Cited by 3,039Epigenetics and DNA MethylationGenomics and Chromatin DynamicsGenetic Syndromes and Imprinting

The DOI matches its Crossref record; 108 of the 108 references it cites were found in a registry or an index.

DNA methylation landscapes: provocative insights from epigenomics

Suzuki, Miho M., Bird, Adrian·2008·Nature Reviews Genetics

Open this paper in CoChat — free account

Abstract

The genomes of many animals, plants and fungi are tagged by methylation of DNA cytosine. To understand the biological significance of this epigenetic mark it is essential to know where in the genome it is located. New techniques are making it easier to map DNA methylation patterns on a large scale and the results have already provided surprises. In particular, the conventional view that DNA methylation functions predominantly to irreversibly silence transcription is being challenged. Not only is promoter methylation often highly dynamic during development, but many organisms also seem to target DNA methylation specifically to the bodies of active genes.

Integrity signals

Registry

Crossref · 10.1038/nrg2341

Cites

108 of 108 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

DNA methylation patterns and epigenetic memory
Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124
Self-citation
DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development
Okano, M., Bell, D. W., Haber, D. A., & Li, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81656-6 · Cited by 6,143
The Epigenomics of Cancer
Jones, P. A., & Baylin, S. B. (2007) · Cell · doi:10.1016/j.cell.2007.01.029 · Cited by 4,515
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
CpG-rich islands and the function of DNA methylation
Bird, A. P. (1986) · Nature · doi:10.1038/321209a0 · Cited by 3,777
Self-citation
Epigenetic differences arise during the lifetime of monozygotic twins
Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500398102 · Cited by 3,602
CpG Islands in vertebrate genomes
Gardiner‐Garden, M., & Frommer, M. (1987) · Journal of Molecular Biology · doi:10.1016/0022-2836(87)90689-9 · Cited by 3,417
A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands
Frommer, M., McDonald, L. E., Millar, D. S., Collis, C. M., Watt, F., Grigg, G. W., Molloy, P. L., & Paul, C. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.5.1827 · Cited by 3,238
Perceptions of epigenetics
Bird, A. (2007) · Nature · doi:10.1038/nature05913 · Cited by 3,011
Self-citation
DNA methylation and human disease
Robertson, K. D. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1655 · Cited by 2,864

Show all 108 references

Sorted by citations

Items 401–500 of 1,007

Epigenetic Effects of Green Tea Polyphenols in Cancer
Henning, S. M., Wang, P., Carpenter, C. L., & Heber, D. (2013) · Epigenomics · doi:10.2217/epi.13.57 · Cited by 106
Lin28A Binds Active Promoters and Recruits Tet1 to Regulate Gene Expression
Zeng, Y., Yao, B., Shin, J., Lin, L., Kim, N., Song, Q., Liu, S., Su, Y., Guo, J. U., Huang, L., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.11.020 · Cited by 102
Epigenetic aberrations in human pluripotent stem cells
Bar, S., & Benvenisty, N. (2019) · The EMBO Journal · doi:10.15252/embj.2018101033 · Cited by 107
Convergent evolution of a vertebrate-like methylome in a marine sponge
de Mendoza, A., Hatleberg, W. L., Pang, K., Leininger, S., Bogdanović, O., Pflueger, J., Buckberry, S., Technau, U., Hejnol, A., Adamska, M., et al. (2019) · Nature Ecology & Evolution · doi:10.1038/s41559-019-0983-2 · Cited by 102
Detailed specificity analysis of antibodies binding to modified histone tails with peptide arrays
Bock, I., Dhayalan, A., Kudithipudi, S., Brandt, O., Rathert, P., & Jeltsch, A. (2011) · Epigenetics · doi:10.4161/epi.6.2.13837 · Cited by 104
The DmtA methyltransferase contributes to Aspergillus flavus conidiation, sclerotial production, aflatoxin biosynthesis and virulence
Yang, K., Liang, L., Ran, F., Liu, Y., Li, Z., Lan, H., Gao, P., Zhuang, Z., Zhang, F., Nie, X., et al. (2016) · Scientific Reports · doi:10.1038/srep23259 · Cited by 104
MeTDiff: A Novel Differential RNA Methylation Analysis for MeRIP-Seq Data
Cui, X., Zhang, L., Meng, J., Rao, M. K., Chen, Y., & Huang, Y. (2015) · IEEE Transactions on Computational Biology and Bioinformatics · doi:10.1109/tcbb.2015.2403355 · Cited by 104
Forensic individual age estimation with DNA: From initial approaches to methylation tests.
Freire-Aradas, A., Phillips, C., & Lareu, M. V. (2017) · PubMed · Cited by 104
Epigenetics and Obesity
Campión, J., Milagro, F. I., & Martínez, J. A. (2010) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-375003-7.00011-x · Cited by 106
Different Binding Properties and Function of CXXC Zinc Finger Domains in Dnmt1 and Tet1
Frauer, C., Rottach, A., Meilinger, D., Bultmann, S., Fellinger, K., Hasenöder, S., Wang, M., Qin, W., Söding, J., Spada, F., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016627 · Cited by 107
Mammalian Su(var) Genes in Chromatin Control
Fodor, B. D., Shukeir, N., Reuter, G., & Jenuwein, T. (2010) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113225 · Cited by 112
Effects of sleeping with reduced carbohydrate availability on acute training responses
Lane, S. C., Camera, D. M., Lassiter, D. G., Areta, J. L., Bird, S. R., Yeo, W. K., Jeacocke, N. A., Krook, A., Zierath, J. R., Burke, L. M., et al. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00857.2014 · Cited by 102
Variations in genomic DNA methylation during the long-term in vitro proliferation of oil palm embryogenic suspension cultures
Rival, A., Ilbert, P., Labeyrie, A., Torres, E., Doulbeau, S., Personne, A., Dussert, S., Beulé, T., Durand-Gasselin, T., Tregear, J. W., et al. (2012) · Plant Cell Reports · doi:10.1007/s00299-012-1369-y · Cited by 105
DNA Methylation of Specific CpG Sites in the Promoter Region Regulates the Transcription of the Mouse Oxytocin Receptor
Mamrut, S., Harony‐Nicolas, H., Sood, R., Shahar-Gold, H., Gainer, H., Shi, Y.-J., Barki‐Harrington, L., & Wagner, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056869 · Cited by 102
Combination therapy: Histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer
Diyabalanage, H. V. K., Granda, M. L., & Hooker, J. M. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.09.018 · Cited by 106
Epigenetic regulation of neurogenesis in the adult mammalian brain
Sun, J., Sun, J., Ming, G., & Song, H. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07607.x · Cited by 105
Origins of Shared Genetic Variation in African Cichlids
Loh, Y. E., Bezault, É., Muenzel, F. M., Roberts, R. B., Swofford, R., Barluenga, M., Kidd, C. E., Howe, A. E., Palma, F. D., Lindblad‐Toh, K., et al. (2012) · Molecular Biology and Evolution · doi:10.1093/molbev/mss326 · Cited by 101
Chromosome 7 gain and DNA hypermethylation at the HOXA10 locus are associated with expression of a stem cell related HOX-signature in glioblastoma
Kurscheid, S., Bady, P., Sciuscio, D., Samaržija, I., Shay, T., Vassallo, I., Criekinge, W. V., Daniel, R. T., van den Bent, M. J., Marosi, C., et al. (2015) · Genome biology · doi:10.1186/s13059-015-0583-7 · Cited by 100
Genetic background and embryonic temperature affect DNA methylation and expression of myogenin and muscle development in Atlantic salmon (Salmo salar)
Burgerhout, E., Mommens, M., Johnsen, H., Aunsmo, A., Santi, N., & Andersen, Ø. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179918 · Cited by 107
Toward a Mechanistic Understanding of DNA Methylation Readout by Transcription Factors
Kribelbauer, J. F., Lu, X., Rohs, R., Mann, R. S., & Bussemaker, H. J. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.10.021 · Cited by 101
Phosphorylation of RelA/p65 promotes DNMT-1 recruitment to chromatin and represses transcription of the tumor metastasis suppressor gene BRMS1
Liu, Y., Mayo, M. W., Nagji, A. S., Smith, P. W., Ramsey, C. S., Li, D., & Jones, D. R. (2011) · Oncogene · doi:10.1038/onc.2011.308 · Cited by 101
A new strategy for methylated DNA detection based on photoelectrochemical immunosensor using Bi2S3 nanorods, methyl bonding domain protein and anti-his tag antibody
Yin, H., Sun, B., Zhou, Y., Wang, M., Xu, Z., Fu, Z., & Ai, S. (2013) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2013.07.040 · Cited by 100
Methylome Diversification through Changes in DNA Methyltransferase Sequence Specificity
Furuta, Y., Namba-Fukuyo, H., Shibata, T., Nishiyama, T., Shigenobu, S., Suzuki, Y., Sugano, S., Hasebe, M., & Kobayashi, I. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004272 · Cited by 97
Emerging Molecular and Biological Functions of MBD2, a Reader of DNA Methylation
Wood, K. H., & Zhou, Z. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00093 · Cited by 104
Global DNA hypomethylation in cancer: review of validated methods and clinical significance
Toraño, E. G., Petrus-Reurer, S., Fernández, A. F., & Fraga, M. F. (2012) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2011-0902 · Cited by 101
Genome-wide profiling of DNA methylation and gene expression in Crassostrea gigas male gametes
Olson, C. E., & Roberts, S. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00224 · Cited by 99
TGF-β signal transduction spreading to a wider field: a broad variety of mechanisms for context-dependent effects of TGF-β
Ikushima, H., & Miyazono, K. (2011) · Cell and Tissue Research · doi:10.1007/s00441-011-1179-5 · Cited by 97
Genome‐wide DNA methylation profiling
Bibikova, M. V., & Fan, J. (2009) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.35 · Cited by 99
Molecular Mechanisms of p53 Deregulation in Cancer: An Overview in Multiple Myeloma
Herrero, A. B., Rojas, E. A., Misiewicz-Krzemińska, I., Krzemiński, P., & Gutierrez, N. C. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122003 · Cited by 102
Evolving Role of MeCP2 in Rett syndrome and Autism
LaSalle, J. M., & Yasui, D. H. (2009) · Epigenomics · doi:10.2217/epi.09.13 · Cited by 98
Comprehensive DNA methylation and hydroxymethylation analysis in the human brain and its implication in mental disorders
Kato, T., & Iwamoto, K. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.12.019 · Cited by 100
Differential Methylation during Maize Leaf Growth Targets Developmentally Regulated Genes
Candaele, J., Demuynck, K., Mosoti, D., Beemster, G. T. S., Inzé, D., & Nelissen, H. (2014) · PLANT PHYSIOLOGY · doi:10.1104/pp.113.233312 · Cited by 97
VEZF1 Elements Mediate Protection from DNA Methylation
Dickson, J. H., Gowher, H., Strogantsev, R., Gaszner, M., Hair, A., Felsenfeld, G., & West, A. G. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000804 · Cited by 97
Functional Conservation of DNA Methylation in the Pea Aphid and the Honeybee
Hunt, B. G., Brisson, J. A., Yi, S. V., & Goodisman, M. A. D. (2010) · Genome Biology and Evolution · doi:10.1093/gbe/evq057 · Cited by 99
Methylation profiles of 22 candidate genes in breast cancer using high-throughput MALDI-TOF mass array
Radpour, R., Kohler, C., Haghighi, M. M., Fan, A. X., Holzgreve, W., & Zhong, X. (2009) · Oncogene · doi:10.1038/onc.2009.149 · Cited by 97
Repeat elements and the Arabidopsis DNA methylation landscape
Teixeira, F. K., & Colot, V. (2010) · Heredity · doi:10.1038/hdy.2010.52 · Cited by 103
The DNA methylome
Pelizzola, M., & Ecker, J. R. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.10.061 · Cited by 102
CHD1 Remodels Chromatin and Influences Transient DNA Methylation at the Clock Gene frequency
Belden, W. J., Lewis, Z., Selker, E. U., Loros, J., & Dunlap, J. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002166 · Cited by 99
Neuroepigenetics and addiction
Walker, D. M., & Nestler, E. J. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64076-5.00048-x · Cited by 101
Current Insights into Oral Cancer Epigenetics
Irimie, A. I., Ciocan, C. A., Gulei, D., Mehterov, N. H., Atanasov, A. G., Dudea, D., & Berindan‐Neagoe, I. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030670 · Cited by 101
4mCpred-EL: An Ensemble Learning Framework for Identification of DNA N4-Methylcytosine Sites in the Mouse Genome
Manavalan, B., Basith, S., Shin, T. H., Lee, D. Y., Wei, L., & Lee, G. (2019) · Cells · doi:10.3390/cells8111332 · Cited by 95
Many paths to one goal? The proteins that recognize methylated DNA in eukaryotes
Sasai, N., & Defossez, P. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082652ns · Cited by 108
Comparative Analyses of DNA Methylation and Sequence Evolution Using Nasonia Genomes
Park, J., Peng, Z., Zeng, J., Elango, N., Park, T., Wheeler, D. A., Werren, J. H., & Yi, S. V. (2011) · Molecular Biology and Evolution · doi:10.1093/molbev/msr168 · Cited by 95
Synthesizing the role of epigenetics in the response and adaptation of species to climate change in freshwater ecosystems
Jeremias, G., Barbosa, J., Marques, S. M., Asselman, J., Gonçalves, F. J. M., & Pereira, J. L. (2018) · Molecular Ecology · doi:10.1111/mec.14727 · Cited by 93
The DNA methylation landscape of small cell lung cancer suggests a differentiation defect of neuroendocrine cells
Kalari, S. K., Jung, M., Kernstine, K. H., Takahashi, T., & Pfeifer, G. P. (2012) · Oncogene · doi:10.1038/onc.2012.362 · Cited by 92
MECP2, a multi-talented modulator of chromatin architecture
Ragione, F. D., Vacca, M., Fioriniello, S., Pepe, G., & D’Esposito, M. (2016) · Briefings in Functional Genomics · doi:10.1093/bfgp/elw023 · Cited by 95
Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancerPreprint
Matsumura, N., Huang, Z., Mori, S., Baba, T., Fujii, S., Konishi, I., Iversen, E. S., Berchuck, A., & Murphy, S. K. (2010) · Genome Research · doi:10.1101/gr.108803.110 · Cited by 95
The Interplay between DNA Methylation, Folate and Neurocognitive Development
Irwin, R. E., Pentieva, K. D., Cassidy, T., Lees‐Murdock, D. J., McLaughlin, M., Prasad, G., McNulty, H., & Walsh, C. P. (2016) · Epigenomics · doi:10.2217/epi-2016-0003 · Cited by 98
Epigenetic impacts of endocrine disruptors in the brain
Walker, D. M., & Gore, A. C. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.09.002 · Cited by 94
The evolving functions of DNA methylation
Zilberman, D. (2008) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2008.07.004 · Cited by 94
Discovery of Novel Hypermethylated Genes in Prostate Cancer Using Genomic CpG Island Microarrays
Kron, K. J., Pethe, V. V., Briollais, L., Sadiković, B., Özçelik, H., Sunderji, A., Venkateswaran, V., Pinthus, J. H., Fleshner, N. E., van der Kwast, T., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004830 · Cited by 91
A Comparison of the Whole Genome Approach of MeDIP-Seq to the Targeted Approach of the Infinium HumanMethylation450 BeadChip® for Methylome Profiling
Clark, C., Palta, P., Joyce, C. J., Scott, C., Grundberg, E., Deloukas, P., Palotie, A. V., & Coffey, A. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050233 · Cited by 94
A DNA 3′ Phosphatase Functions in Active DNA Demethylation in Arabidopsis
Martínez-Macías, M. I., Qian, W., Miki, D., Pontes, O., Liu, Y., Tang, K., Liu, R., Morales‐Ruíz, T., Ariza, R. R., Roldán‐Arjona, T., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2011.11.034 · Cited by 93
Chromatin regulation in drug addiction and depression
Renthal, W. R., & Nestler, E. J. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.3/wrenthal · Cited by 92
Unlocking epigenetic codes in neurogenesisPreprint
Yao, B., & Jin, P. (2014) · Genes & Development · doi:10.1101/gad.241547.114 · Cited by 97
From development to diseases: The role of 5hmC in brain
Sun, W., Zang, L., Shu, Q., & Li, X. (2014) · Genomics · doi:10.1016/j.ygeno.2014.08.021 · Cited by 96
DNA methylation and methylcytosine oxidation in cell fate decisions
Koh, K. P., & Rao, A. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2013.02.014 · Cited by 96
Biocommunication of Fungi
Palková, Z., & Váchová, L. (. (2012) · Springer eBooks · doi:10.1007/978-94-007-4264-2 · Cited by 93
Two thymidine hydroxylases differentially regulate the formation of glucosylated DNA at regions flanking polymerase II polycistronic transcription units throughout the genome of Trypanosoma brucei
Cliffe, L. J., Siegel, T. N., Marshall, M., Cross, G., & Sabatini, R. S. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq146 · Cited by 92
Epigenetic Impacts on Neurodevelopment: Pathophysiological Mechanisms and Genetic Modes of Action
Zahir, F., & Brown, C. J. (2011) · Pediatric Research · doi:10.1203/pdr.0b013e318213565e · Cited by 93
Molecular inversion probe-based SPR biosensing for specific, label-free and real-time detection of regional DNA methylation
Carrascosa, L. G., Sina, A. A. I., Palanisamy, R., Sepúlveda, B., Otte, M. A., Rauf, S., Shiddiky, M. J. A., & Trau, M. (2014) · Chemical Communications · doi:10.1039/c3cc49607d · Cited by 92
The Function of Intragenic DNA Methylation: Insights from Insect Epigenomes
Hunt, B. G., Glastad, K. M., Yi, S. V., & Goodisman, M. A. D. (2013) · Integrative and Comparative Biology · doi:10.1093/icb/ict003 · Cited by 95
Biological Functions of Methyl-CpG-Binding Proteins
Defossez, P., & Stancheva, I. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-387685-0.00012-3 · Cited by 102
Exposing the DNA methylome iceberg
Ndlovu, ’. N., Denis, H., & Fuks, F. (2011) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2011.03.002 · Cited by 90
Transgenerational Epigenetic Contributions to Stress Responses: Fact or Fiction?
Nestler, E. J. (2016) · PLoS Biology · doi:10.1371/journal.pbio.1002426 · Cited by 94
Global DNA methylation variations after short-term heat shock treatment in cultured microspores of Brassica napus cv. Topas
Li, J., Huang, Q., Sun, M., Zhang, T., Li, H., Chen, B., Xu, K., Gao, G., Li, F., Yan, G., et al. (2016) · Scientific Reports · doi:10.1038/srep38401 · Cited by 90
Acceleration of 5-Methylcytosine Deamination in Cyclobutane Dimers by G and Its Implications for UV-Induced C-to-T Mutation Hotspots
Cannistraro, V. J., & Taylor, J. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.07.048 · Cited by 91
Epigenetic regulation in neural crest development
Hu, N., Strobl‐Mazzulla, P. H., & Bronner-Fraser, M. E. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.09.034 · Cited by 95
Engineering of a Histone-Recognition Domain in Dnmt3a Alters the Epigenetic Landscape and Phenotypic Features of Mouse ESCs
Noh, K., Wang, H., Kim, H. R., Wenderski, W., Fang, F., Li, C. H., Dewell, S. B., Hughes, S. H., Melnick, A. M., Patel, D. J., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.05.017 · Cited by 93
Toxicological evaluation of microcystins in aquatic fish species: Current knowledge and future directions
Pavagadhi, S., & Balasubramanian‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬, R. (2013) · Aquatic Toxicology · doi:10.1016/j.aquatox.2013.07.010 · Cited by 91
Genome-wide DNA methylation profiles changes associated with constant heat stress in pigs as measured by bisulfite sequencing
Hao, Y., Cui, Y., & Gu, X. (2016) · Scientific Reports · doi:10.1038/srep27507 · Cited by 95
DNA Methylation Markers for Pan-Cancer Prediction by Deep Learning
Liu, B., Liu, Y., Pan, X., Li, M., Yang, S., & Li, S. C. (2019) · Genes · doi:10.3390/genes10100778 · Cited by 87
Sensing, Imaging, and Therapeutic Strategies Endowing by Conjugate Polymers for Precision Medicine
Shen, Q., Song, G., Lin, H., Bai, H., Huang, Y., Lv, F., & Wang, S. (2024) · Advanced Materials · doi:10.1002/adma.202310032 · Cited by 89
Alterations in global DNA methylation and hydroxymethylation are not detected in A lzheimer's disease
Lashley, T., Gami‐Patel, P., Valizadeh, N., Li, A., Révész, T., & Balázs, R. (2014) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12183 · Cited by 92
DNA Methylation in Cancer: A Gene Silencing Mechanism and the Clinical Potential of Its Biomarkers
Fukushige, S., & Horii, A. (2013) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.229.173 · Cited by 88
Methylation changes associated with early maturation stages in the Atlantic salmon
Morán, P., & Pérez‐Figueroa, A. (2011) · BMC Genetics · doi:10.1186/1471-2156-12-86 · Cited by 88
Epigenetic Effects Induced by Methamphetamine and Methamphetamine-Dependent Oxidative Stress
Limanaqi, F., Gambardella, S., Biagioni, F., Busceti, C., & Fornai, F. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/4982453 · Cited by 84
Lifestyle modifications: coordinating the tRNA epitranscriptome with codon bias to adapt translation during stress responses
Chan, C. S. C., Pham, P., Dedon, P. C., & Begley, T. J. (2018) · Genome biology · doi:10.1186/s13059-018-1611-1 · Cited by 86
Helicobacter pylori CagA: From Pathogenic Mechanisms to Its Use as an Anti-Cancer Vaccine
Stein, M., Ruggiero, P., Rappuoli, R., & Bagnoli, F. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00328 · Cited by 90
Metabolic Memory and Chronic Diabetes Complications: Potential Role for Epigenetic Mechanisms
Intine, R. V. A., & Sarras, M. P. (2012) · Current Diabetes Reports · doi:10.1007/s11892-012-0302-7 · Cited by 89
Plant systems biology: insights, advances and challenges
Sheth, B. P., & Thaker, V. S. (2014) · Planta · doi:10.1007/s00425-014-2059-5 · Cited by 89
Dietary polyphenols and chromatin remodeling
Russo, G. L., Vastolo, V., Ciccarelli, M., Albano, L., Macchia, P. E., & Ungaro, P. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2015.1062353 · Cited by 90
Readers of DNA methylation, the MBD family as potential therapeutic targets
Ginder, G. D., & Williams, D. C. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.11.002 · Cited by 92
DNA N6-methyladenine in metazoans: functional epigenetic mark or bystander?
Luo, G.-Z., & He, C. (2017) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3412 · Cited by 87
Low temperature-induced DNA hypermethylation attenuates expression of RhAG, an AGAMOUS homolog, and increases petal number in rose (Rosa hybrida)
Ma, N., Chen, W., Tiangang, F., Tian, Y., Zhang, S., Zeng, D., & Li, Y. (2015) · BMC Plant Biology · doi:10.1186/s12870-015-0623-1 · Cited by 87
Histone modifications and methyl-CpG-binding domain protein levels at the TNFSF7 (CD70) promoter in SLE CD4+ T cells
Zhou, Y., Qiu, X., Luo, Y., Yuan, J., Li, Y., Zhong, Q., Zhao, M., & Lu, Q. (2011) · Lupus · doi:10.1177/0961203311413412 · Cited by 91
Transcriptional and epigenetic networks of helper T and innate lymphoid cells
Shih, H., Sciumè, G., Poholek, A. C., Vahedi, G., Hirahara, K., Villarino, A. V., Bonelli, M. M., Bosselut, R., Kanno, Y., Muljo, S. A., et al. (2014) · Immunological Reviews · doi:10.1111/imr.12208 · Cited by 91
Differential methylation in CN-AML preferentially targets non-CGI regions and is dictated byDNMT3Amutational status and associated with predominant hypomethylation of HOX genes
Qu, Y., Lennartsson, A., Gaidzik, V. I., Deneberg, S., Karimi, M., Bengtzén, S., Höglund, M., Bullinger, L., Döhner, K., & Lehmann, S. (2014) · Epigenetics · doi:10.4161/epi.29315 · Cited by 92
Universality of the DNA methylation codes in Eucaryotes
Aliaga, B., Bulla, I., Mouahid, G., Duval, D., & Grunau, C. (2019) · Scientific Reports · doi:10.1038/s41598-018-37407-8 · Cited by 88
Epigenetic Mechanisms of Neurodegeneration in Huntington's Disease
Lee, J.-H., Hwang, Y. J., Kim, K. Y., Kowall, N. W., & Ryu, H. (2013) · Neurotherapeutics · doi:10.1007/s13311-013-0206-5 · Cited by 90
DNA Methylation Signatures of Mood Stabilizers and Antipsychotics in Bipolar Disorder
Houtepen, L. C., van Bergen, A. H., Vinkers, C. H., & Boks, M. P. (2016) · Epigenomics · doi:10.2217/epi.15.98 · Cited by 90
Epigenetic modifications induced by early enrichment are associated with changes in timing of induction of BDNF expression
Branchi, I., Karpova, N. N., D’Andrea, I., Castrén, E., & Alleva, E. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.03.038 · Cited by 87
Measuring quantitative effects of methylation on transcription factor–DNA binding affinity
Zuo, Z., Roy, B., Chang, Y. K., Granas, D., & Stormo, G. D. (2017) · Science Advances · doi:10.1126/sciadv.aao1799 · Cited by 86
The methylome of the marbled crayfish links gene body methylation to stable expression of poorly accessible genes
Gatzmann, F., Falckenhayn, C., Gutekunst, J., Hanna, K., Raddatz, G., Carneiro, V. C., & Lyko, F. (2018) · Epigenetics & Chromatin · doi:10.1186/s13072-018-0229-6 · Cited by 85
The Epigenetic Effects of Prenatal Cadmium Exposure
Vilahur, N., Vahter, M., & Bröberg, K. (2015) · Current Environmental Health Reports · doi:10.1007/s40572-015-0049-9 · Cited by 87
Embryonic exposure to benzo(a)pyrene inhibits reproductive capability in adult female zebrafish and correlation with DNA methylation
Gao, D., Lin, J., Ou, K., Chen, Y., Li, H., Dai, Q., Yu, Z., Zuo, Z., & Wang, C. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.04.139 · Cited by 86
Adult porcine genome-wide DNA methylation patterns support pigs as a biomedical model
Schachtschneider, K. M., Madsen, O., Park, C., Rund, L. A., Groenen, M. A. M., & Schook, L. B. (2015) · BMC Genomics · doi:10.1186/s12864-015-1938-x · Cited by 84
Current and Future Prospects for Epigenetic Biomarkers of Substance Use Disorders
Andersen, A. M., Dogan, M. V., Beach, S. R. H., & Philibert, R. A. (2015) · Genes · doi:10.3390/genes6040991 · Cited by 88
The concerted impact of domestication and transposon insertions on methylation patterns between dogs and grey wolves
Koch, I. J., Clark, M. M., Thompson, M. J., Deere, K. A., Wang, J., Duarte, L., Gnanadesikan, G. E., McCoy, E. L., Rubbi, L., Stahler, D. R., et al. (2015) · Molecular Ecology · doi:10.1111/mec.13480 · Cited by 88
Tools and Strategies for Analysis of Genome-Wide and Gene-Specific DNA Methylation Patterns
Chatterjee, A., Rodger, E. J., Morison, I. M., Eccles, M. R., & Stockwell, P. A. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6685-1_15 · Cited by 84

Authors: Suzuki, M. M., & Bird, A.
Affiliations: Wellcome Centre for Cell Biology (GB)
Corresponding author: Suzuki, Miho M.
ORCID: Suzuki, Miho M.
Bird, Adrian
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2008-06
Volume: 9
Issue: 6
Pages: 465-476
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/nrg2341
OpenAlex: W2114970231
Cited by: 3,039
References: 108
Citations by year: 2026: 61 · 2025: 89 · 2024: 120 · 2023: 128 · 2022: 167 · 2021: 236 · 2020: 184 · 2019: 163 · 2018: 173 · 2017: 201 · 2016: 195 · 2015: 195 · 2014: 224 · 2013: 214 · 2012: 198
FWCI: 12.51
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
Keywords: DNA methylation, gene body, promoter methylation, gene silencing, gene expression regulation, epigenomics, cytosine methylation, development (biology), genome-wide methylation mapping
MeSH terms: Animals, Humans, Transcription, Genetic, Genome, DNA Methylation, Genomics, Epigenesis, Genetic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

DNA methylation landscapes: provocative insights from epigenomics

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks