The DOI matches its Crossref record; 108 of the 108 references it cites were found in a registry or an index.
DNA methylation landscapes: provocative insights from epigenomics
Abstract
The genomes of many animals, plants and fungi are tagged by methylation of DNA cytosine. To understand the biological significance of this epigenetic mark it is essential to know where in the genome it is located. New techniques are making it easier to map DNA methylation patterns on a large scale and the results have already provided surprises. In particular, the conventional view that DNA methylation functions predominantly to irreversibly silence transcription is being challenged. Not only is promoter methylation often highly dynamic during development, but many organisms also seem to target DNA methylation specifically to the bodies of active genes.
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“here, increased levels of methylation (i.e.hypermethylation) result in a proportionally increased transcription rate and vice versa hypomethylation leads to reduced transcription levels (Suzuki & Bird, 2008)”
From The applied implications of epigenetics in anxiety, affective and stress-related disorders - A review and synthesis on psychosocial stress, psychotherapy and prevention (2020) · cites this paper as Suzuki & Bird, 2008
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Cites
DNA methylation patterns and epigenetic memory
Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124
Self-citationOkano, M., Bell, D. W., Haber, D. A., & Li, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81656-6 · Cited by 6,143
Jones, P. A., & Baylin, S. B. (2007) · Cell · doi:10.1016/j.cell.2007.01.029 · Cited by 4,515
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
CpG-rich islands and the function of DNA methylation
Bird, A. P. (1986) · Nature · doi:10.1038/321209a0 · Cited by 3,777
Self-citationEpigenetic differences arise during the lifetime of monozygotic twins
Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500398102 · Cited by 3,602
CpG Islands in vertebrate genomes
Gardiner‐Garden, M., & Frommer, M. (1987) · Journal of Molecular Biology · doi:10.1016/0022-2836(87)90689-9 · Cited by 3,417
Frommer, M., McDonald, L. E., Millar, D. S., Collis, C. M., Watt, F., Grigg, G. W., Molloy, P. L., & Paul, C. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.5.1827 · Cited by 3,238
Bird, A. (2007) · Nature · doi:10.1038/nature05913 · Cited by 3,011
Self-citationDNA methylation and human disease
Robertson, K. D. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1655 · Cited by 2,864
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Sarda, S., Das, A., Vinson, C., & Hannenhalli, S. (2017) · Genome Research · doi:10.1101/gr.212050.116 · Cited by 43
Wang, Q., & Su, L. (2019) · mBio · doi:10.1128/mbio.01344-19 · Cited by 34
Laan, L., Klar, J., Sobol, M., Hoeber, J., Shahsavani, M., Kele, M., Fatima, A., Zakaria, M., Annerén, G., Falk, A., et al. (2020) · Clinical Epigenetics · doi:10.1186/s13148-019-0803-1 · Cited by 33
McNerney, M. W., Sheng, T., Nechvatal, J. M., Lee, A. G., Lyons, D. M., Soman, S., Liao, C.-P., O’Hara, R., Hallmayer, J., Taylor, J., et al. (2018) · PLOS ONE · doi:10.1371/journal.pone.0192222 · Cited by 32
Ramo-Fernández, L., Gumpp, A. M., Boeck, C., Krause, S., Bach, A. M., Waller, C., Kolassa, I.-T., & Karabatsiakis, A. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01546-w · Cited by 30
The molecular basis of depression: implications of sex-related differences in epigenetic regulation
Kawatake-Kuno, A., Murai, T., & Uchida, S. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.708004 · Cited by 23
Transcription factors that define the epigenome structures and transcriptomes in microglia
Saeki, K., & Ozato, K. (2025) · Experimental Hematology · doi:10.1016/j.exphem.2025.104814 · Cited by 11
Metadata
- Authors
- Suzuki, M. M., & Bird, A.
- Affiliations
- Wellcome Centre for Cell Biology (GB)
- Corresponding author
- Suzuki, Miho M.
- Venue
- Nature Reviews Genetics
- Published
- 2008-06
- Volume
- 9
- Issue
- 6
- Pages
- 465-476
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2114970231
- Cited by
- 3,039
- References
- 108
- Citations by year
- 2026: 61 · 2025: 89 · 2024: 120 · 2023: 128 · 2022: 167 · 2021: 236 · 2020: 184 · 2019: 163 · 2018: 173 · 2017: 201 · 2016: 195 · 2015: 195 · 2014: 224 · 2013: 214 · 2012: 198
- FWCI
- 12.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Keywords
- DNA methylation, gene body, promoter methylation, gene silencing, gene expression regulation, epigenomics, cytosine methylation, development (biology), genome-wide methylation mapping
- MeSH terms
- Animals, Humans, Transcription, Genetic, Genome, DNA Methylation, Genomics, Epigenesis, Genetic
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