Cited by 3,683Redox biology and oxidative stressAntioxidant Activity and Oxidative StressAlzheimer's disease research and treatments

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Neurodegenerative diseases and oxidative stress

Barnham, Kevin J., Masters, Colin L., Bush, Ashley I.·2004·Nature Reviews Drug Discovery

DOI 10.1038/nrd1330

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Abstract

Oxidative stress has been implicated in the progression of Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Oxygen is vital for life but is also potentially dangerous, and a complex system of checks and balances exists for utilizing this essential element. Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. The systems in place to cope with the biochemistry of oxygen are complex, and many questions about the mechanisms of oxygen regulation remain unanswered. However, this same complexity provides a number of therapeutic targets, and different strategies, including novel metal-protein attenuating compounds, aimed at a variety of targets have shown promise in clinical studies.

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BackgroundInfluential

Authors: Barnham, K. J., Masters, C. L., & Bush, A. I.
Affiliations: Mental Health Research Institute (AU)
Harvard University (US)
Corresponding author: Bush, Ashley I.
ORCID: Barnham, Kevin J.
Masters, Colin L.
Bush, Ashley I.
Venue: Nature Reviews Drug Discovery
Publisher: Springer Science and Business Media LLC
Published: 2004-03
Volume: 3
Issue: 3
Pages: 205-214
ISSN: 1474-1776 (ISSN-L)
1474-1784
DOI: 10.1038/nrd1330
OpenAlex: W2044627978
Cited by: 3,683
References: 140
Citations by year: 2026: 121 · 2025: 164 · 2024: 173 · 2023: 217 · 2022: 194 · 2021: 218 · 2020: 208 · 2019: 228 · 2018: 213 · 2017: 229 · 2016: 196 · 2015: 208 · 2014: 209 · 2013: 168 · 2012: 160
FWCI: 7.81
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Drug Discovery (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: oxidative stress, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, reactive oxygen species, antioxidant homeostasis, oxygen regulation, therapeutic target
MeSH terms: Animals, Antioxidants, Homeostasis, Humans, Clioquinol, Metals, Reactive Oxygen Species, Oxidative Stress, Neurodegenerative Diseases

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