The DOI matches its Crossref record; 139 of the 140 references it cites were found in a registry or an index.
Neurodegenerative diseases and oxidative stress
Abstract
Oxidative stress has been implicated in the progression of Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Oxygen is vital for life but is also potentially dangerous, and a complex system of checks and balances exists for utilizing this essential element. Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. The systems in place to cope with the biochemistry of oxygen are complex, and many questions about the mechanisms of oxygen regulation remain unanswered. However, this same complexity provides a number of therapeutic targets, and different strategies, including novel metal-protein attenuating compounds, aimed at a variety of targets have shown promise in clinical studies.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Thus, these metal ions have been shown to promote Aβ40 aggregation,23–27,29–32”
From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42Peptide (2012) · cites this paper as [24]
In the citing paper
“Remarkably high concentrations of Zn, Cu, and Fe have been found within the amyloid deposits in AD-affected brains,23,24”
From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42Peptide (2012) · cites this paper as [24]
In the citing paper
“For example, the non-specific chelator clioquinol (CQ) showed decreased Aβ aggregate formation that resulted in improved cognition in clinical trials.24,25,43–45”
From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42Peptide (2012) · cites this paper as [24]
In the citing paper
“This is in contrast with a large number of reports showing the aggregation-promoting effect of metal ions on the Aβ peptide.23–27,29–32,37,38”
From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42Peptide (2012) · cites this paper as [24]
In the citing paper
“Chronic oxidative stress and the resultant oxidative damage have been implicated in many human diseases including cardiovascular disease, neurodegenerative diseases, diabetes, cancer, and the aging process [18,19,20,21,22].”
From Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022) · cites this paper as [22]
In the citing paper
“The link between oxidative stress and the pathogenesis of neurodegenerative diseases is well-established [22,105].”
From Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022) · cites this paper as [22]
Citations
Cites
Free radicals in biology and medicine
Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178
Free Radicals in Biology and Medicine
Halliwell, B., & Gutteridge, J. M. C. (2015) · doi:10.1093/acprof:oso/9780198717478.001.0001 · Cited by 8,990
Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., & Goedert, M. (1997) · Nature · doi:10.1038/42166 · Cited by 8,382
Dauer, W., & Przedborski, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00568-3 · Cited by 5,469
Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., & Müller-Hill, B. (1987) · Nature · doi:10.1038/325733a0 · Cited by 4,619
Self-citationAmyloid plaque core protein in Alzheimer disease and Down syndrome.
Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431
Self-citationMotor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation
Gurney, M. E., Pu, H., Chiu, A. Y., Dal Canto, M. C., Polchow, C. Y., Alexander, D. D., Caliendo, J., Hentati, A., Kwon, Y. W., Deng, H.-X., et al. (1994) · Science · doi:10.1126/science.8209258 · Cited by 4,143
Friedreich's Ataxia: Autosomal Recessive Disease Caused by an Intronic GAA Triplet Repeat Expansion
Campuzano, V., Montermini, L., Moltò, M. D., Pianese, L., Cossée, M., Cavalcanti, F., Monros, E., Rodius, F., Duclos, F., Monticelli, A., et al. (1996) · Science · doi:10.1126/science.271.5254.1423 · Cited by 2,786
A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease
Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361704 · Cited by 2,380
Flagged first, then by citations
1 of the 140 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Ferrari, C. K. B. Free radicals, lipid peroxidation and antioxidents in apoptosis: implications in cancer, cardiovascular and neurological diseases. Biologia 55, 581–590 (2000).
Cited by
Sorted by citations
Items 1,001–1,020 of 1,020
Interweaving epilepsy and neurodegeneration: Vitamin E as a treatment approach
Upaganlawar, A. B., Wankhede, N. L., Kale, M. B., Umare, M. D., Sehgal, A., Singh, S., Bhatia, S., Al-Harrasi, A., Najda, A., Nurzyńska-Wierdak, R., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112146 · Cited by 53
Charkoudian, L. K., Dentchev, T., Lukinova, N., Wolkow, N., Dunaief, J. L., & Franz, K. J. (2008) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2008.08.001 · Cited by 49
Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis
Tian, R., Abarientos, A., Hong, J., Hashemi, S. H., Yan, R., Dräger, N., Leng, K., Nalls, M. A., Singleton, A. B., Xu, K., et al. (2020) · doi:10.1101/2020.06.27.175679 · Cited by 414
Specific Domains of Aβ Facilitate Aggregation on and Association with Lipid Bilayers
Yates, E. A., Owens, S. L., Lynch, M. F., Cucco, E. M., Umbaugh, C. S., & Legleiter, J. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.03.022 · Cited by 41
XIAP regulates intracellular ROS by enhancing antioxidant gene expression
Resch, U., Schichl, Y. M., Sattler, S., & de Martin, R. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.07.142 · Cited by 41
Alternative platelet activation pathways and their role in neurodegenerative diseases
Ferrer-Raventós, P., & Beyer, K. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105512 · Cited by 39
“In AD and other diseases, oxidative stress induces platelet and neuronal mitochondrial dysfunction and cell death (Barnham et al., 2004; Beal, 1996).”
BackgroundOlatunji, O. J., Chen, H., & Zhou, Y. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.07.013 · Cited by 38
Gerecke, K. M., Kolobova, A., Allen, S., & Fawer, J. L. (2013) · Brain Research · doi:10.1016/j.brainres.2013.02.027 · Cited by 37
Bae, D., Seol, H., Yoon, H.-G., Na, J.-R., Oh, K., Choi, C. Y., Lee, D.-W., Jun, W., Youl Lee, K., Lee, J., et al. (2012) · Pharmaceutical Biology · doi:10.3109/13880209.2011.642886 · Cited by 35
“…ion complexes which were excessively released from injury to the CNS: according to this theory, Aβ and copper/zinc ions form an Aβ-metal ion complex, which produces reactive oxygen species (ROS), such as O 2 −, H 2 O 2 and OH (Curtain et al., 2001; Barnham et al., 2004; Valko et al., 2005).”
BackgroundExtraction methods, encapsulation techniques, and health benefits of astaxanthin
Panagiotakopoulos, I., & Nasopoulou, C. (2024) · Sustainability · doi:10.3390/su162410859 · Cited by 33
“The most commonly observed neurodegenerative disorders include Alzheimer’s disease and Parkinson’s disease [160,161].”
Liquid-liquid phase separation in Alzheimer’s disease
Fu, Q., Zhang, B., Chen, X., & Chu, L. (2024) · Journal of Molecular Medicine · doi:10.1007/s00109-023-02407-3 · Cited by 33
“Previous researches have demonstrated that metal dysho-meostasis participated in the pathogenesis of AD [64–72].”
Prosdocimi, T., De Gioia, L., Zampella, G., & Bertini, L. (2016) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-015-1322-y · Cited by 32
Discovery of neuroprotective compounds by machine learning approaches
Fang, J., Pang, X., Yan, R., Lian, W., Li, C., Wang, Q., Liu, A.-L., & Du, G.-H. (2016) · RSC Advances · doi:10.1039/c5ra23035g · Cited by 31
Ma, J., Lim, C., Sacher, J. R., Van Houten, B., Qian, W., & Wipf, P. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.06.073 · Cited by 27
Li, X., Li, T., Zhan, F., Cheng, F., Lu, L., Zhang, B., Li, J., Hu, Z., Zhou, S., Jia, Y., et al. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00520 · Cited by 18
1,5-Benzodiazepin-2(3H)-ones: In Vitro Evaluation as Antiparkinsonian Agents
Ortíz de Zárate, A., Pérez-Torralba, M., Bonet Isidro, I., López, C., Claramunt, R. M., Martínez-Casanova, D., Sánchez-Vera, I., Jiménez-González, J., & Lavandera, J. L. (2021) · Antioxidants · doi:10.3390/antiox10101584 · Cited by 11
Comes, G., Manso, Y., Escrig, A., Fernandez-Gayol, O., Sanchis, P., Molinero, A., Giralt, M., Carrasco, J., & Hidalgo, J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020251 · Cited by 10
Zhu, F., Liu, Z., Wu, X., Xu, D., Li, Q., Chen, X., Pang, W., Duan, X., & Wang, Y. (2023) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2023.106618 · Cited by 7
“Excessive production and accumulation of intracellular H2O2 can also lead to oxidative stress, destroy cell components, and then result in a variety of diseases such as neurodegenerative [2,3], cardiovascular disease [4], leukemia [5] and cancer [6].”
BackgroundFamilial amyotrophic lateral sclerosis (FALS): Emerging hints from redox proteomics.
Dalle-Donne, I. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.029 · Cited by 5
Tomasello, M. F., Di Rosa, M. C., Naletova, I., Sciacca, M. F. M., Giuffrida, A., Maccarrone, G., & Attanasio, F. (2025) · Bioinorganic Chemistry and Applications · doi:10.1155/bca/4226220 · Cited by 3
Metadata
- Authors
- Barnham, K. J., Masters, C. L., & Bush, A. I.
- Affiliations
- Mental Health Research Institute (AU)
- Harvard University (US)
- Corresponding author
- Bush, Ashley I.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2004-03
- Volume
- 3
- Issue
- 3
- Pages
- 205-214
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W2044627978
- Cited by
- 3,683
- References
- 140
- Citations by year
- 2026: 121 · 2025: 164 · 2024: 173 · 2023: 217 · 2022: 194 · 2021: 218 · 2020: 208 · 2019: 228 · 2018: 213 · 2017: 229 · 2016: 196 · 2015: 208 · 2014: 209 · 2013: 168 · 2012: 160
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Drug Discovery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- oxidative stress, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, reactive oxygen species, antioxidant homeostasis, oxygen regulation, therapeutic target
- MeSH terms
- Animals, Antioxidants, Homeostasis, Humans, Clioquinol, Metals, Reactive Oxygen Species, Oxidative Stress, Neurodegenerative Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
