The journey of islet cell transplantation and future development

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Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen

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Human mesenchymal stem cells modulate B-cell functions

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Osteogenesis in transplants of bone marrow cells

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Five-Year Follow-Up After Clinical Islet Transplantation

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Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing

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Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

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Differentiation of Embryonic Stem Cells to Insulin-Secreting Structures Similar to Pancreatic Islets

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Mesenchymal Stem Cells Inhibit and Stimulate Mixed Lymphocyte Cultures and Mitogenic Responses Independently of the Major Histocompatibility Complex

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Mesenchymal stem cells inhibit natural killer–cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2

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Production of α1,3-Galactosyltransferase-Deficient Pigs

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Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation

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Type 1 diabetes immunotherapy using polyclonal regulatory T cells

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Semipermeable Microcapsules

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Mesenchymal stem cells avoid allogeneic rejection

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Development of definitive endoderm from embryonic stem cells in culture

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Human Umbilical Cord Perivascular (HUCPV) Cells: A Source of Mesenchymal Progenitors

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Cotransplantation of HLA-Identical Sibling Culture-Expanded Mesenchymal Stem Cells and Hematopoietic Stem Cells in Hematologic Malignancy Patients

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Untitled work

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Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice

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Time trends in the incidence of type 1 diabetes in Finnish children: a cohort study

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Clinical pancreatic islet transplantation

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Immunosuppressive properties of mesenchymal stem cells: advances and applications

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Cytokine expression by human marrow-derived mesenchymal progenitor cells in vitro: Effects of dexamethasone and IL-1α

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Genome-wide inactivation of porcine endogenous retroviruses (PERVs)

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Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets

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Recovery from diabetes in mice by β cell regeneration

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Controlled induction of human pancreatic progenitors produces functional beta‐like cells in vitro

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Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus

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Transplantation of porcine fetal pancreas to diabetic patients

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Transplantation of intact pancreatic islets in rats.

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C-peptide levels and insulin independence following autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus

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Advances in islet encapsulation technologies

Desai, T., & Shea, L. D. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.232 · Cited by 427 · see citing works

β-Cell Death and Mass in Syngeneically Transplanted Islets Exposed to Short- and Long-Term Hyperglycemia

Biarnés, M., Montolio, M., Nacher, V., Raurell, M., Soler, J., & Montanya, E. (2002) · Diabetes · doi:10.2337/diabetes.51.1.66 · Cited by 420 · see citing works

Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells

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Insulin Independence After Islet Transplantation Into Type I Diabetic Patient

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Automated Islet Isolation From Human Pancreas

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A prevascularized subcutaneous device-less site for islet and cellular transplantation

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Pancreatic Extracts in The Treatment of Diabetes Mellitus

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Extracellular Matrix in Pancreatic Islets: Relevance to Scaffold Design and Transplantation

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An encapsulation system for the immunoisolation of pancreatic islets

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Encapsulated islets for diabetes therapy: History, current progress, and critical issues requiring solution

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Improvements in the Life Expectancy of Type 1 Diabetes

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Mesenchymal Stem Cells Prevent the Rejection of Fully Allogenic Islet Grafts by the Immunosuppressive Activity of Matrix Metalloproteinase-2 and -9

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Transplantation of human islets without immunosuppression

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Regulatory T-Cell Therapy in Transplantation: Moving to the ClinicPreprint

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Update on Islet Transplantation

McCall, M., & James Shapiro, A. M. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a007823 · Cited by 226 · see citing works

The Clinical Impact of Islet Transplantation

Fiorina, P., Shapiro, A. M. J., Ricordi, C., & Secchi, A. (2008) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2008.02353.x · Cited by 224 · see citing works

Clinical Benefit of Islet Xenotransplantation for the Treatment of Type 1 Diabetes

Matsumoto, S., Abalovich, A., Wechsler, C., Wynyard, S., & Elliott, R. B. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.08.034 · Cited by 204 · see citing works

Mesenchymal Stem Cells Enhance Allogeneic Islet Engraftment in Nonhuman Primates

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Total or Near Total Pancreatectomy and Islet Autotransplantation for Treatment of Chronic Pancreatitis

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Human placenta-derived mesenchymal progenitor cells support culture expansion of long-term culture-initiating cells from cord blood CD34+ cells

Zhang, Y., Li, C., Jiang, X., Zhang, S., Wu, Y., Liu, B., Tang, P.-H., & Mao, N. (2004) · Experimental Hematology · doi:10.1016/j.exphem.2004.04.001 · Cited by 202 · see citing works

Control of instant blood-mediated inflammatory reaction to improve islets of Langerhans engraftment

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Enhanced Oxygen Supply Improves Islet Viability in a New Bioartificial Pancreas

Barkai, U., Weir, G., Colton, C., Ludwig, B., Bornstein, S., Brendel, M., Neufeld, T., Bremer, C., Leon, A., Evron, Y., et al. (2013) · Cell Transplantation · doi:10.3727/096368912x657341 · Cited by 175 · see citing works

Factors Influencing the Loss of β-Cell Mass in Islet Transplantation

Emamaullee, J. A., & Shapiro, A. M. J. (2007) · Cell Transplantation · doi:10.3727/000000007783464461 · Cited by 172 · see citing works

Clinical and Experimental Pancreatic Islet Transplantation to Striated Muscle

Christoffersson, G., Henriksnäs, J., Johansson, L., Rolny, C., Ahlström, H., Caballero-Corbalan, J., Segersvärd, R., Permert, J., Korsgren, O., Carlsson, P.-O., et al. (2010) · Diabetes · doi:10.2337/db10-0205 · Cited by 167 · see citing works

Bioengineering of an Intraabdominal Endocrine Pancreas

Baidal, D. A., Ricordi, C., Berman, D. M., Alvarez, A., Padilla, N., Ciancio, G., Linetsky, E., Pileggi, A., & Alejandro, R. (2017) · New England Journal of Medicine · doi:10.1056/nejmc1613959 · Cited by 160 · see citing works

Mesenchymal stem cells: Stem cell therapy perspectives for type 1 diabetes

Vija, L., Farge, D., Gautier, J., Vexiau, P., Dumitrache, C., Bourgarit, A., Verrecchia, F., & Larghero, J. (2009) · Diabetes & Metabolism · doi:10.1016/j.diabet.2008.10.003 · Cited by 157 · see citing works

Intramuscular Autotransplantation of Pancreatic Islets in a 7‐Year‐Old Child: A 2‐Year Follow‐Up

Rafael, E., Tibell, A., Rydén, M., Lundgren, T., Sävendahl, L., Borgström, B., Arnelo, U., Isaksson, B., Nilsson, B., Korsgren, O., et al. (2008) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2007.02060.x · Cited by 153 · see citing works

Clinical Porcine Islet Xenotransplantation Under Comprehensive Regulation

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Low Molecular Weight Dextran Sulfate: A Strong Candidate Drug to Block IBMIR in Clinical Islet Transplantation

Johansson, H., Goto, M., Dufrane, D., Siegbahn, A., Elgue, G., Gianello, P., Korsgren, O., & Nilsson, B. (2006) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2005.01186.x · Cited by 142 · see citing works

Bone Marrow-Derived Mesenchymal Stem Cells Ameliorate Autoimmune Enteropathy Independently of Regulatory T Cells

Parekkadan, B., Tilles, A. W., & Yarmush, M. L. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0790 · Cited by 139 · see citing works

Bone Marrow Stromal Cells Can Provide a Local Environment That Favors Migration and Formation of Tubular Structures of Endothelial Cells

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The TheraCyte™ Device Protects against Islet Allograft Rejection in Immunized Hosts

Kumagai-Braesch, M., Jacobson, S., Mori, H., Jia, X., Takahashi, T., Wernerson, A., Flodström-Tullberg, M., & Tibell, A. (2013) · Cell Transplantation · doi:10.3727/096368912x657486 · Cited by 138 · see citing works

Human Mesenchymal Stem Cells Protect Human Islets from Pro-Inflammatory Cytokines

Yeung, T., Seeberger, K. L., Kin, T., Adesida, A. B., Jomha, N. M., Shapiro, A. M. J., & Korbutt, G. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038189 · Cited by 134 · see citing works

Autologous umbilical cord blood infusion for type 1 diabetes

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Survival and Metabolic Function of Syngeneic Rat Islet Grafts Transplanted in the Omental Pouch

Kin, T., Korbutt, G. S., & Rajotte, R. V. (2003) · American Journal of Transplantation · doi:10.1034/j.1600-6143.2003.00049.x · Cited by 132 · see citing works

Advances in islet encapsulation technologies

Desai, T., & Shea, L. (2017) · Nature reviews. Drug discovery · doi:10.1038/nrd.2017.67 · Cited by 130 · see citing works

Inflammatory Response in Islet Transplantation

Kanak, M., Takita, M., Kunnathodi, F., Lawrence, M. C., Levy, M., & Naziruddin, B. (2014) · International Journal of Endocrinology · doi:10.1155/2014/451035 · Cited by 128 · see citing works

Long‐term outcomes of entecavir monotherapy for chronic hepatitis B after liver transplantation: Results up to 8 years

Fung, J., Wong, T. C.-L., Chok, K., Chan, A. C. Y., Cheung, T. T., Dai, J. W.-C., Sin, S., Ma, K., Ng, K. K., Ng, T., et al. (2017) · Hepatology · doi:10.1002/hep.29191 · Cited by 126 · see citing works

Insulin-Heparin Infusions Peritransplant Substantially Improve Single-Donor Clinical Islet Transplant Success

Koh, A., Senior, P. A., Salam, A., Kin, T., Imes, S., Dinyari, P., Malcolm, A. J., Toso, C., Nilsson, B., Korsgren, O., et al. (2010) · Transplantation · doi:10.1097/tp.0b013e3181c478fd · Cited by 122 · see citing works

Portal vein thrombosis is a potentially preventable complication in clinical islet transplantation

Kawahara, T., Kin, T., Kashkoush, S., Gala-Lopez, B., Bigam, D., Kneteman, N., Koh, A., Senior, P., & Shapiro, A. M. J. (2011) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2011.03717.x · Cited by 121 · see citing works

Clinical Islet Xenotransplantation

van der Windt, D. J., Bottino, R., Kumar, G., Wijkstrom, M. N., Hara, H., Ezzelarab, M. B., Ekser, B., Phelps, C. J., Murase, N., Casu, A., et al. (2012) · Diabetes · doi:10.2337/db12-0033 · Cited by 120 · see citing works

Type 1 Diabetes TrialNet–An International Collaborative Clinical Trials Network

Skyler, J. S., Greenbaum, C. J., Lachin, J. M., Leschek, E., Rafkin‐Mervis, L., Savage, P. J., Spain, L. M., & the Type 1 Diabetes TrialNet Study Group (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1447.054 · Cited by 119 · see citing works

Immunological Balance Is Associated with Clinical Outcome after Autologous Hematopoietic Stem Cell Transplantation in Type 1 Diabetes

Malmegrim, K. C. R., de Azevedo, J. T. C., Arruda, L. C. M., Abreu, J. R. F., Couri, C. E. B., de Oliveira, G. L. V., Palma, P. V. B., Scortegagna, G. T., Stracieri, A. B. P. L., Moraes, D. A., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00167 · Cited by 118 · see citing works

Diabetes Is Reversed in a Murine Model by Marginal Mass Syngeneic Islet Transplantation Using a Subcutaneous Cell Pouch Device

Pepper, A. R., Pawlick, R. L., Gala-López, B., MacGillivary, A., Mazzuca, D. M., White, D. J., Toleikis, P. M., & Shapiro, A. M. J. (2015) · Transplantation · doi:10.1097/tp.0000000000000864 · Cited by 116 · see citing works

Inhibition of Human Insulin Gene Transcription by the Immunosuppressive Drugs Cyclosporin A and Tacrolimus in Primary, Mature Islets of Transgenic Mice

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