinib resistance in gastrointestinal stromal tumors
    Wen‐Kuan Huang, Pınar Akçakaya, Anastasia Gangaev, Linkiat Lee, Katarina Zeljić, Praveensingh B. Hajeri, Erik Berglund, Mehran Ghaderi, Jan Åhlén, Robert Bränström et al. · 2018 · Experimental Cell Research
63. Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling
    Shu‐Chen Liu, Tien Hsu, Yu‐Sun Chang, An‐Ko Chung, Shih Sheng Jiang, Chun‐Nan OuYang, Chiou‐Hwa Yuh, Chuen Hsueh, Yaping Liu, Ngan‐Ming Tsang · 2018 · Nature Communications
64. Discovery of a Brigatinib Degrader SIAIS164018 with Destroying Metastasis-Related Oncoproteins and a Reshuffling Kinome Profile
    Chaowei Ren, Ning Sun, Haixia Liu, Ying Kong, Renhong Sun, Xing Qiu, Jinju Chen, Yan Li, Jianshui Zhang, Yuedong Zhou et al. · 2021 · Journal of Medicinal Chemistry
65. Molecular Targets for Gastric Cancer Treatment and Future Perspectives from a Clinical and Translational Point of View
    Justus Körfer, Florian Lordick, Ulrich Thorsten Hacker · 2021 · Cancers
66. The molecular mechanism of baicalein repressing progression of gastric cancer mediating miR-7/FAK/AKT signaling pathway
    Dan Qiao, Jian Xing, Yunxiao Duan, Shiyu Wang, Guangyuan Yao, Shengjun Zhang, Jingchun Jin, Zhenhua Lin, Liyan Chen, Yingshi Piao · 2022 · Phytomedicine
67. Focal adhesion kinase inhibitors in the treatment of solid tumors: Preclinical and clinical evidence
    Patricia A. Quispe, Martín J. Lavecchia, Ignácio E. León · 2021 · Drug Discovery Today
68. The dual FAK-HDAC inhibitor MY-1259 displays potent activities in gastric cancers in vitro and in vivo
    Jian Song, Xu Liu, Yifan Zhang, Xin-Yi Tian, Mengyan Deng, Chen‐Zheng Huang, Sai‐Yang Zhang · 2022 · Bioorganic Chemistry
69. ACTN1 promotes HNSCC tumorigenesis and cisplatin resistance by enhancing MYH9-dependent degradation of GSK-3β and integrin β1-mediated phosphorylation of FAK
    Li Cui, Ye Lu, Jiarong Zheng, Bing Guo, Xinyuan Zhao · 2023 · Journal of Experimental & Clinical Cancer Research
70. Heterogeneous Cell Types in Single-cell-derived Clones of MCF7 and MDA-MB-231 Cells
    Gul Nabi Khan, Eun‐jin Kim, Tae Seop Shin, Sang Ho Lee · 2017 · Anticancer Research
71. Lasp1 promotes malignant phenotype of non-small-cell lung cancer via inducing phosphorylation of FAK-AKT pathway
    Xiupeng Zhang, Yang Liu, Chuifeng Fan, Liang Wang, Ailin Li, Haijing Zhou, Lin Cai, Yuan Miao, Qingchang Li, Xueshan Qiu et al. · 2017 · Oncotarget
72. Galectin-8 induces partial epithelial–mesenchymal transition with invasive tumorigenic capabilities involving a FAK/EGFR/proteasome pathway in Madin–Darby canine kidney cells
    Claudia Oyanadel, Christopher Holmes, Evelyn Pardo, Cláudio Retamal, Ronan Shaughnessy, Patricio C. Smith, Priscilla Cortés, Marcela Bravo‐Zehnder, Claudia Metz, Teo Feuerhake et al. · 2018 · Molecular Biology of the Cell
73. Matrilysin/MMP-7 Cleavage of Perlecan/HSPG2 Complexed with Semaphorin 3A Supports FAK-Mediated Stromal Invasion by Prostate Cancer Cells
    Brian J. Grindel, Jerahme R. Martinez, Tristen V. Tellman, Daniel A. Harrington, Hamim Zafar, Luay K. Nakhleh, Leland W.K. Chung, Mary C. Farach‐Carson · 2018 · Scientific Reports
74. A landmark in drug discovery based on complex natural product synthesis
    Satoshi Kawano, Ken Ito, Kenzo Yahata, Kazunobu Kira, Takanori Abe, Tsuyoshi Akagi, Makoto Asano, Kentaro Iso, Yuki Sato, Fumiyoshi Matsuura et al. · 2019 · Scientific Reports
75. How to awaken your nanomachines: Site-specific activation of focal adhesion kinases through ligand interactions
    Katarzyna W. Walkiewicz, Jean‐Antoine Girault, Stefan T. Arold · 2015 · Progress in Biophysics and Molecular Biology
76. Focal Adhesion Kinase Promotes the Progression of Aortic Aneurysm by Modulating Macrophage Behavior
    Takasuke Harada, Koichi Yoshimura, Osamu Yamashita, Koshiro Ueda, Noriyasu Morikage, Yasuhiro Sawada, Kimikazu Hamano · 2016 · Arteriosclerosis Thrombosis and Vascular Biology
77. The Critical Impact of Sphingolipid Metabolism in Breast Cancer Progression and Drug Response
    Paola Antonia Corsetto, Stefania Zava, Angela Maria Rizzo, Irma Colombo · 2023 · International Journal of Molecular Sciences
78. cMET in NSCLC: Can We Cut off the Head of the Hydra? From the Pathway to the Resistance
    Nele Van Der Steen, Patrick Pauwels, Ignacio Gil Bazo, Eduardo Castañón Álvarez, Luis Estuardo Raez, Federico Cappuzzo, Christian D. Rolfo · 2015 · Cancers
79. Exploiting Radiation-Induced Signaling to Increase the Susceptibility of Resistant Cancer Cells to Targeted Drugs: AKT and mTOR Inhibitors as an Example
    Iris Eke, Adeola Y. Makinde, Molykutty J. Aryankalayil, Veit Sandfort, Sanjeewani T. Palayoor, Barbara Helen Rath, Lance A. Liotta, Mariaelena Pierobon, Emanuel F. Petricoin, Matthew F. Brown et al. · 2017 · Molecular Cancer Therapeutics
80. Collateral Damage Intended—Cancer-Associated Fibroblasts and Vasculature Are Potential Targets in Cancer Therapy
    Ana C. Martins Cavaco, Maryam Rezaei, Stephan Niland, Johannes Andreas Eble · 2017 · International Journal of Molecular Sciences
81. Elevated limb-bud and heart development (LBH) expression indicates poor prognosis and promotes gastric cancer cell proliferation and invasion via upregulating Integrin/FAK/Akt pathway
    Ruoxi Yu, Zhi Li, Chuang Zhang, Huicong Song, Mingming Deng, Liping Laura Sun, Ling Xu, Xiaofang Che, Xuejun Hu, Xiujuan Qu et al. · 2019 · PeerJ
82. Design and synthesis of diphenylpyrimidine derivatives (DPPYs) as potential dual EGFR T790M and FAK inhibitors against a diverse range of cancer cell lines
    Min Ai, Changyuan Wang, Zeyao Tang, Kexin Liu, Xiuli Sun, Tengyue Ma, Yanxia Li, Xiaodong Ma, Lei Li, Lixue Chen · 2019 · Bioorganic Chemistry
83. The landscape of long noncoding RNA-involved and tumor-specific fusions across various cancers
    Mengbiao Guo, Zhen‐Dong Xiao, Zhiming Dai, Ling‐Qiang Zhu, Hang Lei, Li‐Ting Diao, Yuanyan Xiong · 2020 · Nucleic Acids Research
84. Antitumor effects of the multi-target tyrosine kinase inhibitor cabozantinib: a comprehensive review of the preclinical evidence
    Matteo Santoni, Roberto Iacovelli, Valentina Colonna, Stephan G. Klinz, Giorgio Mauri, Marianna Nuti · 2021 · Expert Review of Anticancer Therapy
85. p53 regulates cytoskeleton remodeling to suppress tumor progression
    Keigo Araki, Takahiro Ebata, Alvin Kunyao Guo, Kei Tobiume, Steven John Wolf, Keiko Kawauchi · 2015 · Cellular and Molecular Life Sciences
86. Nanopurpurin-based photodynamic therapy destructs extracellular matrix against intractable tumor metastasis
    Di Zhang, Feng Feng, Qilong Li, Xiuyu Wang, Li Yao · 2018 · Biomaterials
87. Therapeutic Potential of Focal Adhesion Kinase Inhibition in Small Cell Lung Cancer
    Frank Aboubakar Nana, Marylène Lecocq, Maha Zohra Ladjemi, Bruno R. Detry, Sébastien Dupasquier, Olivier Féron, Pierre P. Massion, Yves Sibille, Charles Pilette, Sebahat Ocak · 2018 · Molecular Cancer Therapeutics
88. TGFβ induces epithelial‐mesenchymal transition of thyroid cancer cells by both the BRAF/MEK/ERK and Src/FAK pathways
    Pablo Baquero, Eva Jiménez‐Mora, Adrian Richard Schenberger Santos, Marina Lasa, Antonio Chiloeches · 2015 · Molecular Carcinogenesis
89. Phosphoproteomic Profiling Reveals ALK and MET as Novel Actionable Targets across Synovial Sarcoma Subtypes
    Emmy D.G. Fleuren, Myrella Vlenterie, Winette T.A. van der Graaf, Melissa H.S. Hillebrandt-Roeffen, James Blackburn, Xiuquan Ma, Howard Chan, Mandy C. Magias, Anke E. M. van Erp, Laurens van Houdt et al. · 2017 · Cancer Research
90. Role of BMI1 in epithelial ovarian cancer: investigated via the CRISPR/Cas9 system and RNA sequencing
    Qianying Zhao, Qiuhong Qian, Dongyan Cao, Jiaxin Yang, Ting Gui, Keng Shen · 2018 · Journal of Ovarian Research
91. Schisandrin B prevents ulcerative colitis and colitis-associated-cancer by activating focal adhesion kinase and influence on gut microbiota in an in vivo and in vitro model
    Jiani Li, Yuan Lu, Duowei Wang, Fei Quan, Xin Chen, Rui Sun, Sen Zhao, Zhisen Yang, Weiyan Tao, Dong Ding et al. · 2019 · European Journal of Pharmacology
92. Focal adhesion kinase (FAK) inhibitor‐defactinib suppresses the malignant progression of human esophageal squamous cell carcinoma (ESCC) cells via effective blockade of PI3K/AKT axis and downstream molecular network
    Lingyuan Zhang, Di Zhao, Yan Wang, Weimin Zhang, Jing Zhang, Jiawen Fan, Qimin Zhan, Jie Chen · 2020 · Molecular Carcinogenesis
93. PDE4D promotes FAK-mediated cell invasion in BRAF-mutated melanoma
    Julie Delyon, A. Servy, Florence Laugier, Jocelyne André, Nicolás Ortonne, Maxime Battistella, Samia Mourah, Armand Bensussan, Célèste Lebbé, Nicolas Dumaz · 2017 · Oncogene
94. Analysis of Skin Regeneration and Barrier-Improvement Efficacy of Polydeoxyribonucleotide Isolated from Panax Ginseng (C.A. Mey.) Adventitious Root
    Kwang-Soo Lee, So‐Yeon Lee, Hyesoo Wang, Geonhee Lee, Seolyeong Kim, Yang-Hwan Ryu, Nicole Hyesoo Chang, Yong-Won Kang · 2023 · Molecules
95. RNase L is a negative regulator of cell migration
    Shuvojit Banerjee, Geqiang Li, Yize Li, Christina Gaughan, Danika Baskar, Yvonne Parker, Daniel J. Lindner, Susan Reich Weiss, Robert H. Silverman · 2015 · Oncotarget
96. Small-molecule inhibitors of FGFR, integrins and FAK selectively decrease L1CAM-stimulated glioblastoma cell motility and proliferation
    Hannah Anderson, Deni S. Galileo · 2016 · Cellular Oncology
97. DCYTB is a predictor of outcome in breast cancer that functions via iron-independent mechanisms
    David J. Lemler, Miranda L. Lynch, Lia Tesfay, Zhiyong Deng, Bibbin T. Paul, Xiaohong Wang, Poornima Hegde, David H. Manz, Suzy V. Torti, Frank M. Torti · 2017 · Breast Cancer Research
98. Toxoplasma gondii disrupts β1 integrin signaling and focal adhesion formation during monocyte hypermotility
    Joshua Cook, Norikiyo Ueno, Melissa B. Lodoen · 2018 · Journal of Biological Chemistry
99. Exome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations
    Jiang Chang, Jianbo Tian, Ying Zhu, Rong Zhong, Kan Zhai, Jiaoyuan Li, Juntao Ke, Qiangqiang Han, Jiao Lou, Wei Chen et al. · 2018 · Nature Communications
100. Antitumor effect of focal adhesion kinase inhibitor PF 562271 against human osteosarcoma in vitro and in vivo
     Chuanzhen Hu, Chen Yue Xu, Junxiang Wen, Liangzhi Gong, Zhuochao Liu, Jun Wang, Jing Liang, Fangqiong Hu, Qi Zhou, Wei Li et al. · 2017 · Cancer Science