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Induced pluripotent stem cell technology: a decade of progress.
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Since the advent of induced pluripotent stem cell (iPSC) technology a decade ago, enormous progress has been made in stem cell biology and regenerative medicine. Human iPSCs have been widely used for disease modelling, drug discovery and cell therapy development. Novel pathological mechanisms have been elucidated, new drugs originating from iPSC screens are in the pipeline and the first clinical trial using human iPSC-derived products has been initiated. In particular, the combination of human iPSC technology with recent developments in gene editing and 3D organoids makes iPSC-based platforms even more powerful in each area of their application, including precision medicine. In this Review, we discuss the progress in applications of iPSC technology that are particularly relevant to drug discovery and regenerative medicine, and consider the remaining challenges and the emerging opportunities in the field.
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“In 2006, Takahashi and Yamanaka demonstrated that the expression of four transcription factors, OCT4, SOX2, KLF4, and c-MYC (collectively known as “OSKM”), reprograms the developmental potential of adult cells, enabling them to be converted into various cell types [17, 18].”
From Chemically induced reprogramming to reverse cellular aging (2023) · cites this paper as [18]
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Self-citation
Metadata
- Authors
- Shi, Y., Inoue, H., Wu, J. C., & Yamanaka, S.
- Affiliations
- City Of Hope National Medical Center (US)
- Kyoto University (JP)
- Stanford Cardiovascular Institute (US)
- Gladstone Institutes (US)
- Corresponding author
- Shi, Yanhong
- Inoue, Haruhisa
- Venue
- Nature Reviews Drug Discovery
- Published
- 2016-12-16
- Volume
- 16
- Issue
- 2
- Pages
- 115-130
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- PMC
- PMC6416143
- OpenAlex
- W2565787913
- Cited by
- 1,525
- References
- 224
- Citations by year
- 2026: 96 · 2025: 143 · 2024: 177 · 2023: 185 · 2022: 194 · 2021: 205 · 2020: 199 · 2019: 123 · 2018: 143 · 2017: 56 · 2016: 1
- FWCI
- 9.72
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Drug Discovery (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL128170, R01HL130020)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Keywords
- induced pluripotent stem cells, drug discovery, regenerative medicine, disease modeling, cell therapy, genome editing, 3D organoids, precision medicine, clinical trials
- MeSH terms
- Drug Therapy, Humans, Stem Cell Transplantation, Regenerative Medicine, History, 21st Century, Drug Discovery, Induced Pluripotent Stem Cells, High-Throughput Screening Assays
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