Cited by 3,683Redox biology and oxidative stressAntioxidant Activity and Oxidative StressAlzheimer's disease research and treatments

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Neurodegenerative diseases and oxidative stress

Barnham, Kevin J., Masters, Colin L., Bush, Ashley I.·2004·Nature Reviews Drug Discovery

DOI 10.1038/nrd1330

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Abstract

Oxidative stress has been implicated in the progression of Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Oxygen is vital for life but is also potentially dangerous, and a complex system of checks and balances exists for utilizing this essential element. Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. The systems in place to cope with the biochemistry of oxygen are complex, and many questions about the mechanisms of oxygen regulation remain unanswered. However, this same complexity provides a number of therapeutic targets, and different strategies, including novel metal-protein attenuating compounds, aimed at a variety of targets have shown promise in clinical studies.

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Free radicals in biology and medicine
Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178
Free Radicals in Biology and Medicine
Halliwell, B., & Gutteridge, J. M. C. (2015) · doi:10.1093/acprof:oso/9780198717478.001.0001 · Cited by 8,990
α-Synuclein in Lewy bodies
Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., & Goedert, M. (1997) · Nature · doi:10.1038/42166 · Cited by 8,382
Parkinson's Disease
Dauer, W., & Przedborski, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00568-3 · Cited by 5,469
Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., & Müller-Hill, B. (1987) · Nature · doi:10.1038/325733a0 · Cited by 4,619
Self-citation
Amyloid plaque core protein in Alzheimer disease and Down syndrome.
Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431
Self-citation
Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation
Gurney, M. E., Pu, H., Chiu, A. Y., Dal Canto, M. C., Polchow, C. Y., Alexander, D. D., Caliendo, J., Hentati, A., Kwon, Y. W., Deng, H.-X., et al. (1994) · Science · doi:10.1126/science.8209258 · Cited by 4,143
Friedreich's Ataxia: Autosomal Recessive Disease Caused by an Intronic GAA Triplet Repeat Expansion
Campuzano, V., Montermini, L., Moltò, M. D., Pianese, L., Cossée, M., Cavalcanti, F., Monros, E., Rodius, F., Duclos, F., Monticelli, A., et al. (1996) · Science · doi:10.1126/science.271.5254.1423 · Cited by 2,786
A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease
Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361704 · Cited by 2,380

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Ferrari, C. K. B. Free radicals, lipid peroxidation and antioxidents in apoptosis: implications in cancer, cardiovascular and neurological diseases. Biologia 55, 581–590 (2000).

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Zahedi, H., Eghtesadi, S., Seifirad, S., Rezaee, N., Shidfar, F., Heydari, I., Golestan, B., & Jazayeri, S. (2014) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/s40200-014-0081-6 · Cited by 67
Plasma lipid peroxidation and progression of disability in multiple sclerosis
Koch, M. W., Mostert, J. P., Arutjunyan, A. V., Stepanov, M., Teelken, A. W., Heersema, D. J., & Keyser, J. D. (2007) · European Journal of Neurology · doi:10.1111/j.1468-1331.2007.01739.x · Cited by 67
“What is the significance of our findings? Increased measures of oxidative stress have been described in many neurodegenerative diseases, including Alzheimer’s dementia, amyotrophic lateral sclerosis, Parkinson’s disease and Huntington’s disease [23,24].”
Background
Multi-target-directed triazole derivatives as promising agents for the treatment of Alzheimer’s disease
Kaur, A., Mann, S., Kaur, A., Priyadarshi, N., Goyal, B., Singhal, N. K., & Goyal, D. (2019) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2019.03.058 · Cited by 66
“Moreover, studies highlighted that inappropriate accumulation of redox-active metal ions (Cu and Fe) cause oxidative stress that ultimately lead to neuronal cell death by the generation of reactive oxygen species (ROS) through Haber-Weiss and Fenton-like reactions [25].”
Background
A rhodamine B-based “turn-on” fluorescent sensor for detecting Cu2+ and sulfur anions in aqueous media
Guo, D., Dong, Z., Luo, C., Zan, W., Yan, S., & Yao, X. (2013) · RSC Advances · doi:10.1039/c3ra45931d · Cited by 66
Mining the genome of Arabidopsis thaliana as a basis for the identification of novel bioactive peptides involved in oxidative stress tolerance
Coninck, B. D., Carron, D., Tavormina, P., Willem, L., Craik, D. J., Vos, C., Thevissen, K., Mathys, J., & Cammue, B. P. A. (2013) · Journal of Experimental Botany · doi:10.1093/jxb/ert295 · Cited by 66
A mitochondria-targeting ratiometric fluorescent probe for imaging hydrogen peroxide with long-wavelength emission and large Stokes shift
He, L., Liu, X., Zhang, Y., Yang, L., Fang, Q., Geng, Y., Chen, W., & Song, X. (2018) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2018.08.119 · Cited by 66
Oxidation‐Responsive Materials: Biological Rationale, State of the Art, Multiple Responsiveness, and Open Issues
Mohtadi, F. E., d’Arcy, R., & Tirelli, N. (2018) · Macromolecular Rapid Communications · doi:10.1002/marc.201800699 · Cited by 66
Biomedical Application of Reactive Oxygen Species–Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases
Liu, J., Li, Y., Chen, S., Lin, Y., Lai, H., Chen, B., & Chen, T. (2020) · Frontiers in Chemistry · doi:10.3389/fchem.2020.00838 · Cited by 70
“Additionally, as the concentration of polyunsaturated fatty acids in the cell membrane increases, the brain becomes more prone to lipid peroxidation (Youdim et al., 2000; Barnham et al., 2004).”
Background
Oxidative Modification of Proteins: From Damage to Catalysis, Signaling, and Beyond
Demasi, M., Augusto, O., Bechara, E. J. H., Bicev, R. N., Cerqueira, F. M., da Cunha, F. M., Denicola, A., Gomes, F., Miyamoto, S., Netto, L. E. S., et al. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8176 · Cited by 71
Gut Microbiota Composition and Epigenetic Molecular Changes Connected to the Pathogenesis of Alzheimer’s Disease
Nagu, P., Parashar, A., Behl, T., & Mehta, V. (2021) · Journal of Molecular Neuroscience · doi:10.1007/s12031-021-01829-3 · Cited by 68
“Oxidative stress is characterized by a significant imbalance between the free radical production and antioxidant defense of the brain, which contributes to neurodegeneration, cognitive decline, and ultimately, AD (Rösler et al. 1998; Durany et al. 1999; Christen 2000; Barnham et al. 2004; Sayre et al. 2005, 2008).”
Background
Nanoparticle-Guided Brain Drug Delivery: Expanding the Therapeutic Approach to Neurodegenerative Diseases
Riccardi, C., Napolitano, F., Montesarchio, D., Sampaolo, S., & Melone, M. A. B. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13111897 · Cited by 70
Highly bioactive iridium metal-complex alleviates spinal cord injury via ROS scavenging and inflammation reduction
Ji, Z., Gao, G., Ma, Y., Luo, J., Zhang, G., Yang, H., Li, N., He, Q., & Lin, H. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121481 · Cited by 67
Neural Consequences of Sleep Disordered Breathing: The Role of Intermittent Hypoxia
Morrell, M. J., & Twigg, G. L. (2007) · Springer eBooks · doi:10.1007/978-0-387-34817-9_8 · Cited by 66
Single chemosensor for multiple analytes: chromogenic and fluorogenic detection for fluoride anions and copper ions
Yang, H., Song, H., Zhu, Y., & Yang, S. (2012) · Tetrahedron Letters · doi:10.1016/j.tetlet.2012.01.139 · Cited by 66
Fermented papaya preparation attenuates β-amyloid precursor protein: β-amyloid–mediated copper neurotoxicity in β-amyloid precursor protein and β-amyloid precursor protein Swedish mutation overexpressing SH-SY5Y cells
Zhang, J., Mori, A., Chen, Q., & Zhao, B. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.07.023 · Cited by 66
A single colorimetric sensor for multiple targets: the sequential detection of Co 2+ and cyanide and the selective detection of Cu 2+ in aqueous solution
Jang, H. J., Jo, T. G., & Kim, C. (2017) · RSC Advances · doi:10.1039/c7ra01580a · Cited by 66
β-Caryophyllene (BCP) ameliorates MPP+ induced cytotoxicity
Wang, G., Ma, W., & Du, J. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.03.168 · Cited by 66
Assessment of copper, iron, zinc and manganese status and speciation in patients with Parkinson’s disease: A pilot study
Ajsuvakova, O. P., Tinkov, A. A., Willkommen, D., Skalnaya, A. A., Danilov, A. B., Pilipovich, A. A., Aschner, M., Skalny, A. V., Michalke, B., & Геннадиевна, С. М. (2019) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2019.126423 · Cited by 67
Mitochondria and the Brain: Bioenergetics and Beyond
Belenguer, P., Duarte, J. M. N., Schuck, P. F., & Ferreira, G. C. (2019) · Neurotoxicity Research · doi:10.1007/s12640-019-00061-7 · Cited by 69
Bisdemethoxycurcumin inhibits oxidative stress and antagonizes Alzheimer's disease by up‐regulating SIRT1
Xu, Y., Hu, R., He, D., Zhou, G., Wu, H., Xu, C., He, B., Wu, L., Wang, Y., Chang, Y., et al. (2020) · Brain and Behavior · doi:10.1002/brb3.1655 · Cited by 64
The Neuromelanin Paradox and Its Dual Role in Oxidative Stress and Neurodegeneration
Moreno-García, A., Kun, A., Calero, M., & Calero, O. (2021) · Antioxidants · doi:10.3390/antiox10010124 · Cited by 66
“Therefore, the NM anti-oxidant or pro-oxidant role will greatly depend on the result of the regulation of iron/NM ratio[3].”
Smart nano-micro platforms for ophthalmological applications: The state-of-the-art and future perspectives
Lyu, Q., Peng, L., Hong, X., Fan, T., Li, J., Cui, Y., Zhang, H., & Zhao, J. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120682 · Cited by 65
Production, Characterization, and Antioxidant Activities of an Exopolysaccharide Extracted from Spent Media Wastewater after Leuconostoc mesenteroides WiKim32 Fermentation
Choi, I. S., Ko, S. H., Lee, M. E., Kim, H. M., Yang, J. E., Jeong, S.-G., Lee, K. H., Chang, J. Y., Kim, J., & Park, H. W. (2021) · ACS Omega · doi:10.1021/acsomega.0c06095 · Cited by 68
Role of melatonin in Alzheimer’s disease: From preclinical studies to novel melatonin-based therapies
Roy, J., Wong, K. Y., Aquili, L., Uddin, M. S., Heng, B. C., Tipoe, G. L., Wong, K.-H., Fung, M., & Lim, L. W. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2022.100986 · Cited by 64
4-Hydroxynonenal modulation of p53 family gene expression in the SK-N-BE neuroblastoma cell line
Laurora, S., Tamagno, E., Briatore, F., Bardini, P., Pizzimenti, S., Toaldo, C., Reffo, P., Costelli, P., Dianzani, M. U., Danni, O., et al. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.10.014 · Cited by 65
A new rhodamine-coumarin Cu2+-selective colorimetric and ‘off–on’ fluorescence probe for effective use in chemistry and bioimaging along with its bound X-ray crystal structure
Goswami, S., Sen, D., Das, A. K., Das, N. K., Aich, K., Fun, H., Quah, C. K., Maity, A. K., & Saha, P. (2013) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2013.04.005 · Cited by 65
The Bipyridyl Herbicide Paraquat Induces Proteasome Dysfunction in Human Neuroblastoma SH-SY5Y Cells
Yang, W., & Tiffany‐Castiglioni, E. (2007) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390701459262 · Cited by 66
“There is extensive evidence that proteasome dysfunction is associated with neurodegenerative diseases such as PD, Alzheimer disease (AD), Huntington's disease (HD), and prion disease ( Ciechanover & Brundin, 2003 ; Barnham et al, 2004 ).”
Background
The dose-dependent toxicological effects and potential perturbation on the neurotransmitter secretion in brain following intranasal instillation of copper nanoparticles
Zhang, L., Bai, R., Liu, Y., Meng, L., Bai, L., Wang, L., Xu, L., Guyader, L. L., & Chen, C. (2011) · Nanotoxicology · doi:10.3109/17435390.2011.590906 · Cited by 65
“At the same time, studies on humans have indicated that the copper dyshomeostasis in the brain is related to neurodegenerative diseases such as Alzheimer’s disease (AD), prion diseases, Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS) (Loeffler et al. 1996; Maurer et al. 2000; Caviedes and Segura-Aguil…”
Background
Fabrication of fluorescent SiO 2 @zeolitic imidazolate framework-8 nanosensor for Cu 2+ detection
Song, Y., Hu, D., Liu, F., Chen, S., & Wang, L. (2014) · The Analyst · doi:10.1039/c4an01773k · Cited by 65
Antioxidant Activity of Galantamine and Some of its Derivatives
Tsvetkova, D. D., Obreshkova, D. P., Zheleva‐Dimitrova, D., & Saso, L. (2013) · Current Medicinal Chemistry · doi:10.2174/09298673113209990148 · Cited by 65
“Oxidative stress is implicated in the pathogenesis of aging [1] and different human diseases [2]: neurodegenerative diseases [3, 4], Alzheimer [1, 5-7], Parkinson [7], Huntington [1, 7], amyotrophic lateral sclerosis (Lou Gehrig's disease) [4], Down’s syndrome [7], atherosclerosis [7, 8], vascular disease [9], cancer…”
Background
Calorie restriction and stroke
Manzanero, S., Gelderblom, M., Magnus, T. U., & Arumugam, T. V. (2011) · Experimental & Translational Stroke Medicine · doi:10.1186/2040-7378-3-8 · Cited by 65
Astaxanthin Protects Primary Hippocampal Neurons against Noxious Effects of A β -Oligomers
Lobos, P., Bruna, B., Córdova, A., Veloso, P., Galaz, J. L., Adasme, T., Hidalgo, C., Muñoz, P., & Paula-Lima, A. C. (2016) · Neural Plasticity · doi:10.1155/2016/3456783 · Cited by 66
“The consequent redox imbalance generated by AβOs contributes to the pathological cascade in AD and other neurodegenerative diseases, in which oxidative stress is a common pathological feature [6, 7].”
Background
Multi sensing functions integrated into one carbon-dot based platform via different types of mechanisms
Li, C., Liu, W., Sun, X., Pan, W., & Wang, J. (2017) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2017.06.036 · Cited by 66
Activation of Nrf2 might reduce oxidative stress in human granulosa cells
Akino, N., Wada‐Hiraike, O., Terao, H., Honjoh, H., Isono, W., Fu, H., Hirano, M., Miyamoto, Y., Tanikawa, M., Harada, M., et al. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.10.002 · Cited by 65

Authors: Barnham, K. J., Masters, C. L., & Bush, A. I.
Affiliations: Mental Health Research Institute (AU)
Harvard University (US)
Corresponding author: Bush, Ashley I.
ORCID: Barnham, Kevin J.
Masters, Colin L.
Bush, Ashley I.
Venue: Nature Reviews Drug Discovery
Publisher: Springer Science and Business Media LLC
Published: 2004-03
Volume: 3
Issue: 3
Pages: 205-214
ISSN: 1474-1776 (ISSN-L)
1474-1784
DOI: 10.1038/nrd1330
OpenAlex: W2044627978
Cited by: 3,683
References: 140
Citations by year: 2026: 121 · 2025: 164 · 2024: 173 · 2023: 217 · 2022: 194 · 2021: 218 · 2020: 208 · 2019: 228 · 2018: 213 · 2017: 229 · 2016: 196 · 2015: 208 · 2014: 209 · 2013: 168 · 2012: 160
FWCI: 7.81
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Drug Discovery (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: oxidative stress, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, reactive oxygen species, antioxidant homeostasis, oxygen regulation, therapeutic target
MeSH terms: Animals, Antioxidants, Homeostasis, Humans, Clioquinol, Metals, Reactive Oxygen Species, Oxidative Stress, Neurodegenerative Diseases

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