The DOI matches its Crossref record; 139 of the 140 references it cites were found in a registry or an index.
Neurodegenerative diseases and oxidative stress
Abstract
Oxidative stress has been implicated in the progression of Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Oxygen is vital for life but is also potentially dangerous, and a complex system of checks and balances exists for utilizing this essential element. Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. The systems in place to cope with the biochemistry of oxygen are complex, and many questions about the mechanisms of oxygen regulation remain unanswered. However, this same complexity provides a number of therapeutic targets, and different strategies, including novel metal-protein attenuating compounds, aimed at a variety of targets have shown promise in clinical studies.
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“Thus, these metal ions have been shown to promote Aβ40 aggregation,23–27,29–32”
From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42Peptide (2012) · cites this paper as [24]
In the citing paper
“Remarkably high concentrations of Zn, Cu, and Fe have been found within the amyloid deposits in AD-affected brains,23,24”
From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42Peptide (2012) · cites this paper as [24]
In the citing paper
“For example, the non-specific chelator clioquinol (CQ) showed decreased Aβ aggregate formation that resulted in improved cognition in clinical trials.24,25,43–45”
From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42Peptide (2012) · cites this paper as [24]
In the citing paper
“This is in contrast with a large number of reports showing the aggregation-promoting effect of metal ions on the Aβ peptide.23–27,29–32,37,38”
From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42Peptide (2012) · cites this paper as [24]
In the citing paper
“Chronic oxidative stress and the resultant oxidative damage have been implicated in many human diseases including cardiovascular disease, neurodegenerative diseases, diabetes, cancer, and the aging process [18,19,20,21,22].”
From Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022) · cites this paper as [22]
In the citing paper
“The link between oxidative stress and the pathogenesis of neurodegenerative diseases is well-established [22,105].”
From Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022) · cites this paper as [22]
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A computational study of the Fenton reaction in different pH ranges
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Electrochemical Monitoring of Paclitaxel‐Induced ROS Release from Mitochondria inside Single Cells
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“…(Kanvah et al. 2009; Shibutani et al. 1991) but is also relevant to serious diseases such as cardiovascular disorders (Abe and Berk 1998), neurodegenerative diseases (Barnham et al. 2004), Alzheimer’s disease (Behl et al. 1994) and cancer (Finkel et al. 2007; Murphy et al. 2011; Park et al. 2008).”
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Background
Metadata
- Authors
- Barnham, K. J., Masters, C. L., & Bush, A. I.
- Affiliations
- Mental Health Research Institute (AU)
- Harvard University (US)
- Corresponding author
- Bush, Ashley I.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2004-03
- Volume
- 3
- Issue
- 3
- Pages
- 205-214
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W2044627978
- Cited by
- 3,683
- References
- 140
- Citations by year
- 2026: 121 · 2025: 164 · 2024: 173 · 2023: 217 · 2022: 194 · 2021: 218 · 2020: 208 · 2019: 228 · 2018: 213 · 2017: 229 · 2016: 196 · 2015: 208 · 2014: 209 · 2013: 168 · 2012: 160
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Drug Discovery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- oxidative stress, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, reactive oxygen species, antioxidant homeostasis, oxygen regulation, therapeutic target
- MeSH terms
- Animals, Antioxidants, Homeostasis, Humans, Clioquinol, Metals, Reactive Oxygen Species, Oxidative Stress, Neurodegenerative Diseases
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