Cited by 3,683Redox biology and oxidative stressAntioxidant Activity and Oxidative StressAlzheimer's disease research and treatments

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Neurodegenerative diseases and oxidative stress

Barnham, Kevin J., Masters, Colin L., Bush, Ashley I.·2004·Nature Reviews Drug Discovery

DOI 10.1038/nrd1330

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Abstract

Oxidative stress has been implicated in the progression of Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Oxygen is vital for life but is also potentially dangerous, and a complex system of checks and balances exists for utilizing this essential element. Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. The systems in place to cope with the biochemistry of oxygen are complex, and many questions about the mechanisms of oxygen regulation remain unanswered. However, this same complexity provides a number of therapeutic targets, and different strategies, including novel metal-protein attenuating compounds, aimed at a variety of targets have shown promise in clinical studies.

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Free radicals in biology and medicine
Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178
Free Radicals in Biology and Medicine
Halliwell, B., & Gutteridge, J. M. C. (2015) · doi:10.1093/acprof:oso/9780198717478.001.0001 · Cited by 8,990
α-Synuclein in Lewy bodies
Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., & Goedert, M. (1997) · Nature · doi:10.1038/42166 · Cited by 8,382
Parkinson's Disease
Dauer, W., & Przedborski, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00568-3 · Cited by 5,469
Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., & Müller-Hill, B. (1987) · Nature · doi:10.1038/325733a0 · Cited by 4,619
Self-citation
Amyloid plaque core protein in Alzheimer disease and Down syndrome.
Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431
Self-citation
Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation
Gurney, M. E., Pu, H., Chiu, A. Y., Dal Canto, M. C., Polchow, C. Y., Alexander, D. D., Caliendo, J., Hentati, A., Kwon, Y. W., Deng, H.-X., et al. (1994) · Science · doi:10.1126/science.8209258 · Cited by 4,143
Friedreich's Ataxia: Autosomal Recessive Disease Caused by an Intronic GAA Triplet Repeat Expansion
Campuzano, V., Montermini, L., Moltò, M. D., Pianese, L., Cossée, M., Cavalcanti, F., Monros, E., Rodius, F., Duclos, F., Monticelli, A., et al. (1996) · Science · doi:10.1126/science.271.5254.1423 · Cited by 2,786
A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease
Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361704 · Cited by 2,380

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Ferrari, C. K. B. Free radicals, lipid peroxidation and antioxidents in apoptosis: implications in cancer, cardiovascular and neurological diseases. Biologia 55, 581–590 (2000).

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“HNE is known to interact with cell cycle controlling proteins such as p38 [57] and p53 [66], it can also activate the pro-apoptotic protein caspase-3, and inhibit the NF-κB-dependent activation of the antiapoptotic enzymes Bcl-2 and MnSOD [66].”
BackgroundInfluential
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Olguín‐Albuerne, M., & Morán, J. (2015) · ASN NEURO · doi:10.1177/1759091415578712 · Cited by 78
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Background
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Chen, Y., Zhu, C., Cen, J., Li, J., He, W., Jiao, Y., & Guo, Z. (2013) · Chemical Communications · doi:10.1039/c3cc42959h · Cited by 75
Evaluation of quantitative probes for weaker Cu(i) binding sites completes a set of four capable of detecting Cu(i) affinities from nanomolar to attomolar
Xiao, Z., Gottschlich, L., van der Meulen, R., Udagedara, S. R., & Wedd, A. G. (2013) · Metallomics · doi:10.1039/c3mt00032j · Cited by 77
Sulforaphane induces Nrf2 target genes and attenuates inflammatory gene expression in microglia from brain of young adult and aged mice
Townsend, B. E., & Johnson, R. W. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.11.004 · Cited by 77
“This finding is particularly important because the progression of age-related cognitive decline and neurodegenerative pathologies is closely associated with increased oxidative stress and microglial activation (Barnham et al., 2004; Dröge and Schipper 2007; Liu and Hong 2003).”
Cost-effective approach to detect Cu( ii ) and Hg( ii ) by integrating a smartphone with the colorimetric response from a NBD-benzimidazole based dyad
Anand, T., & Sahoo, S. K. (2019) · Physical Chemistry Chemical Physics · doi:10.1039/c9cp00002j · Cited by 75
Betanin purification from red beetroots and evaluation of its anti-oxidant and anti-inflammatory activity on LPS-activated microglial cells
Ahmadi, H., Nayeri, Z., Minuchehr, Z., Sabouni, F., & Mohammadi, M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0233088 · Cited by 78
“Bearing in mind the correlation between ROS production with oxidative stress and mitochondrial dysfunction [36].”
Background
Formononetin attenuates H2O2-induced cell death through decreasing ROS level by PI3K/Akt-Nrf2-activated antioxidant gene expression and suppressing MAPK-regulated apoptosis in neuronal SH-SY5Y cells
Sugimoto, M., Ko, R., Goshima, H., Koike, A., Shibano, M., & Fujimori, K. (2021) · NeuroToxicology · doi:10.1016/j.neuro.2021.05.014 · Cited by 75
Flexible Nets of Malleable Guardians: Intrinsically Disordered Chaperones in Neurodegenerative Diseases
Uversky, V. N. (2010) · Chemical Reviews · doi:10.1021/cr100186d · Cited by 75
Thioredoxin System Regulation in the Central Nervous System: Experimental Models and Clinical Evidence
Silva‐Adaya, D., Gonsebatt, M. E., & Guevara, J. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/590808 · Cited by 80
A phenothiazine-based “naked-eye” fluorescent probe for the dual detection of Hg2+ and Cu2+: Application as a solid state sensor
Kaur, M., Cho, M. J., & Choi, D. H. (2015) · Dyes and Pigments · doi:10.1016/j.dyepig.2015.09.030 · Cited by 75
Possible nitric oxide mechanism in the protective effect of hesperidin against pentylenetetrazole (PTZ)-induced kindling and associated cognitive dysfunction in mice
Kumar, A., Lalitha, S., & Mishra, J. (2013) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2013.06.007 · Cited by 75
“Various reports suggest that NO plays amajor role in the development of kindling [6], and, recently, it has been reported that oxidative stress and nitrosative stress are the main pathological hallmarks of various neurodegenerative disorders including epilepsy [51,52].”
Dihydroquinazolinone based “turn-off” fluorescence sensor for detection of Cu 2+ ions
Borase, P. N., Thale, P. B., & Shankarling, G. S. (2016) · Dyes and Pigments · doi:10.1016/j.dyepig.2016.07.025 · Cited by 75
Perylene Diimide as a Precise Graphene-like Superoxide Dismutase Mimetic
Jalilov, A. S., Nilewski, L. G., Berka, V., Zhang, C., Yakovenko, A. A., Wu, G., Kent, T. A., Tsai, A.-L., & Tour, J. M. (2017) · ACS Nano · doi:10.1021/acsnano.6b08211 · Cited by 75
“PEG8−PDI •− + O2 • ̶ + 2 H → PEG8−PDI + H2O2 (5)”
IGF-II promotes neuroprotection and neuroplasticity recovery in a long-lasting model of oxidative damage induced by glucocorticoids
Martín‐Montañez, E., Millón, C., Boraldi, F., García-Guirado, F., Pedraza, C., Lara, E., Santín, L. J., Pavía, J., & Garcia‐Fernandez, M. I. (2017) · Redox Biology · doi:10.1016/j.redox.2017.05.012 · Cited by 75
“As a consequence of oxidative stress, both the function and transport of mitochondria to synaptic regions are altered, impairing synaptic function [23–25], which results in neurodegeneration [26].”
Background
The beneficial effects of HMG-CoA reductase inhibitors in the processes of neurodegeneration
Saravi, S. S. S., Saravi, S. S. S., Arefidoust, A., & Dehpour, A. R. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-017-0021-5 · Cited by 77
A new Schiff-base chemosensor for selective detection of Cu2+ and Co2+ and its copper complex for colorimetric sensing of S2− in aqueous solution
Kim, M. S., Lee, S. Y., Jung, J. M., & Kim, C. (2017) · Photochemical & Photobiological Sciences · doi:10.1039/c7pp00229g · Cited by 75
The Chemistry of Neurodegeneration: Kinetic Data and Their Implications
Pavlin, M., Repič, M., Vianello, R., & Mavri, J. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9284-1 · Cited by 75
“In this study, we mainly address the oxidative stressdependent processes of neurodegeneration [8–12] and offer prospective strategies for its prevention.”
Background
Oxidative challenge in Alzheimer's disease: state of knowledge and future needs
Cervellati, C., Wood, P. L., Romani, A., Valacchi, G., Squerzanti, M., Sanz, J. M., Ortolani, B., & Zuliani, G. (2016) · Journal of Investigative Medicine · doi:10.1136/jim-2015-000017 · Cited by 75
Protective effects of sesamol on systemic oxidative stress-induced cognitive impairments via regulation of Nrf2/Keap1 pathway
Ren, B., Yuan, T., Diao, Z., Zhang, C., Liu, Z., & Liu, X. (2018) · Food & Function · doi:10.1039/c8fo01436a · Cited by 74
Expanding Role of Ubiquitin in Translational Control
Dougherty, S. E., Maduka, A. O., Inada, T., & Silva, G. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031151 · Cited by 76
Lipid peroxidation end product 4-hydroxy-trans-2-nonenal triggers unfolded protein response and heme oxygenase-1 expression in PC12 cells: Roles of ROS and MAPK pathways
Lin, M.-H., Yen, J.-H., Weng, C., Wang, L., Ha, C.-L., & Wu, M. (2013) · Toxicology · doi:10.1016/j.tox.2013.11.007 · Cited by 74
Regulation of Prion Gene Expression by Transcription Factors SP1 and Metal Transcription Factor-1
Bellingham, S. A., Coleman, L. A., Masters, C. L., Camakaris, J., & Hill, A. F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804755200 · Cited by 74
Self-citation
Studies on the potential protective effect of cinnamon against bisphenol A- and octylphenol-induced oxidative stress in male albino rats
Morgan, A. M., El-Ballal, S., El‐Bialy, B. E., & El-Borai, N. B. (2014) · Toxicology Reports · doi:10.1016/j.toxrep.2014.04.003 · Cited by 75
“Reactive oxygen species (ROS) are cytotoxic agents that lead to damage of nucleic acid bases, lipids and proteins, thereby leading to cell death [6,43].”
Background
Composition, standardization and chemical profiling of Banisteriopsis caapi, a plant for the treatment of neurodegenerative disorders relevant to Parkinson's disease
Wang, Y., Samoylenko, V., Tekwani, B. L., Khan, I. A., Miller, L. S., Chaurasiya, N. D., Rahman, M. M., Tripathi, L. M., Khan, S. I., Joshi, V. C., et al. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.02.013 · Cited by 74
“In addition, oxidative stress induced by reactive oxygen species has been strongly associated with the pathogenesis of neurodegenerative disorders, including Alzheimer’s diseases (Barnham et al., 2004).”
Solvent-dependent fluorescent-colorimetric probe for dual monitoring of Al 3+ and Cu 2+ in aqueous solution: an application to bio-imaging
Ghorai, A., Mondal, J., Chowdhury, S., & Patra, G. K. (2016) · Dalton Transactions · doi:10.1039/c6dt01795a · Cited by 74
A novel colorimetric chemosensor for multiple target metal ions Fe2+, Co2+, and Cu2+ in a near-perfect aqueous solution: Experimental and theoretical studies
Jung, J. M., Lee, S. Y., & Kim, C. (2017) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2017.05.055 · Cited by 74
Targeting lipid peroxidation and mitochondrial imbalance in Friedreich's ataxia
Abeti, R., Uzun, E., Renganathan, I., Honda, T., Pook, M. A., & Giunti, P. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.05.015 · Cited by 77
Pyridoxal derived chemosensor for chromogenic sensing of Cu 2+ and fluorogenic sensing of Fe 3+ in semi-aqueous medium
Sahoo, S. K., Sharma, D., Moirangthem, A., Kuba, A., Thomas, R., Kumar, R., Kuwar, A., Choi, H., & Basu, A. (2015) · Journal of Luminescence · doi:10.1016/j.jlumin.2015.12.035 · Cited by 73
Circular RNA-ZNF609 regulates retinal neurodegeneration by acting as miR-615 sponge
Wang, J.-J., Liu, C., Shan, K. Y., Liu, B.-H., Li, X., Zhang, S.-J., Zhou, R.-M., Dong, R., Yan, B., & Sun, X.-H. (2018) · Theranostics · doi:10.7150/thno.25156 · Cited by 75
“A broad range of neurodegenerative disorders, including amyotrophic lateral sclerosis, Parkinson's, Alzheimer's, Huntington's, and glaucoma, are usually characterized by neuronal damage [1, 2].”
Background
A Copper Nanocluster-Based Fluorescent Probe for Real-Time Imaging and Ratiometric Biosensing of Calcium Ions in Neurons
Liu, Z., Jing, X., Zhang, S., & Tian, Y. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.8b05360 · Cited by 72
Synchronous detection of glutathione/hydrogen peroxide for monitoring redox status in vivo with a ratiometric upconverting nanoprobe
Zheng, J., Wu, Y., Xing, D., & Zhang, T. (2019) · Nano Research · doi:10.1007/s12274-019-2327-6 · Cited by 73
Effects of Isorhamnetin on Diabetes and Its Associated Complications: A Review of In Vitro and In Vivo Studies and a Post Hoc Transcriptome Analysis of Involved Molecular Pathways
Kalai, F. Z., Boulaaba, M., Ferdousi, F., & Isoda, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020704 · Cited by 78
“Several researchers have shown that long-term exposure to free radicals contributes to the development of chronic diseases, such as cancer [60], diabetes [61], cardiovascular problems [62], and neurodegenerative disease [63].”
Background
Proton dissociation is important to understanding structure–activity relationships of gallic acid antioxidants
Ji, H., Zhang, H., & Shen, L. (2006) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.04.096 · Cited by 75
Involvement of oxidative stress-activated JNK signaling in the methamphetamine-induced cell death of human SH-SY5Y cells
Wang, S., Yen, J., Yin, P., Chi, C., & Lee, H. (2008) · Toxicology · doi:10.1016/j.tox.2008.01.020 · Cited by 73

Authors: Barnham, K. J., Masters, C. L., & Bush, A. I.
Affiliations: Mental Health Research Institute (AU)
Harvard University (US)
Corresponding author: Bush, Ashley I.
ORCID: Barnham, Kevin J.
Masters, Colin L.
Bush, Ashley I.
Venue: Nature Reviews Drug Discovery
Publisher: Springer Science and Business Media LLC
Published: 2004-03
Volume: 3
Issue: 3
Pages: 205-214
ISSN: 1474-1776 (ISSN-L)
1474-1784
DOI: 10.1038/nrd1330
OpenAlex: W2044627978
Cited by: 3,683
References: 140
Citations by year: 2026: 121 · 2025: 164 · 2024: 173 · 2023: 217 · 2022: 194 · 2021: 218 · 2020: 208 · 2019: 228 · 2018: 213 · 2017: 229 · 2016: 196 · 2015: 208 · 2014: 209 · 2013: 168 · 2012: 160
FWCI: 7.81
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Drug Discovery (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: oxidative stress, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, reactive oxygen species, antioxidant homeostasis, oxygen regulation, therapeutic target
MeSH terms: Animals, Antioxidants, Homeostasis, Humans, Clioquinol, Metals, Reactive Oxygen Species, Oxidative Stress, Neurodegenerative Diseases

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